ASB4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASB4_HUMAN
• UniProt AC: Q9Y574
• Protein Name: Ankyrin repeat and SOCS box protein 4
• Gene Name: ASB4
• Organism: Homo sapiens (Human).
• Sequence Length: 426
• Protein Description: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity)..
• Protein Sequence: MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	TTAPVTKSGAAKLVK CCCCCCHHHHHHHHH	25.05	-
109	Phosphorylation	NCRPNGKTPLHVACE ECCCCCCCCCHHEEH	32.26	-
169	"N6,N6-dimethyllysine"	RGANVNMKTNNQDEE CCCCCCCCCCCCCCC	42.78	-
169	Methylation	RGANVNMKTNNQDEE CCCCCCCCCCCCCCC	42.78	-
246	Hydroxylation	LDYKAEVNARDDDFK HHHHHHHCCCCCCCC	22.29	-
408	Phosphorylation	HRAIPLLSLPLSLKK HHHHHHHHCCCCHHH	35.31	-
412	Phosphorylation	PLLSLPLSLKKYLLL HHHHCCCCHHHHHHH	35.88	-
426	Phosphorylation	LEPEGIIY------- HCCCCCCC-------	15.58	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASB4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
246	N	Hydroxylation	Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASB4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL2_HUMAN	CUL2	physical	17636018
CUL5_HUMAN	CUL5	physical	17636018
ELOB_HUMAN	TCEB2	physical	17636018
RIT1_HUMAN	RIT1	physical	17636018
HIF1N_HUMAN	HIF1AN	physical	17636018
CSN1_HUMAN	GPS1	physical	17276034
CUL4A_HUMAN	CUL4A	physical	24337577
TFR1_HUMAN	TFRC	physical	24337577
HSPB8_HUMAN	HSPB8	physical	24337577
TBB8_HUMAN	TUBB8	physical	24337577
CUL5_HUMAN	CUL5	physical	24337577
TBB3_HUMAN	TUBB3	physical	24337577
DNJB5_HUMAN	DNAJB5	physical	24337577
SYFA_HUMAN	FARSA	physical	24337577
CHIP_HUMAN	STUB1	physical	24337577
DNJB4_HUMAN	DNAJB4	physical	24337577
TBB4A_HUMAN	TUBB4A	physical	24337577
HSPB1_HUMAN	HSPB1	physical	24337577
CH60_HUMAN	HSPD1	physical	24337577
RS27L_HUMAN	RPS27L	physical	24337577
RBX2_HUMAN	RNF7	physical	24337577
TBB2A_HUMAN	TUBB2A	physical	24337577
DDB1_HUMAN	DDB1	physical	24337577
ID2_HUMAN	ID2	physical	24586788
UB2D1_HUMAN	UBE2D1	physical	24586788
HIF1N_HUMAN	HIF1AN	physical	26186194
DNJB5_HUMAN	DNAJB5	physical	26186194
DNJB5_HUMAN	DNAJB5	physical	28514442
HIF1N_HUMAN	HIF1AN	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.