ID2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ID2_HUMAN
• UniProt AC: Q02363
• Protein Name: DNA-binding protein inhibitor ID-2
• Gene Name: ID2
• Organism: Homo sapiens (Human).
• Sequence Length: 134
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism..
• Protein Sequence: MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVSKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKALCG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MKAFSPVRSVRK ---CCCCCCCCHHHC	27.61	9029153
12	Ubiquitination	SPVRSVRKNSLSDHS CCCCHHHCCCCCCCC	49.05	2097226
14	Phosphorylation	VRSVRKNSLSDHSLG CCHHHCCCCCCCCCC	32.08	23401153
16	Phosphorylation	SVRKNSLSDHSLGIS HHHCCCCCCCCCCCC	32.85	23911959
19	Phosphorylation	KNSLSDHSLGISRSK CCCCCCCCCCCCCCC	33.03	24117733
23	Phosphorylation	SDHSLGISRSKTPVD CCCCCCCCCCCCCCC	28.80	24117733
25	Phosphorylation	HSLGISRSKTPVDDP CCCCCCCCCCCCCCH	33.81	27080861
27	Phosphorylation	LGISRSKTPVDDPMS CCCCCCCCCCCCHHH	29.77	28450419
34	Phosphorylation	TPVDDPMSLLYNMND CCCCCHHHHHHHHHH	22.17	27080861
43	Phosphorylation	LYNMNDCYSKLKELV HHHHHHHHHHHHHHC	16.23	-
44	Phosphorylation	YNMNDCYSKLKELVP HHHHHHHHHHHHHCC	37.53	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
5	S	Phosphorylation	Kinase	CDK2	P24941	PhosphoELM
27	T	Phosphorylation	Kinase	DYRK1B	Q9Y463	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	ASB4	Q9Y574	PMID:24586788
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:16810178

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ID2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ID2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HTF4_HUMAN	TCF12	physical	9242638
RBM48_HUMAN	RBM48	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
CASL_HUMAN	NEDD9	physical	10502414
BCAR1_HUMAN	BCAR1	physical	10502414
TFE2_HUMAN	TCF3	physical	9242638
ITF2_HUMAN	TCF4	physical	9242638
MYOD1_HUMAN	MYOD1	physical	9242638
MYF5_HUMAN	MYF5	physical	9242638
GATA4_HUMAN	GATA4	physical	16556596
NKX25_HUMAN	NKX2-5	physical	16556596
UBP1_HUMAN	USP1	physical	21925315
RB_HUMAN	RB1	physical	11034201
RBL1_HUMAN	RBL1	physical	11034201
RBL2_HUMAN	RBL2	physical	11034201
TFE2_HUMAN	TCF3	physical	19321746
HTF4_HUMAN	TCF12	physical	19321746
ID2_HUMAN	ID2	physical	21988832
MK08_HUMAN	MAPK8	physical	21988832
FCL_HUMAN	TSTA3	physical	21988832
KDM1A_HUMAN	KDM1A	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
SUV92_HUMAN	SUV39H2	physical	23455924
ASB4_HUMAN	ASB4	physical	24586788
DYR1A_HUMAN	DYRK1A	physical	26735018
DYR1B_HUMAN	DYRK1B	physical	26735018
TFE2_HUMAN	TCF3	physical	26735018
HTF4_HUMAN	TCF12	physical	26735018
R113A_HUMAN	RNF113A	physical	26735018
ELOC_HUMAN	TCEB1	physical	26735018
ELP4_HUMAN	ELP4	physical	26735018
GRP78_HUMAN	HSPA5	physical	26735018
STK38_HUMAN	STK38	physical	26735018
HSP7C_HUMAN	HSPA8	physical	26735018
TBB4B_HUMAN	TUBB4B	physical	26735018
TBA1B_HUMAN	TUBA1B	physical	26735018
EF1A2_HUMAN	EEF1A2	physical	26735018
GRP75_HUMAN	HSPA9	physical	26735018
HS71L_HUMAN	HSPA1L	physical	26735018
TBB5_HUMAN	TUBB	physical	26735018
ANM5_HUMAN	PRMT5	physical	26735018
VHL_HUMAN	VHL	physical	26735018
TFE2_HUMAN	TCF3	physical	28514442
ITF2_HUMAN	TCF4	physical	28514442
HTF4_HUMAN	TCF12	physical	28514442
ID4_HUMAN	ID4	physical	28514442
PHF3_HUMAN	PHF3	physical	28514442
WBP11_HUMAN	WBP11	physical	28514442
CLAP2_HUMAN	CLASP2	physical	28514442
TYY1_HUMAN	YY1	physical	28514442
ZGPAT_HUMAN	ZGPAT	physical	28514442
MACF1_HUMAN	MACF1	physical	28514442
DIDO1_HUMAN	DIDO1	physical	28514442
SLTM_HUMAN	SLTM	physical	28514442
RCBT2_HUMAN	RCBTB2	physical	28514442
RABL6_HUMAN	RABL6	physical	28514442
CA131_HUMAN	C1orf131	physical	28514442
AFAD_HUMAN	MLLT4	physical	28514442
RBM27_HUMAN	RBM27	physical	28514442
HDGR2_HUMAN	HDGFRP2	physical	28514442
UB2E1_HUMAN	UBE2E1	physical	28514442
CFDP1_HUMAN	CFDP1	physical	28514442
KI20B_HUMAN	KIF20B	physical	28514442
KLH20_HUMAN	KLHL20	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.