LSM8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSM8_HUMAN
• UniProt AC: O95777
• Protein Name: U6 snRNA-associated Sm-like protein LSm8
• Gene Name: LSM8
• Organism: Homo sapiens (Human).
• Sequence Length: 96
• Subcellular Localization: Nucleus .
• Protein Description: Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome..
• Protein Sequence: MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTSALENYI ------CCHHHHHHH		22223895
2	Phosphorylation	------MTSALENYI ------CCHHHHHHH		23186163
3	Phosphorylation	-----MTSALENYIN -----CCHHHHHHHC		23186163
18	Phosphorylation	RTVAVITSDGRMIVG CEEEEEECCCCEEEE		21712546
26	O-linked_Glycosylation	DGRMIVGTLKGFDQT CCCEEEEEECCCHHH		25367160
28	Ubiquitination	RMIVGTLKGFDQTIN CEEEEEECCCHHHHH		-
47	Phosphorylation	ESHERVFSSSQGVEQ CCHHHHCCCCCCCEE		25159151
48	Phosphorylation	SHERVFSSSQGVEQV CHHHHCCCCCCCEEE		28464451
49	Phosphorylation	HERVFSSSQGVEQVV HHHHCCCCCCCEEEE		22617229
60	Phosphorylation	EQVVLGLYIVRGDNV EEEEEEEEEEECCEE		27080861
77	Phosphorylation	IGEIDEETDSALDLG EEEECCCCCCCCCCC		25693802
79	Phosphorylation	EIDEETDSALDLGNI EECCCCCCCCCCCCC		25693802
93	Phosphorylation	IRAEPLNSVAH---- CCCEECCCCCC----		26091039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LSM8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSM8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSM8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
6PGD_HUMAN	PGD	physical	15231747
SMBP2_HUMAN	IGHMBP2	physical	15231747
SMD1_HUMAN	SNRPD1	physical	15231747
GTF2I_HUMAN	GTF2I	physical	15231747
TALDO_HUMAN	TALDO1	physical	15231747
CONA1_HUMAN	COL23A1	physical	15231747
DBF4A_HUMAN	DBF4	physical	15231747
KCTD3_HUMAN	KCTD3	physical	15231747
EXOS6_HUMAN	EXOSC6	physical	15231747
DCP1A_HUMAN	DCP1A	physical	15231747
THUM3_HUMAN	THUMPD3	physical	15231747
RSMB_HUMAN	SNRPB	physical	22365833
RBM5_HUMAN	RBM5	physical	22365833
U520_HUMAN	SNRNP200	physical	22365833
U5S1_HUMAN	EFTUD2	physical	22365833
LSM2_HUMAN	LSM2	physical	22365833
LSM3_HUMAN	LSM3	physical	22365833
SMU1_HUMAN	SMU1	physical	22365833
NDKM_HUMAN	NME4	physical	21988832
PHF11_HUMAN	PHF11	physical	21988832
RSCA1_HUMAN	RSC1A1	physical	21988832
MPRIP_HUMAN	MPRIP	physical	21988832
MGAP_HUMAN	MGA	physical	21988832
SEP10_HUMAN	SEPT10	physical	21988832
LSM2_HUMAN	LSM2	physical	15231747
LSM4_HUMAN	LSM4	physical	15231747
PDCD2_HUMAN	PDCD2	physical	15231747
ISOC2_HUMAN	ISOC2	physical	15231747
RL24_HUMAN	RPL24	physical	15231747
SEPT5_HUMAN	SEPT5	physical	15231747
MTHR_HUMAN	MTHFR	physical	15231747
URP2_HUMAN	FERMT3	physical	15231747
ITSN2_HUMAN	ITSN2	physical	15231747
MINY1_HUMAN	FAM63A	physical	15231747
GMPPA_HUMAN	GMPPA	physical	15231747
GPT_HUMAN	DPAGT1	physical	15231747
RM48_HUMAN	MRPL48	physical	15231747
LSM7_HUMAN	LSM7	physical	15231747
LSM3_HUMAN	LSM3	physical	15231747
LSM6_HUMAN	LSM6	physical	15231747
EXOSX_HUMAN	EXOSC10	physical	15231747
RENT1_HUMAN	UPF1	physical	15231747
INLR1_HUMAN	IFNLR1	physical	15231747
HNRPR_HUMAN	HNRNPR	physical	22863883
LSM4_HUMAN	LSM4	physical	27173435
LSM6_HUMAN	LSM6	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.