NR1H2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR1H2_HUMAN
• UniProt AC: P55055
• Protein Name: Oxysterols receptor LXR-beta
• Gene Name: NR1H2
• Organism: Homo sapiens (Human).
• Sequence Length: 460
• Subcellular Localization: Nucleus .
• Protein Description: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. [PubMed: 25661920 Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4 Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex]
• Protein Sequence: MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSPTTSSL ------CCCCCCCCC	45.05	25159151
3	Phosphorylation	-----MSSPTTSSLD -----CCCCCCCCCC	25.60	25159151
5	Phosphorylation	---MSSPTTSSLDTP ---CCCCCCCCCCCC	41.06	23090842
6	Phosphorylation	--MSSPTTSSLDTPL --CCCCCCCCCCCCC	21.50	25159151
7	Phosphorylation	-MSSPTTSSLDTPLP -CCCCCCCCCCCCCC	31.23	23090842
8	Phosphorylation	MSSPTTSSLDTPLPG CCCCCCCCCCCCCCC	28.33	23090842
11	Phosphorylation	PTTSSLDTPLPGNGP CCCCCCCCCCCCCCC	31.83	23090842
25	Phosphorylation	PPQPGAPSSSPTVKE CCCCCCCCCCCCCCC	42.80	25850435
26	Phosphorylation	PQPGAPSSSPTVKEE CCCCCCCCCCCCCCC	39.00	25850435
27	Phosphorylation	QPGAPSSSPTVKEEG CCCCCCCCCCCCCCC	29.00	25850435
29	Phosphorylation	GAPSSSPTVKEEGPE CCCCCCCCCCCCCCC	46.27	23090842
31	Sumoylation	PSSSPTVKEEGPEPW CCCCCCCCCCCCCCC	53.15	-
126	Methylation	GARRYACRGGGTCQM CCCCCCCCCCCCCHH	38.32	30760333
150	Ubiquitination	QCRLRKCKEAGMREQ HHHHHHHHHHCCHHH	54.34	-
200	Phosphorylation	SASGPGASPGGSEAG CCCCCCCCCCCCCCC	29.96	24275569
247	Ubiquitination	RSFSDQPKVTPWPLG CCCCCCCCCCCCCCC	53.78	-
398	Phosphorylation	VEALQQPYVEALLSY HHHHCCHHHHHHHHH	13.44	28450419
404	Phosphorylation	PYVEALLSYTRIKRP HHHHHHHHHHCCCCH	25.88	28450419
406	Phosphorylation	VEALLSYTRIKRPQD HHHHHHHHCCCCHHH	23.65	28450419
409	Sumoylation	LLSYTRIKRPQDQLR HHHHHCCCCHHHHCC	55.52	-
409	Sumoylation	LLSYTRIKRPQDQLR HHHHHCCCCHHHHCC	55.52	20159957
426	Phosphorylation	RMLMKLVSLRTLSSV HHHHHHHHHHHHHHC	23.67	24719451
447	Sumoylation	ALRLQDKKLPPLLSE HHHHCCCCCCCHHHH	74.62	-
447	Sumoylation	ALRLQDKKLPPLLSE HHHHCCCCCCCHHHH	74.62	20159957
447	Ubiquitination	ALRLQDKKLPPLLSE HHHHCCCCCCCHHHH	74.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
426	S	Phosphorylation	Kinase	CAMK2A	Q9UQM7	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
409	K	Sumoylation	Sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.	20159957
447	K	Sumoylation	Sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.	20159957

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR1H2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RXRA_HUMAN	RXRA	physical	7760852
SIR1_HUMAN	SIRT1	physical	17936707
SMCA4_HUMAN	SMARCA4	physical	15774904
NPY_HUMAN	NPY	physical	15604093
FOXO3_HUMAN	FOXO3	physical	15604093
RXRA_HUMAN	RXRA	physical	15604093
7B2_HUMAN	SCG5	physical	15604093
UBC9_HUMAN	UBE2I	physical	15604093
NCOR2_HUMAN	NCOR2	physical	15604093
NCOR1_HUMAN	NCOR1	physical	15604093
NCOA3_HUMAN	NCOA3	physical	15604093
RXRG_HUMAN	RXRG	physical	15604093
T161A_HUMAN	TMEM161A	physical	15604093
ING3_HUMAN	ING3	physical	15604093
RXRB_HUMAN	RXRB	physical	15604093
PCD17_HUMAN	PCDH17	physical	15604093
RXRG_HUMAN	RXRG	physical	21900206
ERG28_HUMAN	C14orf1	physical	21900206
ROBO2_HUMAN	ROBO2	physical	21900206
CHD3_HUMAN	CHD3	physical	21900206
EM55_HUMAN	MPP1	physical	21900206
ASM_HUMAN	SMPD1	physical	21900206
CSAD_HUMAN	CSAD	physical	21900206
VIME_HUMAN	VIM	physical	21900206
CO4A5_HUMAN	COL4A5	physical	21900206
SRBS2_HUMAN	SORBS2	physical	21900206
BAG6_HUMAN	BAG6	physical	21900206
UB2D1_HUMAN	UBE2D1	physical	21900206
RMI1_HUMAN	RMI1	physical	21900206
HMGX4_HUMAN	HMGXB4	physical	21900206
FAF1_HUMAN	FAF1	physical	21900206
COR2A_HUMAN	CORO2A	physical	21331046
SENP3_HUMAN	SENP3	physical	21331046
PIAS1_HUMAN	PIAS1	physical	22969086
PRGC2_HUMAN	PPARGC1B	physical	22969086
UBP7_HUMAN	USP7	physical	22939629
PDCD4_HUMAN	PDCD4	physical	22939629
NCOR2_HUMAN	NCOR2	physical	16219912
MDFI_HUMAN	MDFI	physical	19060904
KDM1A_HUMAN	KDM1A	physical	23455924
ACVL1_HUMAN	ACVRL1	physical	12393874
TYY1_HUMAN	YY1	physical	21988832
SUV91_HUMAN	SUV39H1	physical	23455924
NCOA1_HUMAN	NCOA1	physical	15604093
NR0B2_HUMAN	NR0B2	physical	27485016
PIAS1_HUMAN	PIAS1	physical	27485016
STAT1_HUMAN	STAT1	physical	27485016

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.