dbPTM

HSPB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HSPB1_HUMAN
UniProt AC	P04792
Protein Name	Heat shock protein beta-1
Gene Name	HSPB1
Organism	Homo sapiens (Human).
Sequence Length	205
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle . Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles o
Protein Description	Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. [PubMed: 10383393]
Protein Sequence	MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Methylation	---MTERRVPFSLLR ---CCCCCCCCHHHC	33.94	58854747
9	Phosphorylation	TERRVPFSLLRGPSW CCCCCCCHHHCCCCC	22.03	20886841
12	Methylation	RVPFSLLRGPSWDPF CCCCHHHCCCCCCCC	61.34	24129315
15	Phosphorylation	FSLLRGPSWDPFRDW CHHHCCCCCCCCHHC	47.11	19664994
23	Phosphorylation	WDPFRDWYPHSRLFD CCCCHHCCCCHHHHH	8.71	23927012
26	Phosphorylation	FRDWYPHSRLFDQAF CHHCCCCHHHHHHHH	26.61	23927012
37	Methylation	DQAFGLPRLPEEWSQ HHHHCCCCCCHHHHH	68.84	26494247
43	Phosphorylation	PRLPEEWSQWLGGSS CCCCHHHHHHHCCCC	18.11	20873877
49	Phosphorylation	WSQWLGGSSWPGYVR HHHHHCCCCCCCCCC	27.68	26356563
50	Phosphorylation	SQWLGGSSWPGYVRP HHHHCCCCCCCCCCC	40.33	26657352
54	Phosphorylation	GGSSWPGYVRPLPPA CCCCCCCCCCCCCHH	6.82	26356563
56	Methylation	SSWPGYVRPLPPAAI CCCCCCCCCCCHHHC	20.67	54556783
65	Phosphorylation	LPPAAIESPAVAAPA CCHHHCCCCCCHHHH	16.43	28355574
73	Phosphorylation	PAVAAPAYSRALSRQ CCCHHHHHHHHHHHH	9.53	26657352
74	O-linked_Glycosylation	AVAAPAYSRALSRQL CCHHHHHHHHHHHHH	17.12	32574038
74	Phosphorylation	AVAAPAYSRALSRQL CCHHHHHHHHHHHHH	17.12	26657352
78	Phosphorylation	PAYSRALSRQLSSGV HHHHHHHHHHHHCCC	19.59	20201521
82	Phosphorylation	RALSRQLSSGVSEIR HHHHHHHHCCCHHHH	19.39	19664994
83	Phosphorylation	ALSRQLSSGVSEIRH HHHHHHHCCCHHHHH	52.37	22167270
86	Phosphorylation	RQLSSGVSEIRHTAD HHHHCCCHHHHHCCC	30.72	23927012
89	Methylation	SSGVSEIRHTADRWR HCCCHHHHHCCCCEE	19.63	115367653
91	Phosphorylation	GVSEIRHTADRWRVS CCHHHHHCCCCEEEE	22.02	30183078
98	Phosphorylation	TADRWRVSLDVNHFA CCCCEEEEEECCCCC	15.41	30266825
110	Phosphorylation	HFAPDELTVKTKDGV CCCCCCCEEEECCCE	20.22	23403867
112	Ubiquitination	APDELTVKTKDGVVE CCCCCEEEECCCEEE	44.62	21906983
112	2-Hydroxyisobutyrylation	APDELTVKTKDGVVE CCCCCEEEECCCEEE	44.62	-
112	Malonylation	APDELTVKTKDGVVE CCCCCEEEECCCEEE	44.62	26320211
112	Acetylation	APDELTVKTKDGVVE CCCCCEEEECCCEEE	44.62	23236377
113	Phosphorylation	PDELTVKTKDGVVEI CCCCEEEECCCEEEE	29.99	20068231
114	2-Hydroxyisobutyrylation	DELTVKTKDGVVEIT CCCEEEECCCEEEEC	46.93	-
114	Sumoylation	DELTVKTKDGVVEIT CCCEEEECCCEEEEC	46.93	-
114	Malonylation	DELTVKTKDGVVEIT CCCEEEECCCEEEEC	46.93	26320211
114	Acetylation	DELTVKTKDGVVEIT CCCEEEECCCEEEEC	46.93	26051181
114	Glycation	DELTVKTKDGVVEIT CCCEEEECCCEEEEC	46.93	-
114	Sumoylation	DELTVKTKDGVVEIT CCCEEEECCCEEEEC	46.93	-
114	Ubiquitination	DELTVKTKDGVVEIT CCCEEEECCCEEEEC	46.93	-
121	Phosphorylation	KDGVVEITGKHEERQ CCCEEEECCCCCCCC	27.03	20068231
123	Glycation	GVVEITGKHEERQDE CEEEECCCCCCCCCC	38.91	-
123	Acetylation	GVVEITGKHEERQDE CEEEECCCCCCCCCC	38.91	19608861
123	Ubiquitination	GVVEITGKHEERQDE CEEEECCCCCCCCCC	38.91	19608861
123	2-Hydroxyisobutyrylation	GVVEITGKHEERQDE CEEEECCCCCCCCCC	38.91	-
123	Malonylation	GVVEITGKHEERQDE CEEEECCCCCCCCCC	38.91	26320211
133	Phosphorylation	ERQDEHGYISRCFTR CCCCCCCCEEEEEEC	9.53	24927040
135	Phosphorylation	QDEHGYISRCFTRKY CCCCCCEEEEEECCC	17.95	28152594
139	Phosphorylation	GYISRCFTRKYTLPP CCEEEEEECCCCCCC	29.85	-
141	Acetylation	ISRCFTRKYTLPPGV EEEEEECCCCCCCCC	39.26	26051181
141	Ubiquitination	ISRCFTRKYTLPPGV EEEEEECCCCCCCCC	39.26	-
142	Phosphorylation	SRCFTRKYTLPPGVD EEEEECCCCCCCCCC	15.37	23663014
143	Phosphorylation	RCFTRKYTLPPGVDP EEEECCCCCCCCCCH	35.50	26657352
151	Phosphorylation	LPPGVDPTQVSSSLS CCCCCCHHHCCCCCC	36.82	23663014
154	Phosphorylation	GVDPTQVSSSLSPEG CCCHHHCCCCCCCCC	12.37	23663014
155	Phosphorylation	VDPTQVSSSLSPEGT CCHHHCCCCCCCCCC	36.12	23663014
156	Phosphorylation	DPTQVSSSLSPEGTL CHHHCCCCCCCCCCE	25.92	23663014
158	Phosphorylation	TQVSSSLSPEGTLTV HHCCCCCCCCCCEEE	23.89	23663014
162	Phosphorylation	SSLSPEGTLTVEAPM CCCCCCCCEEEECCC	20.00	23663014
164	Phosphorylation	LSPEGTLTVEAPMPK CCCCCCEEEECCCCC	19.01	23663014
171	Ubiquitination	TVEAPMPKLATQSNE EEECCCCCCCCCCCE	44.49	-
174	O-linked_Glycosylation	APMPKLATQSNEITI CCCCCCCCCCCEEEE	42.86	32574038
174	Phosphorylation	APMPKLATQSNEITI CCCCCCCCCCCEEEE	42.86	30266825
176	O-linked_Glycosylation	MPKLATQSNEITIPV CCCCCCCCCEEEEEE	31.88	32574038
176	Phosphorylation	MPKLATQSNEITIPV CCCCCCCCCEEEEEE	31.88	30266825
180	Phosphorylation	ATQSNEITIPVTFES CCCCCEEEEEEEECC	17.04	30266825
180	O-linked_Glycosylation	ATQSNEITIPVTFES CCCCCEEEEEEEECC	17.04	32574038
184	Phosphorylation	NEITIPVTFESRAQL CEEEEEEEECCHHHH	19.14	30266825
184	O-linked_Glycosylation	NEITIPVTFESRAQL CEEEEEEEECCHHHH	19.14	32574038
187	O-linked_Glycosylation	TIPVTFESRAQLGGP EEEEEECCHHHHCCC	28.82	32574038
187	Phosphorylation	TIPVTFESRAQLGGP EEEEEECCHHHHCCC	28.82	30266825
198	Sumoylation	LGGPEAAKSDETAAK HCCCHHHCCHHHCCC	66.54	-
198	2-Hydroxyisobutyrylation	LGGPEAAKSDETAAK HCCCHHHCCHHHCCC	66.54	-
198	Malonylation	LGGPEAAKSDETAAK HCCCHHHCCHHHCCC	66.54	26320211
198	Ubiquitination	LGGPEAAKSDETAAK HCCCHHHCCHHHCCC	66.54	2190698
198	Sumoylation	LGGPEAAKSDETAAK HCCCHHHCCHHHCCC	66.54	-
198	Acetylation	LGGPEAAKSDETAAK HCCCHHHCCHHHCCC	66.54	26051181
199	O-linked_Glycosylation	GGPEAAKSDETAAK- CCCHHHCCHHHCCC-	35.63	32574038
199	Phosphorylation	GGPEAAKSDETAAK- CCCHHHCCHHHCCC-	35.63	29255136
202	Phosphorylation	EAAKSDETAAK---- HHHCCHHHCCC----	36.58	30266825
205	Ubiquitination	KSDETAAK------- CCHHHCCC-------	59.41	-
205	Acetylation	KSDETAAK------- CCHHHCCC-------	59.41	156059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
15	S	Phosphorylation	Kinase	MAPKAPK3	Q16644	Uniprot
15	S	Phosphorylation	Kinase	MAPK2	P49137	PhosphoELM
15	S	Phosphorylation	Kinase	PRKG1	Q13976-2	GPS
78	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
78	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
78	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	Uniprot
78	S	Phosphorylation	Kinase	MAPKAPK3	Q16644	Uniprot
78	S	Phosphorylation	Kinase	MAPK2	P49137	PhosphoELM
78	S	Phosphorylation	Kinase	RPS6KB2	Q9UBS0	GPS
78	S	Phosphorylation	Kinase	PRKG1	Q13976-2	GPS
82	S	Phosphorylation	Kinase	PRKD1	Q15139	PSP
82	S	Phosphorylation	Kinase	PRKD2	Q9BZL6	GPS
82	S	Phosphorylation	Kinase	RPS6KB2	Q9UBS0	GPS
82	S	Phosphorylation	Kinase	PRKG1	Q13976-2	GPS
82	S	Phosphorylation	Kinase	MAPK2	P49137	PhosphoELM
82	S	Phosphorylation	Kinase	AKT1	P31749	PSP
82	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
82	S	Phosphorylation	Kinase	MAPKAPK3	Q16644	Uniprot
82	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
82	S	Phosphorylation	Kinase	MAPKAPK5	Q8IW41	Uniprot
82	S	Phosphorylation	Kinase	PKD1	P98161	PhosphoELM
143	T	Phosphorylation	Kinase	PRKG1 ISOFORM ALPHA	-	GPS
143	T	Phosphorylation	Kinase	PRKG2	Q13237	GPS
143	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
143	T	Phosphorylation	Kinase	PRKACB	P22694	GPS
143	T	Phosphorylation	Kinase	PRKG1	Q13976-2	GPS
176	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HSPB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HSPB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGS21_HUMAN	IGSF21	physical	16169070
IPYR_HUMAN	PPA1	physical	16169070
MED31_HUMAN	MED31	physical	16169070
RBM48_HUMAN	RBM48	physical	16169070
LRIF1_HUMAN	LRIF1	physical	16169070
P53_HUMAN	TP53	physical	16169070
CYC_HUMAN	CYCS	physical	11784858
CRYAA_HUMAN	CRYAA	physical	11700327
CRYAB_HUMAN	CRYAB	physical	11700327
CRBB2_HUMAN	CRYBB2	physical	11700327
TGFI1_HUMAN	TGFB1I1	physical	11546764
KPCD1_HUMAN	PRKD1	physical	15728188
G6PD_HUMAN	G6PD	physical	21157431
GATA1_HUMAN	GATA1	physical	20410505
NEP_HUMAN	MME	physical	17342744
UBC9_HUMAN	UBE2I	physical	19597476
HSF1_HUMAN	HSF1	physical	19597476
TNFA_HUMAN	TNF	physical	21245386
UNG_HUMAN	UNG	physical	10629618
STAT2_HUMAN	STAT2	physical	22238643
HDAC6_HUMAN	HDAC6	physical	22238643
CASP3_HUMAN	CASP3	physical	22238643
PHLA1_HUMAN	PHLDA1	physical	17024176
CRYAB_HUMAN	CRYAB	physical	17916631
SMN_HUMAN	SMN1	physical	17916631
SMUF2_HUMAN	SMURF2	physical	21967197
PNPT1_HUMAN	PNPT1	physical	22939629
PUM1_HUMAN	PUM1	physical	22939629
PALLD_HUMAN	PALLD	physical	22939629
NRDC_HUMAN	NRD1	physical	22939629
PEX19_HUMAN	PEX19	physical	22939629
TPM3_HUMAN	TPM3	physical	22939629
RN114_HUMAN	RNF114	physical	22939629
UBC9_HUMAN	UBE2I	physical	23155000
IKKA_HUMAN	CHUK	physical	16840786
IKKB_HUMAN	IKBKB	physical	16840786
SF3B3_HUMAN	SF3B3	physical	22365833
U5S1_HUMAN	EFTUD2	physical	22365833
PRP19_HUMAN	PRPF19	physical	22365833
MFAP1_HUMAN	MFAP1	physical	22365833
HSPB1_HUMAN	HSPB1	physical	22365833
WDR83_HUMAN	WDR83	physical	22365833
HSPB1_HUMAN	HSPB1	physical	10383393
CISY_HUMAN	CS	physical	10383393
INS_HUMAN	INS	physical	10383393
CISY_PIG	CS	physical	8093612
AMYG_YEAST	SGA1	physical	8093612
LBP_HUMAN	LBP	physical	21988832
PPM1A_HUMAN	PPM1A	physical	21988832
SMRD1_HUMAN	SMARCD1	physical	21988832
SRTD1_HUMAN	SERTAD1	physical	21988832
AKT1_HUMAN	AKT1	physical	11042204
M3K7_HUMAN	MAP3K7	physical	24686082
LCE3A_HUMAN	LCE3A	physical	25036637
AKT1_HUMAN	AKT1	physical	17510053
ACBD6_HUMAN	ACBD6	physical	25277244
ACTN1_HUMAN	ACTN1	physical	25277244
ACTN4_HUMAN	ACTN4	physical	25277244
ADCY9_HUMAN	ADCY9	physical	25277244
ARHL2_HUMAN	ADPRHL2	physical	25277244
AGAP5_HUMAN	AGAP5	physical	25277244
AGAP4_HUMAN	AGAP4	physical	25277244
PPBI_HUMAN	ALPI	physical	25277244
ANK1_HUMAN	ANK1	physical	25277244
ANXA1_HUMAN	ANXA1	physical	25277244
BAG3_HUMAN	BAG3	physical	25277244
BAT1_HUMAN	SLC7A9	physical	25277244
CCD32_HUMAN	C15orf57	physical	25277244
UQCC2_HUMAN	UQCC2	physical	25277244
ARMT1_HUMAN	C6orf211	physical	25277244
CALR_HUMAN	CALR	physical	25277244
CCHCR_HUMAN	CCHCR1	physical	25277244
CD123_HUMAN	CDC123	physical	25277244
CK5P3_HUMAN	CDK5RAP3	physical	25277244
CENPK_HUMAN	CENPK	physical	25277244
CEP78_HUMAN	CEP78	physical	25277244
AGAP7_HUMAN	AGAP7P	physical	25277244
DFFA_HUMAN	DFFA	physical	25277244
IF1AX_HUMAN	EIF1AX	physical	25277244
IF2A_HUMAN	EIF2S1	physical	25277244
IF4A2_HUMAN	EIF4A2	physical	25277244
E41L1_HUMAN	EPB41L1	physical	25277244
FRIH_HUMAN	FTH1	physical	25277244
GARS_HUMAN	GARS	physical	25277244
HAUS8_HUMAN	HAUS8	physical	25277244
HECD1_HUMAN	HECTD1	physical	25277244
HNRH2_HUMAN	HNRNPH2	physical	25277244
HS90A_HUMAN	HSP90AA1	physical	25277244
KCMF1_HUMAN	KCMF1	physical	25277244
KCTD3_HUMAN	KCTD3	physical	25277244
ECM29_HUMAN	KIAA0368	physical	25277244
IMA4_HUMAN	KPNA3	physical	25277244
K1C18_HUMAN	KRT18	physical	25277244
LSM3_HUMAN	LSM3	physical	25277244
MCM6_HUMAN	MCM6	physical	25277244
ML12A_HUMAN	MYL12A	physical	25277244
RT23_HUMAN	MRPS23	physical	25277244
MSL1_HUMAN	MSL1	physical	25277244
IF2M_HUMAN	MTIF2	physical	25277244
NP1L1_HUMAN	NAP1L1	physical	25277244
NEXN_HUMAN	NEXN	physical	25277244
NSE4A_HUMAN	NSMCE4A	physical	25277244
NVL_HUMAN	NVL	physical	25277244
PELO_HUMAN	PELO	physical	25277244
PNPT1_HUMAN	PNPT1	physical	25277244
PPM1A_HUMAN	PPM1A	physical	25277244
PSA3_HUMAN	PSMA3	physical	25277244
PSA6_HUMAN	PSMA6	physical	25277244
PSB2_HUMAN	PSMB2	physical	25277244
PSMD1_HUMAN	PSMD1	physical	25277244
TEBP_HUMAN	PTGES3	physical	25277244
PTPRA_HUMAN	PTPRA	physical	25277244
RASF9_HUMAN	RASSF9	physical	25277244
RBM25_HUMAN	RBM25	physical	25277244
RBX1_HUMAN	RBX1	physical	25277244
RPAP3_HUMAN	RPAP3	physical	25277244
RYBP_HUMAN	RYBP	physical	25277244
S10A4_HUMAN	S100A4	physical	25277244
SAT1_HUMAN	SAT1	physical	25277244
SF3A3_HUMAN	SF3A3	physical	25277244
U520_HUMAN	SNRNP200	physical	25277244
RUXF_HUMAN	SNRPF	physical	25277244
SQSTM_HUMAN	SQSTM1	physical	25277244
CHIP_HUMAN	STUB1	physical	25277244
TRBP2_HUMAN	TARBP2	physical	25277244
SYTC_HUMAN	TARS	physical	25277244
TOM70_HUMAN	TOMM70A	physical	25277244
TOX4_HUMAN	TOX4	physical	25277244
TCTP_HUMAN	TPT1	physical	25277244
UFD1_HUMAN	UFD1L	physical	25277244
QCR7_HUMAN	UQCRB	physical	25277244
WWP1_HUMAN	WWP1	physical	25277244
XPO1_HUMAN	XPO1	physical	25277244
XRCC5_HUMAN	XRCC5	physical	25277244
1433B_HUMAN	YWHAB	physical	25277244
ZBT17_HUMAN	ZBTB17	physical	25277244
ZN197_HUMAN	ZNF197	physical	25277244
EIF3M_HUMAN	EIF3M	physical	25277244
IF5_HUMAN	EIF5	physical	25277244
IF4G3_HUMAN	EIF4G3	physical	25277244
FLNB_HUMAN	FLNB	physical	25277244
FKBP4_HUMAN	FKBP4	physical	25277244
GSTO1_HUMAN	GSTO1	physical	25277244
RM40_HUMAN	MRPL40	physical	25277244
OBSL1_HUMAN	OBSL1	physical	25277244
PGM2_HUMAN	PGM2	physical	25277244
PAF1_HUMAN	PAF1	physical	25277244
RD23A_HUMAN	RAD23A	physical	25277244
SUH_HUMAN	RBPJ	physical	25277244
ZO2_HUMAN	TJP2	physical	25277244
THOC5_HUMAN	THOC5	physical	25277244
ACTN2_HUMAN	ACTN2	physical	25277244
ARBK2_HUMAN	ADRBK2	physical	25277244
AGAP3_HUMAN	AGAP3	physical	25277244
DCAM_HUMAN	AMD1	physical	25277244
APC7_HUMAN	ANAPC7	physical	25277244
ANKR7_HUMAN	ANKRD7	physical	25277244
AP2B1_HUMAN	AP2B1	physical	25277244
ARHG7_HUMAN	ARHGEF7	physical	25277244
ARI1_HUMAN	ARIH1	physical	25277244
ARRD5_HUMAN	ARRDC5	physical	25277244
POPD1_HUMAN	BVES	physical	25277244
SPAC7_HUMAN	SPACA7	physical	25277244
ERIP6_HUMAN	ERICH6	physical	25277244
KCC1A_HUMAN	CAMK1	physical	25277244
CBX1_HUMAN	CBX1	physical	25277244
WASC3_HUMAN	CCDC53	physical	25277244
BICL1_HUMAN	CCDC64	physical	25277244
CCD70_HUMAN	CCDC70	physical	25277244
CCNC_HUMAN	CCNC	physical	25277244
CETN3_HUMAN	CETN3	physical	25277244
CLCN3_HUMAN	CLCN3	physical	25277244
CPSF3_HUMAN	CPSF3	physical	25277244
CRNL1_HUMAN	CRNKL1	physical	25277244
DESM_HUMAN	DES	physical	25277244
DMAP1_HUMAN	DMAP1	physical	25277244
EHD1_HUMAN	EHD1	physical	25277244
ENPP2_HUMAN	ENPP2	physical	25277244
E41L3_HUMAN	EPB41L3	physical	25277244
ERCC5_HUMAN	ERCC5	physical	25277244
FA71D_HUMAN	FAM71D	physical	25277244
CB073_HUMAN	C2orf73	physical	25277244
FXR1_HUMAN	FXR1	physical	25277244
GAPD1_HUMAN	GAPVD1	physical	25277244
GLMN_HUMAN	GLMN	physical	25277244
GNPAT_HUMAN	GNPAT	physical	25277244
GUC1A_HUMAN	GUCA1A	physical	25277244
ROA2_HUMAN	HNRNPA2B1	physical	25277244
HNRPU_HUMAN	HNRNPU	physical	25277244
HSP74_HUMAN	HSPA4	physical	25277244
SYIM_HUMAN	IARS2	physical	25277244
INP5K_HUMAN	INPP5K	physical	25277244
I20L2_HUMAN	ISG20L2	physical	25277244
KANL1_HUMAN	KANSL1	physical	25277244
KLC1_HUMAN	KLC1	physical	25277244
K2C72_HUMAN	KRT72	physical	25277244
LONF1_HUMAN	LONRF1	physical	25277244
LUZP1_HUMAN	LUZP1	physical	25277244
RM28_HUMAN	MRPL28	physical	25277244
MYL9_HUMAN	MYL9	physical	25277244
MYLK_HUMAN	MYLK	physical	25277244
NBAS_HUMAN	NBAS	physical	25277244
SNAA_HUMAN	NAPA	physical	25277244
SPN90_HUMAN	NCKIPSD	physical	25277244
NEK10_HUMAN	NEK10	physical	25277244
NFU1_HUMAN	NFU1	physical	25277244
OPTN_HUMAN	OPTN	physical	25277244
OSBL9_HUMAN	OSBPL9	physical	25277244
PALM3_HUMAN	PALM3	physical	25277244
PHIPL_HUMAN	PHYHIPL	physical	25277244
P2R3C_HUMAN	PPP2R3C	physical	25277244
PR40A_HUMAN	PRPF40A	physical	25277244
PTN3_HUMAN	PTPN3	physical	25277244
RAB41_HUMAN	RAB41	physical	25277244
RALA_HUMAN	RALA	physical	25277244
RSSA_HUMAN	RPSA	physical	25277244
RSPH3_HUMAN	RSPH3	physical	25277244
MTMR5_HUMAN	SBF1	physical	25277244
SEC13_HUMAN	SEC13	physical	25277244
PNISR_HUMAN	PNISR	physical	25277244
SMCA2_HUMAN	SMARCA2	physical	25277244
SPAT7_HUMAN	SPATA7	physical	25277244
SPIN1_HUMAN	SPIN1	physical	25277244
SPTB2_HUMAN	SPTBN1	physical	25277244
SRP72_HUMAN	SRP72	physical	25277244
SPT5H_HUMAN	SUPT5H	physical	25277244
SYCE1_HUMAN	SYCE1	physical	25277244
TBCD1_HUMAN	TBC1D1	physical	25277244
TMCO3_HUMAN	TMCO3	physical	25277244
TIF1A_HUMAN	TRIM24	physical	25277244
TRI54_HUMAN	TRIM54	physical	25277244
TXIP1_HUMAN	TSNAXIP1	physical	25277244
TTC3_HUMAN	TTC3	physical	25277244
TT39C_HUMAN	TTC39C	physical	25277244
TXNL1_HUMAN	TXNL1	physical	25277244
CF251_HUMAN	WDR66	physical	25277244
1433E_HUMAN	YWHAE	physical	25277244
ZBT37_HUMAN	ZBTB37	physical	25277244
ZFAT_HUMAN	ZFAT	physical	25277244
ZNRF3_HUMAN	ZNRF3	physical	25277244
ACAP2_HUMAN	ACAP2	physical	25277244
RBM39_HUMAN	RBM39	physical	25277244
ADDG_HUMAN	ADD3	physical	25277244
ATX10_HUMAN	ATXN10	physical	25277244
SKAP_HUMAN	KNSTRN	physical	25277244
MRGBP_HUMAN	MRGBP	physical	25277244
CCDB1_HUMAN	CCNDBP1	physical	25277244
CCNO_HUMAN	CCNO	physical	25277244
DJC21_HUMAN	DNAJC21	physical	25277244
IF4G2_HUMAN	EIF4G2	physical	25277244
E41L2_HUMAN	EPB41L2	physical	25277244
GDIB_HUMAN	GDI2	physical	25277244
GOG8A_HUMAN	GOLGA8A	physical	25277244
GRAP1_HUMAN	GRIPAP1	physical	25277244
GTSF1_HUMAN	GTSF1	physical	25277244
VIGLN_HUMAN	HDLBP	physical	25277244
HNRPF_HUMAN	HNRNPF	physical	25277244
HS90B_HUMAN	HSP90AB1	physical	25277244
GRP78_HUMAN	HSPA5	physical	25277244
HSPB1_HUMAN	HSPB1	physical	25277244
HUWE1_HUMAN	HUWE1	physical	25277244
IGBP1_HUMAN	IGBP1	physical	25277244
DNLI1_HUMAN	LIG1	physical	25277244
MPH6_HUMAN	MPHOSPH6	physical	25277244
ML12B_HUMAN	MYL12B	physical	25277244
PRS4_HUMAN	PSMC1	physical	25277244
SMCA4_HUMAN	SMARCA4	physical	25277244
SNW1_HUMAN	SNW1	physical	25277244
VIME_HUMAN	VIM	physical	25277244
1433F_HUMAN	YWHAH	physical	25277244
1433T_HUMAN	YWHAQ	physical	25277244
1433Z_HUMAN	YWHAZ	physical	25277244
ZN131_HUMAN	ZNF131	physical	25277244
SAHH_HUMAN	AHCY	physical	26344197
AHNK_HUMAN	AHNAK	physical	26344197
GDIR1_HUMAN	ARHGDIA	physical	26344197
PUR9_HUMAN	ATIC	physical	26344197
CHSP1_HUMAN	CARHSP1	physical	26344197
CDK1_HUMAN	CDK1	physical	26344197
CSRP1_HUMAN	CSRP1	physical	26344197
DUT_HUMAN	DUT	physical	26344197
EF1A1_HUMAN	EEF1A1	physical	26344197
EF1B_HUMAN	EEF1B2	physical	26344197
LGUL_HUMAN	GLO1	physical	26344197
GLOD4_HUMAN	GLOD4	physical	26344197
GUAA_HUMAN	GMPS	physical	26344197
GRPE1_HUMAN	GRPEL1	physical	26344197
HMGN5_HUMAN	HMGN5	physical	26344197
JUPI1_HUMAN	HN1	physical	26344197
JUPI2_HUMAN	HN1L	physical	26344197
HNRH1_HUMAN	HNRNPH1	physical	26344197
HNRH2_HUMAN	HNRNPH2	physical	26344197
HSP7C_HUMAN	HSPA8	physical	26344197
GRP75_HUMAN	HSPA9	physical	26344197
IPO7_HUMAN	IPO7	physical	26344197
ITPA_HUMAN	ITPA	physical	26344197
MOES_HUMAN	MSN	physical	26344197
OLA1_HUMAN	OLA1	physical	26344197
PDLI1_HUMAN	PDLIM1	physical	26344197
PFD2_HUMAN	PFDN2	physical	26344197
PIPNA_HUMAN	PITPNA	physical	26344197
PIPNB_HUMAN	PITPNB	physical	26344197
PRDX6_HUMAN	PRDX6	physical	26344197
SERC_HUMAN	PSAT1	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
STMN1_HUMAN	STMN1	physical	26344197
TADBP_HUMAN	TARDBP	physical	26344197
TES_HUMAN	TES	physical	26344197
TKT_HUMAN	TKT	physical	26344197
TBA4A_HUMAN	TUBA4A	physical	26344197
UAP1_HUMAN	UAP1	physical	26344197
SAE2_HUMAN	UBA2	physical	26344197
UBE2N_HUMAN	UBE2N	physical	26344197
UGDH_HUMAN	UGDH	physical	26344197
ZYX_HUMAN	ZYX	physical	26344197
DAXX_HUMAN	DAXX	physical	25241761
P53_HUMAN	TP53	physical	25241761
MAPK3_HUMAN	MAPKAPK3	physical	25241761
MAPK2_HUMAN	MAPKAPK2	physical	25241761
MAPK5_HUMAN	MAPKAPK5	physical	19166925
AKT1_HUMAN	AKT1	physical	12740362

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
606595	Charcot-Marie-Tooth disease 2F (CMT2F)
608634	Neuronopathy, distal hereditary motor, 2B (HMN2B)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HSPB1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123, AND MASS SPECTROMETRY.	19608861 [Abstract]
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-123, AND MASS SPECTROMETRY.	16916647 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.	19369195 [Abstract]
"PKA-induced F-actin rearrangement requires phosphorylation of Hsp27by the MAPKAP kinase MK5."; Kostenko S., Johannessen M., Moens U.; Cell. Signal. 21:712-718(2009). Cited for: PHOSPHORYLATION AT SER-78 AND SER-82.	19166925 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-82 AND SER-199,AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-65; SER-82 ANDSER-199, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-82, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.	18187866 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-65; SER-82;SER-83 AND SER-199, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15 AND SER-82, AND MASSSPECTROMETRY.	16565220 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-82 AND SER-83,AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-65 AND SER-82,AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome analysis on human HepG2 hepatocytes usingreversed-phase diagonal LC."; Gevaert K., Staes A., Van Damme J., De Groot S., Hugelier K.,Demol H., Martens L., Goethals M., Vandekerckhove J.; Proteomics 5:3589-3599(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82, AND MASSSPECTROMETRY.	16097034 [Abstract]
"Heat shock protein 27 is associated with freedom from graftvasculopathy after human cardiac transplantation."; De Souza A.I., Wait R., Mitchell A.G., Banner N.R., Dunn M.J.,Rose M.L.; Circ. Res. 97:192-198(2005). Cited for: PHOSPHORYLATION AT SER-78 AND SER-82, AND MASS SPECTROMETRY.	15976317 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Regulation of Hsp27 oligomerization, chaperone function, andprotective activity against oxidative stress/tumor necrosis factoralpha by phosphorylation."; Rogalla T., Ehrnsperger M., Preville X., Kotlyarov A., Lutsch G.,Ducasse C., Paul C., Wieske M., Arrigo A.P., Buchner J., Gaestel M.; J. Biol. Chem. 274:18947-18956(1999). Cited for: PHOSPHORYLATION AT SER-15; SER-78 AND SER-82, AND MUTAGENESIS OFSER-15; SER-78 AND SER-82.	10383393 [Abstract]
"A comparison of the substrate specificity of MAPKAP kinase-2 andMAPKAP kinase-3 and their activation by cytokines and cellularstress."; Clifton A.D., Young P.R., Cohen P.; FEBS Lett. 392:209-214(1996). Cited for: PHOSPHORYLATION AT SER-15; SER-78 AND SER-82.	8774846 [Abstract]
"Identification of MAPKAP kinase 2 as a major enzyme responsible forthe phosphorylation of the small mammalian heat shock proteins."; Stokoe D., Engel K., Campbell D.G., Cohen P., Gaestel M.; FEBS Lett. 313:307-313(1992). Cited for: PHOSPHORYLATION AT SER-15; SER-78 AND SER-82 BY MAPKAPK2.	1332886 [Abstract]
"Human HSP27 is phosphorylated at serines 78 and 82 by heat shock andmitogen-activated kinases that recognize the same amino acid motif asS6 kinase II."; Landry J., Lambert H., Zhou M., Lavoie J.N., Hickey E., Weber L.A.,Anderson C.W.; J. Biol. Chem. 267:794-803(1992). Cited for: PROTEIN SEQUENCE OF 76-89, AND PHOSPHORYLATION AT SER-78 AND SER-82.	1730670 [Abstract]