FBX11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FBX11_HUMAN
• UniProt AC: Q86XK2
• Protein Name: F-box only protein 11
• Gene Name: FBXO11
• Organism: Homo sapiens (Human).
• Sequence Length: 927
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53..
• Protein Sequence: MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPQQQPPPPPQQQQQQQPPPPPPPPPPLPQERNNVGERDDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKNSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPILRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13 (in isoform 6)	Phosphorylation	-	33.18	25159151
13 (in isoform 3)	Phosphorylation	-	33.18	25159151
32	Ubiquitination	QQPPQQPPPQPPQQQ CCCCCCCCCCCCCCC	35.50	32015554
90	Phosphorylation	ADMVAEESGPGAQNS HHHHCCCCCCCCCCC	41.62	20068231
97	Phosphorylation	SGPGAQNSPYQLRRK CCCCCCCCHHHHCHH	16.95	26055452
99	Phosphorylation	PGAQNSPYQLRRKTL CCCCCCHHHHCHHHC	21.72	25850435
111	Phosphorylation	KTLLPKRTACPTKNS HHCCCCCCCCCCCCC	38.44	23312004
113 (in isoform 3)	Ubiquitination	-	4.32	21906983
113 (in isoform 2)	Ubiquitination	-	4.32	21906983
113	Ubiquitination	LLPKRTACPTKNSME CCCCCCCCCCCCCCC	4.32	21963094
115	Phosphorylation	PKRTACPTKNSMEGA CCCCCCCCCCCCCCC	42.62	23312004
116	Acetylation	KRTACPTKNSMEGAS CCCCCCCCCCCCCCC	31.97	26051181
116	Ubiquitination	KRTACPTKNSMEGAS CCCCCCCCCCCCCCC	31.97	32015554
118	Phosphorylation	TACPTKNSMEGASTS CCCCCCCCCCCCCCC	21.55	23312004
123	Phosphorylation	KNSMEGASTSTTENF CCCCCCCCCCCCCCH	33.47	23312004
124	Phosphorylation	NSMEGASTSTTENFG CCCCCCCCCCCCCHH	29.56	23312004
125	Phosphorylation	SMEGASTSTTENFGH CCCCCCCCCCCCHHH	30.73	23312004
142	Acetylation	KRARVSGKSQDLSAA HHHCCCCCCCCCCCC	37.12	23749302
143	Phosphorylation	RARVSGKSQDLSAAP HHCCCCCCCCCCCCC	32.24	25159151
162	Ubiquitination	LQEKLPDEVVLKIFS HHHHCCHHHHHHHHH	32.36	29967540
196	Ubiquitination	LANDPILWKRLYMEV HHCCHHHHHHHHHHH	5.62	21963094
197 (in isoform 1)	Ubiquitination	-	29.13	21906983
197	Ubiquitination	ANDPILWKRLYMEVF HCCHHHHHHHHHHHH	29.13	21906983
197 (in isoform 5)	Ubiquitination	-	29.13	21906983
246	Ubiquitination	LYKGAHVKPGFAEHF HHCCCCCCCCHHHHC	29.56	29967540
328	Phosphorylation	IIENTRDSTFVFMEG EEECCCCCEEEEEEC	22.06	26270265
329	Phosphorylation	IENTRDSTFVFMEGS EECCCCCEEEEEECC	28.27	26270265
487	Phosphorylation	AGFEVKAYANPTVVR CEEEEEEECCCEEEE	10.95	22496350
613	Phosphorylation	VIEENEVYSNTLAGV EECCCCEECCCCCEE	7.04	22468782
624	Phosphorylation	LAGVWVTTGSTPVLR CCEEEEECCCCCEEE	21.37	30576142
626	Phosphorylation	GVWVTTGSTPVLRRN EEEEECCCCCEEEEC	27.69	22468782
627	Phosphorylation	VWVTTGSTPVLRRNR EEEECCCCCEEEECC	20.82	30576142
637	Phosphorylation	LRRNRIHSGKQVGVY EEECCCCCCCEEEEE	45.36	22468782
744	Ubiquitination	IFNGGRGLLEENDIF EECCCCCCCCCCCHH	5.39	22817900
762	Phosphorylation	QAGVLISTNSHPILR CCCEEEECCCCHHHC	33.47	27762562
786	Ubiquitination	AGIEITNHATATLEG EEEEEECCCEEEEEC	18.79	33845483
787	Ubiquitination	GIEITNHATATLEGN EEEEECCCEEEEECC	10.86	33845483
827	Ubiquitination	MNNQDAIEKAVSRGQ CCCHHHHHHHHHHCC	36.36	22817900
828	Ubiquitination	NNQDAIEKAVSRGQC CCHHHHHHHHHHCCC	48.23	22817900
828 (in isoform 1)	Ubiquitination	-	48.23	21906983
828 (in isoform 5)	Ubiquitination	-	48.23	21906983
869	Ubiquitination	NAICVNCIKKCHQGH CEEEHHHHHHHHCCC	3.94	27667366
870	Ubiquitination	AICVNCIKKCHQGHD EEEHHHHHHHHCCCC	52.10	33845483
871	Ubiquitination	ICVNCIKKCHQGHDV EEHHHHHHHHCCCCC	19.62	33845483
871 (in isoform 5)	Ubiquitination	-	19.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FBX11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FBX11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FBX11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL1_HUMAN	CUL1	physical	17098746
SKP1_HUMAN	SKP1	physical	17098746
RBX1_HUMAN	RBX1	physical	17098746
P53_HUMAN	TP53	physical	17098746
BCL6_HUMAN	BCL6	physical	22113614
SKP1_HUMAN	SKP1	physical	22113614
CUL1_HUMAN	CUL1	physical	22113614
DTL_HUMAN	DTL	physical	23478441
SKP1_HUMAN	SKP1	physical	23478441
CUL1_HUMAN	CUL1	physical	23319600
FBX11_HUMAN	FBXO11	physical	28691247
SKP1_HUMAN	SKP1	physical	28614300

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.