HNF6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HNF6_HUMAN
• UniProt AC: Q9UBC0
• Protein Name: Hepatocyte nuclear factor 6
• Gene Name: ONECUT1
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Nucleus.
• Protein Description: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription..
• Protein Sequence: MNAQLTMEAIGELHGVSHEPVPAPADLLGGSPHARSSVAHRGSHLPPAHPRSMGMASLLDGGSGGGDYHHHHRAPEHSLAGPLHPTMTMACETPPGMSMPTTYTTLTPLQPLPPISTVSDKFPHHHHHHHHHHHPHHHQRLAGNVSGSFTLMRDERGLASMNNLYTPYHKDVAGMGQSLSPLSSSGLGSIHNSQQGLPHYAHPGAAMPTDKMLTPNGFEAHHPAMLGRHGEQHLTPTSAGMVPINGLPPHHPHAHLNAQGHGQLLGTAREPNPSVTGAQVSNGSNSGQMEEINTKEVAQRITTELKRYSIPQAIFAQRVLCRSQGTLSDLLRNPKPWSKLKSGRETFRRMWKWLQEPEFQRMSALRLAACKRKEQEHGKDRGNTPKKPRLVFTDVQRRTLHAIFKENKRPSKELQITISQQLGLELSTVSNFFMNARRRSLDKWQDEGSSNSGNSSSSSSTCTKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	PADLLGGSPHARSSV CHHHCCCCCCCCHHC	16.24	24275569
68	Phosphorylation	GGSGGGDYHHHHRAP CCCCCCCCCCCCCCC	13.31	-
168	Phosphorylation	MNNLYTPYHKDVAGM HCCCCCCCCCCCCCC	17.44	-
214	Phosphorylation	MPTDKMLTPNGFEAH CCCCCCCCCCCHHHC	15.94	23532336
308	Phosphorylation	ITTELKRYSIPQAIF HHHHHHHHCHHHHHH	14.90	-
326	Phosphorylation	VLCRSQGTLSDLLRN HHHHCCCCHHHHHHC	18.56	-
328	Phosphorylation	CRSQGTLSDLLRNPK HHCCCCHHHHHHCCC	26.50	-
339	Acetylation	RNPKPWSKLKSGRET HCCCCHHHCHHHHHH	56.94	-
440	Phosphorylation	FMNARRRSLDKWQDE HHHHHHHCHHHHHCC	38.82	-
449	Phosphorylation	DKWQDEGSSNSGNSS HHHHCCCCCCCCCCC	25.05	22468782
450	Phosphorylation	KWQDEGSSNSGNSSS HHHCCCCCCCCCCCC	45.96	-
455	Phosphorylation	GSSNSGNSSSSSSTC CCCCCCCCCCCCCCC	34.81	30576142
461	Phosphorylation	NSSSSSSTCTKA--- CCCCCCCCCCCC---	26.58	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HNF6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HNF6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HNF6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT2B_HUMAN	KAT2B	physical	10811635
KAT2B_HUMAN	KAT2B	genetic	10811635
SPB13_HUMAN	SERPINB13	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.