NECP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NECP2_HUMAN
• UniProt AC: Q9NVZ3
• Protein Name: Adaptin ear-binding coat-associated protein 2
• Gene Name: NECAP2
• Organism: Homo sapiens (Human).
• Sequence Length: 263
• Subcellular Localization: Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell membrane. Colocalizes with AP-2 at the plasma membrane..
• Protein Description: Involved in endocytosis..
• Protein Sequence: MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIANMKKKEGAAGNPRVRPASTGGLSLLPPPPGGKTSTLIPPPGEQLAVGGSLVQPAVAPSSGGAPVPWPQPNPATADIWGDFTKSTGSTSSQTQPGTGWVQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MEESGYESVLCVK --CCCCCCEEEEEEC	17.82	27642862
19	Phosphorylation	VKPDVHVYRIPPRAT ECCCCEEEECCCCCC	6.48	25884760
54	Sulfoxidation	RITAKGQMAYIKLED EEEECCCEEEEEEEC	4.10	30846556
56	Phosphorylation	TAKGQMAYIKLEDRT EECCCEEEEEEECCC	8.01	28188228
58	Ubiquitination	KGQMAYIKLEDRTSG CCCEEEEEEECCCCC	32.90	-
58 (in isoform 2)	Ubiquitination	-	32.90	-
130	Ubiquitination	QDHFKWVKQQCEFAK HHHHHHHHHHHHHHH	33.27	-
130	Acetylation	QDHFKWVKQQCEFAK HHHHHHHHHHHHHHH	33.27	25953088
137	Ubiquitination	KQQCEFAKQAQNPDQ HHHHHHHHHCCCCCC	52.03	-
137 (in isoform 2)	Ubiquitination	-	52.03	-
137	Acetylation	KQQCEFAKQAQNPDQ HHHHHHHHHCCCCCC	52.03	25953088
153	Ubiquitination	PKLDLGFKEGQTIKL CCCCCCCCCCCEEEE	60.17	-
153	Methylation	PKLDLGFKEGQTIKL CCCCCCCCCCCEEEE	60.17	-
157	Phosphorylation	LGFKEGQTIKLNIAN CCCCCCCEEEEEEEC	30.82	22210691
166	Methylation	KLNIANMKKKEGAAG EEEEECCCCCCCCCC	61.57	115973871
181	Phosphorylation	NPRVRPASTGGLSLL CCCCCCCCCCCCCCC	30.21	29255136
182	Phosphorylation	PRVRPASTGGLSLLP CCCCCCCCCCCCCCC	37.06	30266825
186	Phosphorylation	PASTGGLSLLPPPPG CCCCCCCCCCCCCCC	31.00	30266825
246	Phosphorylation	IWGDFTKSTGSTSSQ EECCCCCCCCCCCCC	34.64	23186163
251	Phosphorylation	TKSTGSTSSQTQPGT CCCCCCCCCCCCCCC	23.34	23186163
252	Phosphorylation	KSTGSTSSQTQPGTG CCCCCCCCCCCCCCC	37.02	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NECP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NECP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NECP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP1G1_HUMAN	AP1G1	physical	14665628
A4_HUMAN	APP	physical	21832049
AP2M1_HUMAN	AP2M1	physical	26186194
AP2S1_HUMAN	AP2S1	physical	26186194
CARM1_HUMAN	CARM1	physical	26186194
AP2A2_HUMAN	AP2A2	physical	26186194
AP2A1_HUMAN	AP2A1	physical	26186194
AP2B1_HUMAN	AP2B1	physical	26186194
AP1B1_HUMAN	AP1B1	physical	26186194
ZY11B_HUMAN	ZYG11B	physical	26186194
FBX11_HUMAN	FBXO11	physical	26186194
AP1G1_HUMAN	AP1G1	physical	26186194
NECP1_HUMAN	NECAP1	physical	26186194
TES_HUMAN	TES	physical	26186194
AP1M1_HUMAN	AP1M1	physical	26186194
ITSN1_HUMAN	ITSN1	physical	26186194
ANR28_HUMAN	ANKRD28	physical	26186194
AP2M1_HUMAN	AP2M1	physical	28514442
AP2A2_HUMAN	AP2A2	physical	28514442
AP1B1_HUMAN	AP1B1	physical	28514442
AP2A1_HUMAN	AP2A1	physical	28514442
NECP1_HUMAN	NECAP1	physical	28514442
AP2B1_HUMAN	AP2B1	physical	28514442
TES_HUMAN	TES	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442
ITSN1_HUMAN	ITSN1	physical	28514442
ANR28_HUMAN	ANKRD28	physical	28514442
CARM1_HUMAN	CARM1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.