dbPTM

MUSC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MUSC_HUMAN
UniProt AC	O60682
Protein Name	Musculin
Gene Name	MSC
Organism	Homo sapiens (Human).
Sequence Length	206
Subcellular Localization	Nucleus.
Protein Description	Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation..
Protein Sequence	MSTGSVSDPEEMELRGLQREYPVPASKRPPLRGVERSYASPSDNSSAEEEDPDGEEERCALGTAGSAEGCKRKRPRVAGGGGAGGSAGGGGKKPLPAKGSAAECKQSQRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQEDRYENGYVHPVNLTWPFVVSGRPDSDTKEVSAANRLCGTTA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTGSVSDP ------CCCCCCCCH	41.28	30108239
3	Phosphorylation	-----MSTGSVSDPE -----CCCCCCCCHH	31.98	30108239
5	Phosphorylation	---MSTGSVSDPEEM ---CCCCCCCCHHHH	20.66	30108239
7	Phosphorylation	-MSTGSVSDPEEMEL -CCCCCCCCHHHHHH	49.50	30108239
21	Phosphorylation	LRGLQREYPVPASKR HHCCCCCCCCCHHHC	16.24	-
27	Ubiquitination	EYPVPASKRPPLRGV CCCCCHHHCCCCCCC	71.65	-
45	Phosphorylation	YASPSDNSSAEEEDP CCCCCCCCCCCCCCC	35.60	-
46	Phosphorylation	ASPSDNSSAEEEDPD CCCCCCCCCCCCCCC	46.05	-
128	Phosphorylation	RVLSKAFSRLKTSLP HHHHHHHHHHHHCCC	41.38	26437602
132	Phosphorylation	KAFSRLKTSLPWVPP HHHHHHHHCCCCCCC	39.84	26074081
133	Phosphorylation	AFSRLKTSLPWVPPD HHHHHHHCCCCCCCC	30.74	26074081
141	Phosphorylation	LPWVPPDTKLSKLDT CCCCCCCCCHHHHHH	39.39	26074081
144	Phosphorylation	VPPDTKLSKLDTLRL CCCCCCHHHHHHHHH	32.50	26074081
148	Phosphorylation	TKLSKLDTLRLASSY CCHHHHHHHHHHHHH	24.98	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MUSC_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MUSC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MUSC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ID2_HUMAN	ID2	physical	11560778

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MUSC_HUMAN

Related Literatures of Post-Translational Modification