dbPTM

HMGN5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HMGN5_HUMAN
UniProt AC	P82970
Protein Name	High mobility group nucleosome-binding domain-containing protein 5
Gene Name	HMGN5
Organism	Homo sapiens (Human).
Sequence Length	282
Subcellular Localization	Nucleus . Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin..
Protein Description	Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction..
Protein Sequence	MPKRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSIV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MPKRKAAGQGDM ---CCCCCCCCCCCC	49.03	7668519
5	Methylation	---MPKRKAAGQGDM ---CCCCCCCCCCCC	49.03	7668519
20	Phosphorylation	RQEPKRRSARLSAML CCCHHHHHHHHHHHE	23.05	25159151
24	Phosphorylation	KRRSARLSAMLVPVT HHHHHHHHHHEECCC	13.18	25159151
25	Ubiquitination	RRSARLSAMLVPVTP HHHHHHHHHEECCCC	10.42	24816145
26	Sulfoxidation	RSARLSAMLVPVTPE HHHHHHHHEECCCCC	3.31	21406390
31	Phosphorylation	SAMLVPVTPEVKPKR HHHEECCCCCCCCCC	13.99	29255136
35	Acetylation	VPVTPEVKPKRTSSS ECCCCCCCCCCCCCC	43.06	23954790
35	Ubiquitination	VPVTPEVKPKRTSSS ECCCCCCCCCCCCCC	43.06	24816145
41	Phosphorylation	VKPKRTSSSRKMKTK CCCCCCCCCCCCCCH	33.28	-
42	Phosphorylation	KPKRTSSSRKMKTKS CCCCCCCCCCCCCHH	35.37	-
47	Phosphorylation	SSSRKMKTKSDMMEE CCCCCCCCHHHHHHH	32.08	27690223
48	Acetylation	SSRKMKTKSDMMEEN CCCCCCCHHHHHHHH	38.65	26822725
48	Ubiquitination	SSRKMKTKSDMMEEN CCCCCCCHHHHHHHH	38.65	-
49	Phosphorylation	SRKMKTKSDMMEENI CCCCCCHHHHHHHHH	35.65	29214152
51	Sulfoxidation	KMKTKSDMMEENIDT CCCCHHHHHHHHHCH	4.74	21406390
58	Phosphorylation	MMEENIDTSAQAVAE HHHHHHCHHHHHHHH	23.36	27690223
59	Phosphorylation	MEENIDTSAQAVAET HHHHHCHHHHHHHHH	18.03	28674419
67	Sumoylation	AQAVAETKQEAVVEE HHHHHHHHHHHHHHH	37.33	28112733
67	Sumoylation	AQAVAETKQEAVVEE HHHHHHHHHHHHHHH	37.33	-
76	Phosphorylation	EAVVEEDYNENAKNG HHHHHHHHHHHCCCC	27.88	29978859
81	Acetylation	EDYNENAKNGEAKIT HHHHHHCCCCCCEEC	76.65	26051181
88	Phosphorylation	KNGEAKITEAPASEK CCCCCEECCCCCCHH	25.95	30266825
93	Phosphorylation	KITEAPASEKEIVEV EECCCCCCHHHHEEE	48.41	30266825
95	Ubiquitination	TEAPASEKEIVEVKE CCCCCCHHHHEEEHH	50.69	29967540
95	Acetylation	TEAPASEKEIVEVKE CCCCCCHHHHEEEHH	50.69	23954790
101	Ubiquitination	EKEIVEVKEENIEDA HHHHEEEHHHHHHHH	45.89	32015554
101	Sumoylation	EKEIVEVKEENIEDA HHHHEEEHHHHHHHH	45.89	25114211
101	Sumoylation	EKEIVEVKEENIEDA HHHHEEEHHHHHHHH	45.89	-
101	Acetylation	EKEIVEVKEENIEDA HHHHEEEHHHHHHHH	45.89	26051181
111	Acetylation	NIEDATEKGGEKKEA HHHHHHHHCCHHHHH	68.79	23954790
124	Sumoylation	EAVAAEVKNEEEDQK HHHHHHHCCHHHHHH	50.58	25218447
124	Sumoylation	EAVAAEVKNEEEDQK HHHHHHHCCHHHHHH	50.58	-
149	Ubiquitination	GEAGKEDKDEKGEED CCCCCCCCCCCCCCC	69.73	29967540
152	Ubiquitination	GKEDKDEKGEEDGKE CCCCCCCCCCCCCCC	80.09	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
20	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
24	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS
31	T	Phosphorylation	Kinase	CDK1	P06493	PSP
31	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HMGN5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HMGN5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HMGN5_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HMGN5_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-24 AND THR-31,AND MASS SPECTROMETRY.	18669648 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-76, AND MASSSPECTROMETRY.	15592455 [Abstract]