NECP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NECP1_HUMAN
• UniProt AC: Q8NC96
• Protein Name: Adaptin ear-binding coat-associated protein 1
• Gene Name: NECAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 275
• Subcellular Localization: Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell membrane. Colocalizes with AP-2 at the plasma membrane..
• Protein Description: Involved in endocytosis..
• Protein Sequence: MATELEYESVLCVKPDVSVYRIPPRASNRGYRASDWKLDQPDWTGRLRITSKGKTAYIKLEDKVSGELFAQAPVEQYPGIAVETVTDSSRYFVIRIQDGTGRSAFIGIGFTDRGDAFDFNVSLQDHFKWVKQESEISKESQEMDARPKLDLGFKEGQTIKLCIGNITNKKGGASKPRTARGGGLSLLPPPPGGKVTIPPPSSSVAISNHVTPPPIPKSNHGGSDADILLDLDSPAPVTTPAPTPVSVSNDLWGDFSTASSSVPNQAPQPSNWVQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MATELEYESV -----CCCCCEEEEE	39.54	23663014
7	Phosphorylation	-MATELEYESVLCVK -CCCCCEEEEEEEEC	26.57	23663014
9	Phosphorylation	ATELEYESVLCVKPD CCCCEEEEEEEECCC	21.35	23663014
18	Phosphorylation	LCVKPDVSVYRIPPR EEECCCCEEEECCCC	22.32	23663014
20	Phosphorylation	VKPDVSVYRIPPRAS ECCCCEEEECCCCCC	8.70	23663014
46	Methylation	DQPDWTGRLRITSKG CCCCCCCCEEEECCC	17.26	115484785
59	Ubiquitination	KGKTAYIKLEDKVSG CCCEEEEEEECCCCC	32.90	29967540
103	Phosphorylation	IQDGTGRSAFIGIGF EECCCCCEEEEEEEE	28.95	24719451
131	Ubiquitination	QDHFKWVKQESEISK HHHHHHHHHHHHHCH	47.43	29967540
140	Phosphorylation	ESEISKESQEMDARP HHHHCHHHHHHCCCC	34.87	25159151
154	Ubiquitination	PKLDLGFKEGQTIKL CCCCCCCCCCCEEEE	60.17	-
154	Methylation	PKLDLGFKEGQTIKL CCCCCCCCCCCEEEE	60.17	-
154	Acetylation	PKLDLGFKEGQTIKL CCCCCCCCCCCEEEE	60.17	25953088
160	Ubiquitination	FKEGQTIKLCIGNIT CCCCCEEEEEEECCC	40.47	29967540
169	Malonylation	CIGNITNKKGGASKP EEECCCCCCCCCCCC	44.11	26320211
180	Methylation	ASKPRTARGGGLSLL CCCCCCCCCCCCCCC	43.61	24129315
196	Phosphorylation	PPPGGKVTIPPPSSS CCCCCCEECCCCCCC	31.11	23403867
201	Phosphorylation	KVTIPPPSSSVAISN CEECCCCCCCEEEEC	40.81	23403867
202	Phosphorylation	VTIPPPSSSVAISNH EECCCCCCCEEEECC	34.31	23403867
203	Phosphorylation	TIPPPSSSVAISNHV ECCCCCCCEEEECCC	21.65	23403867
207	Phosphorylation	PSSSVAISNHVTPPP CCCCEEEECCCCCCC	15.90	22617229
211	Phosphorylation	VAISNHVTPPPIPKS EEEECCCCCCCCCCC	23.64	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NECP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NECP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NECP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP1G1_HUMAN	AP1G1	physical	14665628
A4_HUMAN	APP	physical	21832049
CHSP1_HUMAN	CARHSP1	physical	26344197
BLOM7_HUMAN	KIAA0907	physical	26344197
SERA_HUMAN	PHGDH	physical	26344197
PIPNA_HUMAN	PITPNA	physical	26344197
UFC1_HUMAN	UFC1	physical	26344197
AP1G1_HUMAN	AP1G1	physical	14973137

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615833: Epileptic encephalopathy, early infantile, 21 (EIEE21)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-207, AND MASSSPECTROMETRY.
PubMed: 18691976