NEK10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEK10_HUMAN
• UniProt AC: Q6ZWH5
• Protein Name: Serine/threonine-protein kinase Nek10
• Gene Name: NEK10
• Organism: Homo sapiens (Human).
• Sequence Length: 1172
• Protein Sequence: MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKSEPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLISREWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQHTVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSANAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKLILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVSSMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETFEKASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYSEVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQSQTRDFTGGTGSRPRPALLPLDLLLKVPPHMLRAHIKEIEAELVTGWQSHSLPAVILRNLKDHGPQMGTFLWQASAGIAVSQRKVRQISDPIQQILIQLHKIIYITQLPPALHHNLKRRVIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTSIELEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNHPTKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Ubiquitination	LLNVQSSKQQLPAIN HHHCCCCCCCCCCCC	47.51	2190698
42 (in isoform 4)	Ubiquitination	-	47.51	21906983
42 (in isoform 3)	Ubiquitination	-	47.51	21906983
42 (in isoform 2)	Ubiquitination	-	47.51	21906983
42 (in isoform 1)	Ubiquitination	-	47.51	21906983
98	Phosphorylation	YKNERNFSKHPQRKL CCCCCCCCCCHHHHH	33.34	-
189	Phosphorylation	VDKLVNMTYIFQKLA HHHHHHHHHHHHHHH	14.30	-
213	Phosphorylation	TTSGAHKTLVNLLGA ECCCHHHHHHHHHCC	26.52	24114839
505	Phosphorylation	QIAENIESINQNKAP HHHHHHHHHHCCCCC	24.04	28450419
583	Phosphorylation	TIIKEQLYHPNIVRY HHHHHHHCCCHHHHH	18.22	-
590	Phosphorylation	YHPNIVRYYKTFLEN CCCHHHHHHHHHHHC	9.83	-
591	Phosphorylation	HPNIVRYYKTFLEND CCHHHHHHHHHHHCC	7.93	-
759	Phosphorylation	GIYSEKVTDTISRCL CCCCCCCCCHHHHHC	38.19	24275569
763	Phosphorylation	EKVTDTISRCLTPDA CCCCCHHHHHCCCCH	21.02	24275569
931	Phosphorylation	TFNILKRSFSASGGE HHHHHHHHHCCCCCC	23.20	22985185
933	Phosphorylation	NILKRSFSASGGERQ HHHHHHHCCCCCCCC	23.83	22985185
950	Phosphorylation	TRDFTGGTGSRPRPA CCCCCCCCCCCCCCC	33.07	22468782
952	Phosphorylation	DFTGGTGSRPRPALL CCCCCCCCCCCCCEE	38.66	22468782
1067	Phosphorylation	VIERFKKSLFSQQSN HHHHHHHHHHCCCCC	34.93	29978859
1070	Phosphorylation	RFKKSLFSQQSNPCN HHHHHHHCCCCCCCC	32.38	29978859
1073	Phosphorylation	KSLFSQQSNPCNLKS HHHHCCCCCCCCHHH	34.79	29978859
1080	Phosphorylation	SNPCNLKSEIKKLSQ CCCCCHHHHHHHHHC	47.96	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEK10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEK10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEK10_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of NEK10_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.