CASB_HUMAN - dbPTM
CASB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CASB_HUMAN
UniProt AC P05814
Protein Name Beta-casein
Gene Name CSN2
Organism Homo sapiens (Human).
Sequence Length 226
Subcellular Localization Secreted.
Protein Description Important role in determination of the surface properties of the casein micelles..
Protein Sequence MKVLILACLVALALARETIESLSSSEESITEYKQKVEKVKHEDQQQGEDEHQDKIYPSFQPQPLIYPFVEPIPYGFLPQNILPLAQPAVVLPVPQPEIMEVPKAKDTVYTKGRVMPVLKSPTIPFFDPQIPKLTDLENLHLPLPLLQPLMQQVPQPIPQTLALPPQPLWSVPQPKVLPIPQQVVPYPQRAVPVQALLLNQELLLNPTHQIYPVTQPLAPVHNPISV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationALALARETIESLSSS
HHHHHHHHHHHHCCC
25.2120068231
21PhosphorylationLARETIESLSSSEES
HHHHHHHHHCCCCHH
29.6920068231
23PhosphorylationRETIESLSSSEESIT
HHHHHHHCCCCHHHH
40.8920068231
24PhosphorylationETIESLSSSEESITE
HHHHHHCCCCHHHHH
47.2420068231
25PhosphorylationTIESLSSSEESITEY
HHHHHCCCCHHHHHH
41.8420068231
28PhosphorylationSLSSSEESITEYKQK
HHCCCCHHHHHHHHH
30.6620068231
30PhosphorylationSSSEESITEYKQKVE
CCCCHHHHHHHHHHH
42.4120068231
32PhosphorylationSEESITEYKQKVEKV
CCHHHHHHHHHHHHH
15.2920068231
120PhosphorylationRVMPVLKSPTIPFFD
CEEEEECCCCCCCCC
24.1027251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CASB_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
24SPhosphorylation

6715339
25SPhosphorylation

6715339

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CASB_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FHL2_HUMANFHL2physical
25416956
COR2A_HUMANCORO2Aphysical
28514442
PP2BC_HUMANPPP3CCphysical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CASB_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of the human casein phosphoproteome by 2-D electrophoresisand MALDI-TOF/TOF MS reveals new phosphoforms.";
Poth A.G., Deeth H.C., Alewood P.F., Holland J.W.;
J. Proteome Res. 7:5017-5027(2008).
Cited for: PROTEIN SEQUENCE OF 18-33, PHOSPHORYLATION AT THR-18; SER-21; SER-23;SER-24 AND SER-25, AND MASS SPECTROMETRY.
"Human beta-casein. Amino acid sequence and identification ofphosphorylation sites.";
Greenberg R., Groves M.L., Dower H.J.;
J. Biol. Chem. 259:5132-5138(1984).
Cited for: PROTEIN SEQUENCE OF 16-226, AND PHOSPHORYLATION AT THR-18; SER-21;SER-23; SER-24 AND SER-25.

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