NDF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDF1_HUMAN
• UniProt AC: Q13562
• Protein Name: Neurogenic differentiation factor 1
• Gene Name: NEUROD1
• Organism: Homo sapiens (Human).
• Sequence Length: 356
• Subcellular Localization: Cytoplasm. Nucleus . In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus..
• Protein Description: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity)..
• Protein Sequence: MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDDLETMNAEEDSLRNGGEEEDEDEDLEEEEEEEEEDDDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNQDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGAQSHGSIFSGTAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
149	Phosphorylation	TLRLAKNYIWALSEI HHHHHHHHHHHHHHH	9.35	-
162	Phosphorylation	EILRSGKSPDLVSFV HHHHCCCCHHHHHHH	27.46	30631047
171	Phosphorylation	DLVSFVQTLCKGLSQ HHHHHHHHHHHCCCC	28.90	30631047
259	Phosphorylation	ALEPFFESPLTDCTS CCHHHHCCCCCCCCC	21.76	-
266	Phosphorylation	SPLTDCTSPSFDGPL CCCCCCCCCCCCCCC	25.52	-
274	Phosphorylation	PSFDGPLSPPLSING CCCCCCCCCCEEECC	27.83	-
284	Phosphorylation	LSINGNFSFKHEPSA EEECCCCEECCCCCH	37.07	24719451
335	Phosphorylation	IPIDNIMSFDSHSHH CCCCCEECCCCCCHH	23.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
335	S	Phosphorylation	Kinase	CAMK2	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
266	S	Phosphorylation	Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells (By similarity).	-
274	S	Phosphorylation	In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization.	-
274	S	Phosphorylation	Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells (By similarity).	-
335	S	Phosphorylation	In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HAP1_HUMAN	HAP1	physical	12881483
M3K10_HUMAN	MAP3K10	physical	12881483
HD_HUMAN	HTT	physical	12881483
CCND1_HUMAN	CCND1	genetic	11788592
CCND1_HUMAN	CCND1	physical	11788592
EP300_HUMAN	EP300	physical	11756538
ODPX_HUMAN	PDHX	physical	11756538
ITF2_HUMAN	TCF4	physical	26186194
TFE2_HUMAN	TCF3	physical	26186194
HTF4_HUMAN	TCF12	physical	26186194
DPF3_HUMAN	DPF3	physical	26186194
LACRT_HUMAN	LACRT	physical	26186194
EP300_HUMAN	EP300	physical	14752053
TFE2_HUMAN	TCF3	physical	28514442
ITF2_HUMAN	TCF4	physical	28514442
HTF4_HUMAN	TCF12	physical	28514442
DPF3_HUMAN	DPF3	physical	28514442
LACRT_HUMAN	LACRT	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.