SH3L1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SH3L1_HUMAN
• UniProt AC: O75368
• Protein Name: SH3 domain-binding glutamic acid-rich-like protein
• Gene Name: SH3BGRL
• Organism: Homo sapiens (Human).
• Sequence Length: 114
• Protein Sequence: MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MVIRVYIASSSGS --CEEEEEEECCCCC	4.86	24114839
10	Phosphorylation	IRVYIASSSGSTAIK EEEEEECCCCCHHHH	29.69	21712546
11	Phosphorylation	RVYIASSSGSTAIKK EEEEECCCCCHHHHH	33.98	20068231
13	Phosphorylation	YIASSSGSTAIKKKQ EEECCCCCHHHHHHH	19.33	22985185
14	Phosphorylation	IASSSGSTAIKKKQQ EECCCCCHHHHHHHH	35.61	20068231
17	Acetylation	SSGSTAIKKKQQDVL CCCCHHHHHHHHHHH	51.99	25953088
17	Malonylation	SSGSTAIKKKQQDVL CCCCHHHHHHHHHHH	51.99	26320211
17	2-Hydroxyisobutyrylation	SSGSTAIKKKQQDVL CCCCHHHHHHHHHHH	51.99	-
19	Ubiquitination	GSTAIKKKQQDVLGF CCHHHHHHHHHHHHH	48.46	-
31	Ubiquitination	LGFLEANKIGFEEKD HHHHHHHCCCCCHHH	51.78	-
37	Ubiquitination	NKIGFEEKDIAANEE HCCCCCHHHHCCCHH	47.43	-
37	Acetylation	NKIGFEEKDIAANEE HCCCCCHHHHCCCHH	47.43	23749302
63	Phosphorylation	NSRPATGYPLPPQIF CCCCCCCCCCCHHHC	9.39	-
79	Phosphorylation	ESQYRGDYDAFFEAR CHHCCCCHHHHHHHH	16.40	27642862
92	Phosphorylation	ARENNAVYAFLGLTA HHHCCCEEEEEEEEC	6.82	-
98	Phosphorylation	VYAFLGLTAPPGSKE EEEEEEEECCCCCHH	35.01	28348404
103	Phosphorylation	GLTAPPGSKEAEVQA EEECCCCCHHHHHHH	32.85	21712546
111	Acetylation	KEAEVQAKQQA---- HHHHHHHHHHC----	26.33	18530255
111	Ubiquitination	KEAEVQAKQQA---- HHHHHHHHHHC----	26.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SH3L1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SH3L1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SH3L1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHIP_HUMAN	STUB1	physical	22939629
STAT6_HUMAN	STAT6	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.