dbPTM

E41L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	E41L1_HUMAN
UniProt AC	Q9H4G0
Protein Name	Band 4.1-like protein 1
Gene Name	EPB41L1
Organism	Homo sapiens (Human).
Sequence Length	881
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases..
Protein Sequence	MTTETGPDSEVKKAQEEAPQQPEAAAAVTTPVTPAGHGHPEANSNEKHPSQQDTRPAEQSLDMEEKDYSEADGLSERTTPSKAQKSPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDADSQKNWLDPSKEIKKQIRSSPWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRDEDGESGGQRSEAEEGEVRTPTKIKELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKANERAGLREGSEEKVKPPRPRAPESDTGDEDQDQERDTVFLKDNHLAIERKCSSITVSSTSSLEAEVDFTVIGDYHGSAFEDFSRSLPELDRDKSDSDTEGLLFSRDLNKGAPSQDDESGGIEDSPDRGACSTPDMPQFEPVKTETMTVSSLAIRKKIEPEAVLQTRVSAMDNTQQVDGSASVGREFIATTPSITTETISTTMENSLKSGKGAAAMIPGPQTVATEIRSLSPIIGKDVLTSTYGATAETLSTSTTTHVTKTVKGGFSETRIEKRIIITGDEDVDQDQALALAIKEAKLQHPDMLVTKAVVYRETDPSPEERDKKPQES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1 (in isoform 2)	Acetylation	-	10.64	22814378
1 (in isoform 3)	Acetylation	-	10.64	22814378
2	Phosphorylation	------MTTETGPDS ------CCCCCCCHH	33.08	28857561
6 (in isoform 2)	Phosphorylation	-	20.13	25159151
6 (in isoform 3)	Phosphorylation	-	20.13	25159151
7 (in isoform 2)	Phosphorylation	-	49.74	25056879
7 (in isoform 3)	Phosphorylation	-	49.74	25056879
9	Phosphorylation	TTETGPDSEVKKAQE CCCCCCHHHHHHHHH	47.63	28857561
13 (in isoform 2)	Phosphorylation	-	61.55	25849741
13 (in isoform 3)	Phosphorylation	-	61.55	25849741
23 (in isoform 4)	Phosphorylation	-	46.75	25056879
26 (in isoform 4)	Phosphorylation	-	14.98	20068231
29	Phosphorylation	PEAAAAVTTPVTPAG HHHHHHCCCCCCCCC	22.21	28857561
29 (in isoform 4)	Phosphorylation	-	22.21	20068231
30	Phosphorylation	EAAAAVTTPVTPAGH HHHHHCCCCCCCCCC	14.79	26657352
33	Phosphorylation	AAVTTPVTPAGHGHP HHCCCCCCCCCCCCC	14.50	25159151
37 (in isoform 4)	Phosphorylation	-	33.23	20068231
38 (in isoform 4)	Phosphorylation	-	36.81	20068231
44	Phosphorylation	HGHPEANSNEKHPSQ CCCCCCCCCCCCCCC	54.11	20068231
44 (in isoform 4)	Phosphorylation	-	54.11	20068231
47 (in isoform 4)	Phosphorylation	-	66.13	20068231
48 (in isoform 4)	Phosphorylation	-	22.51	20068231
50	Phosphorylation	NSNEKHPSQQDTRPA CCCCCCCCCCCCCHH	39.95	26657352
50 (in isoform 4)	Phosphorylation	-	39.95	20068231
54	Phosphorylation	KHPSQQDTRPAEQSL CCCCCCCCCHHHHHC	33.93	23663014
60	Phosphorylation	DTRPAEQSLDMEEKD CCCHHHHHCCCCCCC	20.17	23663014
68	Phosphorylation	LDMEEKDYSEADGLS CCCCCCCCHHCCCCC	21.34	23927012
69	Phosphorylation	DMEEKDYSEADGLSE CCCCCCCHHCCCCCC	36.12	21955146
75	Phosphorylation	YSEADGLSERTTPSK CHHCCCCCCCCCCCH	30.48	25159151
78	Phosphorylation	ADGLSERTTPSKAQK CCCCCCCCCCCHHCC	38.72	30278072
79	Phosphorylation	DGLSERTTPSKAQKS CCCCCCCCCCHHCCC	31.61	28355574
81	Phosphorylation	LSERTTPSKAQKSPQ CCCCCCCCHHCCCHH	38.23	30278072
86	Phosphorylation	TPSKAQKSPQKIAKK CCCHHCCCHHHHHHH	22.08	27422710
89	Ubiquitination	KAQKSPQKIAKKYKS HHCCCHHHHHHHHHH	48.27	-
92	Ubiquitination	KSPQKIAKKYKSAIC CCHHHHHHHHHHCCC	61.17	-
93	Ubiquitination	SPQKIAKKYKSAICR CHHHHHHHHHHCCCE	49.22	-
102	Phosphorylation	KSAICRVTLLDASEY HHCCCEEEEEEHHHC	11.40	-
107	Phosphorylation	RVTLLDASEYECEVE EEEEEEHHHCEEEEE	40.14	24076635
109	Phosphorylation	TLLDASEYECEVEKH EEEEHHHCEEEEEEC	24.31	-
149	Ubiquitination	FCDADSQKNWLDPSK ECCCCCCCCCCCCCH	54.78	-
155	Phosphorylation	QKNWLDPSKEIKKQI CCCCCCCCHHHHHHH	42.46	20068231
202	Phosphorylation	QLRADIITGRLPCSF HHHHHHHCCCCCHHH	19.31	20068231
261	Phosphorylation	IMELHKTYRGMTPGE HHHHHHHHCCCCCCC	15.24	-
283	Phosphorylation	NAKKLSMYGVDLHHA HHHHHEEECCCCCCC	15.60	25332170
323	Ubiquitination	INRFAWPKILKISYK CCCCHHHEEEEEEEE	50.39	-
328	Phosphorylation	WPKILKISYKRSNFY HHEEEEEEEECCCEE	24.02	20068231
329	Phosphorylation	PKILKISYKRSNFYI HEEEEEEEECCCEEE	17.56	20068231
343	Phosphorylation	IKIRPGEYEQFESTI EEECCCCCCEECCCC	22.42	21945579
348	Phosphorylation	GEYEQFESTIGFKLP CCCCEECCCCCCCCC	26.98	21945579
349	Phosphorylation	EYEQFESTIGFKLPN CCCEECCCCCCCCCC	20.23	21945579
378	Phosphorylation	HTFFRLVSPEPPPKG CCEEEECCCCCCCCC	28.30	28731282
378 (in isoform 3)	Phosphorylation	-	28.30	25849741
391	Phosphorylation	KGFLVMGSKFRYSGR CCEEEECCCCEECCC	15.55	28857561
395	Phosphorylation	VMGSKFRYSGRTQAQ EECCCCEECCCCHHH	20.71	26434776
396	Phosphorylation	MGSKFRYSGRTQAQT ECCCCEECCCCHHHH	19.97	28355574
399	Phosphorylation	KFRYSGRTQAQTRQA CCEECCCCHHHHHHH	31.61	29449344
401 (in isoform 3)	Phosphorylation	-	16.46	25849741
403	Phosphorylation	SGRTQAQTRQASALI CCCCHHHHHHHHHHC	27.97	29449344
407	Phosphorylation	QAQTRQASALIDRPA HHHHHHHHHHCCCCC	18.44	28355574
413 (in isoform 2)	Phosphorylation	-	40.30	25849741
420	Phosphorylation	PAPFFERSSSKRYTM CCCCCCCCCCCCEEE	31.59	28102081
421	Phosphorylation	APFFERSSSKRYTMS CCCCCCCCCCCEEEC	46.21	28348404
422	Phosphorylation	PFFERSSSKRYTMSR CCCCCCCCCCEEECC	23.54	25056879
425	Phosphorylation	ERSSSKRYTMSRSLD CCCCCCCEEECCCCC	15.55	22817900
428	Phosphorylation	SSKRYTMSRSLDGAE CCCCEEECCCCCCCC	15.77	24719451
430	Phosphorylation	KRYTMSRSLDGAEFS CCEEECCCCCCCCCC	24.41	19664994
436 (in isoform 2)	Phosphorylation	-	8.12	25849741
437	Phosphorylation	SLDGAEFSRPASVSE CCCCCCCCCCCCCCC	28.94	30266825
441	Phosphorylation	AEFSRPASVSENHDA CCCCCCCCCCCCCCC	28.94	29255136
443	Phosphorylation	FSRPASVSENHDAGP CCCCCCCCCCCCCCC	30.13	30266825
444 (in isoform 4)	Phosphorylation	-	57.33	25849741
461	Phosphorylation	KRDEDGESGGQRSEA CCCCCCCCCCCCCCH	54.47	28355574
466	Phosphorylation	GESGGQRSEAEEGEV CCCCCCCCCHHCCCC	33.02	28355574
467 (in isoform 4)	Phosphorylation	-	63.39	25849741
475	Phosphorylation	AEEGEVRTPTKIKEL HHCCCCCCCCCHHHC	40.25	28355574
477	Phosphorylation	EGEVRTPTKIKELKP CCCCCCCCCHHHCCC	44.80	29255136
488	Phosphorylation	ELKPEQETTPRHKQE HCCCCCCCCHHHHHH	41.62	27732954
489	Phosphorylation	LKPEQETTPRHKQEF CCCCCCCCHHHHHHH	19.99	27732954
499	Ubiquitination	HKQEFLDKPEDVLLK HHHHHHHCHHHHHHH	53.07	-
501 (in isoform 4)	Phosphorylation	-	67.50	25849741
503 (in isoform 4)	Phosphorylation	-	6.86	25849741
506	Methylation	KPEDVLLKHQASINE CHHHHHHHHHHHHHH	29.52	24129315
506	Ubiquitination	KPEDVLLKHQASINE CHHHHHHHHHHHHHH	29.52	-
507 (in isoform 4)	Phosphorylation	-	28.54	25849741
510	Phosphorylation	VLLKHQASINELKRT HHHHHHHHHHHHHHH	21.26	22167270
515	Methylation	QASINELKRTLKEPN HHHHHHHHHHHHCCC	36.84	-
515	Ubiquitination	QASINELKRTLKEPN HHHHHHHHHHHHCCC	36.84	-
517	Phosphorylation	SINELKRTLKEPNSK HHHHHHHHHHCCCCC	40.36	28555341
523	O-linked_Glycosylation	RTLKEPNSKLIHRDR HHHHCCCCCCCCCCC	39.28	30059200
540	Phosphorylation	ERERRLPSSPASPSP HHHHCCCCCCCCCCC	54.25	27273156
541	Phosphorylation	RERRLPSSPASPSPK HHHCCCCCCCCCCCC	23.65	22167270
544	Phosphorylation	RLPSSPASPSPKGTP CCCCCCCCCCCCCCH	29.33	22167270
546	Phosphorylation	PSSPASPSPKGTPEK CCCCCCCCCCCCHHH	36.43	22167270
550	Phosphorylation	ASPSPKGTPEKANER CCCCCCCCHHHHHHH	34.11	22167270
564	Phosphorylation	RAGLREGSEEKVKPP HCCCCCCCCCCCCCC	37.52	28355574
578	Phosphorylation	PRPRAPESDTGDEDQ CCCCCCCCCCCCCCC	39.14	22167270
580	Phosphorylation	PRAPESDTGDEDQDQ CCCCCCCCCCCCCCC	56.67	28355574
591	Phosphorylation	DQDQERDTVFLKDNH CCCCCCCEEEEECCC	21.27	28176443
595	Ubiquitination	ERDTVFLKDNHLAIE CCCEEEEECCCEEEE	45.05	-
612	Phosphorylation	CSSITVSSTSSLEAE CEEEEECCCCCEEEE	28.15	22468782
613	Phosphorylation	SSITVSSTSSLEAEV EEEEECCCCCEEEEE	18.15	22468782
628	Phosphorylation	DFTVIGDYHGSAFED EEEEECCCCHHHHHH	11.67	20736484
639	Phosphorylation	AFEDFSRSLPELDRD HHHHHHHCCCCCCCC	47.26	30266825
648	Phosphorylation	PELDRDKSDSDTEGL CCCCCCCCCCCCCCE	46.78	22167270
650	Phosphorylation	LDRDKSDSDTEGLLF CCCCCCCCCCCCEEE	54.23	22167270
652	Phosphorylation	RDKSDSDTEGLLFSR CCCCCCCCCCEEEEC	35.58	30266825
653 (in isoform 2)	Phosphorylation	-	53.48	24719451
657 (in isoform 2)	Phosphorylation	-	7.28	25159151
658	Phosphorylation	DTEGLLFSRDLNKGA CCCCEEEECCCCCCC	25.50	23927012
663	Ubiquitination	LFSRDLNKGAPSQDD EEECCCCCCCCCCCC	64.84	-
667	Phosphorylation	DLNKGAPSQDDESGG CCCCCCCCCCCCCCC	45.79	23927012
672	Phosphorylation	APSQDDESGGIEDSP CCCCCCCCCCCCCCC	49.68	23927012
678	Phosphorylation	ESGGIEDSPDRGACS CCCCCCCCCCCCCCC	18.86	19664994
685	Phosphorylation	SPDRGACSTPDMPQF CCCCCCCCCCCCCCC	42.30	30266825
686	Phosphorylation	PDRGACSTPDMPQFE CCCCCCCCCCCCCCC	24.16	30266825
697	O-linked_Glycosylation	PQFEPVKTETMTVSS CCCCCCCCCEEEEEH	36.60	30059200
697	Phosphorylation	PQFEPVKTETMTVSS CCCCCCCCCEEEEEH	36.60	30266825
699	O-linked_Glycosylation	FEPVKTETMTVSSLA CCCCCCCEEEEEHHH	24.31	30059200
699	Phosphorylation	FEPVKTETMTVSSLA CCCCCCCEEEEEHHH	24.31	28348404
701	Phosphorylation	PVKTETMTVSSLAIR CCCCCEEEEEHHHHH	25.34	28348404
703	Phosphorylation	KTETMTVSSLAIRKK CCCEEEEEHHHHHHC	15.52	28857561
704	Phosphorylation	TETMTVSSLAIRKKI CCEEEEEHHHHHHCC	19.93	28857561
710	Ubiquitination	SSLAIRKKIEPEAVL EHHHHHHCCCHHHHH	42.31	-
722	Phosphorylation	AVLQTRVSAMDNTQQ HHHEEEEECCCCCCE	18.00	19060867
727	Phosphorylation	RVSAMDNTQQVDGSA EEECCCCCCEECCCC	19.00	19060867
733	Phosphorylation	NTQQVDGSASVGREF CCCEECCCCEECCCE	16.95	28348404
735	Phosphorylation	QQVDGSASVGREFIA CEECCCCEECCCEEE	27.14	28348404
743	Phosphorylation	VGREFIATTPSITTE ECCCEEEECCCEEEC	34.13	28857561
744	Phosphorylation	GREFIATTPSITTET CCCEEEECCCEEECC	13.15	24719451
746	Phosphorylation	EFIATTPSITTETIS CEEEECCCEEECCCC	30.40	28348404
748	Phosphorylation	IATTPSITTETISTT EEECCCEEECCCCHH	23.94	28857561
749	Phosphorylation	ATTPSITTETISTTM EECCCEEECCCCHHH	29.48	28348404
753	Phosphorylation	SITTETISTTMENSL CEEECCCCHHHHHHH	25.83	27251275
754	Phosphorylation	ITTETISTTMENSLK EEECCCCHHHHHHHH	26.72	24719451
755	Phosphorylation	TTETISTTMENSLKS EECCCCHHHHHHHHC	18.72	27251275
759	Phosphorylation	ISTTMENSLKSGKGA CCHHHHHHHHCCCCC	24.70	28348404
775	O-linked_Glycosylation	AMIPGPQTVATEIRS EECCCCHHHHHHHHH	18.42	30059200
775	Phosphorylation	AMIPGPQTVATEIRS EECCCCHHHHHHHHH	18.42	29514088
778	O-linked_Glycosylation	PGPQTVATEIRSLSP CCCHHHHHHHHHHCC	27.84	30059200
778	Phosphorylation	PGPQTVATEIRSLSP CCCHHHHHHHHHHCC	27.84	20068231
782	Phosphorylation	TVATEIRSLSPIIGK HHHHHHHHHCCCCCH	38.57	30266825
784	Phosphorylation	ATEIRSLSPIIGKDV HHHHHHHCCCCCHHH	18.46	19664994
789	Acetylation	SLSPIIGKDVLTSTY HHCCCCCHHHHHCCC	33.97	23954790
793	O-linked_Glycosylation	IIGKDVLTSTYGATA CCCHHHHHCCCCCEE	20.90	30059200
793	Phosphorylation	IIGKDVLTSTYGATA CCCHHHHHCCCCCEE	20.90	27486199
794	O-linked_Glycosylation	IGKDVLTSTYGATAE CCHHHHHCCCCCEEE	18.57	30059200
794	Phosphorylation	IGKDVLTSTYGATAE CCHHHHHCCCCCEEE	18.57	28152594
795	Phosphorylation	GKDVLTSTYGATAET CHHHHHCCCCCEEEE	22.27	28152594
796	Phosphorylation	KDVLTSTYGATAETL HHHHHCCCCCEEEEE	12.44	25884760
799	Phosphorylation	LTSTYGATAETLSTS HHCCCCCEEEEECCC	22.21	28152594
802	Phosphorylation	TYGATAETLSTSTTT CCCCEEEEECCCCCE	24.44	28152594
804	Phosphorylation	GATAETLSTSTTTHV CCEEEEECCCCCEEE	27.94	28152594
805	Phosphorylation	ATAETLSTSTTTHVT CEEEEECCCCCEEEE	32.95	28152594
806	Phosphorylation	TAETLSTSTTTHVTK EEEEECCCCCEEEEE	22.00	28152594
807	Phosphorylation	AETLSTSTTTHVTKT EEEECCCCCEEEEEE	35.48	28152594
808	Phosphorylation	ETLSTSTTTHVTKTV EEECCCCCEEEEEEE	18.05	28152594
809	Phosphorylation	TLSTSTTTHVTKTVK EECCCCCEEEEEEEC	17.90	20860994
812	Phosphorylation	TSTTTHVTKTVKGGF CCCCEEEEEEECCCC	17.25	20860994
820	Phosphorylation	KTVKGGFSETRIEKR EEECCCCCCCEEEEE	41.14	21815630
822	Phosphorylation	VKGGFSETRIEKRII ECCCCCCCEEEEEEE	35.43	28102081
831	Phosphorylation	IEKRIIITGDEDVDQ EEEEEEEECCCCCCH	28.33	29978859
847	Ubiquitination	QALALAIKEAKLQHP HHHHHHHHHHHCCCC	46.11	-
864	Phosphorylation	LVTKAVVYRETDPSP EEEEEEEEECCCCCH	8.99	21945579
867	Phosphorylation	KAVVYRETDPSPEER EEEEEECCCCCHHHH	44.18	21945579
870	Phosphorylation	VYRETDPSPEERDKK EEECCCCCHHHHCCC	47.99	21945579
881	Phosphorylation	RDKKPQES------- HCCCCCCC-------	40.03	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of E41L1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of E41L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of E41L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUMA1_HUMAN	NUMA1	physical	10594058
ITPR1_HUMAN	ITPR1	physical	12676536
AGAP2_HUMAN	AGAP2	physical	11136977
A4_HUMAN	APP	physical	21832049
NOP16_HUMAN	NOP16	physical	22939629
HNRL1_HUMAN	HNRNPUL1	physical	22939629
ACACA_HUMAN	ACACA	physical	22863883
ICAL_HUMAN	CAST	physical	22863883
CSN3_HUMAN	COPS3	physical	22863883
CSN4_HUMAN	COPS4	physical	22863883
CSN5_HUMAN	COPS5	physical	22863883
KINH_HUMAN	KIF5B	physical	22863883
PSA4_HUMAN	PSMA4	physical	22863883
PSA5_HUMAN	PSMA5	physical	22863883
PSB3_HUMAN	PSMB3	physical	22863883
PSB4_HUMAN	PSMB4	physical	22863883
PSB5_HUMAN	PSMB5	physical	22863883
PSB7_HUMAN	PSMB7	physical	22863883

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614257	Mental retardation, autosomal dominant 11 (MRD11)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of E41L1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; THR-79; THR-475;SER-540; SER-541; SER-544; SER-546; SER-578; SER-648; SER-650 ANDSER-784, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-650, AND MASSSPECTROMETRY.	18220336 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378 AND SER-784, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-437; SER-441; SER-546AND SER-564, AND MASS SPECTROMETRY.	17081983 [Abstract]