dbPTM

DCAM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DCAM_HUMAN
UniProt AC	P17707
Protein Name	S-adenosylmethionine decarboxylase proenzyme
Gene Name	AMD1
Organism	Homo sapiens (Human).
Sequence Length	334
Subcellular Localization
Protein Description	Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels..
Protein Sequence	MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
63	Phosphorylation	KTDKQEAYVLSESSM CCCHHHEEEEEHHHH	10.94	21609022
68	Pyruvic acid (Ser)	EAYVLSESSMFVSKR HEEEEEHHHHCCCCC	24.59	-
68	Phosphorylation	EAYVLSESSMFVSKR HEEEEEHHHHCCCCC	24.59	22210691
68	Pyruvate	EAYVLSESSMFVSKR HEEEEEHHHHCCCCC	24.59	2460457
69	Phosphorylation	AYVLSESSMFVSKRR EEEEEHHHHCCCCCC	16.52	22210691
73	Phosphorylation	SESSMFVSKRRFILK EHHHHCCCCCCHHHH	14.80	46162855
96	Ubiquitination	KALVPLLKLARDYSG HHHHHHHHHHCCCCC	48.02	21890473
112	Phosphorylation	DSIQSFFYSRKNFMK HHHHHHHHCCCCCCC	12.93	31137017
113	Phosphorylation	SIQSFFYSRKNFMKP HHHHHHHCCCCCCCC	31.46	50564919
153	Ubiquitination	AYCMGRMNSDCWYLY HHHCCCCCCCCEEEE	33.08	21890473
201	Ubiquitination	MKDGVTAKDVTRESG CCCCCCHHHCCCCCC	43.28	21890473
276	Ubiquitination	RKVVEVFKPGKFVTT HHHHHHHCCCCEEEE	59.02	-
291	Ubiquitination	LFVNQSSKCRTVLAS EEECCCCCCCEEEEC	32.74	-
298	Phosphorylation	KCRTVLASPQKIEGF CCCEEEECHHHCCCC	24.57	25159151
301	Ubiquitination	TVLASPQKIEGFKRL EEEECHHHCCCCCCC	46.22	21890473
324	Phosphorylation	DYNFVFTSFAKKQQQ CCHHHHHHHHHHHHH	16.25	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DCAM_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DCAM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DCAM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
DCAM_HUMAN	AMD1	physical	10378277

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
DB00118	S-Adenosylmethionine

Regulatory Network of DCAM_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298, AND MASSSPECTROMETRY.	18669648 [Abstract]