COR2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COR2A_HUMAN
• UniProt AC: Q92828
• Protein Name: Coronin-2A
• Gene Name: CORO2A
• Organism: Homo sapiens (Human).
• Sequence Length: 525
• Protein Sequence: MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRNLTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQDVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVLQEASYKGHRASKVLFLGNLKKLMSTGTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYYEVSADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVPRRSESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPGSELLRPHPLPAERPIFNSMAPASPRLLNQTEKLAAEDGWRSSSLLEEKMPRWAAEHRLEEKKTWLTNGFDVFECPPPKTENELLQMFYRQQEEIRRLRELLTQREVQAKQLELEIKNLRMGSEQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Methylation	VFGKPASKENCYDSV CCCCCCCCCCCCCCC	55.86	-
26	Phosphorylation	PASKENCYDSVPITR CCCCCCCCCCCCCCC	23.88	-
111	Phosphorylation	DATIKIWSIPKQLLT CCEEEEEECCHHHHH	32.27	-
114	Ubiquitination	IKIWSIPKQLLTRNL EEEEECCHHHHHCCC	52.48	-
122	Phosphorylation	QLLTRNLTAYRKELV HHHHCCCHHHHHHHH	25.78	19664995
124	Phosphorylation	LTRNLTAYRKELVGH HHCCCHHHHHHHHHC	19.58	19664995
221	Ubiquitination	VLQEASYKGHRASKV HHEHHCCCCCCHHEE	45.83	-
221	Methylation	VLQEASYKGHRASKV HHEHHCCCCCCHHEE	45.83	-
226	Phosphorylation	SYKGHRASKVLFLGN CCCCCCHHEEEEECC	24.21	-
235	Ubiquitination	VLFLGNLKKLMSTGT EEEECCHHHHHCCCC	48.11	-
239	Phosphorylation	GNLKKLMSTGTSRWN CCHHHHHCCCCCCCC	33.84	24732914
240	Phosphorylation	NLKKLMSTGTSRWNN CHHHHHCCCCCCCCC	30.43	24732914
242	Phosphorylation	KKLMSTGTSRWNNRQ HHHHCCCCCCCCCCE	18.40	24732914
297	Phosphorylation	KGDGNIRYYEVSADK CCCCCEEEEEECCCC	10.53	26657352
301	Phosphorylation	NIRYYEVSADKPHLS CEEEEEECCCCCCEE	20.86	22210691
308	Phosphorylation	SADKPHLSYLTEYRS CCCCCCEEHHHHHHC	18.30	26657352
313	Phosphorylation	HLSYLTEYRSYNPQK CEEHHHHHHCCCCCC	10.30	26657352
320	Ubiquitination	YRSYNPQKGIGVMPK HHCCCCCCCCCCCCC	54.47	-
327	Acetylation	KGIGVMPKRGLDVSS CCCCCCCCCCCCHHH	40.79	7708519
342	Ubiquitination	CEIFRFYKLITTKSL CCHHHHHHHHCCHHH	30.60	-
346	Phosphorylation	RFYKLITTKSLIEPI HHHHHHCCHHHHCEE	16.19	-
347	Ubiquitination	FYKLITTKSLIEPIS HHHHHCCHHHHCEEE	34.32	-
348	Phosphorylation	YKLITTKSLIEPISM HHHHCCHHHHCEEEE	32.27	21406692
354	Phosphorylation	KSLIEPISMIVPRRS HHHHCEEEEECCCCC	17.11	21406692
363	Phosphorylation	IVPRRSESYQEDIYP ECCCCCCCCCCCCCC	33.10	-
364	Phosphorylation	VPRRSESYQEDIYPP CCCCCCCCCCCCCCC	16.33	-
396	Phosphorylation	NRDPILVSLRPGSEL CCCCEEEEECCCCCC	18.40	24719451
418	Phosphorylation	AERPIFNSMAPASPR CCCCCCCCCCCCCHH	12.94	29255136
423	Phosphorylation	FNSMAPASPRLLNQT CCCCCCCCHHHHHHH	14.97	29255136
432	Ubiquitination	RLLNQTEKLAAEDGW HHHHHHHHHHHHCCC	46.98	-
441	Phosphorylation	AAEDGWRSSSLLEEK HHHCCCCCCHHHHHH	20.12	28857561
442	Phosphorylation	AEDGWRSSSLLEEKM HHCCCCCCHHHHHHH	19.21	23312004
443	Phosphorylation	EDGWRSSSLLEEKMP HCCCCCCHHHHHHHH	37.91	25159151
516	Ubiquitination	KQLELEIKNLRMGSE HHHHHHHHHHHCCCC	40.32	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COR2A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COR2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COR2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOR1_HUMAN	NCOR1	physical	12628926
NR1H2_HUMAN	NR1H2	physical	21331046
BCLF1_HUMAN	BCLAF1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.