LSM4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LSM4_HUMAN
• UniProt AC: Q9Y4Z0
• Protein Name: U6 snRNA-associated Sm-like protein LSm4
• Gene Name: LSM4
• Organism: Homo sapiens (Human).
• Sequence Length: 139
• Subcellular Localization: Nucleus .
• Protein Description: Binds specifically to the 3'-terminal U-tract of U6 snRNA..
• Protein Sequence: MLPLSLLKTAQNHPMLVELKNGETYNGHLVSCDNWMNINLREVICTSRDGDKFWRMPECYIRGSTIKYLRIPDEIIDMVKEEVVAKGRGRGGLQQQKQQKGRGMGGAGRGVFGGRGRGGIPGTGRGQPEKKPGRQAGKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MLPLSLLK -------CCCHHHHH	8.63	-
5	Phosphorylation	---MLPLSLLKTAQN ---CCCHHHHHHHHC	29.71	24719451
8	Ubiquitination	MLPLSLLKTAQNHPM CCCHHHHHHHHCCCE	47.29	21890473
52	Acetylation	CTSRDGDKFWRMPEC EECCCCCCEEECCCE	52.97	25953088
52	Ubiquitination	CTSRDGDKFWRMPEC EECCCCCCEEECCCE	52.97	-
59	S-nitrosylation	KFWRMPECYIRGSTI CEEECCCEEECCCEE	2.56	24105792
62	Methylation	RMPECYIRGSTIKYL ECCCEEECCCEEEEE	13.41	115482375
67	Acetylation	YIRGSTIKYLRIPDE EECCCEEEEEECCHH	38.02	25953088
67	Ubiquitination	YIRGSTIKYLRIPDE EECCCEEEEEECCHH	38.02	-
78	Sulfoxidation	IPDEIIDMVKEEVVA CCHHHHHHHHHHHHH	3.06	21406390
80	Sumoylation	DEIIDMVKEEVVAKG HHHHHHHHHHHHHHC	41.33	28112733
80	Acetylation	DEIIDMVKEEVVAKG HHHHHHHHHHHHHHC	41.33	26051181
80	Ubiquitination	DEIIDMVKEEVVAKG HHHHHHHHHHHHHHC	41.33	21890473
88	Methylation	EEVVAKGRGRGGLQQ HHHHHHCCCCCHHHH	30.81	81450679
88	Dimethylation	EEVVAKGRGRGGLQQ HHHHHHCCCCCHHHH	30.81	-
90	Methylation	VVAKGRGRGGLQQQK HHHHCCCCCHHHHHH	34.35	80701389
90	Dimethylation	VVAKGRGRGGLQQQK HHHHCCCCCHHHHHH	34.35	-
100	Ubiquitination	LQQQKQQKGRGMGGA HHHHHHHCCCCCCCC	48.35	-
102	Methylation	QQKQQKGRGMGGAGR HHHHHCCCCCCCCCC	38.67	54557185
102	Dimethylation	QQKQQKGRGMGGAGR HHHHHCCCCCCCCCC	38.67	-
109	Methylation	RGMGGAGRGVFGGRG CCCCCCCCCCCCCCC	37.25	80701395
109	Dimethylation	RGMGGAGRGVFGGRG CCCCCCCCCCCCCCC	37.25	-
115	Methylation	GRGVFGGRGRGGIPG CCCCCCCCCCCCCCC	31.82	24395903
117	Dimethylation	GVFGGRGRGGIPGTG CCCCCCCCCCCCCCC	38.51	-
117	Methylation	GVFGGRGRGGIPGTG CCCCCCCCCCCCCCC	38.51	24383275
125	Dimethylation	GGIPGTGRGQPEKKP CCCCCCCCCCCCCCC	40.17	-
125	Methylation	GGIPGTGRGQPEKKP CCCCCCCCCCCCCCC	40.17	24383281
138	Acetylation	KPGRQAGKQ------ CCCCCCCCC------	56.71	18530827

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LSM4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LSM4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LSM4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUXE_HUMAN	SNRPE	physical	15231747
XRN1_HUMAN	XRN1	physical	15231747
LSM1_HUMAN	LSM1	physical	11920408
LSM2_HUMAN	LSM2	physical	11920408
LSM3_HUMAN	LSM3	physical	11920408
LSM6_HUMAN	LSM6	physical	11920408
LSM7_HUMAN	LSM7	physical	11920408
LSM8_HUMAN	LSM8	physical	11920408
LSM6_HUMAN	LSM6	physical	22939629
LSM7_HUMAN	LSM7	physical	22939629
LSM8_HUMAN	LSM8	physical	22939629
LSM5_HUMAN	LSM5	physical	22939629
DX39B_HUMAN	DDX39B	physical	22939629
PRP18_HUMAN	PRPF18	physical	22939629
VAC14_HUMAN	VAC14	physical	22939629
TCEA2_HUMAN	TCEA2	physical	22939629
WDR44_HUMAN	WDR44	physical	22939629
PYRD1_HUMAN	PYROXD1	physical	22939629
METH_HUMAN	MTR	physical	22939629
RMI2_HUMAN	RMI2	physical	22939629
TF2B_HUMAN	GTF2B	physical	22939629
RD23A_HUMAN	RAD23A	physical	22939629
SGTA_HUMAN	SGTA	physical	22939629
PPIB_HUMAN	PPIB	physical	22939629
VIP1_HUMAN	PPIP5K1	physical	22939629
LSM7_HUMAN	LSM7	physical	22365833
SMU1_HUMAN	SMU1	physical	22365833
TOE1_HUMAN	TOE1	physical	22365833
S22A2_HUMAN	SLC22A2	physical	21988832
LSM7_HUMAN	LSM7	physical	21988832
LSM8_HUMAN	LSM8	physical	15231747
LSM7_HUMAN	LSM7	physical	15231747
SIM14_HUMAN	SMIM14	physical	15231747
NMI_HUMAN	NMI	physical	15231747
RHXF2_HUMAN	RHOXF2	physical	15231747
COX5B_HUMAN	COX5B	physical	15231747
PKHA5_HUMAN	PLEKHA5	physical	15231747
ZBT10_HUMAN	ZBTB10	physical	25416956
LMBL3_HUMAN	L3MBTL3	physical	25416956
HNRPR_HUMAN	HNRNPR	physical	26344197
KLC2_HUMAN	KLC2	physical	26344197
LPPRC_HUMAN	LRPPRC	physical	26344197
LSM1_HUMAN	LSM1	physical	26344197
LSM2_HUMAN	LSM2	physical	26344197
LSM3_HUMAN	LSM3	physical	26344197
LSM6_HUMAN	LSM6	physical	26344197
LSM7_HUMAN	LSM7	physical	26344197
LSMD1_HUMAN	NAA38	physical	26344197
SF3A3_HUMAN	SF3A3	physical	26344197
SF3B3_HUMAN	SF3B3	physical	26344197
HNRPQ_HUMAN	SYNCRIP	physical	26344197
ZMAT2_HUMAN	ZMAT2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.