| UniProt ID | ITF2_HUMAN | |
|---|---|---|
| UniProt AC | P15884 | |
| Protein Name | Transcription factor 4 | |
| Gene Name | TCF4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 667 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.. | |
| Protein Sequence | MHHQQRMAALGTDKELSDLLDFSAMFSPPVSSGKNGPTSLASGHFTGSNVEDRSSSGSWGNGGHPSPSRNYGDGTPYDHMTSRDLGSHDNLSPPFVNSRIQSKTERGSYSSYGRESNLQGCHQQSLLGGDMDMGNPGTLSPTKPGSQYYQYSSNNPRRRPLHSSAMEVQTKKVRKVPPGLPSSVYAPSASTADYNRDSPGYPSSKPATSTFPSSFFMQDGHHSSDPWSSSSGMNQPGYAGMLGNSSHIPQSSSYCSLHPHERLSYPSHSSADINSSLPPMSTFHRSGTNHYSTSSCTPPANGTDSIMANRGSGAAGSSQTGDALGKALASIYSPDHTNNSFSSNPSTPVGSPPSLSAGTAVWSRNGGQASSSPNYEGPLHSLQSRIEDRLERLDDAIHVLRNHAVGPSTAMPGGHGDMHGIIGPSHNGAMGGLGSGYGTGLLSANRHSLMVGTHREDGVALRGSHSLLPNQVPVPQLPVQSATSPDLNPPQDPYRGMPPGLQGQSVSSGSSEIKSDDEGDENLQDTKSSEDKKLDDDKKDIKSITSNNDDEDLTPEQKAEREKERRMANNARERLRVRDINEAFKELGRMVQLHLKSDKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSSEPPPLSLAGPHPGMGDASNHMGQM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 (in isoform 9) | Phosphorylation | - | 11.17 | 27251275 | |
| 10 (in isoform 9) | Phosphorylation | - | 5.72 | 25159151 | |
| 17 (in isoform 11) | Phosphorylation | - | 27.57 | 30631047 | |
| 17 (in isoform 7) | Phosphorylation | - | 27.57 | 30631047 | |
| 18 (in isoform 11) | Phosphorylation | - | 64.97 | 30631047 | |
| 18 (in isoform 7) | Phosphorylation | - | 64.97 | 30631047 | |
| 27 | Phosphorylation | LDFSAMFSPPVSSGK HCHHHHCCCCCCCCC | 18.40 | 22199227 | |
| 28 (in isoform 2) | Phosphorylation | - | 23.26 | 27732954 | |
| 28 (in isoform 6) | Phosphorylation | - | 23.26 | 27732954 | |
| 30 (in isoform 2) | Phosphorylation | - | 8.92 | 27732954 | |
| 30 (in isoform 6) | Phosphorylation | - | 8.92 | 27732954 | |
| 31 (in isoform 2) | Phosphorylation | - | 38.86 | 27732954 | |
| 31 (in isoform 6) | Phosphorylation | - | 38.86 | 27732954 | |
| 34 (in isoform 2) | Phosphorylation | - | 61.76 | 27732954 | |
| 34 (in isoform 6) | Phosphorylation | - | 61.76 | 27732954 | |
| 38 (in isoform 2) | Phosphorylation | - | 37.46 | 27732954 | |
| 38 (in isoform 6) | Phosphorylation | - | 37.46 | 27732954 | |
| 41 (in isoform 2) | Phosphorylation | - | 17.15 | 27732954 | |
| 41 (in isoform 6) | Phosphorylation | - | 17.15 | 27732954 | |
| 43 (in isoform 2) | Phosphorylation | - | 17.83 | 27732954 | |
| 43 (in isoform 6) | Phosphorylation | - | 17.83 | 27732954 | |
| 44 (in isoform 2) | Phosphorylation | - | 18.01 | 27732954 | |
| 44 (in isoform 6) | Phosphorylation | - | 18.01 | 27732954 | |
| 54 | Phosphorylation | GSNVEDRSSSGSWGN CCCCCCCCCCCCCCC | 40.97 | 27732954 | |
| 55 | Phosphorylation | SNVEDRSSSGSWGNG CCCCCCCCCCCCCCC | 39.34 | 27732954 | |
| 56 | Phosphorylation | NVEDRSSSGSWGNGG CCCCCCCCCCCCCCC | 37.79 | 27732954 | |
| 58 | Phosphorylation | EDRSSSGSWGNGGHP CCCCCCCCCCCCCCC | 33.48 | 27732954 | |
| 66 | Phosphorylation | WGNGGHPSPSRNYGD CCCCCCCCCCCCCCC | 29.81 | 25954137 | |
| 68 | Phosphorylation | NGGHPSPSRNYGDGT CCCCCCCCCCCCCCC | 37.18 | 27732954 | |
| 71 | Phosphorylation | HPSPSRNYGDGTPYD CCCCCCCCCCCCCCC | 18.58 | 23186163 | |
| 75 | Phosphorylation | SRNYGDGTPYDHMTS CCCCCCCCCCCCCCH | 24.34 | 23186163 | |
| 77 | Phosphorylation | NYGDGTPYDHMTSRD CCCCCCCCCCCCHHC | 20.51 | 23186163 | |
| 81 | Phosphorylation | GTPYDHMTSRDLGSH CCCCCCCCHHCCCCC | 19.72 | 23186163 | |
| 82 | Phosphorylation | TPYDHMTSRDLGSHD CCCCCCCHHCCCCCC | 19.07 | 23186163 | |
| 87 | Phosphorylation | MTSRDLGSHDNLSPP CCHHCCCCCCCCCCC | 34.66 | 23403867 | |
| 92 | Phosphorylation | LGSHDNLSPPFVNSR CCCCCCCCCCCCCHH | 36.46 | 23401153 | |
| 98 | Phosphorylation | LSPPFVNSRIQSKTE CCCCCCCHHHCCCCC | 26.01 | 23403867 | |
| 106 | Methylation | RIQSKTERGSYSSYG HHCCCCCCCCCCCCC | 44.59 | 115918337 | |
| 125 | Phosphorylation | LQGCHQQSLLGGDMD CCCCHHCCCCCCCCC | 20.99 | 23186163 | |
| 138 | Phosphorylation | MDMGNPGTLSPTKPG CCCCCCCCCCCCCCC | 25.89 | 23663014 | |
| 140 | Phosphorylation | MGNPGTLSPTKPGSQ CCCCCCCCCCCCCCC | 30.29 | 23663014 | |
| 142 | Phosphorylation | NPGTLSPTKPGSQYY CCCCCCCCCCCCCCC | 46.63 | 23403867 | |
| 146 | Phosphorylation | LSPTKPGSQYYQYSS CCCCCCCCCCCCCCC | 24.44 | 23403867 | |
| 148 | Phosphorylation | PTKPGSQYYQYSSNN CCCCCCCCCCCCCCC | 8.34 | 24117733 | |
| 149 | Phosphorylation | TKPGSQYYQYSSNNP CCCCCCCCCCCCCCC | 8.04 | 24117733 | |
| 151 | Phosphorylation | PGSQYYQYSSNNPRR CCCCCCCCCCCCCCC | 9.65 | 24117733 | |
| 152 | Phosphorylation | GSQYYQYSSNNPRRR CCCCCCCCCCCCCCC | 15.86 | 27732954 | |
| 153 | Phosphorylation | SQYYQYSSNNPRRRP CCCCCCCCCCCCCCC | 35.37 | 27732954 | |
| 163 | Phosphorylation | PRRRPLHSSAMEVQT CCCCCCCCCCHHHCC | 27.72 | 22468782 | |
| 168 | Phosphorylation | LHSSAMEVQTKKVRK CCCCCHHHCCCHHCC | 5.86 | 27251275 | |
| 183 | Phosphorylation | VPPGLPSSVYAPSAS CCCCCCCCEECCCCC | 19.73 | 19690332 | |
| 185 | Phosphorylation | PGLPSSVYAPSASTA CCCCCCEECCCCCCC | 18.10 | 19690332 | |
| 190 | Phosphorylation | SVYAPSASTADYNRD CEECCCCCCCCCCCC | 28.59 | 19690332 | |
| 194 | Phosphorylation | PSASTADYNRDSPGY CCCCCCCCCCCCCCC | 15.05 | 26657352 | |
| 198 | Phosphorylation | TADYNRDSPGYPSSK CCCCCCCCCCCCCCC | 19.58 | 25627689 | |
| 201 | Phosphorylation | YNRDSPGYPSSKPAT CCCCCCCCCCCCCCC | 11.88 | 27732954 | |
| 242 | Phosphorylation | QPGYAGMLGNSSHIP CCCCCHHCCCCCCCC | 6.01 | 27251275 | |
| 293 | Phosphorylation | SGTNHYSTSSCTPPA CCCCCCCCCCCCCCC | 19.93 | 28348404 | |
| 294 | Phosphorylation | GTNHYSTSSCTPPAN CCCCCCCCCCCCCCC | 19.92 | 28348404 | |
| 295 | Phosphorylation | TNHYSTSSCTPPANG CCCCCCCCCCCCCCC | 23.30 | 28348404 | |
| 297 | Phosphorylation | HYSTSSCTPPANGTD CCCCCCCCCCCCCCC | 33.97 | 23401153 | |
| 312 | Phosphorylation | SIMANRGSGAAGSSQ CCCCCCCCCCCCCCH | 23.25 | 27732954 | |
| 317 | Phosphorylation | RGSGAAGSSQTGDAL CCCCCCCCCHHHHHH | 17.97 | 30108239 | |
| 318 | Phosphorylation | GSGAAGSSQTGDALG CCCCCCCCHHHHHHH | 30.73 | 25159151 | |
| 320 | Phosphorylation | GAAGSSQTGDALGKA CCCCCCHHHHHHHHH | 38.69 | 30108239 | |
| 328 (in isoform 12) | Phosphorylation | - | 4.35 | 25921289 | |
| 330 | Phosphorylation | ALGKALASIYSPDHT HHHHHHHHHCCCCCC | 23.94 | 25921289 | |
| 331 (in isoform 12) | Phosphorylation | - | 3.08 | 25921289 | |
| 332 | Phosphorylation | GKALASIYSPDHTNN HHHHHHHCCCCCCCC | 16.20 | 30177828 | |
| 333 | Phosphorylation | KALASIYSPDHTNNS HHHHHHCCCCCCCCC | 23.37 | 25921289 | |
| 335 (in isoform 12) | Phosphorylation | - | 56.13 | 25921289 | |
| 337 | Phosphorylation | SIYSPDHTNNSFSSN HHCCCCCCCCCCCCC | 43.40 | 30177828 | |
| 340 | Phosphorylation | SPDHTNNSFSSNPST CCCCCCCCCCCCCCC | 28.68 | 25921289 | |
| 342 | Phosphorylation | DHTNNSFSSNPSTPV CCCCCCCCCCCCCCC | 29.09 | 25921289 | |
| 343 | Phosphorylation | HTNNSFSSNPSTPVG CCCCCCCCCCCCCCC | 51.23 | 25921289 | |
| 346 | Phosphorylation | NSFSSNPSTPVGSPP CCCCCCCCCCCCCCC | 49.98 | 30177828 | |
| 347 | Phosphorylation | SFSSNPSTPVGSPPS CCCCCCCCCCCCCCC | 24.21 | 25921289 | |
| 349 (in isoform 12) | Phosphorylation | - | 13.86 | 25921289 | |
| 351 | Phosphorylation | NPSTPVGSPPSLSAG CCCCCCCCCCCCCCC | 33.59 | 25921289 | |
| 354 | Phosphorylation | TPVGSPPSLSAGTAV CCCCCCCCCCCCCEE | 38.04 | 30177828 | |
| 356 | Phosphorylation | VGSPPSLSAGTAVWS CCCCCCCCCCCEEEE | 29.05 | 30177828 | |
| 359 | Phosphorylation | PPSLSAGTAVWSRNG CCCCCCCCEEEECCC | 20.11 | 30177828 | |
| 370 | Phosphorylation | SRNGGQASSSPNYEG ECCCCCCCCCCCCCC | 24.38 | 23403867 | |
| 371 | Phosphorylation | RNGGQASSSPNYEGP CCCCCCCCCCCCCCC | 53.48 | 30108239 | |
| 372 | Phosphorylation | NGGQASSSPNYEGPL CCCCCCCCCCCCCCH | 18.05 | 23401153 | |
| 375 | Phosphorylation | QASSSPNYEGPLHSL CCCCCCCCCCCHHHH | 26.16 | 30108239 | |
| 381 | Phosphorylation | NYEGPLHSLQSRIED CCCCCHHHHHHHHHH | 35.47 | 28450419 | |
| 383 (in isoform 2) | Phosphorylation | - | 33.41 | - | |
| 384 | Phosphorylation | GPLHSLQSRIEDRLE CCHHHHHHHHHHHHH | 40.28 | 28450419 | |
| 387 (in isoform 2) | Phosphorylation | - | 35.65 | 22985185 | |
| 389 (in isoform 2) | Phosphorylation | - | 26.17 | 25884760 | |
| 390 (in isoform 2) | Phosphorylation | - | 7.50 | 27251275 | |
| 398 (in isoform 2) | Phosphorylation | - | 17.80 | 26714015 | |
| 408 | Phosphorylation | RNHAVGPSTAMPGGH HHCCCCCCCCCCCCC | 23.91 | 22210691 | |
| 409 | Phosphorylation | NHAVGPSTAMPGGHG HCCCCCCCCCCCCCC | 30.06 | 22210691 | |
| 420 | Phosphorylation | GGHGDMHGIIGPSHN CCCCCCCCEECCCCC | 13.43 | 27251275 | |
| 425 | Phosphorylation | MHGIIGPSHNGAMGG CCCEECCCCCCCCCC | 25.11 | 22210691 | |
| 435 | Phosphorylation | GAMGGLGSGYGTGLL CCCCCCCCCCHHCHH | 33.61 | 22210691 | |
| 437 | Phosphorylation | MGGLGSGYGTGLLSA CCCCCCCCHHCHHHC | 17.14 | 22210691 | |
| 439 | Phosphorylation | GLGSGYGTGLLSANR CCCCCCHHCHHHCCC | 19.03 | 22210691 | |
| 443 | Phosphorylation | GYGTGLLSANRHSLM CCHHCHHHCCCCEEE | 28.65 | 22210691 | |
| 445 | Phosphorylation | GTGLLSANRHSLMVG HHCHHHCCCCEEECC | 38.53 | 27251275 | |
| 449 | Phosphorylation | LSANRHSLMVGTHRE HHCCCCEEECCCCCC | 2.35 | 27251275 | |
| 466 | Phosphorylation | VALRGSHSLLPNQVP EEECCCCCCCCCCCC | 33.04 | 24667141 | |
| 472 (in isoform 11) | Phosphorylation | - | 7.02 | - | |
| 473 | Phosphorylation | SLLPNQVPVPQLPVQ CCCCCCCCCCCCCCC | 23.47 | 27251275 | |
| 476 (in isoform 11) | Phosphorylation | - | 59.64 | 22985185 | |
| 478 (in isoform 11) | Phosphorylation | - | 19.49 | 25884760 | |
| 479 (in isoform 11) | Phosphorylation | - | 10.77 | 27251275 | |
| 481 | Phosphorylation | VPQLPVQSATSPDLN CCCCCCCCCCCCCCC | 33.47 | 23401153 | |
| 483 | Phosphorylation | QLPVQSATSPDLNPP CCCCCCCCCCCCCCC | 46.14 | 28450419 | |
| 483 (in isoform 4) | Phosphorylation | - | 46.14 | - | |
| 484 | Phosphorylation | LPVQSATSPDLNPPQ CCCCCCCCCCCCCCC | 19.01 | 23401153 | |
| 487 (in isoform 11) | Phosphorylation | - | 13.56 | 26714015 | |
| 487 (in isoform 4) | Phosphorylation | - | 13.56 | 22985185 | |
| 489 (in isoform 4) | Phosphorylation | - | 34.91 | 25884760 | |
| 490 (in isoform 4) | Phosphorylation | - | 50.57 | 27251275 | |
| 498 (in isoform 4) | Phosphorylation | - | 23.72 | 26714015 | |
| 505 | Phosphorylation | PPGLQGQSVSSGSSE CCCCCCCCCCCCCCC | 30.69 | 23403867 | |
| 507 | Phosphorylation | GLQGQSVSSGSSEIK CCCCCCCCCCCCCCC | 33.94 | 26657352 | |
| 508 | Phosphorylation | LQGQSVSSGSSEIKS CCCCCCCCCCCCCCC | 40.30 | 23403867 | |
| 510 | Phosphorylation | GQSVSSGSSEIKSDD CCCCCCCCCCCCCCC | 27.09 | 26657352 | |
| 511 | Phosphorylation | QSVSSGSSEIKSDDE CCCCCCCCCCCCCCC | 47.03 | 23403867 | |
| 515 | Phosphorylation | SGSSEIKSDDEGDEN CCCCCCCCCCCCCCC | 56.83 | 20164059 | |
| 518 | Ubiquitination | SEIKSDDEGDENLQD CCCCCCCCCCCCCCC | 73.80 | - | |
| 519 (in isoform 13) | Phosphorylation | - | 55.30 | - | |
| 523 (in isoform 13) | Phosphorylation | - | 4.60 | 22985185 | |
| 525 (in isoform 13) | Phosphorylation | - | 60.30 | 25884760 | |
| 526 | Phosphorylation | GDENLQDTKSSEDKK CCCCCCCCCCCCCCC | 21.62 | 23403867 | |
| 526 (in isoform 13) | Phosphorylation | - | 21.62 | 27251275 | |
| 528 | Phosphorylation | ENLQDTKSSEDKKLD CCCCCCCCCCCCCCC | 40.84 | 25921289 | |
| 534 | Ubiquitination | KSSEDKKLDDDKKDI CCCCCCCCCCCHHHH | 12.29 | - | |
| 534 (in isoform 13) | Phosphorylation | - | 12.29 | 26714015 | |
| 542 | Ubiquitination | DDDKKDIKSITSNND CCCHHHHHHHHCCCC | 46.03 | - | |
| 543 | Phosphorylation | DDKKDIKSITSNNDD CCHHHHHHHHCCCCC | 31.28 | 27732954 | |
| 543 (in isoform 3) | Phosphorylation | - | 31.28 | - | |
| 545 | Phosphorylation | KKDIKSITSNNDDED HHHHHHHHCCCCCCC | 32.28 | 27732954 | |
| 546 | Phosphorylation | KDIKSITSNNDDEDL HHHHHHHCCCCCCCC | 31.78 | 27732954 | |
| 547 (in isoform 3) | Phosphorylation | - | 47.50 | 22985185 | |
| 549 (in isoform 3) | Phosphorylation | - | 66.00 | 25884760 | |
| 550 (in isoform 3) | Phosphorylation | - | 54.13 | 27251275 | |
| 554 | Phosphorylation | NNDDEDLTPEQKAER CCCCCCCCHHHHHHH | 36.78 | 27732954 | |
| 558 | Ubiquitination | EDLTPEQKAEREKER CCCCHHHHHHHHHHH | 51.02 | - | |
| 558 (in isoform 3) | Phosphorylation | - | 51.02 | 26714015 | |
| 585 | Ubiquitination | RDINEAFKELGRMVQ HHHHHHHHHHHHHHH | 60.11 | - | |
| 586 | Phosphorylation | DINEAFKELGRMVQL HHHHHHHHHHHHHHH | 50.42 | 27251275 | |
| 617 | Phosphorylation | AVAVILSLEQQVRER HHHHHHHHHHHHHHC | 6.54 | 27251275 | |
| 629 | Ubiquitination | RERNLNPKAACLKRR HHCCCCHHHHHHHHH | 47.76 | - | |
| 649 | Phosphorylation | SSEPPPLSLAGPHPG CCCCCCCCCCCCCCC | 23.19 | 27251275 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 54 | S | Phosphorylation | Kinase | CSK21 | P68400 | PhosphoELM |
| 54 | S | Phosphorylation | Kinase | CSNK2A1 | P19139 | GPS |
| 55 | S | Phosphorylation | Kinase | CSK21 | P68400 | PhosphoELM |
| 55 | S | Phosphorylation | Kinase | CSNK2A1 | P19139 | GPS |
| 56 | S | Phosphorylation | Kinase | CSK21 | P68400 | PhosphoELM |
| 56 | S | Phosphorylation | Kinase | CSNK2A1 | P19139 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ITF2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ITF2_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 610954 | Pitt-Hopkins syndrome (PTHS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, AND MASSSPECTROMETRY. | |
