dbPTM

NEDD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NEDD8_HUMAN
UniProt AC	Q15843
Protein Name	NEDD8
Gene Name	NEDD8
Organism	Homo sapiens (Human).
Sequence Length	81
Subcellular Localization	Nucleus . Mainly nuclear.
Protein Description	Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins..
Protein Sequence	MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLRQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MLIKVKTLTGK ----CEEEEEECCCC	33.45	27667366
6	Ubiquitination	--MLIKVKTLTGKEI --CEEEEEECCCCEE	32.58	23000965
7	Phosphorylation	-MLIKVKTLTGKEIE -CEEEEEECCCCEEE	32.32	26657352
9	Phosphorylation	LIKVKTLTGKEIEID EEEEEECCCCEEEEE	51.98	26074081
11	Acetylation	KVKTLTGKEIEIDIE EEEECCCCEEEEECC	50.73	26051181
11	Ubiquitination	KVKTLTGKEIEIDIE EEEECCCCEEEEECC	50.73	23000965
11	Sumoylation	KVKTLTGKEIEIDIE EEEECCCCEEEEECC	50.73	-
20	Phosphorylation	IEIDIEPTDKVERIK EEEECCCCHHHHHHH	35.34	21406692
22	Ubiquitination	IDIEPTDKVERIKER EECCCCHHHHHHHHH	48.77	21906983
22	Acetylation	IDIEPTDKVERIKER EECCCCHHHHHHHHH	48.77	23236377
27	Ubiquitination	TDKVERIKERVEEKE CHHHHHHHHHHHHHC	45.77	21906983
33	Ubiquitination	IKERVEEKEGIPPQQ HHHHHHHHCCCCHHH	47.97	21906983
45	Phosphorylation	PQQQRLIYSGKQMND HHHHHEEEECCCCCC	18.90	29496907
46	Phosphorylation	QQQRLIYSGKQMNDE HHHHEEEECCCCCCC	32.30	-
48	Malonylation	QRLIYSGKQMNDEKT HHEEEECCCCCCCCC	40.20	26320211
48	Sumoylation	QRLIYSGKQMNDEKT HHEEEECCCCCCCCC	40.20	19608861
48	Ubiquitination	QRLIYSGKQMNDEKT HHEEEECCCCCCCCC	40.20	23000965
48	Sumoylation	QRLIYSGKQMNDEKT HHEEEECCCCCCCCC	40.20	-
48	Acetylation	QRLIYSGKQMNDEKT HHEEEECCCCCCCCC	40.20	23954790
54	Ubiquitination	GKQMNDEKTAADYKI CCCCCCCCCHHHHEE	46.45	23000965
54	Acetylation	GKQMNDEKTAADYKI CCCCCCCCCHHHHEE	46.45	23749302
55	Phosphorylation	KQMNDEKTAADYKIL CCCCCCCCHHHHEEH	25.65	22210691
59	Phosphorylation	DEKTAADYKILGGSV CCCCHHHHEEHHHHH	8.66	22817900
60	Ubiquitination	EKTAADYKILGGSVL CCCHHHHEEHHHHHH	31.81	19782077
65	Phosphorylation	DYKILGGSVLHLVLA HHEEHHHHHHHHHHH	21.51	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NEDD8_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NEDD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NEDD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UCHL1_HUMAN	UCHL1	physical	16169070
AHR_HUMAN	AHR	physical	12215427
UCHL3_HUMAN	UCHL3	physical	9790970
NUB1_HUMAN	NUB1	physical	11585840
SAE2_HUMAN	UBA2	physical	10217437
UBA3_HUMAN	UBA3	physical	16620772
ULA1_HUMAN	NAE1	physical	16620772
UBC12_HUMAN	UBE2M	physical	16620772
DNM3B_HUMAN	DNMT3B	physical	20847044
NUB1_HUMAN	NUB1	physical	20101219
FBW1A_HUMAN	BTRC	physical	17318178
ULA1_HUMAN	NAE1	physical	16503656
UBA3_HUMAN	UBA3	physical	16503656
UBC12_HUMAN	UBE2M	physical	16503656
UCHL3_HUMAN	UCHL3	physical	16503656
SKP1_HUMAN	SKP1	physical	16503656
CUL1_HUMAN	CUL1	physical	16503656
CUL2_HUMAN	CUL2	physical	16503656
VHL_HUMAN	VHL	physical	16503656
CUL3_HUMAN	CUL3	physical	16503656
RBX1_HUMAN	RBX1	physical	16503656
ELOB_HUMAN	TCEB2	physical	16503656
ELOC_HUMAN	TCEB1	physical	16503656
MEI1_HUMAN	MEI1	physical	16503656
CSN2_HUMAN	COPS2	physical	16503656
CSN3_HUMAN	COPS3	physical	16503656
CSN4_HUMAN	COPS4	physical	16503656
CSN5_HUMAN	COPS5	physical	16503656
CSN6_HUMAN	COPS6	physical	16503656
CSN7A_HUMAN	COPS7A	physical	16503656
ZYX_HUMAN	ZYX	physical	16503656
CUL4A_HUMAN	CUL4A	physical	16503656
DDB1_HUMAN	DDB1	physical	16503656
CUL4B_HUMAN	CUL4B	physical	16503656
NUB1_HUMAN	NUB1	physical	16503656
PSA1_HUMAN	PSMA1	physical	16503656
PSA2_HUMAN	PSMA2	physical	16503656
PSA3_HUMAN	PSMA3	physical	16503656
PSA4_HUMAN	PSMA4	physical	16503656
PSA5_HUMAN	PSMA5	physical	16503656
PSA6_HUMAN	PSMA6	physical	16503656
PSA7_HUMAN	PSMA7	physical	16503656
NUB1_HUMAN	NUB1	physical	12816948
UB2D2_HUMAN	UBE2D2	physical	17206147
ACTB_HUMAN	ACTB	physical	21145461
ACTBL_HUMAN	ACTBL2	physical	21145461
SAHH_HUMAN	AHCY	physical	21145461
ARI1_HUMAN	ARIH1	physical	21145461
BAG4_HUMAN	BAG4	physical	21145461
BTBD9_HUMAN	BTBD9	physical	21145461
C1QBP_HUMAN	C1QBP	physical	21145461
DFFB_HUMAN	DFFB	physical	21145461
CIRBP_HUMAN	CIRBP	physical	21145461
CLH1_HUMAN	CLTC	physical	21145461
CLH2_HUMAN	CLTCL1	physical	21145461
CSN2_HUMAN	COPS2	physical	21145461
CSN3_HUMAN	COPS3	physical	21145461
CSN4_HUMAN	COPS4	physical	21145461
CSN5_HUMAN	COPS5	physical	21145461
CSN6_HUMAN	COPS6	physical	21145461
CSN7A_HUMAN	COPS7A	physical	21145461
CSN7B_HUMAN	COPS7B	physical	21145461
CSN8_HUMAN	COPS8	physical	21145461
YBOX3_HUMAN	YBX3	physical	21145461
PYRG1_HUMAN	CTPS1	physical	21145461
CUL1_HUMAN	CUL1	physical	21145461
CUL2_HUMAN	CUL2	physical	21145461
CUL3_HUMAN	CUL3	physical	21145461
CUL4A_HUMAN	CUL4A	physical	21145461
CUL4B_HUMAN	CUL4B	physical	21145461
DAZP1_HUMAN	DAZAP1	physical	21145461
DCTP1_HUMAN	DCTPP1	physical	21145461
DDB1_HUMAN	DDB1	physical	21145461
DDX1_HUMAN	DDX1	physical	21145461
DDX17_HUMAN	DDX17	physical	21145461
DDX3X_HUMAN	DDX3X	physical	21145461
DDX5_HUMAN	DDX5	physical	21145461
DHX9_HUMAN	DHX9	physical	21145461
DJC10_HUMAN	DNAJC10	physical	21145461
DESP_HUMAN	DSP	physical	21145461
EF1A1_HUMAN	EEF1A1	physical	21145461
EF1A2_HUMAN	EEF1A2	physical	21145461
EF1G_HUMAN	EEF1G	physical	21145461
EWS_HUMAN	EWSR1	physical	21145461
FBX3_HUMAN	FBXO3	physical	21145461
FBW1B_HUMAN	FBXW11	physical	21145461
FEM1B_HUMAN	FEM1B	physical	21145461
FUS_HUMAN	FUS	physical	21145461
G3P_HUMAN	GAPDH	physical	21145461
CSN1_HUMAN	GPS1	physical	21145461
H12_HUMAN	HIST1H1C	physical	21145461
ROA0_HUMAN	HNRNPA0	physical	21145461
ROA1_HUMAN	HNRNPA1	physical	21145461
ROA2_HUMAN	HNRNPA2B1	physical	21145461
ROA3_HUMAN	HNRNPA3	physical	21145461
ROAA_HUMAN	HNRNPAB	physical	21145461
HNRPC_HUMAN	HNRNPC	physical	21145461
HNRPD_HUMAN	HNRNPD	physical	21145461
HNRPF_HUMAN	HNRNPF	physical	21145461
HNRH1_HUMAN	HNRNPH1	physical	21145461
HNRH3_HUMAN	HNRNPH3	physical	21145461
HNRPK_HUMAN	HNRNPK	physical	21145461
HNRPR_HUMAN	HNRNPR	physical	21145461
HNRPU_HUMAN	HNRNPU	physical	21145461
HNRL1_HUMAN	HNRNPUL1	physical	21145461
HNRDL_HUMAN	HNRNPDL	physical	21145461
HS90A_HUMAN	HSP90AA1	physical	21145461
HS71L_HUMAN	HSPA1L	physical	21145461
HSP74_HUMAN	HSPA4	physical	21145461
GRP78_HUMAN	HSPA5	physical	21145461
HSP76_HUMAN	HSPA6	physical	21145461
HSP7C_HUMAN	HSPA8	physical	21145461
GRP75_HUMAN	HSPA9	physical	21145461
CH60_HUMAN	HSPD1	physical	21145461
IF2B1_HUMAN	IGF2BP1	physical	21145461
ILF2_HUMAN	ILF2	physical	21145461
ILF3_HUMAN	ILF3	physical	21145461
KBTB6_HUMAN	KBTBD6	physical	21145461
KBTB7_HUMAN	KBTBD7	physical	21145461
BACD3_HUMAN	KCTD10	physical	21145461
KCTD3_HUMAN	KCTD3	physical	21145461
FUBP2_HUMAN	KHSRP	physical	21145461
KLD10_HUMAN	KLHDC10	physical	21145461
KLH12_HUMAN	KLHL12	physical	21145461
KLH15_HUMAN	KLHL15	physical	21145461
KLH22_HUMAN	KLHL22	physical	21145461
KLHL9_HUMAN	KLHL9	physical	21145461
IMA1_HUMAN	KPNA2	physical	21145461
K2C1_HUMAN	KRT1	physical	21145461
K1C10_HUMAN	KRT10	physical	21145461
K1C13_HUMAN	KRT13	physical	21145461
K1C14_HUMAN	KRT14	physical	21145461
K1C16_HUMAN	KRT16	physical	21145461
K22E_HUMAN	KRT2	physical	21145461
K1C24_HUMAN	KRT24	physical	21145461
K2C5_HUMAN	KRT5	physical	21145461
K2C75_HUMAN	KRT75	physical	21145461
K22O_HUMAN	KRT76	physical	21145461
K1C9_HUMAN	KRT9	physical	21145461
LG3BP_HUMAN	LGALS3BP	physical	21145461
MATR3_HUMAN	MATR3	physical	21145461
CSN9_HUMAN	MYEOV2	physical	21145461
ULA1_HUMAN	NAE1	physical	21145461
NUCL_HUMAN	NCL	physical	21145461
NEDD8_HUMAN	NEDD8	physical	21145461
TIRR_HUMAN	NUDT16L1	physical	21145461
NU155_HUMAN	NUP155	physical	21145461
PABP1_HUMAN	PABPC1	physical	21145461
PPIA_HUMAN	PPIA	physical	21145461
PRDX1_HUMAN	PRDX1	physical	21145461
PWP1_HUMAN	PWP1	physical	21145461
QPCT_HUMAN	QPCT	physical	21145461
RN187_HUMAN	RNF187	physical	21145461
RL11_HUMAN	RPL11	physical	21145461
RL15_HUMAN	RPL15	physical	21145461
RL19_HUMAN	RPL19	physical	21145461
RL23A_HUMAN	RPL23A	physical	21145461
RL31_HUMAN	RPL31	physical	21145461
RL35_HUMAN	RPL35	physical	21145461
HNRH2_HUMAN	HNRNPH2	physical	21145461
RL4_HUMAN	RPL4	physical	21145461
RL5_HUMAN	RPL5	physical	21145461
RL6_HUMAN	RPL6	physical	21145461
RL8_HUMAN	RPL8	physical	21145461
RLA0_HUMAN	RPLP0	physical	21145461
RLA1_HUMAN	RPLP1	physical	21145461
RLA2_HUMAN	RPLP2	physical	21145461
RS10_HUMAN	RPS10	physical	21145461
RS15A_HUMAN	RPS15A	physical	21145461
RS16_HUMAN	RPS16	physical	21145461
RS20_HUMAN	RPS20	physical	21145461
RS23_HUMAN	RPS23	physical	21145461
RS3_HUMAN	RPS3	physical	21145461
RS3A_HUMAN	RPS3A	physical	21145461
RS4X_HUMAN	RPS4X	physical	21145461
RS8_HUMAN	RPS8	physical	21145461
SDHA_HUMAN	SDHA	physical	21145461
SC23A_HUMAN	SEC23A	physical	21145461
PAIRB_HUMAN	SERBP1	physical	21145461
SRSF2_HUMAN	SRSF2	physical	21145461
SRSF7_HUMAN	SRSF7	physical	21145461
SHKB1_HUMAN	SHKBP1	physical	21145461
SKP1_HUMAN	SKP1	physical	21145461
RU1C_HUMAN	SNRPC	physical	21145461
SMD1_HUMAN	SNRPD1	physical	21145461
SPTN1_HUMAN	SPTAN1	physical	21145461
SPTB2_HUMAN	SPTBN1	physical	21145461
LA_HUMAN	SSB	physical	21145461
STRBP_HUMAN	STRBP	physical	21145461
HNRPQ_HUMAN	SYNCRIP	physical	21145461
RBP56_HUMAN	TAF15	physical	21145461
TBC15_HUMAN	TBC1D15	physical	21145461
ELOC_HUMAN	TCEB1	physical	21145461
ELOB_HUMAN	TCEB2	physical	21145461
TFG_HUMAN	TFG	physical	21145461
TIAR_HUMAN	TIAL1	physical	21145461
TNR6B_HUMAN	TNRC6B	physical	21145461
TITIN_HUMAN	TTN	physical	21145461
TBA1C_HUMAN	TUBA1C	physical	21145461
TBA4A_HUMAN	TUBA4A	physical	21145461
TBB5_HUMAN	TUBB	physical	21145461
TBB4B_HUMAN	TUBB4B	physical	21145461
UBA3_HUMAN	UBA3	physical	21145461
UBC_HUMAN	UBC	physical	21145461
UBP11_HUMAN	USP11	physical	21145461
DCAF1_HUMAN	VPRBP	physical	21145461
DCA11_HUMAN	DCAF11	physical	21145461
YBOX1_HUMAN	YBX1	physical	21145461
1433E_HUMAN	YWHAE	physical	21145461
1433T_HUMAN	YWHAQ	physical	21145461
1433Z_HUMAN	YWHAZ	physical	21145461
ZY11B_HUMAN	ZYG11B	physical	21145461
H2A1B_HUMAN	HIST1H2AE	physical	21145461
H2A1J_HUMAN	HIST1H2AJ	physical	21145461
H2A1_HUMAN	HIST1H2AI	physical	21145461
ATX3_HUMAN	ATXN3	physical	17935801
OR4S2_HUMAN	OR4S2	physical	22939629
THTR_HUMAN	TST	physical	22939629
RASH_HUMAN	HRAS	physical	22939629
BRAP_HUMAN	BRAP	physical	23554956
BRAP_MOUSE	Brap	physical	23554956
ARI2_HUMAN	ARIH2	physical	24076655
UBXN7_HUMAN	UBXN7	physical	24076655
LTP_EBVB9	BPLF1	physical	24130483
ARLY_HUMAN	ASL	physical	22863883
HGS_HUMAN	HGS	physical	16735510
UCHL3_HUMAN	UCHL3	physical	14673145
CUL3_HUMAN	CUL3	physical	17192413
VATF_HUMAN	ATP6V1F	physical	26344197
HIBCH_HUMAN	HIBCH	physical	26344197
MEMO1_HUMAN	MEMO1	physical	26344197
MPI_HUMAN	MPI	physical	26344197
NIT1_HUMAN	NIT1	physical	26344197
PRDX5_HUMAN	PRDX5	physical	26344197
RAB8B_HUMAN	RAB8B	physical	26344197
GHR_HUMAN	GHR	physical	25505247
SMUF2_HUMAN	SMURF2	physical	28169289
SMUF1_HUMAN	SMURF1	physical	28169289

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NEDD8_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48, AND MASS SPECTROMETRY.	19608861 [Abstract]