dbPTM

UBP34_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP34_HUMAN
UniProt AC	Q70CQ2
Protein Name	Ubiquitin carboxyl-terminal hydrolase 34
Gene Name	USP34
Organism	Homo sapiens (Human).
Sequence Length	3546
Subcellular Localization
Protein Description	Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins..
Protein Sequence	MCENCADLVEVLNEISDVEGGDGLQLRKEHTLKIFTYINSWTQRQCLCCFKEYKHLEIFNQVVCALINLVIAQVQVLRDQLCKHCTTINIDSTWQDESNQAEEPLNIDRECNEGSTERQKSIEKKSNSTRICNLTEEESSKSSDPFSLWSTDEKEKLLLCVAKIFQIQFPLYTAYKHNTHPTIEDISTQESNILGAFCDMNDVEVPLHLLRYVCLFCGKNGLSLMKDCFEYGTPETLPFLIAHAFITVVSNIRIWLHIPAVMQHIIPFRTYVIRYLCKLSDQELRQSAARNMADLMWSTVKEPLDTTLCFDKESLDLAFKYFMSPTLTMRLAGLSQITNQLHTFNDVCNNESLVSDTETSIAKELADWLISNNVVEHIFGPNLHIEIIKQCQVILNFLAAEGRLSTQHIDCIWAAAQLKHCSRYIHDLFPSLIKNLDPVPLRHLLNLVSALEPSVHTEQTLYLASMLIKALWNNALAAKAQLSKQSSFASLLNTNIPIGNKKEEEELRRTAPSPWSPAASPQSSDNSDTHQSGGSDIEMDEQLINRTKHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHSDGSSNEVNSSHASQSAGSPGSEVQSEDIADIEALKEEDEDDDHGHNPPKSSCGTDLRNRKLESQAGICLGDSQGMSERNGTSSGTGKDLVFNTESLPSVDNRMRMLDACSHSEDPEHDISGEMNATHIAQGSQESCITRTGDFLGETIGNELFNCRQFIGPQHHHHHHHHHHHHDGHMVDDMLSADDVSCSSSQVSAKSEKNMADFDGEESGCEEELVQINSHAELTSHLQQHLPNLASIYHEHLSQGPVVHKHQFNSNAVTDINLDNVCKKGNTLLWDIVQDEDAVNLSEGLINEAEKLLCSLVCWFTDRQIRMRFIEGCLENLGNNRSVVISLRLLPKLFGTFQQFGSSYDTHWITMWAEKELNMMKLFFDNLVYYIQTVREGRQKHALYSHSAEVQVRLQFLTCVFSTLGSPDHFRLSLEQVDILWHCLVEDSECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCNLARLATSAYDGCSNSELCGMDQFWGIALRAQSGDVSRAAIQYINSYYINGKTGLEKEQEFISKCMESLMIASSSLEQESHSSLMVIERGLLMLKTHLEAFRRRFAYHLRQWQIEGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEMYPSDQVADLRAEVTHWYENLQKEQINQQAQLQEFGQSNRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAPRRERKGEGVQLPASCLPPPQKDNIPMLLLLQEPHLTTLFDLLEMLASFKPPSGKVAVDDSESLRCEELHLHAENLSRRVWELLMLLPTCPNMLMAFQNISDEQSNDGFNWKELLKIKSAHKLLYALEIIEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVENSKNSWSCKFVAAGGLQQLLEIFNSGILEPKEQESWTVWQLDCLACLLKLICQFAVDPSDLDLAYHDVFAWSGIAESHRKRTWPGKSRKAAGDHAKGLHIPRLTEVFLVLVQGTSLIQRLMSVAYTYDNLAPRVLKAQSDHRSRHEVSHYSMWLLVSWAHCCSLVKSSLADSDHLQDWLKKLTLLIPETAVRHESCSGLYKLSLSGLDGGDSINRSFLLLAASTLLKFLPDAQALKPIRIDDYEEEPILKPGCKEYFWLLCKLVDNIHIKDASQTTLLDLDALARHLADCIRSREILDHQDGNVEDDGLTGLLRLATSVVKHKPPFKFSREGQEFLRDIFNLLFLLPSLKDRQQPKCKSHSSRAAAYDLLVEMVKGSVENYRLIHNWVMAQHMQSHAPYKWDYWPHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPEARQAVFTAKYSEDMKHKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIEEMSPELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVADMKNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMGKSERKEGFKEVSDHSKDSESYEYDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGEMTTKTYDSVTDKFMDFSFEKTHSAYMLFYKRMEPEEENGREYKFDVSSELLEWIWHDNMQFLQDKNIFEHTYFGFMWQLCSCIPSTLPDPKAVSLMTAKLSTSFVLETFIHSKEKPTMLQWIELLTKQFNNSQAACEWFLDRMADDDWWPMQILIKCPNQIVRQMFQRLCIHVIQRLRPVHAHLYLQPGMEDGSDDMDTSVEDIGGRSCVTRFVRTLLLIMEHGVKPHSKHLTEYFAFLYEFAKMGEEESQFLLSLQAISTMVHFYMGTKGPENPQVEVLSEEEGEEEEEEEDILSLAEEKYRPAALEKMIALVALLVEQSRSERHLTLSQTDMAALTGGKGFPFLFQHIRDGINIRQTCNLIFSLCRYNNRLAEHIVSMLFTSIAKLTPEAANPFFKLLTMLMEFAGGPPGMPPFASYILQRIWEVIEYNPSQCLDWLAVQTPRNKLAHSWVLQNMENWVERFLLAHNYPRVRTSAAYLLVSLIPSNSFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNVLLGLLSRAKLYVDAAVHGTTKLVPYFSFMTYCLISKTEKLMFSTYFMDLWNLFQPKLSEPAIATNHNKQALLSFWYNVCADCPENIRLIVQNPVVTKNIAFNYILADHDDQDVVLFNRGMLPAYYGILRLCCEQSPAFTRQLASHQNIQWAFKNLTPHASQYPGAVEELFNLMQLFIAQRPDMREEELEDIKQFKKTTISCYLRCLDGRSCWTTLISAFRILLESDEDRLLVVFNRGLILMTESFNTLHMMYHEATACHVTGDLVELLSIFLSVLKSTRPYLQRKDVKQALIQWQERIEFAHKLLTLLNSYSPPELRNACIDVLKELVLLSPHDFLHTLVPFLQHNHCTYHHSNIPMSLGPYFPCRENIKLIGGKSNIRPPRPELNMCLLPTMVETSKGKDDVYDRMLLDYFFSYHQFIHLLCRVAINCEKFTETLVKLSVLVAYEGLPLHLALFPKLWTELCQTQSAMSKNCIKLLCEDPVFAEYIKCILMDERTFLNNNIVYTFMTHFLLKVQSQVFSEANCANLISTLITNLISQYQNLQSDFSNRVEISKASASLNGDLRALALLLSVHTPKQLNPALIPTLQELLSKCRTCLQQRNSLQEQEAKERKTKDDEGATPIKRRRVSSDEEHTVDSCISDMKTETREVLTPTSTSDNETRDSSIIDPGTEQDLPSPENSSVKEYRMEVPSSFSEDMSNIRSQHAEEQSNNGRYDDCKEFKDLHCSKDSTLAEEESEFPSTSISAVLSDLADLRSCDGQALPSQDPEVALSLSCGHSRGLFSHMQQHDILDTLCRTIESTIHVVTRISGKGNQAAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	DSTWQDESNQAEEPL CCCCCCCCCCCCCCC	42.40	30576142
135	Phosphorylation	STRICNLTEEESSKS CCCCCCCCHHHHCCC	27.62	22210691
141	Ubiquitination	LTEEESSKSSDPFSL CCHHHHCCCCCCCCC	64.36	29967540
142	Phosphorylation	TEEESSKSSDPFSLW CHHHHCCCCCCCCCC	41.75	28851738
143	Phosphorylation	EEESSKSSDPFSLWS HHHHCCCCCCCCCCC	53.70	28851738
147	Phosphorylation	SKSSDPFSLWSTDEK CCCCCCCCCCCCCHH	34.03	28851738
150	Phosphorylation	SDPFSLWSTDEKEKL CCCCCCCCCCHHHHH	31.13	22210691
151	Phosphorylation	DPFSLWSTDEKEKLL CCCCCCCCCHHHHHH	36.27	22210691
154	Ubiquitination	SLWSTDEKEKLLLCV CCCCCCHHHHHHHHH	64.06	29967540
172	Phosphorylation	FQIQFPLYTAYKHNT HCCCCHHHCCCCCCC	6.91	26074081
173	Phosphorylation	QIQFPLYTAYKHNTH CCCCHHHCCCCCCCC	31.06	26074081
175	Phosphorylation	QFPLYTAYKHNTHPT CCHHHCCCCCCCCCC	12.65	26074081
179	Phosphorylation	YTAYKHNTHPTIEDI HCCCCCCCCCCHHHC	29.02	26074081
182	Phosphorylation	YKHNTHPTIEDISTQ CCCCCCCCHHHCCCC	29.42	26074081
187	Phosphorylation	HPTIEDISTQESNIL CCCHHHCCCCCHHCH	36.04	26074081
188	Phosphorylation	PTIEDISTQESNILG CCHHHCCCCCHHCHH	36.37	26074081
191	Phosphorylation	EDISTQESNILGAFC HHCCCCCHHCHHHCC	21.25	26074081
298	Phosphorylation	NMADLMWSTVKEPLD HHHHHHHHHCCCCCC	14.90	-
301	Ubiquitination	DLMWSTVKEPLDTTL HHHHHHCCCCCCCEE	54.42	29967540
307	Phosphorylation	VKEPLDTTLCFDKES CCCCCCCEECCCHHH	22.61	21815630
312	Acetylation	DTTLCFDKESLDLAF CCEECCCHHHHHHHH	29.02	7970957
321	Phosphorylation	SLDLAFKYFMSPTLT HHHHHHHHHHCCHHH	9.69	-
324	Phosphorylation	LAFKYFMSPTLTMRL HHHHHHHCCHHHHHH	12.58	-
326	Phosphorylation	FKYFMSPTLTMRLAG HHHHHCCHHHHHHHC	27.79	-
328	Phosphorylation	YFMSPTLTMRLAGLS HHHCCHHHHHHHCHH	11.61	-
333 (in isoform 2)	Ubiquitination	-	30.38	21890473
333 (in isoform 3)	Ubiquitination	-	30.38	21890473
352	Phosphorylation	NDVCNNESLVSDTET CHHCCCCCCCCCCCH	35.87	18669648
355	Phosphorylation	CNNESLVSDTETSIA CCCCCCCCCCCHHHH	44.07	18669648
357	Phosphorylation	NESLVSDTETSIAKE CCCCCCCCCHHHHHH	33.39	28348404
431	Phosphorylation	YIHDLFPSLIKNLDP HHHHHHHHHHHCCCC	35.08	24719451
465	Phosphorylation	EQTLYLASMLIKALW HHHHHHHHHHHHHHH	16.13	-
479	Ubiquitination	WNNALAAKAQLSKQS HHHHHHHHHHHHCHH	30.93	22817900
483	Phosphorylation	LAAKAQLSKQSSFAS HHHHHHHHCHHHHHH	19.30	28450419
484	Ubiquitination	AAKAQLSKQSSFASL HHHHHHHCHHHHHHH	63.89	22817900
484 (in isoform 1)	Ubiquitination	-	63.89	21890473
484 (in isoform 3)	Ubiquitination	-	63.89	21890473
486	Phosphorylation	KAQLSKQSSFASLLN HHHHHCHHHHHHHHC	31.03	28450419
487	Phosphorylation	AQLSKQSSFASLLNT HHHHCHHHHHHHHCC	23.49	23898821
490	Phosphorylation	SKQSSFASLLNTNIP HCHHHHHHHHCCCCC	31.23	28450419
494	Phosphorylation	SFASLLNTNIPIGNK HHHHHHCCCCCCCCC	34.20	23312004
498	Phosphorylation	LLNTNIPIGNKKEEE HHCCCCCCCCCHHHH	9.34	17525332
507	Phosphorylation	NKKEEEELRRTAPSP CCHHHHHHHHHCCCC	5.20	17525332
510	Phosphorylation	EEEELRRTAPSPWSP HHHHHHHHCCCCCCC	36.16	25137130
513	Phosphorylation	ELRRTAPSPWSPAAS HHHHHCCCCCCCCCC	36.22	25137130
516	Phosphorylation	RTAPSPWSPAASPQS HHCCCCCCCCCCCCC	14.19	25137130
527	Phosphorylation	SPQSSDNSDTHQSGG CCCCCCCCCCCCCCC	49.21	25137130
529	Phosphorylation	QSSDNSDTHQSGGSD CCCCCCCCCCCCCCC	22.95	25137130
532	Phosphorylation	DNSDTHQSGGSDIEM CCCCCCCCCCCCHHH	37.20	25137130
535	Phosphorylation	DTHQSGGSDIEMDEQ CCCCCCCCCHHHCHH	38.65	25137130
590	Phosphorylation	SGHSDGSSNEVNSSH CCCCCCCCCCCCHHH	42.41	-
649	Phosphorylation	LRNRKLESQAGICLG HHHCCHHHCCCEECC	35.45	17525332
658	Phosphorylation	AGICLGDSQGMSERN CCEECCCCCCCCCCC	27.17	17525332
667	Phosphorylation	GMSERNGTSSGTGKD CCCCCCCCCCCCCCC	24.22	20068231
668	Phosphorylation	MSERNGTSSGTGKDL CCCCCCCCCCCCCCC	28.33	20068231
669	Phosphorylation	SERNGTSSGTGKDLV CCCCCCCCCCCCCCE	39.96	20068231
671	Phosphorylation	RNGTSSGTGKDLVFN CCCCCCCCCCCCEEC	42.90	20068231
679	Phosphorylation	GKDLVFNTESLPSVD CCCCEECCCCCCCCC	18.58	20068231
681	Phosphorylation	DLVFNTESLPSVDNR CCEECCCCCCCCCHH	43.47	30576142
684	Phosphorylation	FNTESLPSVDNRMRM ECCCCCCCCCHHHHH	47.60	30576142
696	Phosphorylation	MRMLDACSHSEDPEH HHHHHHCCCCCCCCC	31.59	28348404
698	Phosphorylation	MLDACSHSEDPEHDI HHHHCCCCCCCCCCC	27.66	28348404
718	Phosphorylation	ATHIAQGSQESCITR HHHHCCCCHHHCCCC	20.77	17478428
721	Phosphorylation	IAQGSQESCITRTGD HCCCCHHHCCCCCCC	11.81	28348404
724	Phosphorylation	GSQESCITRTGDFLG CCHHHCCCCCCCCCC	26.89	28348404
827	Phosphorylation	LPNLASIYHEHLSQG CCCHHHHHHHHHHCC	9.92	-
832	Phosphorylation	SIYHEHLSQGPVVHK HHHHHHHHCCCCCCC	34.69	22468782
844	Phosphorylation	VHKHQFNSNAVTDIN CCCCCCCCCCCCEEC	27.70	-
857	Ubiquitination	INLDNVCKKGNTLLW ECHHHHHCCCCEEEE	60.47	29967540
858	Ubiquitination	NLDNVCKKGNTLLWD CHHHHHCCCCEEEEE	52.87	-
920	Phosphorylation	NNRSVVISLRLLPKL CCCEEEEEHHHHHHH	8.88	21060948
983 (in isoform 2)	Ubiquitination	-	36.18	21890473
983 (in isoform 3)	Ubiquitination	-	36.18	21890473
1039	Ubiquitination	FLNQVRSKDQHAMGM HHHHHHCCCCCCCCH	51.33	-
1048	Phosphorylation	QHAMGMETYKHLFLE CCCCCHHHHHHHHHH	29.04	20068231
1049	Phosphorylation	HAMGMETYKHLFLEK CCCCHHHHHHHHHHH	5.32	20068231
1129	Ubiquitination	NSYYINGKTGLEKEQ HHHHHCCCCCCHHHH	34.63	22817900
1134	Ubiquitination	NGKTGLEKEQEFISK CCCCCCHHHHHHHHH	70.51	22817900
1134 (in isoform 1)	Ubiquitination	-	70.51	21890473
1145	Phosphorylation	FISKCMESLMIASSS HHHHHHHHHHHCCCC	9.06	24043423
1150	Phosphorylation	MESLMIASSSLEQES HHHHHHCCCCCCCCC	14.99	24043423
1151	Phosphorylation	ESLMIASSSLEQESH HHHHHCCCCCCCCCC	29.89	24043423
1152	Phosphorylation	SLMIASSSLEQESHS HHHHCCCCCCCCCCH	33.17	24043423
1157	Phosphorylation	SSSLEQESHSSLMVI CCCCCCCCCHHHHHH	28.50	24043423
1159	Phosphorylation	SLEQESHSSLMVIER CCCCCCCHHHHHHHH	34.15	24043423
1160	Phosphorylation	LEQESHSSLMVIERG CCCCCCHHHHHHHHH	18.30	24043423
1194	Phosphorylation	RQWQIEGTGISSHLK HCCEEECCCHHHHHH	20.67	-
1197	Phosphorylation	QIEGTGISSHLKALS EEECCCHHHHHHHHC	17.04	-
1198	Phosphorylation	IEGTGISSHLKALSD EECCCHHHHHHHHCC	30.80	-
1204	Phosphorylation	SSHLKALSDKQSLPL HHHHHHHCCCCCCCE	47.85	-
1206	Ubiquitination	HLKALSDKQSLPLRV HHHHHCCCCCCCEEE	38.11	27667366
1208	Phosphorylation	KALSDKQSLPLRVVC HHHCCCCCCCEEEEE	37.38	24719451
1231	Phosphorylation	MTIEMYPSDQVADLR EEEEEECCHHHHHHH	24.16	27050516
1250	Ubiquitination	HWYENLQKEQINQQA HHHHHHHHHHHHHHH	55.54	29967540
1283	Phosphorylation	MGPVRMISSGHELTT CCCEEEECCCCCCCC	22.41	-
1284	Phosphorylation	GPVRMISSGHELTTD CCEEEECCCCCCCCC	32.99	-
1362	Phosphorylation	DLLEMLASFKPPSGK HHHHHHHCCCCCCCC	29.82	24719451
1375	Phosphorylation	GKVAVDDSESLRCEE CCEECCCHHHCCHHH	25.31	24300666
1377	Phosphorylation	VAVDDSESLRCEELH EECCCHHHCCHHHHH	25.68	20068231
1416 (in isoform 2)	Ubiquitination	-	54.91	21890473
1416 (in isoform 3)	Ubiquitination	-	54.91	21890473
1423 (in isoform 2)	Ubiquitination	-	12.59	21890473
1423 (in isoform 3)	Ubiquitination	-	12.59	21890473
1458	Phosphorylation	NRRIRRESTGSYSDL CCCCCCCCCCCCCCC	35.94	27273156
1459	Phosphorylation	RRIRRESTGSYSDLY CCCCCCCCCCCCCCC	25.95	30576142
1461	Phosphorylation	IRRESTGSYSDLYPD CCCCCCCCCCCCCCC	22.88	18669648
1462	Phosphorylation	RRESTGSYSDLYPDS CCCCCCCCCCCCCCC	13.93	25137130
1463	Phosphorylation	RESTGSYSDLYPDSD CCCCCCCCCCCCCCC	23.88	27273156
1466	Phosphorylation	TGSYSDLYPDSDDSS CCCCCCCCCCCCCCC	15.24	23090842
1469	Phosphorylation	YSDLYPDSDDSSEDQ CCCCCCCCCCCCHHH	38.52	27273156
1472	Phosphorylation	LYPDSDDSSEDQVEN CCCCCCCCCHHHHHH	40.39	27273156
1473	Phosphorylation	YPDSDDSSEDQVENS CCCCCCCCHHHHHHC	52.79	27273156
1480	Phosphorylation	SEDQVENSKNSWSCK CHHHHHHCCCCCHHH	21.51	27732954
1503	Phosphorylation	QLLEIFNSGILEPKE HHHHHHHCCCCCCCC	19.23	19060867
1560	O-linked_Glycosylation	AESHRKRTWPGKSRK HHHHHCCCCCCCCCC	38.76	30379171
1560	Phosphorylation	AESHRKRTWPGKSRK HHHHHCCCCCCCCCC	38.76	26074081
1564	Ubiquitination	RKRTWPGKSRKAAGD HCCCCCCCCCCCCCC	42.90	22817900
1565	O-linked_Glycosylation	KRTWPGKSRKAAGDH CCCCCCCCCCCCCCC	44.95	30379171
1565	Phosphorylation	KRTWPGKSRKAAGDH CCCCCCCCCCCCCCC	44.95	26074081
1567	Ubiquitination	TWPGKSRKAAGDHAK CCCCCCCCCCCCCCC	50.07	22817900
1567 (in isoform 1)	Ubiquitination	-	50.07	21890473
1574	Ubiquitination	KAAGDHAKGLHIPRL CCCCCCCCCCCCCCH	59.59	22817900
1574 (in isoform 1)	Ubiquitination	-	59.59	21890473
1603	Phosphorylation	QRLMSVAYTYDNLAP HHHHHHHHHHCCHHH	12.04	30576142
1604	Phosphorylation	RLMSVAYTYDNLAPR HHHHHHHHHCCHHHH	18.05	30576142
1646	Phosphorylation	CCSLVKSSLADSDHL HHHHHHHHCCCCHHH	23.12	22617229
1650	Phosphorylation	VKSSLADSDHLQDWL HHHHCCCCHHHHHHH	22.71	22617229
1658	Ubiquitination	DHLQDWLKKLTLLIP HHHHHHHHHHHHHCC	41.29	29967540
1714	Ubiquitination	LPDAQALKPIRIDDY CCCHHHCCCEECCCC	41.22	33845483
1721	Phosphorylation	KPIRIDDYEEEPILK CCEECCCCCCCCCCC	22.84	27642862
1728	Ubiquitination	YEEEPILKPGCKEYF CCCCCCCCCCHHHHH	39.83	29967540
1748	Ubiquitination	LVDNIHIKDASQTTL HHCCCCCCCCCCCCC	32.83	32015554
1751	Phosphorylation	NIHIKDASQTTLLDL CCCCCCCCCCCCCCH	37.89	17478428
1817 (in isoform 2)	Ubiquitination	-	1.67	21890473
1817 (in isoform 3)	Ubiquitination	-	1.67	21890473
1826	Phosphorylation	NLLFLLPSLKDRQQP HHHHHHHHHCCCCCC	48.28	24719451
1917 (in isoform 2)	Ubiquitination	-	45.63	-
1924	Phosphorylation	EARQAVFTAKYSEDM HHHHHHHHHHCCCHH	18.68	24732914
1949 (in isoform 2)	Ubiquitination	-	40.57	21890473
1949 (in isoform 3)	Ubiquitination	-	40.57	21890473
1950	Phosphorylation	MFTYLMESECKAYNP HHHHHHHHHHHHCCC	34.04	-
1951 (in isoform 2)	Ubiquitination	-	27.08	21890473
1951 (in isoform 3)	Ubiquitination	-	27.08	21890473
1962	Ubiquitination	YNPRPFCKTYTMDKQ CCCCCCCCEEECCCC	44.97	23503661
1968	Ubiquitination	CKTYTMDKQPLNTGE CCEEECCCCCCCCCC	42.89	32142685
1968 (in isoform 1)	Ubiquitination	-	42.89	21890473
1977	Ubiquitination	PLNTGEQKDMTEFFT CCCCCCCCHHHHHHH	45.20	29967540
1980	Phosphorylation	TGEQKDMTEFFTDLI CCCCCHHHHHHHHHH	39.51	27732954
1984	Phosphorylation	KDMTEFFTDLITKIE CHHHHHHHHHHHHHH	34.91	27732954
1988	Phosphorylation	EFFTDLITKIEEMSP HHHHHHHHHHHHHCH	33.01	27732954
1994	Phosphorylation	ITKIEEMSPELKNTV HHHHHHHCHHHHHHH	20.64	24719451
2010	Phosphorylation	SLFGGVITNNVVSLD HHHCCHHCCCEEEEC	20.52	-
2015	Phosphorylation	VITNNVVSLDCEHVS HHCCCEEEECCCHHH	17.76	-
2042	Phosphorylation	VADMKNIYESLDEVT HCCHHHHHHHCCEEE	14.62	-
2060	Phosphorylation	TLEGDNMYTCSHCGK CCCCCCEEECCCCCH	15.73	-
2067	Ubiquitination	YTCSHCGKKVRAEKR EECCCCCHHHHHHHH	54.19	23503661
2068	Ubiquitination	TCSHCGKKVRAEKRA ECCCCCHHHHHHHHH	23.41	23503661
2068 (in isoform 2)	Ubiquitination	-	23.41	21890473
2068 (in isoform 3)	Ubiquitination	-	23.41	21890473
2073	Ubiquitination	GKKVRAEKRACFKKL CHHHHHHHHHHHHHH	44.29	23503661
2085	Phosphorylation	KKLPRILSFNTMRYT HHHHHHHHHHCCEEE	17.68	28796482
2088	Phosphorylation	PRILSFNTMRYTFNM HHHHHHHCCEEEEEH	10.87	28796482
2091	Phosphorylation	LSFNTMRYTFNMVTM HHHHCCEEEEEHHHH	12.59	28796482
2092	Phosphorylation	SFNTMRYTFNMVTMM HHHCCEEEEEHHHHC	9.73	28796482
2097	Phosphorylation	RYTFNMVTMMKEKVN EEEEEHHHHCHHHCC	10.77	28796482
2100	Ubiquitination	FNMVTMMKEKVNTHF EEHHHHCHHHCCCCC	43.49	23000965
2100 (in isoform 1)	Ubiquitination	-	43.49	21890473
2102	Ubiquitination	MVTMMKEKVNTHFSF HHHHCHHHCCCCCCC	34.95	23000965
2102 (in isoform 1)	Ubiquitination	-	34.95	21890473
2116	Phosphorylation	FPLRLDMTPYTEDFL CCEECCCCCCCHHHC	16.89	-
2126	Ubiquitination	TEDFLMGKSERKEGF CHHHCCCCHHCCCCC	34.87	-
2127	Phosphorylation	EDFLMGKSERKEGFK HHHCCCCHHCCCCCC	36.58	28348404
2215	Phosphorylation	MTTKTYDSVTDKFMD CCCCCCCHHHHHCCC	19.26	21815630
2219	Ubiquitination	TYDSVTDKFMDFSFE CCCHHHHHCCCCCCC	32.97	23000965
2219 (in isoform 1)	Ubiquitination	-	32.97	21890473
2227	Ubiquitination	FMDFSFEKTHSAYML CCCCCCCHHCCEEEE	49.91	33845483
2255	Phosphorylation	EYKFDVSSELLEWIW EEECCCCHHHHHHHH	31.92	-
2304	Phosphorylation	PKAVSLMTAKLSTSF HHHHHHHHHHHCHHH	26.40	24719451
2334	Ubiquitination	QWIELLTKQFNNSQA HHHHHHHHHCCCCHH	53.51	-
2339	Phosphorylation	LTKQFNNSQAACEWF HHHHCCCCHHHHHHH	23.46	30631047
2357 (in isoform 2)	Ubiquitination	-	10.68	21890473
2357 (in isoform 3)	Ubiquitination	-	10.68	21890473
2363	Ubiquitination	WPMQILIKCPNQIVR CCHHHHHHCHHHHHH	39.95	-
2392	Phosphorylation	RPVHAHLYLQPGMED CCCEEEEECCCCCCC	8.07	30387612
2401	Phosphorylation	QPGMEDGSDDMDTSV CCCCCCCCCCCCCCH	42.64	29523821
2406	Phosphorylation	DGSDDMDTSVEDIGG CCCCCCCCCHHHCCC	28.21	29214152
2407	Phosphorylation	GSDDMDTSVEDIGGR CCCCCCCCHHHCCCH	21.17	29523821
2488	Phosphorylation	NPQVEVLSEEEGEEE CCCEEEECHHCCCCH	48.41	30278072
2503	Phosphorylation	EEEEDILSLAEEKYR HHHHHHHHHHHHHHC	26.35	29116813
2508	Ubiquitination	ILSLAEEKYRPAALE HHHHHHHHHCHHHHH	37.76	21906983
2508 (in isoform 1)	Ubiquitination	-	37.76	21890473
2509	Phosphorylation	LSLAEEKYRPAALEK HHHHHHHHCHHHHHH	25.71	29396449
2677	Phosphorylation	RFLLAHNYPRVRTSA HHHHHCCCHHHHHHH	5.20	-
2686	Phosphorylation	RVRTSAAYLLVSLIP HHHHHHHHHHHHHCC	10.57	24719451
2690	Phosphorylation	SAAYLLVSLIPSNSF HHHHHHHHHCCCCHH	22.13	24719451
2694	Phosphorylation	LLVSLIPSNSFRQMF HHHHHCCCCHHHHHH	37.81	24719451
2703	Phosphorylation	SFRQMFRSTRSLHIP HHHHHHHHCCCCCCC	19.53	24043423
2704	Phosphorylation	FRQMFRSTRSLHIPT HHHHHHHCCCCCCCC	21.74	24043423
2706	Phosphorylation	QMFRSTRSLHIPTRD HHHHHCCCCCCCCCC	25.12	24043423
2711	Phosphorylation	TRSLHIPTRDLPLSP CCCCCCCCCCCCCCC	35.89	24043423
2721	Phosphorylation	LPLSPDTTVVLHQVY CCCCCCCHHHHHHHH	18.92	-
2865	Phosphorylation	LRLCCEQSPAFTRQL HHHHHCCCHHHHHHH	8.90	-
2866 (in isoform 3)	Ubiquitination	-	30.96	21890473
2947	Phosphorylation	SCWTTLISAFRILLE HHHHHHHHHHHHHHC	25.19	24719451
2949 (in isoform 2)	Ubiquitination	-	3.89	21890473
3007	Phosphorylation	IFLSVLKSTRPYLQR HHHHHHHHCCHHHCC	26.03	24719451
3011	Phosphorylation	VLKSTRPYLQRKDVK HHHHCCHHHCCCCHH	16.51	24719451
3100	Ubiquitination	FPCRENIKLIGGKSN CCCCCCCEECCCCCC	45.71	23000965
3100 (in isoform 1)	Ubiquitination	-	45.71	21890473
3105	Ubiquitination	NIKLIGGKSNIRPPR CCEECCCCCCCCCCC	34.81	23000965
3108	Phosphorylation	LIGGKSNIRPPRPEL ECCCCCCCCCCCCCC	10.12	18669648
3126	Phosphorylation	LLPTMVETSKGKDDV ECCCCCCCCCCCCCH	25.07	30576142
3127	Phosphorylation	LPTMVETSKGKDDVY CCCCCCCCCCCCCHH	26.38	30576142
3195	Phosphorylation	LWTELCQTQSAMSKN HHHHHHHHHHHHCCH	24.40	30631047
3202 (in isoform 2)	Ubiquitination	-	25.99	-
3205	Ubiquitination	AMSKNCIKLLCEDPV HHCCHHHHHHHCCHH	37.29	29967540
3259	Phosphorylation	ANCANLISTLITNLI HHHHHHHHHHHHHHH	21.96	18669648
3322	Ubiquitination	TLQELLSKCRTCLQQ HHHHHHHHHHHHHHH	27.92	-
3339	Acetylation	SLQEQEAKERKTKDD HHHHHHHHHHCCCCC	58.25	20167786
3344	Ubiquitination	EAKERKTKDDEGATP HHHHHCCCCCCCCCC	67.24	24816145
3350	Phosphorylation	TKDDEGATPIKRRRV CCCCCCCCCCCCCCC	36.08	29255136
3353	Ubiquitination	DEGATPIKRRRVSSD CCCCCCCCCCCCCCC	40.84	23503661
3358	Phosphorylation	PIKRRRVSSDEEHTV CCCCCCCCCCCCCCH	30.20	29255136
3359	Phosphorylation	IKRRRVSSDEEHTVD CCCCCCCCCCCCCHH	46.30	29255136
3364	Phosphorylation	VSSDEEHTVDSCISD CCCCCCCCHHHHHHH	29.32	29255136
3367	Phosphorylation	DEEHTVDSCISDMKT CCCCCHHHHHHHCCC	14.71	23927012
3370	Phosphorylation	HTVDSCISDMKTETR CCHHHHHHHCCCCCE	35.66	23927012
3374	Phosphorylation	SCISDMKTETREVLT HHHHHCCCCCEEECC	35.63	23312004
3376	Phosphorylation	ISDMKTETREVLTPT HHHCCCCCEEECCCC	37.04	23927012
3381	Phosphorylation	TETREVLTPTSTSDN CCCEEECCCCCCCCC	29.69	29255136
3383	Phosphorylation	TREVLTPTSTSDNET CEEECCCCCCCCCCC	39.13	25159151
3384	Phosphorylation	REVLTPTSTSDNETR EEECCCCCCCCCCCC	27.41	23401153
3385	Phosphorylation	EVLTPTSTSDNETRD EECCCCCCCCCCCCC	42.45	29255136
3386	Phosphorylation	VLTPTSTSDNETRDS ECCCCCCCCCCCCCC	37.90	29255136
3390	Phosphorylation	TSTSDNETRDSSIID CCCCCCCCCCCCCCC	46.13	29255136
3393	Phosphorylation	SDNETRDSSIIDPGT CCCCCCCCCCCCCCC	21.83	23403867
3394	Phosphorylation	DNETRDSSIIDPGTE CCCCCCCCCCCCCCC	28.05	25159151
3400	Phosphorylation	SSIIDPGTEQDLPSP CCCCCCCCCCCCCCC	35.54	30266825
3406	Phosphorylation	GTEQDLPSPENSSVK CCCCCCCCCCCCCCC	52.74	29255136
3410	Phosphorylation	DLPSPENSSVKEYRM CCCCCCCCCCCEEEE	34.54	30266825
3411	Phosphorylation	LPSPENSSVKEYRME CCCCCCCCCCEEEEE	49.11	30266825
3415	Phosphorylation	ENSSVKEYRMEVPSS CCCCCCEEEEECCCC	15.00	18669648
3421	Phosphorylation	EYRMEVPSSFSEDMS EEEEECCCCCCHHHH	49.55	28555341
3422	Phosphorylation	YRMEVPSSFSEDMSN EEEECCCCCCHHHHH	27.07	24719451
3485	Phosphorylation	SDLADLRSCDGQALP HHHHHHHCCCCCCCC	24.69	25849741
3493	Phosphorylation	CDGQALPSQDPEVAL CCCCCCCCCCHHHHH	48.33	23186163
3501	Phosphorylation	QDPEVALSLSCGHSR CCHHHHHHHCCCCCC	14.43	23663014
3503	Phosphorylation	PEVALSLSCGHSRGL HHHHHHHCCCCCCCH	18.06	17525332
3507	Phosphorylation	LSLSCGHSRGLFSHM HHHCCCCCCCHHHHH	17.21	23663014

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
718	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1751	S	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBP34_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP34_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UFC1_HUMAN	UFC1	physical	22939629
UFM1_HUMAN	UFM1	physical	22939629
ZRAB2_HUMAN	ZRANB2	physical	22939629
UBQL1_HUMAN	UBQLN1	physical	22939629
UBXN7_HUMAN	UBXN7	physical	22939629
UCHL3_HUMAN	UCHL3	physical	22939629
UBQL2_HUMAN	UBQLN2	physical	22939629
UBXN1_HUMAN	UBXN1	physical	22939629
ANCHR_HUMAN	ZFYVE19	physical	22939629
UBQL4_HUMAN	UBQLN4	physical	22939629
VATB2_HUMAN	ATP6V1B2	physical	22939629
USP9X_HUMAN	USP9X	physical	22939629
UNK_HUMAN	UNK	physical	22939629
VPS4B_HUMAN	VPS4B	physical	22939629

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP34_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2488 AND THR-3381, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-352; SER-355; SER-3358;SER-3359 AND SER-3406, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1503, AND MASSSPECTROMETRY.	18187866 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-649 AND SER-658, ANDMASS SPECTROMETRY.	17525332 [Abstract]