JUPI2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JUPI2_HUMAN
• UniProt AC: Q9H910
• Protein Name: Jupiter microtubule associated homolog 2 {ECO:0000312|HGNC:HGNC:14137}
• Gene Name: JPT2 {ECO:0000312|HGNC:HGNC:14137}
• Organism: Homo sapiens (Human).
• Sequence Length: 190
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Sequence: MFQVPDSEGGRAGSRAMKPPGGESSNLFGSPEEATPSSRPNRMASNIFGPTEEPQNIPKRTNPPGGKGSGIFDESTPVQTRQHLNPPGGKTSDIFGSPVTATSRLAHPNKPKDHVFLCEGEEPKSDLKAARSIPAGAEPGEKGSARKAGPAKEQEPMPTVDSHEPRLGPRPRSHNKVLNPPGGKSSISFY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MFQVPDSE -------CCCCCCCC		22814378
7	Phosphorylation	-MFQVPDSEGGRAGS -CCCCCCCCCCCCCC		25159151
9 (in isoform 2)	Phosphorylation	-		25159151
14 (in isoform 2)	Phosphorylation	-		25159151
14	Phosphorylation	SEGGRAGSRAMKPPG CCCCCCCCCCCCCCC		26074081
17	Sulfoxidation	GRAGSRAMKPPGGES CCCCCCCCCCCCCCC		30846556
18	Ubiquitination	RAGSRAMKPPGGESS CCCCCCCCCCCCCCC		24816145
18	Acetylation	RAGSRAMKPPGGESS CCCCCCCCCCCCCCC		26051181
24	Phosphorylation	MKPPGGESSNLFGSP CCCCCCCCCCCCCCH		23401153
25	Phosphorylation	KPPGGESSNLFGSPE CCCCCCCCCCCCCHH		29255136
30	O-linked_Glycosylation	ESSNLFGSPEEATPS CCCCCCCCHHHCCCC		28657654
30	Phosphorylation	ESSNLFGSPEEATPS CCCCCCCCHHHCCCC		29255136
35	Phosphorylation	FGSPEEATPSSRPNR CCCHHHCCCCCCCCC		23927012
35	O-linked_Glycosylation	FGSPEEATPSSRPNR CCCHHHCCCCCCCCC		OGP
37	Phosphorylation	SPEEATPSSRPNRMA CHHHCCCCCCCCCCH		23927012
37	O-linked_Glycosylation	SPEEATPSSRPNRMA CHHHCCCCCCCCCCH		28657654
38	Phosphorylation	PEEATPSSRPNRMAS HHHCCCCCCCCCCHH		23927012
38	O-linked_Glycosylation	PEEATPSSRPNRMAS HHHCCCCCCCCCCHH		OGP
43	Sulfoxidation	PSSRPNRMASNIFGP CCCCCCCCHHCCCCC		21406390
45	Phosphorylation	SRPNRMASNIFGPTE CCCCCCHHCCCCCCC		25159151
51	Phosphorylation	ASNIFGPTEEPQNIP HHCCCCCCCCCCCCC		28555341
51	O-linked_Glycosylation	ASNIFGPTEEPQNIP HHCCCCCCCCCCCCC		OGP
59	Ubiquitination	EEPQNIPKRTNPPGG CCCCCCCCCCCCCCC		24816145
61	Phosphorylation	PQNIPKRTNPPGGKG CCCCCCCCCCCCCCC		26074081
67	Ubiquitination	RTNPPGGKGSGIFDE CCCCCCCCCCCCCCC		33845483
67	Acetylation	RTNPPGGKGSGIFDE CCCCCCCCCCCCCCC		23954790
67	Methylation	RTNPPGGKGSGIFDE CCCCCCCCCCCCCCC		66728197
69	Phosphorylation	NPPGGKGSGIFDEST CCCCCCCCCCCCCCC		29255136
75	O-linked_Glycosylation	GSGIFDESTPVQTRQ CCCCCCCCCCCCCCC		OGP
75	Phosphorylation	GSGIFDESTPVQTRQ CCCCCCCCCCCCCCC		30266825
76	O-linked_Glycosylation	SGIFDESTPVQTRQH CCCCCCCCCCCCCCC		OGP
76	Phosphorylation	SGIFDESTPVQTRQH CCCCCCCCCCCCCCC		29255136
80	Phosphorylation	DESTPVQTRQHLNPP CCCCCCCCCCCCCCC		29255136
90	Acetylation	HLNPPGGKTSDIFGS CCCCCCCCHHHCCCC		26051181
90	Ubiquitination	HLNPPGGKTSDIFGS CCCCCCCCHHHCCCC		29967540
91	Phosphorylation	LNPPGGKTSDIFGSP CCCCCCCHHHCCCCC		23927012
92	Phosphorylation	NPPGGKTSDIFGSPV CCCCCCHHHCCCCCC		26074081
92	O-linked_Glycosylation	NPPGGKTSDIFGSPV CCCCCCHHHCCCCCC		28657654
97	Phosphorylation	KTSDIFGSPVTATSR CHHHCCCCCCCCCCC		19664994
100	Phosphorylation	DIFGSPVTATSRLAH HCCCCCCCCCCCCCC		30266825
100	O-linked_Glycosylation	DIFGSPVTATSRLAH HCCCCCCCCCCCCCC		OGP
102	Phosphorylation	FGSPVTATSRLAHPN CCCCCCCCCCCCCCC		23927012
102	O-linked_Glycosylation	FGSPVTATSRLAHPN CCCCCCCCCCCCCCC		OGP
103	Phosphorylation	GSPVTATSRLAHPNK CCCCCCCCCCCCCCC		23927012
104	Methylation	SPVTATSRLAHPNKP CCCCCCCCCCCCCCC		115478839
110	Ubiquitination	SRLAHPNKPKDHVFL CCCCCCCCCCCEEEE		29967540
112	Acetylation	LAHPNKPKDHVFLCE CCCCCCCCCEEEEEC		23954790
124	Ubiquitination	LCEGEEPKSDLKAAR EECCCCCHHHHHHHH		24816145
124	Acetylation	LCEGEEPKSDLKAAR EECCCCCHHHHHHHH		26051181
125	Phosphorylation	CEGEEPKSDLKAARS ECCCCCHHHHHHHHC		25159151
128	Ubiquitination	EEPKSDLKAARSIPA CCCHHHHHHHHCCCC		33845483
132	Phosphorylation	SDLKAARSIPAGAEP HHHHHHHCCCCCCCC		25159151
132	O-linked_Glycosylation	SDLKAARSIPAGAEP HHHHHHHCCCCCCCC		28657654
142	Acetylation	AGAEPGEKGSARKAG CCCCCCCCCCCCCCC		23954790
142	Ubiquitination	AGAEPGEKGSARKAG CCCCCCCCCCCCCCC		24816145
144	Phosphorylation	AEPGEKGSARKAGPA CCCCCCCCCCCCCCC		23927012
147	Methylation	GEKGSARKAGPAKEQ CCCCCCCCCCCCCCC		116253805
152	Ubiquitination	ARKAGPAKEQEPMPT CCCCCCCCCCCCCCC		24816145
157	Sulfoxidation	PAKEQEPMPTVDSHE CCCCCCCCCCCCCCC		21406390
159	Phosphorylation	KEQEPMPTVDSHEPR CCCCCCCCCCCCCCC		26657352
159	O-linked_Glycosylation	KEQEPMPTVDSHEPR CCCCCCCCCCCCCCC		50589911
162	Phosphorylation	EPMPTVDSHEPRLGP CCCCCCCCCCCCCCC		26657352
173	Phosphorylation	RLGPRPRSHNKVLNP CCCCCCCCCCCCCCC		28102081
176	Ubiquitination	PRPRSHNKVLNPPGG CCCCCCCCCCCCCCC		29967540
184	Ubiquitination	VLNPPGGKSSISFY- CCCCCCCCCCCEEC-		23000965
184	Acetylation	VLNPPGGKSSISFY- CCCCCCCCCCCEEC-		25953088
184	Methylation	VLNPPGGKSSISFY- CCCCCCCCCCCEEC-		30589305
185	Phosphorylation	LNPPGGKSSISFY-- CCCCCCCCCCEEC--		27251275
186	Phosphorylation	NPPGGKSSISFY--- CCCCCCCCCEEC---		22617229
188	Phosphorylation	PGGKSSISFY----- CCCCCCCEEC-----		25348954
190	Phosphorylation	GKSSISFY------- CCCCCEEC-------		25348954
212	Ubiquitination	----------------------------- -----------------------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
97	S	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JUPI2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JUPI2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FIGL1_HUMAN	FIGNL1	physical	28514442
CARM1_HUMAN	CARM1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.