UFC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UFC1_HUMAN
• UniProt AC: Q9Y3C8
• Protein Name: Ubiquitin-fold modifier-conjugating enzyme 1
• Gene Name: UFC1
• Organism: Homo sapiens (Human).
• Sequence Length: 167
• Protein Description: E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage..
• Protein Sequence: MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCNQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MADEATRR -------CCHHHHHH	10.80	-
17	Ubiquitination	VSEIPVLKTNAGPRD HHCCCEECCCCCCCC	39.71	32015554
33	Acetylation	ELWVQRLKEEYQSLI HHHHHHHHHHHHHHH	51.17	23749302
33	Ubiquitination	ELWVQRLKEEYQSLI HHHHHHHHHHHHHHH	51.17	23000965
33	Ubiquitination	ELWVQRLKEEYQSLI HHHHHHHHHHHHHHH	51.17	21890473
36	Phosphorylation	VQRLKEEYQSLIRYV HHHHHHHHHHHHHHH	12.42	22817900
38	Phosphorylation	RLKEEYQSLIRYVEN HHHHHHHHHHHHHHH	25.51	24719451
42	Phosphorylation	EYQSLIRYVENNKNA HHHHHHHHHHHCCCC	12.72	22817900
47	Ubiquitination	IRYVENNKNADNDWF HHHHHHCCCCCCCCE	66.16	29967540
60	Ubiquitination	WFRLESNKEGTRWFG CEEEEECCCCCEEEE	67.79	33845483
68	Ubiquitination	EGTRWFGKCWYIHDL CCCEEEEEEEEHHHH	16.48	32015554
114	Ubiquitination	AKMYRGGKICLTDHF EEEECCCEEEECCCC	32.82	29967540
114	Acetylation	AKMYRGGKICLTDHF EEEECCCEEEECCCC	32.82	25953088
116	S-nitrosocysteine	MYRGGKICLTDHFKP EECCCEEEECCCCHH	3.69	-
116	S-nitrosylation	MYRGGKICLTDHFKP EECCCEEEECCCCHH	3.69	19483679
118	Phosphorylation	RGGKICLTDHFKPLW CCCEEEECCCCHHHH	24.02	25159151
122	Acetylation	ICLTDHFKPLWARNV EEECCCCHHHHHCCC	35.46	21791702
122	Ubiquitination	ICLTDHFKPLWARNV EEECCCCHHHHHCCC	35.46	22817900
122	Ubiquitination	ICLTDHFKPLWARNV EEECCCCHHHHHCCC	35.46	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UFC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UFC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UFC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UFM1_HUMAN	UFM1	physical	15071506
UFM1_HUMAN	UFM1	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
UNK_HUMAN	UNK	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
USP9X_HUMAN	USP9X	physical	22939629
ANCHR_HUMAN	ZFYVE19	physical	22939629
VATB2_HUMAN	ATP6V1B2	physical	22939629
ZYX_HUMAN	ZYX	physical	22939629
VINC_HUMAN	VCL	physical	22939629
UFM1_HUMAN	UFM1	physical	24966333
CATA_HUMAN	CAT	physical	26344197
COX17_HUMAN	COX17	physical	26344197
ETFA_HUMAN	ETFA	physical	26344197
FKB1A_HUMAN	FKBP1A	physical	26344197
LDHB_HUMAN	LDHB	physical	26344197
LYPA2_HUMAN	LYPLA2	physical	26344197
NECP2_HUMAN	NECAP2	physical	26344197
NEDD8_HUMAN	NEDD8	physical	26344197
TAGL2_HUMAN	TAGLN2	physical	26344197
TALDO_HUMAN	TALDO1	physical	26344197
UFM1_HUMAN	UFM1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-122, AND MASS SPECTROMETRY.
PubMed: 19608861