RUXF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RUXF_HUMAN
• UniProt AC: P62306
• Protein Name: Small nuclear ribonucleoprotein F
• Gene Name: SNRPF
• Organism: Homo sapiens (Human).
• Sequence Length: 86
• Subcellular Localization: Cytoplasm, cytosol . Nucleus . SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
• Protein Description: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing..
• Protein Sequence: MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQLANTEEYIDGALSGHLGEVLIRCNNVLYIRGVEEEEEDGEMRE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLPLNPKP ------CCCCCCCCC	38.40	25159151
2	Acetylation	------MSLPLNPKP ------CCCCCCCCC	38.40	20068231
8	Acetylation	MSLPLNPKPFLNGLT CCCCCCCCCCCCCCC	47.53	30592555
8	Ubiquitination	MSLPLNPKPFLNGLT CCCCCCCCCCCCCCC	47.53	23000965
15	Phosphorylation	KPFLNGLTGKPVMVK CCCCCCCCCCEEEEE	44.55	20068231
17	Ubiquitination	FLNGLTGKPVMVKLK CCCCCCCCEEEEEEE	29.24	23000965
17	Succinylation	FLNGLTGKPVMVKLK CCCCCCCCEEEEEEE	29.24	23954790
22	Ubiquitination	TGKPVMVKLKWGMEY CCCEEEEEEEECCEE	26.67	23000965
22	2-Hydroxyisobutyrylation	TGKPVMVKLKWGMEY CCCEEEEEEEECCEE	26.67	-
24	Acetylation	KPVMVKLKWGMEYKG CEEEEEEEECCEEEE	35.66	25825284
24	Ubiquitination	KPVMVKLKWGMEYKG CEEEEEEEECCEEEE	35.66	23000965
24	2-Hydroxyisobutyrylation	KPVMVKLKWGMEYKG CEEEEEEEECCEEEE	35.66	-
30	Ubiquitination	LKWGMEYKGYLVSVD EEECCEEEEEEEEEE	27.98	23000965
66	S-nitrosylation	LGEVLIRCNNVLYIR HHHHEEEECCEEEEE	3.26	25040305
71	Phosphorylation	IRCNNVLYIRGVEEE EEECCEEEEECCCCC	5.58	28152594
73	Methylation	CNNVLYIRGVEEEEE ECCEEEEECCCCCCC	29.55	115917401
85	Methylation	EEEDGEMRE------ CCCCCCCCC------	42.02	115917405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RUXF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RUXF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RUXF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSA3_HUMAN	PSMA3	physical	16169070
SMD2_HUMAN	SNRPD2	physical	9417867
RUXE_HUMAN	SNRPE	physical	9417867
SC24C_HUMAN	SEC24C	physical	22939629
TBCA_HUMAN	TBCA	physical	22939629
S100P_HUMAN	S100P	physical	22939629
TAGL2_HUMAN	TAGLN2	physical	22939629
SH3L1_HUMAN	SH3BGRL	physical	22939629
S10A4_HUMAN	S100A4	physical	22939629
SMD2_HUMAN	SNRPD2	physical	22365833
RUXE_HUMAN	SNRPE	physical	22365833
RUXG_HUMAN	SNRPG	physical	22365833
RU2A_HUMAN	SNRPA1	physical	22365833
PUF60_HUMAN	PUF60	physical	22365833
SRRT_HUMAN	SRRT	physical	22365833
SRSF5_HUMAN	SRSF5	physical	22365833
LSM5_HUMAN	LSM5	physical	22365833
LSM6_HUMAN	LSM6	physical	22365833
LSM7_HUMAN	LSM7	physical	22365833
ICLN_HUMAN	CLNS1A	physical	22365833
IL7RA_HUMAN	IL7R	physical	23151878
MARE1_HUMAN	MAPRE1	physical	22863883
1433S_HUMAN	SFN	physical	22863883
COIL_HUMAN	COIL	physical	25416956
HOME3_HUMAN	HOMER3	physical	25416956
IKZF1_HUMAN	IKZF1	physical	25416956
LSM5_HUMAN	LSM5	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
SMD1_HUMAN	SNRPD1	physical	26344197
RUXE_HUMAN	SNRPE	physical	26344197
RSMN_HUMAN	SNRPN	physical	28514442
BPIA2_HUMAN	BPIFA2	physical	28514442
LSM10_HUMAN	LSM10	physical	28514442
CMTR2_HUMAN	CMTR2	physical	28514442
PDCD7_HUMAN	PDCD7	physical	28514442
SNR48_HUMAN	SNRNP48	physical	28514442
ZMAT5_HUMAN	ZMAT5	physical	28514442
U1SBP_HUMAN	SNRNP35	physical	28514442
GPBL1_HUMAN	GPBP1L1	physical	28514442
U2AFM_HUMAN	ZRSR2	physical	28514442
WBP4_HUMAN	WBP4	physical	28514442
RBM40_HUMAN	RNPC3	physical	28514442
PRPF3_HUMAN	PRPF3	physical	28514442
RU17_HUMAN	SNRNP70	physical	28514442
TGS1_HUMAN	TGS1	physical	28514442
LSM11_HUMAN	LSM11	physical	28514442
STPAP_HUMAN	TUT1	physical	28514442
SNRPA_HUMAN	SNRPA	physical	28514442
ICLN_HUMAN	CLNS1A	physical	28514442
SMD2_HUMAN	SNRPD2	physical	28514442
GPTC1_HUMAN	GPATCH1	physical	28514442
SMD1_HUMAN	SNRPD1	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
RU2B_HUMAN	SNRPB2	physical	28514442
GEMI8_HUMAN	GEMIN8	physical	28514442
MEPCE_HUMAN	MEPCE	physical	28514442
RU2A_HUMAN	SNRPA1	physical	28514442
DHX35_HUMAN	DHX35	physical	28514442
PRP17_HUMAN	CDC40	physical	28514442
TOE1_HUMAN	TOE1	physical	28514442
PAXB1_HUMAN	PAXBP1	physical	28514442
RSMB_HUMAN	SNRPB	physical	28514442
SART3_HUMAN	SART3	physical	28514442
SF3A2_HUMAN	SF3A2	physical	28514442
WDR83_HUMAN	WDR83	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
DDX23_HUMAN	DDX23	physical	28514442
SYF1_HUMAN	XAB2	physical	28514442
GEMI6_HUMAN	GEMIN6	physical	28514442
AQR_HUMAN	AQR	physical	28514442
TSSC4_HUMAN	TSSC4	physical	28514442
LSM8_HUMAN	LSM8	physical	28514442
GEMI2_HUMAN	GEMIN2	physical	28514442
AKA7A_HUMAN	AKAP7	physical	28514442
AKA7G_HUMAN	AKAP7	physical	28514442
C19L2_HUMAN	CWF19L2	physical	28514442
SMD3_HUMAN	SNRPD3	physical	28514442
U520_HUMAN	SNRNP200	physical	28514442
CYTD_HUMAN	CST5	physical	28514442
RU1C_HUMAN	SNRPC	physical	28514442
PRP8_HUMAN	PRPF8	physical	28514442
GEMI5_HUMAN	GEMIN5	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442
PRP6_HUMAN	PRPF6	physical	28514442
PRP4_HUMAN	PRPF4	physical	28514442
CD2B2_HUMAN	CD2BP2	physical	28514442
GEMI4_HUMAN	GEMIN4	physical	28514442
KLHL8_HUMAN	KLHL8	physical	28514442
GPT11_HUMAN	GPATCH11	physical	28514442
HTSF1_HUMAN	HTATSF1	physical	28514442
RBM22_HUMAN	RBM22	physical	28514442
TXN4A_HUMAN	TXNL4A	physical	28514442
RSRC1_HUMAN	RSRC1	physical	28514442
CRNL1_HUMAN	CRNKL1	physical	28514442
PRP31_HUMAN	PRPF31	physical	28514442
DDX20_HUMAN	DDX20	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
NADAP_HUMAN	SLC4A1AP	physical	28514442
LSM2_HUMAN	LSM2	physical	28514442
SF3A3_HUMAN	SF3A3	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
LSM1_HUMAN	LSM1	physical	28514442
U5S1_HUMAN	EFTUD2	physical	28514442
SF3B1_HUMAN	SF3B1	physical	28514442
PPIE_HUMAN	PPIE	physical	28514442
SNR40_HUMAN	SNRNP40	physical	28514442
SF3A1_HUMAN	SF3A1	physical	28514442
ISY1_HUMAN	ISY1	physical	28514442
ZCRB1_HUMAN	ZCRB1	physical	28514442
SF3B4_HUMAN	SF3B4	physical	28514442
SMR3B_HUMAN	SMR3B	physical	28514442
SNW1_HUMAN	SNW1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.