dbPTM

FUBP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FUBP2_HUMAN
UniProt AC	Q92945
Protein Name	Far upstream element-binding protein 2
Gene Name	KHSRP
Organism	Homo sapiens (Human).
Sequence Length	711
Subcellular Localization	Nucleus . Cytoplasm . A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites..
Protein Description	Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs..
Protein Sequence	MSDYSTGGPPPGPPPPAGGGGGAGGAGGGPPPGPPGAGDRGGGGPGGGGPGGGSAGGPSQPPGGGGPGIRKDAFADAVQRARQIAAKIGGDAATTVNNSTPDFGFGGQKRQLEDGDQPESKKLASQGDSISSQLGPIHPPPRTSMTEEYRVPDGMVGLIIGRGGEQINKIQQDSGCKVQISPDSGGLPERSVSLTGAPESVQKAKMMLDDIVSRGRGGPPGQFHDNANGGQNGTVQEIMIPAGKAGLVIGKGGETIKQLQERAGVKMILIQDGSQNTNVDKPLRIIGDPYKVQQACEMVMDILRERDQGGFGDRNEYGSRIGGGIDVPVPRHSVGVVIGRSGEMIKKIQNDAGVRIQFKQDDGTGPEKIAHIMGPPDRCEHAARIINDLLQSLRSGPPGPPGGPGMPPGGRGRGRGQGNWGPPGGEMTFSIPTHKCGLVIGRGGENVKAINQQTGAFVEISRQLPPNGDPNFKLFIIRGSPQQIDHAKQLIEEKIEGPLCPVGPGPGGPGPAGPMGPFNPGPFNQGPPGAPPHAGGPPPHQYPPQGWGNTYPQWQPPAPHDPSKAAAAAADPNAAWAAYYSHYYQQPPGPVPGPAPAPAAPPAQGEPPQPPPTGQSDYTKAWEEYYKKIGQQPQQPGAPPQQDYTKAWEEYYKKQAQVATGGGPGAPPGSQPDYSAAWAEYYRQQAAYYGQTPGPGGPQPPPTQQGQQQAQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDYSTGGP ------CCCCCCCCC	45.30	19413330
2	Phosphorylation	------MSDYSTGGP ------CCCCCCCCC	45.30	28188228
4	Phosphorylation	----MSDYSTGGPPP ----CCCCCCCCCCC	10.79	21406692
5	Phosphorylation	---MSDYSTGGPPPG ---CCCCCCCCCCCC	26.10	18491316
6	Phosphorylation	--MSDYSTGGPPPGP --CCCCCCCCCCCCC	39.67	18491316
25	Ubiquitination	GGGGGAGGAGGGPPP CCCCCCCCCCCCCCC	22.10	24816145
27	Ubiquitination	GGGAGGAGGGPPPGP CCCCCCCCCCCCCCC	44.88	22053931
33	Ubiquitination	AGGGPPPGPPGAGDR CCCCCCCCCCCCCCC	46.97	23000965
40	Methylation	GPPGAGDRGGGGPGG CCCCCCCCCCCCCCC	44.75	-
43	Ubiquitination	GAGDRGGGGPGGGGP CCCCCCCCCCCCCCC	41.78	23000965
54	Phosphorylation	GGGPGGGSAGGPSQP CCCCCCCCCCCCCCC	27.32	28985074
59	Phosphorylation	GGSAGGPSQPPGGGG CCCCCCCCCCCCCCC	59.60	27251275
59	Ubiquitination	GGSAGGPSQPPGGGG CCCCCCCCCCCCCCC	59.60	23000965
61	Ubiquitination	SAGGPSQPPGGGGPG CCCCCCCCCCCCCCC	33.56	21890473
65	Ubiquitination	PSQPPGGGGPGIRKD CCCCCCCCCCCHHHH	45.07	23000965
71	Malonylation	GGGPGIRKDAFADAV CCCCCHHHHHHHHHH	52.03	26320211
71	Methylation	GGGPGIRKDAFADAV CCCCCHHHHHHHHHH	52.03	54390711
71	Ubiquitination	GGGPGIRKDAFADAV CCCCCHHHHHHHHHH	52.03	22053931
77	Ubiquitination	RKDAFADAVQRARQI HHHHHHHHHHHHHHH	8.91	23000965
78	Ubiquitination	KDAFADAVQRARQIA HHHHHHHHHHHHHHH	3.99	23000965
87	Acetylation	RARQIAAKIGGDAAT HHHHHHHHHCCCHHH	32.63	23954790
87	Ubiquitination	RARQIAAKIGGDAAT HHHHHHHHHCCCHHH	32.63	23000965
94	O-linked_Glycosylation	KIGGDAATTVNNSTP HHCCCHHHCCCCCCC	32.75	30059200
94	Phosphorylation	KIGGDAATTVNNSTP HHCCCHHHCCCCCCC	32.75	23401153
95	O-linked_Glycosylation	IGGDAATTVNNSTPD HCCCHHHCCCCCCCC	19.26	30059200
95	Phosphorylation	IGGDAATTVNNSTPD HCCCHHHCCCCCCCC	19.26	29255136
99	O-linked_Glycosylation	AATTVNNSTPDFGFG HHHCCCCCCCCCCCC	35.79	30059200
99	Phosphorylation	AATTVNNSTPDFGFG HHHCCCCCCCCCCCC	35.79	29255136
100	Phosphorylation	ATTVNNSTPDFGFGG HHCCCCCCCCCCCCC	29.06	29255136
107	Ubiquitination	TPDFGFGGQKRQLED CCCCCCCCCCCCCCC	27.81	23000965
109	Acetylation	DFGFGGQKRQLEDGD CCCCCCCCCCCCCCC	45.44	23749302
109	Methylation	DFGFGGQKRQLEDGD CCCCCCCCCCCCCCC	45.44	91365
109	Ubiquitination	DFGFGGQKRQLEDGD CCCCCCCCCCCCCCC	45.44	23000965
109 (in isoform 1)	Ubiquitination	-	45.44	21890473
113	Ubiquitination	GGQKRQLEDGDQPES CCCCCCCCCCCCHHH	52.16	23000965
120	Phosphorylation	EDGDQPESKKLASQG CCCCCHHHHHHHHCC	41.60	25159151
121	Acetylation	DGDQPESKKLASQGD CCCCHHHHHHHHCCC	50.58	25953088
121	Sumoylation	DGDQPESKKLASQGD CCCCHHHHHHHHCCC	50.58	25114211
121	Ubiquitination	DGDQPESKKLASQGD CCCCHHHHHHHHCCC	50.58	23000965
122	Acetylation	GDQPESKKLASQGDS CCCHHHHHHHHCCCC	59.57	30584043
122	Ubiquitination	GDQPESKKLASQGDS CCCHHHHHHHHCCCC	59.57	23000965
125	Phosphorylation	PESKKLASQGDSISS HHHHHHHHCCCCHHH	45.17	25159151
125	Ubiquitination	PESKKLASQGDSISS HHHHHHHHCCCCHHH	45.17	24816145
129	Phosphorylation	KLASQGDSISSQLGP HHHHCCCCHHHHCCC	31.06	25159151
131	Phosphorylation	ASQGDSISSQLGPIH HHCCCCHHHHCCCCC	18.91	25159151
132	Phosphorylation	SQGDSISSQLGPIHP HCCCCHHHHCCCCCC	27.96	17525332
133	Ubiquitination	QGDSISSQLGPIHPP CCCCHHHHCCCCCCC	43.58	23000965
137	Ubiquitination	ISSQLGPIHPPPRTS HHHHCCCCCCCCCCC	7.85	23000965
143	Phosphorylation	PIHPPPRTSMTEEYR CCCCCCCCCCCCEEE	28.73	30108239
144	O-linked_Glycosylation	IHPPPRTSMTEEYRV CCCCCCCCCCCEEEC	25.61	30059200
144	Phosphorylation	IHPPPRTSMTEEYRV CCCCCCCCCCCEEEC	25.61	21815630
146	Phosphorylation	PPPRTSMTEEYRVPD CCCCCCCCCEEECCC	25.98	28857561
149	Phosphorylation	RTSMTEEYRVPDGMV CCCCCCEEECCCCCE	15.64	28985074
159	Ubiquitination	PDGMVGLIIGRGGEQ CCCCEEEEECCCHHH	2.30	23000965
161	Ubiquitination	GMVGLIIGRGGEQIN CCEEEEECCCHHHHH	18.39	21890473
162	Methylation	MVGLIIGRGGEQINK CEEEEECCCHHHHHH	39.26	115480997
169	Acetylation	RGGEQINKIQQDSGC CCHHHHHHHHHHCCC	43.45	25953088
169	Ubiquitination	RGGEQINKIQQDSGC CCHHHHHHHHHHCCC	43.45	33845483
174	Phosphorylation	INKIQQDSGCKVQIS HHHHHHHCCCEEEEC	41.58	20068231
176	S-nitrosocysteine	KIQQDSGCKVQISPD HHHHHCCCEEEECCC	4.52	-
176	Glutathionylation	KIQQDSGCKVQISPD HHHHHCCCEEEECCC	4.52	22555962
176	S-nitrosylation	KIQQDSGCKVQISPD HHHHHCCCEEEECCC	4.52	20140087
177	2-Hydroxyisobutyrylation	IQQDSGCKVQISPDS HHHHCCCEEEECCCC	40.47	-
177	Acetylation	IQQDSGCKVQISPDS HHHHCCCEEEECCCC	40.47	25953088
177	Ubiquitination	IQQDSGCKVQISPDS HHHHCCCEEEECCCC	40.47	23000965
181	Phosphorylation	SGCKVQISPDSGGLP CCCEEEECCCCCCCC	12.93	19664994
184	Phosphorylation	KVQISPDSGGLPERS EEEECCCCCCCCCCC	37.84	29255136
191	O-linked_Glycosylation	SGGLPERSVSLTGAP CCCCCCCCEECCCCC	17.88	30059200
191	Phosphorylation	SGGLPERSVSLTGAP CCCCCCCCEECCCCC	17.88	30266825
193	Phosphorylation	GLPERSVSLTGAPES CCCCCCEECCCCCHH	22.81	30266825
195	Phosphorylation	PERSVSLTGAPESVQ CCCCEECCCCCHHHH	24.64	30266825
200	Phosphorylation	SLTGAPESVQKAKMM ECCCCCHHHHHHHHH	28.87	30266825
203	Acetylation	GAPESVQKAKMMLDD CCCHHHHHHHHHHHH	48.06	25953088
203	Ubiquitination	GAPESVQKAKMMLDD CCCHHHHHHHHHHHH	48.06	23000965
205	Ubiquitination	PESVQKAKMMLDDIV CHHHHHHHHHHHHHH	31.70	23000965
205 (in isoform 1)	Ubiquitination	-	31.70	21890473
206	Sulfoxidation	ESVQKAKMMLDDIVS HHHHHHHHHHHHHHH	3.73	21406390
207	Sulfoxidation	SVQKAKMMLDDIVSR HHHHHHHHHHHHHHC	3.51	28183972
207	Ubiquitination	SVQKAKMMLDDIVSR HHHHHHHHHHHHHHC	3.51	23000965
213	Ubiquitination	MMLDDIVSRGRGGPP HHHHHHHHCCCCCCC	29.38	23000965
215	Ubiquitination	LDDIVSRGRGGPPGQ HHHHHHCCCCCCCCC	25.69	24816145
234	Phosphorylation	ANGGQNGTVQEIMIP CCCCCCCEEEEEEEC	26.94	-
237	Ubiquitination	GQNGTVQEIMIPAGK CCCCEEEEEEECCCC	30.13	23000965
251	Acetylation	KAGLVIGKGGETIKQ CCEEEECCCCHHHHH	53.25	25953088
251	Ubiquitination	KAGLVIGKGGETIKQ CCEEEECCCCHHHHH	53.25	23000965
251 (in isoform 1)	Ubiquitination	-	53.25	21890473
255	Phosphorylation	VIGKGGETIKQLQER EECCCCHHHHHHHHH	36.43	22817900
257	2-Hydroxyisobutyrylation	GKGGETIKQLQERAG CCCCHHHHHHHHHHC	52.99	-
257	Acetylation	GKGGETIKQLQERAG CCCCHHHHHHHHHHC	52.99	25953088
257	Ubiquitination	GKGGETIKQLQERAG CCCCHHHHHHHHHHC	52.99	23000965
257 (in isoform 1)	Ubiquitination	-	52.99	21890473
266	Acetylation	LQERAGVKMILIQDG HHHHHCCEEEEEECC	21.21	25953088
267	Sulfoxidation	QERAGVKMILIQDGS HHHHCCEEEEEECCC	2.54	28183972
274	Phosphorylation	MILIQDGSQNTNVDK EEEEECCCCCCCCCC	28.66	23401153
277	Phosphorylation	IQDGSQNTNVDKPLR EECCCCCCCCCCCEE	29.05	30183078
281	2-Hydroxyisobutyrylation	SQNTNVDKPLRIIGD CCCCCCCCCEEECCC	41.49	-
281	Acetylation	SQNTNVDKPLRIIGD CCCCCCCCCEEECCC	41.49	25953088
281	Ubiquitination	SQNTNVDKPLRIIGD CCCCCCCCCEEECCC	41.49	23000965
296	Glutathionylation	PYKVQQACEMVMDIL HHHHHHHHHHHHHHH	2.77	22555962
298	Sulfoxidation	KVQQACEMVMDILRE HHHHHHHHHHHHHHH	2.81	21406390
303	Ubiquitination	CEMVMDILRERDQGG HHHHHHHHHHHHCCC	3.97	24816145
304	Ubiquitination	EMVMDILRERDQGGF HHHHHHHHHHHCCCC	36.92	23000965
314	Methylation	DQGGFGDRNEYGSRI HCCCCCCCCCCCCCC	37.95	115480949
315	Ubiquitination	QGGFGDRNEYGSRIG CCCCCCCCCCCCCCC	52.13	24816145
317	Phosphorylation	GFGDRNEYGSRIGGG CCCCCCCCCCCCCCC	24.77	28152594
319	Phosphorylation	GDRNEYGSRIGGGID CCCCCCCCCCCCCCC	21.59	28152594
333	Phosphorylation	DVPVPRHSVGVVIGR CCCCCHHHEEEEECC	23.11	24719451
340	Methylation	SVGVVIGRSGEMIKK HEEEEECCCHHHHHH	30.29	115480957
341	Phosphorylation	VGVVIGRSGEMIKKI EEEEECCCHHHHHHH	33.61	24719451
344	Ubiquitination	VIGRSGEMIKKIQND EECCCHHHHHHHHHC	6.58	21890473
346	2-Hydroxyisobutyrylation	GRSGEMIKKIQNDAG CCCHHHHHHHHHCCC	42.38	-
346	Acetylation	GRSGEMIKKIQNDAG CCCHHHHHHHHHCCC	42.38	25953088
347	2-Hydroxyisobutyrylation	RSGEMIKKIQNDAGV CCHHHHHHHHHCCCC	38.30	-
347	Ubiquitination	RSGEMIKKIQNDAGV CCHHHHHHHHHCCCC	38.30	24816145
355	Methylation	IQNDAGVRIQFKQDD HHHCCCCEEEEECCC	18.97	-
359	Sumoylation	AGVRIQFKQDDGTGP CCCEEEEECCCCCCH	36.12	-
359	2-Hydroxyisobutyrylation	AGVRIQFKQDDGTGP CCCEEEEECCCCCCH	36.12	-
359	Acetylation	AGVRIQFKQDDGTGP CCCEEEEECCCCCCH	36.12	25953088
359	Sumoylation	AGVRIQFKQDDGTGP CCCEEEEECCCCCCH	36.12	-
359	Ubiquitination	AGVRIQFKQDDGTGP CCCEEEEECCCCCCH	36.12	33845483
368	Acetylation	DDGTGPEKIAHIMGP CCCCCHHHHHHHHCC	48.61	25953088
373	Sulfoxidation	PEKIAHIMGPPDRCE HHHHHHHHCCHHHHH	4.78	21406390
378	Methylation	HIMGPPDRCEHAARI HHHCCHHHHHHHHHH	33.23	115480965
379	Glutathionylation	IMGPPDRCEHAARII HHCCHHHHHHHHHHH	6.15	22555962
394	Methylation	NDLLQSLRSGPPGPP HHHHHHHHCCCCCCC	44.83	115480973
395	Phosphorylation	DLLQSLRSGPPGPPG HHHHHHHCCCCCCCC	62.03	28961369
404	Ubiquitination	PPGPPGGPGMPPGGR CCCCCCCCCCCCCCC	41.65	23000965
406	Sulfoxidation	GPPGGPGMPPGGRGR CCCCCCCCCCCCCCC	3.99	21406390
411	Dimethylation	PGMPPGGRGRGRGQG CCCCCCCCCCCCCCC	37.23	-
411	Methylation	PGMPPGGRGRGRGQG CCCCCCCCCCCCCCC	37.23	24129315
413	Dimethylation	MPPGGRGRGRGQGNW CCCCCCCCCCCCCCC	30.21	-
413	Methylation	MPPGGRGRGRGQGNW CCCCCCCCCCCCCCC	30.21	24129315
415	Dimethylation	PGGRGRGRGQGNWGP CCCCCCCCCCCCCCC	32.66	-
415	Methylation	PGGRGRGRGQGNWGP CCCCCCCCCCCCCCC	32.66	24129315
428	Phosphorylation	GPPGGEMTFSIPTHK CCCCCEEEEECCCCC	15.21	30257219
430	Phosphorylation	PGGEMTFSIPTHKCG CCCEEEEECCCCCCC	20.63	30257219
433	Phosphorylation	EMTFSIPTHKCGLVI EEEEECCCCCCCEEE	32.09	30257219
436	S-nitrosocysteine	FSIPTHKCGLVIGRG EECCCCCCCEEECCC	3.85	-
436	Glutathionylation	FSIPTHKCGLVIGRG EECCCCCCCEEECCC	3.85	22555962
436	S-nitrosylation	FSIPTHKCGLVIGRG EECCCCCCCEEECCC	3.85	20140087
442	Dimethylation	KCGLVIGRGGENVKA CCCEEECCCCCCHHH	38.53	-
442	Methylation	KCGLVIGRGGENVKA CCCEEECCCCCCHHH	38.53	24129315
444	Ubiquitination	GLVIGRGGENVKAIN CEEECCCCCCHHHHH	23.19	21890473
448	Acetylation	GRGGENVKAINQQTG CCCCCCHHHHHHCCC	55.95	26051181
448	Methylation	GRGGENVKAINQQTG CCCCCCHHHHHHCCC	55.95	54390695
448	Ubiquitination	GRGGENVKAINQQTG CCCCCCHHHHHHCCC	55.95	23000965
461	Phosphorylation	TGAFVEISRQLPPNG CCCEEEEECCCCCCC	10.64	-
478	Methylation	NFKLFIIRGSPQQID CCEEEEEECCHHHHH	34.42	115480989
480	Phosphorylation	KLFIIRGSPQQIDHA EEEEEECCHHHHHHH	15.08	26846344
483	Ubiquitination	IIRGSPQQIDHAKQL EEECCHHHHHHHHHH	46.60	22817900
484	Ubiquitination	IRGSPQQIDHAKQLI EECCHHHHHHHHHHH	3.36	22817900
488	2-Hydroxyisobutyrylation	PQQIDHAKQLIEEKI HHHHHHHHHHHHHHC	42.07	-
488	Acetylation	PQQIDHAKQLIEEKI HHHHHHHHHHHHHHC	42.07	26051181
488	Ubiquitination	PQQIDHAKQLIEEKI HHHHHHHHHHHHHHC	42.07	22817900
488 (in isoform 1)	Ubiquitination	-	42.07	21890473
502	Ubiquitination	IEGPLCPVGPGPGGP CCCCCCCCCCCCCCC	16.43	22817900
509	Ubiquitination	VGPGPGGPGPAGPMG CCCCCCCCCCCCCCC	52.05	22817900
510	Ubiquitination	GPGPGGPGPAGPMGP CCCCCCCCCCCCCCC	28.15	22817900
577	Ubiquitination	ADPNAAWAAYYSHYY CCCCHHHHHHHHHHC	4.85	22817900
583	Phosphorylation	WAAYYSHYYQQPPGP HHHHHHHHCCCCCCC	9.31	22817900
583	Ubiquitination	WAAYYSHYYQQPPGP HHHHHHHHCCCCCCC	9.31	22817900
584	Ubiquitination	AAYYSHYYQQPPGPV HHHHHHHCCCCCCCC	8.68	22817900
585	Ubiquitination	AYYSHYYQQPPGPVP HHHHHHCCCCCCCCC	41.98	22817900
602	Ubiquitination	APAPAAPPAQGEPPQ CCCCCCCCCCCCCCC	32.27	22817900
609	Ubiquitination	PAQGEPPQPPPTGQS CCCCCCCCCCCCCCC	74.07	22817900
610	Ubiquitination	AQGEPPQPPPTGQSD CCCCCCCCCCCCCCH	42.48	22817900
625	Phosphorylation	YTKAWEEYYKKIGQQ HHHHHHHHHHHHCCC	14.74	28152594
626	Phosphorylation	TKAWEEYYKKIGQQP HHHHHHHHHHHCCCC	14.75	28152594
627	Acetylation	KAWEEYYKKIGQQPQ HHHHHHHHHHCCCCC	36.69	19608861
627	Malonylation	KAWEEYYKKIGQQPQ HHHHHHHHHHCCCCC	36.69	26320211
627	Ubiquitination	KAWEEYYKKIGQQPQ HHHHHHHHHHCCCCC	36.69	27667366
628	Ubiquitination	AWEEYYKKIGQQPQQ HHHHHHHHHCCCCCC	35.63	21906983
628 (in isoform 1)	Ubiquitination	-	35.63	21890473
644	Phosphorylation	GAPPQQDYTKAWEEY CCCCCCHHHHHHHHH	13.05	22817900
646	Acetylation	PPQQDYTKAWEEYYK CCCCHHHHHHHHHHH	45.32	26051181
646	Ubiquitination	PPQQDYTKAWEEYYK CCCCHHHHHHHHHHH	45.32	21906983
646 (in isoform 1)	Ubiquitination	-	45.32	21890473
651	Phosphorylation	YTKAWEEYYKKQAQV HHHHHHHHHHHHHCH	14.74	28152594
652	Phosphorylation	TKAWEEYYKKQAQVA HHHHHHHHHHHHCHH	18.26	28152594
653	Acetylation	KAWEEYYKKQAQVAT HHHHHHHHHHHCHHC	37.19	27452117
653	Malonylation	KAWEEYYKKQAQVAT HHHHHHHHHHHCHHC	37.19	26320211
653	Ubiquitination	KAWEEYYKKQAQVAT HHHHHHHHHHHCHHC	37.19	22817900
654	Ubiquitination	AWEEYYKKQAQVATG HHHHHHHHHHCHHCC	34.44	22817900
654 (in isoform 1)	Ubiquitination	-	34.44	21890473
670	O-linked_Glycosylation	GPGAPPGSQPDYSAA CCCCCCCCCCCHHHH	44.29	30059200
670	Phosphorylation	GPGAPPGSQPDYSAA CCCCCCCCCCCHHHH	44.29	17525332
674	Phosphorylation	PPGSQPDYSAAWAEY CCCCCCCHHHHHHHH	13.59	17360941
681	Phosphorylation	YSAAWAEYYRQQAAY HHHHHHHHHHHHHHH	9.01	-
682	Phosphorylation	SAAWAEYYRQQAAYY HHHHHHHHHHHHHHH	8.08	-
688	Phosphorylation	YYRQQAAYYGQTPGP HHHHHHHHHCCCCCC	15.90	20090780
689	Phosphorylation	YRQQAAYYGQTPGPG HHHHHHHHCCCCCCC	9.68	28555341
692	Phosphorylation	QAAYYGQTPGPGGPQ HHHHHCCCCCCCCCC	26.33	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
193	S	Phosphorylation	Kinase	AKT1	P31749	PSP
193	S	Phosphorylation	Kinase	AKT2	P31751	PSP
274	S	Phosphorylation	Kinase	ATM	Q13315	PSP
317	Y	Phosphorylation	Kinase	SRC	P12931	PSP
583	Y	Phosphorylation	Kinase	SRC	P12931	PSP
670	S	Phosphorylation	Kinase	ATM	Q13315	PSP
688	Y	Phosphorylation	Kinase	SRC	P12931	PSP
692	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL12	Q53G59	PMID:27899653:32032490

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
193	S	Phosphorylation		23186163
Phosphorylation at Ser-193 leads to the unfolding of the unstable KH domain 1, creating a site for 14-3-3 YWHAZ binding, which promotes nuclear localization and impairs the RNA degradation function.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FUBP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXOS2_HUMAN	EXOSC2	physical	15175153
PARN_HUMAN	PARN	physical	15175153
PTBP2_HUMAN	PTBP2	physical	11003644
ROA1_HUMAN	HNRNPA1	physical	11003644
HNRH1_HUMAN	HNRNPH1	physical	11003644
GARS_HUMAN	GARS	physical	22863883
GFPT1_HUMAN	GFPT1	physical	22863883
HNRPD_HUMAN	HNRNPD	physical	22863883
NP1L4_HUMAN	NAP1L4	physical	22863883
CHCH2_HUMAN	CHCHD2	physical	26344197
CPSF6_HUMAN	CPSF6	physical	26344197
CPSF7_HUMAN	CPSF7	physical	26344197
FUBP3_HUMAN	FUBP3	physical	26344197
HTRA2_HUMAN	HTRA2	physical	26344197
KYNU_HUMAN	KYNU	physical	26344197
NUP50_HUMAN	NUP50	physical	26344197
PRDX2_HUMAN	PRDX2	physical	26344197
PRDX5_HUMAN	PRDX5	physical	26344197
SIN3A_HUMAN	SIN3A	physical	26344197
SMRC1_HUMAN	SMARCC1	physical	26344197
SMRC2_HUMAN	SMARCC2	physical	26344197
SYMPK_HUMAN	SYMPK	physical	26344197
KLH12_HUMAN	KLHL12	physical	27899653
CUL3_HUMAN	CUL3	physical	27899653
RNC_HUMAN	DROSHA	physical	29020972
DGCR8_HUMAN	DGCR8	physical	29020972

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FUBP2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-87, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Phosphorylation-mediated unfolding of a KH domain regulates KSRPlocalization via 14-3-3 binding."; Diaz-Moreno I., Hollingworth D., Frenkiel T.A., Kelly G., Martin S.,Howell S., Garcia-Mayoral M., Gherzi R., Briata P., Ramos A.; Nat. Struct. Mol. Biol. 16:238-246(2009). Cited for: STRUCTURE BY NMR OF 130-218 AND 221-305, PHOSPHORYLATION AT SER-193,AND SUBCELLULAR LOCATION.	19198587 [Abstract]
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