K22O_HUMAN - dbPTM
K22O_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID K22O_HUMAN
UniProt AC Q01546
Protein Name Keratin, type II cytoskeletal 2 oral
Gene Name KRT76
Organism Homo sapiens (Human).
Sequence Length 638
Subcellular Localization
Protein Description Probably contributes to terminal cornification..
Protein Sequence MNRQVCKKSFSGRSQGFSGRSAVVSGSSRMSCVARSGGAGGGACGFRSGAGSFGSRSLYNLGSNKSISISVAAGSSRAGGFGGGRSSCGFAGGYGGGFGGSYGGGFGGGRGVGSGFGGAGGFGGAGGFGGPGVFGGPGSFGGPGGFGPGGFPGGIQEVIVNQSLLQPLNVEIDPQIGQVKAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYISFLCKQLDSLLGERGNLEGELKSMQDLVEDFKKKYEDEINKRTAAENEFVGLKKDVDAAFMNKVELQAKVDSLTDEVSFLRTLYEMELSQMQSHASDTSVVLSMDNNRCLDLGSIIAEVRAQYEEIAQRSKSEAEALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKKQNANLQTAIAEAEQRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEECRMSGECQSAVCISVVSNVTSTSGSSGSSRGVFGGVSGSGSGGYKGGSSSSSSSGYGVSGGSGSGYGGVSSGSTGGRGSSGSYQSSSSGSRLGGAGSISVSHSGMGSSSGSIQTSGGSGYKSGGGGSTSIRFSQTTSSSQHSSTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationKKSFSGRSQGFSGRS
CCCCCCCCCCCCCCE		37.8722210691
18PhosphorylationSGRSQGFSGRSAVVS
CCCCCCCCCCEEEEC		39.87-
21PhosphorylationSQGFSGRSAVVSGSS
CCCCCCCEEEECCCC		29.01-
25PhosphorylationSGRSAVVSGSSRMSC
CCCEEEECCCCCEEE		26.7622210691
27PhosphorylationRSAVVSGSSRMSCVA
CEEEECCCCCEEEEE		13.7822210691
48PhosphorylationGGACGFRSGAGSFGS
CCCCCCCCCCCCCCC		30.6321955146
52PhosphorylationGFRSGAGSFGSRSLY
CCCCCCCCCCCCCEE		26.3721955146
55PhosphorylationSGAGSFGSRSLYNLG
CCCCCCCCCCEEECC		19.3821955146
57PhosphorylationAGSFGSRSLYNLGSN
CCCCCCCCEEECCCC		36.5821955146
59PhosphorylationSFGSRSLYNLGSNKS
CCCCCCEEECCCCCC		15.0221955146
63PhosphorylationRSLYNLGSNKSISIS
CCEEECCCCCCEEEE		44.2221955146
70PhosphorylationSNKSISISVAAGSSR
CCCCEEEEEECCCCC		10.0220860994
75PhosphorylationSISVAAGSSRAGGFG
EEEEECCCCCCCCCC		16.3620860994
76PhosphorylationISVAAGSSRAGGFGG
EEEECCCCCCCCCCC		25.82-
85MethylationAGGFGGGRSSCGFAG
CCCCCCCCCCCCCCC		28.77-
110MethylationGGGFGGGRGVGSGFG
CCCCCCCCCCCCCCC		39.64-
188UbiquitinationAQEREQIKTLNNKFA
HHHHHHHHHHHHHHH		46.8022817900
189PhosphorylationQEREQIKTLNNKFAS
HHHHHHHHHHHHHHH		36.0324719451
193AcetylationQIKTLNNKFASFIDK
HHHHHHHHHHHHHHH		41.03133011
193SumoylationQIKTLNNKFASFIDK
HHHHHHHHHHHHHHH		41.03-
193NeddylationQIKTLNNKFASFIDK
HHHHHHHHHHHHHHH		41.0332015554
193UbiquitinationQIKTLNNKFASFIDK
HHHHHHHHHHHHHHH		41.0321963094
193SumoylationQIKTLNNKFASFIDK
HHHHHHHHHHHHHHH		41.03-
193MethylationQIKTLNNKFASFIDK
HHHHHHHHHHHHHHH		41.03133011
196PhosphorylationTLNNKFASFIDKVRF
HHHHHHHHHHHHHHH		26.3528355574
200UbiquitinationKFASFIDKVRFLEQQ
HHHHHHHHHHHHHHH		30.4121963094
200AcetylationKFASFIDKVRFLEQQ
HHHHHHHHHHHHHHH		30.417705843
209UbiquitinationRFLEQQNKVLETKWE
HHHHHHHHHHHHHHH		43.8116196087
272UbiquitinationLVEDFKKKYEDEINK
HHHHHHHHHHHHHHH		55.2320972266
272NeddylationLVEDFKKKYEDEINK
HHHHHHHHHHHHHHH		55.2332015554
361PhosphorylationIAEVRAQYEEIAQRS
HHHHHHHHHHHHHHC		17.9726356563
376PhosphorylationKSEAEALYQTKLGEL
HHHHHHHHHHHHHHH		22.60-
378PhosphorylationEAEALYQTKLGELQT
HHHHHHHHHHHHHHC		18.06-
385PhosphorylationTKLGELQTTAGRHGD
HHHHHHHCCCCCCCH		31.10-
427PhosphorylationKQNANLQTAIAEAEQ
HHCCCHHHHHHHHHH		24.1726657352
468PhosphorylationLARLLRDYQELMNVK
HHHHHHHHHHHHCHH		9.4620068231
487UbiquitinationVEIATYRKLLEGEEC
HHHHHHHHHHCCCCC		47.1922817900
495MethylationLLEGEECRMSGECQS
HHCCCCCCCCCCCCC		26.11-
537PhosphorylationSGSGSGGYKGGSSSS
CCCCCCCCCCCCCCC		15.2423532336
541PhosphorylationSGGYKGGSSSSSSSG
CCCCCCCCCCCCCCC		35.40-
542PhosphorylationGGYKGGSSSSSSSGY
CCCCCCCCCCCCCCC		37.20-
544PhosphorylationYKGGSSSSSSSGYGV
CCCCCCCCCCCCCCC		35.87-
549PhosphorylationSSSSSSGYGVSGGSG
CCCCCCCCCCCCCCC		19.12-
584MethylationQSSSSGSRLGGAGSI
CCCCCCCCCCCCCEE		40.66-
590PhosphorylationSRLGGAGSISVSHSG
CCCCCCCEEEECCCC		15.9120068231
592PhosphorylationLGGAGSISVSHSGMG
CCCCCEEEECCCCCC		21.1820068231
594PhosphorylationGAGSISVSHSGMGSS
CCCEEEECCCCCCCC		12.7320068231
596PhosphorylationGSISVSHSGMGSSSG
CEEEECCCCCCCCCC		23.9820068231
600PhosphorylationVSHSGMGSSSGSIQT
ECCCCCCCCCCCEEE		16.6720068231
601PhosphorylationSHSGMGSSSGSIQTS
CCCCCCCCCCCEEEC		32.7520068231
602PhosphorylationHSGMGSSSGSIQTSG
CCCCCCCCCCEEECC		37.9520068231
604PhosphorylationGMGSSSGSIQTSGGS
CCCCCCCCEEECCCC		17.3020068231
607PhosphorylationSSSGSIQTSGGSGYK
CCCCCEEECCCCCCC		27.8925332170
608PhosphorylationSSGSIQTSGGSGYKS
CCCCEEECCCCCCCC		25.4420068231
611PhosphorylationSIQTSGGSGYKSGGG
CEEECCCCCCCCCCC		42.3420068231
613PhosphorylationQTSGGSGYKSGGGGS
EECCCCCCCCCCCCC		12.0420068231
615PhosphorylationSGGSGYKSGGGGSTS
CCCCCCCCCCCCCCE		33.9020068231
620PhosphorylationYKSGGGGSTSIRFSQ
CCCCCCCCCEEEEEE		23.4320068231
621PhosphorylationKSGGGGSTSIRFSQT
CCCCCCCCEEEEEEC		31.2930576142
622PhosphorylationSGGGGSTSIRFSQTT
CCCCCCCEEEEEECC		17.2920068231
626PhosphorylationGSTSIRFSQTTSSSQ
CCCEEEEEECCCCCC		19.4430576142
628PhosphorylationTSIRFSQTTSSSQHS
CEEEEEECCCCCCCC		27.7020068231
629PhosphorylationSIRFSQTTSSSQHSS
EEEEEECCCCCCCCC		20.9720068231
630PhosphorylationIRFSQTTSSSQHSST
EEEEECCCCCCCCCC		31.2320068231
631PhosphorylationRFSQTTSSSQHSSTK
EEEECCCCCCCCCCC		31.7420068231
632PhosphorylationFSQTTSSSQHSSTK-
EEECCCCCCCCCCC-		31.5130576142
635PhosphorylationTTSSSQHSSTK----
CCCCCCCCCCC----		31.8722964224
636PhosphorylationTSSSQHSSTK-----
CCCCCCCCCC-----		37.7822964224
637PhosphorylationSSSQHSSTK------
CCCCCCCCC------		43.7322964224
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of K22O_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of K22O_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of K22O_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of K22O_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of K22O_HUMAN

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Related Literatures of Post-Translational Modification

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