dbPTM

SPAC7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SPAC7_HUMAN
UniProt AC	Q96KW9
Protein Name	Sperm acrosome-associated protein 7 {ECO:0000312\|HGNC:HGNC:29575}
Gene Name	SPACA7 {ECO:0000312\|HGNC:HGNC:29575}
Organism	Homo sapiens (Human).
Sequence Length	195
Subcellular Localization	Secreted . Cytoplasmic vesicle, secretory vesicle, acrosome . Cytoplasmic vesicle, secretory vesicle, acrosome lumen . Localized in perinuclear pro-acrosomal granules in round spermatides. Localized between the inner and outer acrosomal membranes (ma
Protein Description	Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion..
Protein Sequence	MAVSQGDGTLCFVLLLCCWQETELRPRTVIPGSPTEIPFSSKQEDMSELLDEILVQEILDLNKTTPSEMPSTASTLSTPLHAGIDENYQAGGSENYHELLENLQFSPGIEVKISNDEANANANLHGDPSENYRGPQVSPGSEKSVSSKEKNSKNTQYENLSILDQILQNIGRSSGNIFHKEQQRTSAQRRSQGSQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	N-linked_Glycosylation	VQEILDLNKTTPSEM HHHHHHHCCCCCCCC	39.02	UniProtKB CARBOHYD
144	Phosphorylation	VSPGSEKSVSSKEKN CCCCCCCCCCCCCCC	24.15	-
157	Phosphorylation	KNSKNTQYENLSILD CCCCCCHHHHHHHHH	12.54	-
159	N-linked_Glycosylation	SKNTQYENLSILDQI CCCCHHHHHHHHHHH	33.87	UniProtKB CARBOHYD
174	Phosphorylation	LQNIGRSSGNIFHKE HHHHCCCCCCCCCHH	34.20	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SPAC7_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SPAC7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SPAC7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SPAC7_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SPAC7_HUMAN

Related Literatures of Post-Translational Modification