HTRA2_HUMAN - dbPTM
HTRA2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HTRA2_HUMAN
UniProt AC O43464
Protein Name Serine protease HTRA2, mitochondrial
Gene Name HTRA2
Organism Homo sapiens (Human).
Sequence Length 458
Subcellular Localization Mitochondrion intermembrane space. Mitochondrion membrane
Single-pass membrane protein . Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria
Protein Description Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive..
Protein Sequence MAAPRAGRGAGWSLRAWRALGGIRWGRRPRLTPDLRALLTSGTSDPRARVTYGTPSLWARLSVGVTEPRACLTSGTPGPRAQLTAVTPDTRTREASENSGTRSRAWLAVALGAGGAVLLLLWGGGRGPPAVLAAVPSPPPASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHVVADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPEVTE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Methylation---MAAPRAGRGAGW
---CCCCCCCCCCCC		44.9730760047
8MethylationMAAPRAGRGAGWSLR
CCCCCCCCCCCCCHH		30.7054556843
13PhosphorylationAGRGAGWSLRAWRAL
CCCCCCCCHHHHHHH		13.6824719451
40PhosphorylationPDLRALLTSGTSDPR
HHHHHHHHCCCCCCC		26.4320873877
41PhosphorylationDLRALLTSGTSDPRA
HHHHHHHCCCCCCCC		39.7920873877
43PhosphorylationRALLTSGTSDPRARV
HHHHHCCCCCCCCEE		29.7120873877
44PhosphorylationALLTSGTSDPRARVT
HHHHCCCCCCCCEEE		49.4920873877
51PhosphorylationSDPRARVTYGTPSLW
CCCCCEEEECCHHHH		15.6422817900
54PhosphorylationRARVTYGTPSLWARL
CCEEEECCHHHHHHE		10.1722817900
56PhosphorylationRVTYGTPSLWARLSV
EEEECCHHHHHHEEC		36.0624719451
62PhosphorylationPSLWARLSVGVTEPR
HHHHHHEECCCCCCC		15.9824888630
73PhosphorylationTEPRACLTSGTPGPR
CCCCEECCCCCCCCC		25.6224719451
96PhosphorylationDTRTREASENSGTRS
CCCCHHHHCCCCCCH		32.34-
101PhosphorylationEASENSGTRSRAWLA
HHHCCCCCCHHHHHH		25.8728787133
142PhosphorylationVPSPPPASPRSQYNF
CCCCCCCCCHHHCCC		26.9821701498
157PhosphorylationIADVVEKTAPAVVYI
HHHHHHHHCCEEEEE		25.11-
212PhosphorylationRVRVRLLSGDTYEAV
CEEEEEECCCCEEEE		38.9317311912
215PhosphorylationVRLLSGDTYEAVVTA
EEEECCCCEEEEEEE		27.1326434776
216PhosphorylationRLLSGDTYEAVVTAV
EEECCCCEEEEEEEE		13.4626434776
221PhosphorylationDTYEAVVTAVDPVAD
CCEEEEEEEEECCCC		17.8627732954
237UbiquitinationATLRIQTKEPLPTLP
EEEEECCCCCCCCCC		40.7421890473
237 (in isoform 4)Ubiquitination-40.7421890473
237 (in isoform 3)Ubiquitination-40.7421890473
237 (in isoform 1)Ubiquitination-40.7421890473
242PhosphorylationQTKEPLPTLPLGRSA
CCCCCCCCCCCCCCC		49.00-
285 (in isoform 2)Phosphorylation-6.7330624053
286 (in isoform 2)Phosphorylation-39.3330624053
287 (in isoform 2)Phosphorylation-3.5530624053
290 (in isoform 2)Phosphorylation-39.0130624053
292 (in isoform 2)Phosphorylation-7.2030624053
296 (in isoform 2)Phosphorylation-32.2130624053
326PhosphorylationGVNTMKVTAGISFAI
EEEEEEEEEEEEEEE		17.41-
330PhosphorylationMKVTAGISFAIPSDR
EEEEEEEEEEECHHH		14.01-
335PhosphorylationGISFAIPSDRLREFL
EEEEEECHHHHHHHH		29.2926330541
350PhosphorylationHRGEKKNSSSGISGS
HHCCCCCCCCCCCHH		34.4630576142
351PhosphorylationRGEKKNSSSGISGSQ
HCCCCCCCCCCCHHH		41.8127251275
352PhosphorylationGEKKNSSSGISGSQR
CCCCCCCCCCCHHHH		39.7122210691
360 (in isoform 3)Phosphorylation-21.5630624053
361PhosphorylationISGSQRRYIGVMMLT
CCHHHHHEEEEEEEE		12.2922817900
361 (in isoform 3)Phosphorylation-12.2930624053
362 (in isoform 3)Phosphorylation-2.9630624053
365 (in isoform 3)Phosphorylation-1.2130624053
367 (in isoform 3)Phosphorylation-2.0530624053
371 (in isoform 3)Phosphorylation-28.6230624053
395 (in isoform 1)Ubiquitination-24.7921890473
395UbiquitinationQHGVLIHKVILGSPA
CCCEEEEEHHHCCHH		24.7921890473
400PhosphorylationIHKVILGSPAHRAGL
EEEHHHCCHHHHCCC		18.5721701498
433PhosphorylationDVYEAVRTQSQLAVQ
HHHHHHHHHHHHHHH		26.4426437602
435PhosphorylationYEAVRTQSQLAVQIR
HHHHHHHHHHHHHHH		26.9226437602
453PhosphorylationETLTLYVTPEVTE--
CEEEEEECCCCCC--		10.52-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
142SPhosphorylationKinaseMAPK12P53778
GPS
142SPhosphorylationKinaseP38AQ16539
PSP
212SPhosphorylationKinaseAKT1P31749
PSP
212SPhosphorylationKinaseAKT2P31751
PSP
400SPhosphorylationKinaseCDK5Q00535
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HTRA2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HTRA2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MK14_HUMANMAPK14physical
10644717
XIAP_HUMANXIAPphysical
12865429
BIRC2_HUMANBIRC2physical
12865429
BIRC3_HUMANBIRC3physical
12865429
BIRC6_HUMANBIRC6physical
15781261
LATS1_HUMANLATS1physical
17130845
APC_HUMANAPCphysical
16007220
LATS1_HUMANLATS1physical
16007220
BIRC6_HUMANBIRC6physical
15507451
HTRA2_HUMANHTRA2physical
15201285
CASB_HUMANCSN2physical
15201285
XIAP_HUMANXIAPphysical
15201285
XIAP_HUMANXIAPphysical
11602612
CASB_HUMANCSN2physical
11583623
XIAP_HUMANXIAPphysical
11606597
DBLOH_HUMANDIABLOphysical
11606597
HAX1_HUMANHAX1physical
17906618
XIAP_HUMANXIAPphysical
17906618
PINK1_HUMANPINK1physical
17906618
TIM9_HUMANTIMM9physical
22939629
NDUV1_HUMANNDUFV1physical
22939629
OPA1_HUMANOPA1physical
22939629
ACTS_HUMANACTA1physical
17266347
TBA1A_HUMANTUBA1Aphysical
17266347
TBB5_HUMANTUBBphysical
17266347
TBB6_HUMANTUBB6physical
17266347
VIME_HUMANVIMphysical
17266347
AL1A2_HUMANALDH1A2physical
17266347
HCD2_HUMANHSD17B10physical
17266347
IF4G1_HUMANEIF4G1physical
17266347
EF1A1_HUMANEEF1A1physical
17266347
TIF1B_HUMANTRIM28physical
17266347
PYR1_HUMANCADphysical
17266347
VPS4B_HUMANVPS4Bphysical
17266347
CCAR2_HUMANCCAR2physical
17266347
PDXD1_HUMANPDXDC1physical
17266347
HTRA2_HUMANHTRA2physical
17266347
AREL1_HUMANAREL1physical
23479728
LATS1_HUMANLATS1physical
22641346
XIAP_HUMANXIAPphysical
24698088
ASSY_HUMANASS1physical
26344197
DEST_HUMANDSTNphysical
26344197
AATC_HUMANGOT1physical
26344197
PDC6I_HUMANPDCD6IPphysical
26344197
TIA1_HUMANTIA1physical
26344197
TERA_HUMANVCPphysical
26389662
MUL1_HUMANMUL1physical
24709290
RBP10_HUMANRANBP10physical
27173435
MKLN1_HUMANMKLN1physical
27173435
WDR26_HUMANWDR26physical
27173435
ARMC8_HUMANARMC8physical
27173435
Drug and Disease Associations
Kegg Disease
H00057 Parkinson's disease (PD)
OMIM Disease
610297Parkinson disease 13 (PARK13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HTRA2_HUMAN

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Related Literatures of Post-Translational Modification

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