NR0B2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR0B2_HUMAN
• UniProt AC: Q15466
• Protein Name: Nuclear receptor subfamily 0 group B member 2
• Gene Name: NR0B2
• Organism: Homo sapiens (Human).
• Sequence Length: 257
• Subcellular Localization: Nucleus . Cytoplasm . Colocalizes with NEUROD1 in the nucleus.
• Protein Description: Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1..
• Protein Sequence: MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDVPGLQAASHIGHLQQEAHWVLCEVLEPWCPAAQGRLTRVLLTASTLKSIPTSLLGDLFFRPIIGDVDIAGLLGDMLLLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Symmetric dimethylarginine	VQLCAPHRTCREALD CEECCCCCHHHHHHH	34.17	-
55	Phosphorylation	QLCAPHRTCREALDV EECCCCCHHHHHHHH	16.93	-
57	Methylation	CAPHRTCREALDVLA CCCCCHHHHHHHHHH	31.45	57404601
57	Symmetric dimethylarginine	CAPHRTCREALDVLA CCCCCHHHHHHHHHH	31.45	-
116	Phosphorylation	VAEAPVPSILKKILL HCCCCCCHHHHHHHC	40.56	24719451
170	Acetylation	PKEYACLKGTILFNP HHHEEEEECEEEECC	54.62	30422853
238	Dimethylation	LLGDLFFRPIIGDVD HHHHHHCCCCCCCCC	17.74	-
238	Methylation	LLGDLFFRPIIGDVD HHHHHHCCCCCCCCC	17.74	24379833

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
55	T	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	MDM2	Q00987	PMID:22575647

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NR0B2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR0B2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANDR_HUMAN	AR	physical	11735420
HNF4A_HUMAN	HNF4A	physical	10594021
RXRA_HUMAN	RXRA	physical	10594021
RARA_HUMAN	RARA	physical	8650544
RXRG_HUMAN	RXRG	physical	8650544
THA_HUMAN	THRA	physical	8650544
ESR1_HUMAN	ESR1	physical	9773978
RARA_HUMAN	RARA	physical	9773978
NR1H3_HUMAN	NR1H3	physical	12198243
NR1H2_HUMAN	NR1H2	physical	12198243
RXRA_HUMAN	RXRA	physical	12198243
NR5A2_HUMAN	NR5A2	physical	12198243
RPB1_HUMAN	POLR2A	physical	12198243
NR5A2_HUMAN	NR5A2	physical	11668176
SP2_HUMAN	SP2	physical	17071613
KLF6_HUMAN	KLF6	physical	17071613
HNF6_HUMAN	ONECUT1	physical	18459945
EID1_HUMAN	EID1	physical	11964378
HDAC1_HUMAN	HDAC1	physical	15835920
HDAC3_HUMAN	HDAC3	physical	15835920
HDAC6_HUMAN	HDAC6	physical	15835920
SMCA2_HUMAN	SMARCA2	physical	15314177
SIN3A_HUMAN	SIN3A	physical	15314177
SNF5_HUMAN	SMARCB1	physical	15314177
SMCE1_HUMAN	SMARCE1	physical	15314177
SMRC1_HUMAN	SMARCC1	physical	15314177
SIR1_HUMAN	SIRT1	physical	20375098
SIR6_HUMAN	SIRT6	physical	20375098
SIR7_HUMAN	SIRT7	physical	20375098
ANM5_MOUSE	Prmt5	physical	21262773
SMCA2_HUMAN	SMARCA2	physical	21262773
HDAC1_HUMAN	HDAC1	physical	21262773
NR5A2_HUMAN	NR5A2	physical	21262773
RUNX2_HUMAN	RUNX2	physical	19594294
TRAF6_HUMAN	TRAF6	physical	21725320
MDM2_HUMAN	MDM2	physical	22575647
P53_HUMAN	TP53	physical	22575647
GPS2_HUMAN	GPS2	physical	17895379
HDAC1_HUMAN	HDAC1	physical	17895379
HDAC3_HUMAN	HDAC3	physical	17895379
P53_HUMAN	TP53	physical	22737255
NR5A2_HUMAN	NR5A2	physical	14963109
NR1I3_MOUSE	Nr1i3	physical	14963109
ERR3_HUMAN	ESRRG	physical	14963109
PEF1_HUMAN	PEF1	physical	21988832
ZMY10_HUMAN	ZMYND10	physical	21988832
SMAD4_HUMAN	SMAD4	physical	21988832
PLS1_HUMAN	PLSCR1	physical	21988832
RXRA_HUMAN	RXRA	physical	21988832
ZAP70_HUMAN	ZAP70	physical	21988832
RET5_HUMAN	RBP5	physical	21988832
ICK_HUMAN	ICK	physical	26186194
NDF1_HUMAN	NEUROD1	physical	14752053
ID2_HUMAN	ID2	physical	14752053
NR1I2_HUMAN	NR1I2	physical	16455805
ICK_HUMAN	ICK	physical	28514442
VCIP1_HUMAN	VCPIP1	physical	28514442
PIAS1_HUMAN	PIAS1	physical	27485016

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601665: Obesity (OBESITY)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.