VATF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATF_HUMAN
• UniProt AC: Q16864
• Protein Name: V-type proton ATPase subunit F
• Gene Name: ATP6V1F
• Organism: Homo sapiens (Human).
• Sequence Length: 119
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MAGRGKLIAVIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIEDTFRQFLNRDDIGIILINQYIAEMVRHALDAHQQSIPAVLEIPSKEHPYDAAKDSILRRARGMFTAEDLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MAGRGKLIAVIGD --CCCCCCEEEEECC	35.05	-
30	Ubiquitination	GGIGELNKNRHPNFL ECHHHHCCCCCCCEE	68.90	-
32	Methylation	IGELNKNRHPNFLVV HHHHCCCCCCCEEEE	48.53	-
84	Phosphorylation	ALDAHQQSIPAVLEI HHHHHHCCCCEEEEC	24.78	-
93	Phosphorylation	PAVLEIPSKEHPYDA CEEEECCCCCCCCHH	57.23	24719451
94	Ubiquitination	AVLEIPSKEHPYDAA EEEECCCCCCCCHHH	55.47	21906983
102	Ubiquitination	EHPYDAAKDSILRRA CCCCHHHHHHHHHHH	54.45	21906983
102	2-Hydroxyisobutyrylation	EHPYDAAKDSILRRA CCCCHHHHHHHHHHH	54.45	-
104	Phosphorylation	PYDAAKDSILRRARG CCHHHHHHHHHHHCC	23.86	24719451
112	Sulfoxidation	ILRRARGMFTAEDLR HHHHHCCCCCHHHCC	1.94	21406390
119	Methylation	MFTAEDLR------- CCCHHHCC-------	57.74	-
130	Ubiquitination	------------------ ------------------		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CE126_HUMAN	KIAA1377	physical	16169070
VATH_HUMAN	ATP6V1H	physical	22939629
ZRAB2_HUMAN	ZRANB2	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
VDAC2_HUMAN	VDAC2	physical	22939629
VP26A_HUMAN	VPS26A	physical	22939629
HYOU1_HUMAN	HYOU1	physical	22863883
AIMP1_HUMAN	AIMP1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.