AL1A2_HUMAN - dbPTM
AL1A2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AL1A2_HUMAN
UniProt AC O94788
Protein Name Retinal dehydrogenase 2
Gene Name ALDH1A2
Organism Homo sapiens (Human).
Sequence Length 518
Subcellular Localization Cytoplasm.
Protein Description Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity)..
Protein Sequence MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTSSKIEMP
------CCCCCCCCC		41.5323186163
3Phosphorylation-----MTSSKIEMPG
-----CCCCCCCCCC		28.4723186163
4Phosphorylation----MTSSKIEMPGE
----CCCCCCCCCCC		28.6123186163
22PhosphorylationDPAALMASLHLLPSP
CHHHHHHHHCCCCCC		11.4527251275
28PhosphorylationASLHLLPSPTPNLEI
HHHCCCCCCCCCCEE		41.1828857561
87UbiquitinationAVQAARLAFSLGSVW
HHHHHHHHHHHHHHH		6.0929967540
108UbiquitinationERGRLLDKLADLVER
HHHHHHHHHHHHHHH		45.6129967540
108AcetylationERGRLLDKLADLVER
HHHHHHHHHHHHHHH		45.6125038526
168PhosphorylationTIPVDGDYFTFTRHE
EEEECCCEEEEECCC		15.2823917254
170PhosphorylationPVDGDYFTFTRHEPI
EECCCEEEEECCCCC		20.1930804109
172PhosphorylationDGDYFTFTRHEPIGV
CCCEEEEECCCCCCC		28.2346161935
173UbiquitinationGDYFTFTRHEPIGVC
CCEEEEECCCCCCCC		28.1629967540
215PhosphorylationVIKPAEQTPLSALYM
EECCCCCCCCHHHHH		20.0828842319
218PhosphorylationPAEQTPLSALYMGAL
CCCCCCCHHHHHHHH		19.8928842319
221PhosphorylationQTPLSALYMGALIKE
CCCCHHHHHHHHHHH		8.0128842319
248UbiquitinationGYGPTAGAAIASHIG
CCCCCHHHHHHHHHC		8.0129967540
269UbiquitinationTGSTEVGKLIQEAAG
ECCHHHHHHHHHHHC		47.8222817900
270UbiquitinationGSTEVGKLIQEAAGR
CCHHHHHHHHHHHCC		3.9322817900
274UbiquitinationVGKLIQEAAGRSNLK
HHHHHHHHHCCCCCC		9.9921890473
278PhosphorylationIQEAAGRSNLKRVTL
HHHHHCCCCCCEEEE		45.6746161929
284PhosphorylationRSNLKRVTLELGGKS
CCCCCEEEEECCCCC		20.6720166139
288UbiquitinationKRVTLELGGKSPNII
CEEEEECCCCCCCEE		31.9122505724
294UbiquitinationLGGKSPNIIFADADL
CCCCCCCEEEEECCH		2.8822505724
299UbiquitinationPNIIFADADLDYAVE
CCEEEEECCHHHHHH		18.8122505724
319UbiquitinationVFFNQGQCCTAGSRI
CCCCCCCCCCCCCEE		2.5922505724
327UbiquitinationCTAGSRIFVEESIYE
CCCCCEEEEEHHHHH		5.7122817900
328UbiquitinationTAGSRIFVEESIYEE
CCCCEEEEEHHHHHH		8.1022817900
332 (in isoform 2)Ubiquitination-5.9321890473
332UbiquitinationRIFVEESIYEEFVRR
EEEEEHHHHHHHHHH		5.9321890473
333UbiquitinationIFVEESIYEEFVRRS
EEEEHHHHHHHHHHH		20.7724816145
333PhosphorylationIFVEESIYEEFVRRS
EEEEHHHHHHHHHHH		20.777580215
344UbiquitinationVRRSVERAKRRVVGS
HHHHHHHHHHHHCCC		9.0122817900
345UbiquitinationRRSVERAKRRVVGSP
HHHHHHHHHHHCCCC		47.1322817900
346UbiquitinationRSVERAKRRVVGSPF
HHHHHHHHHHCCCCC		35.3222505724
349UbiquitinationERAKRRVVGSPFDPT
HHHHHHHCCCCCCCC		6.2721890473
351PhosphorylationAKRRVVGSPFDPTTE
HHHHHCCCCCCCCCC		15.7014702039
352UbiquitinationKRRVVGSPFDPTTEQ
HHHHCCCCCCCCCCC		31.5622505724
357UbiquitinationGSPFDPTTEQGPQID
CCCCCCCCCCCCCCC		31.5322505724
363UbiquitinationTTEQGPQIDKKQYNK
CCCCCCCCCHHHHHH		10.6322505724
365UbiquitinationEQGPQIDKKQYNKIL
CCCCCCCHHHHHHHH		43.3222817900
366UbiquitinationQGPQIDKKQYNKILE
CCCCCCHHHHHHHHH		55.0222817900
369UbiquitinationQIDKKQYNKILELIQ
CCCHHHHHHHHHHHH		23.5422505724
370 (in isoform 1)Ubiquitination-43.6721890473
370UbiquitinationIDKKQYNKILELIQS
CCHHHHHHHHHHHHH		43.6721890473
370UbiquitinationIDKKQYNKILELIQS
CCHHHHHHHHHHHHH		43.6722817900
374UbiquitinationQYNKILELIQSGVAE
HHHHHHHHHHHCCCC		3.7522505724
377UbiquitinationKILELIQSGVAEGAK
HHHHHHHHCCCCCCE		28.3922505724
384AcetylationSGVAEGAKLECGGKG
HCCCCCCEEEECCCC		56.5330586853
384UbiquitinationSGVAEGAKLECGGKG
HCCCCCCEEEECCCC		56.5322505724
390UbiquitinationAKLECGGKGLGRKGF
CEEEECCCCCCCCCC		35.9222505724
390AcetylationAKLECGGKGLGRKGF
CEEEECCCCCCCCCC		35.9224847131
391UbiquitinationKLECGGKGLGRKGFF
EEEECCCCCCCCCCE		36.3224816145
394UbiquitinationCGGKGLGRKGFFIEP
ECCCCCCCCCCEECC		40.7522505724
395UbiquitinationGGKGLGRKGFFIEPT
CCCCCCCCCCEECCE		59.2722505724
408UbiquitinationPTVFSNVTDDMRIAK
CEEECCCCCCCHHHH		30.4524816145
411UbiquitinationFSNVTDDMRIAKEEI
ECCCCCCCHHHHHHH		3.5729967540
415UbiquitinationTDDMRIAKEEIFGPV
CCCCHHHHHHHHCCH		54.2122505724
429UbiquitinationVQEILRFKTMDEVIE
HHHHHCCCCHHHHHH		36.1824816145
469UbiquitinationSAMQAGTVWINCYNA
HHHHCCCEEEECCCC		4.7729967540
486UbiquitinationAQSPFGGFKMSGNGR
CCCCCCCEEECCCCC		6.5029967540
507UbiquitinationLREYSEVKTVTVKIP
CCCCCEEEEEEEECC		32.9729967540
512UbiquitinationEVKTVTVKIPQKNS-
EEEEEEEECCCCCC-		39.02-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AL1A2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AL1A2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AL1A2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of AL1A2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00755Tretinoin
DB00162Vitamin A
Regulatory Network of AL1A2_HUMAN

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Related Literatures of Post-Translational Modification

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