ZMAT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZMAT2_HUMAN
• UniProt AC: Q96NC0
• Protein Name: Zinc finger matrin-type protein 2
• Gene Name: ZMAT2
• Organism: Homo sapiens (Human).
• Sequence Length: 199
• Subcellular Localization: Nucleus .
• Protein Sequence: MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPVKRELLRHRDYKVDLESKLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSTLDQVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYKKEKQKEKKRRAEEDLTFEEDDEMAAVMGFSGFGSTKKSY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGSGTKN ------CCCCCCCCC	23.69	22814378
3	Phosphorylation	-----MASGSGTKNL -----CCCCCCCCCC	31.99	24719451
5	Phosphorylation	---MASGSGTKNLDF ---CCCCCCCCCCCH	40.57	22617229
8	Sumoylation	MASGSGTKNLDFRRK CCCCCCCCCCCHHHH	60.07	-
8	Ubiquitination	MASGSGTKNLDFRRK CCCCCCCCCCCHHHH	60.07	24816145
8	Sumoylation	MASGSGTKNLDFRRK CCCCCCCCCCCHHHH	60.07	28112733
18	Acetylation	DFRRKWDKDEYEKLA CHHHHCCHHHHHHHH	51.88	26051181
21	Phosphorylation	RKWDKDEYEKLAEKR HHCCHHHHHHHHHHH	28.62	28796482
23	Ubiquitination	WDKDEYEKLAEKRLT CCHHHHHHHHHHHHH	52.69	33845483
36	Ubiquitination	LTEEREKKDGKPVQP HHHHHHHHCCCCCCH	67.94	24816145
36	Sumoylation	LTEEREKKDGKPVQP HHHHHHHHCCCCCCH	67.94	28112733
39	Sumoylation	EREKKDGKPVQPVKR HHHHHCCCCCCHHHH	52.75	28112733
39	Ubiquitination	EREKKDGKPVQPVKR HHHHHCCCCCCHHHH	52.75	33845483
39	Acetylation	EREKKDGKPVQPVKR HHHHHCCCCCCHHHH	52.75	23749302
45	Sumoylation	GKPVQPVKRELLRHR CCCCCHHHHHHHHCC	47.00	-
45	Sumoylation	GKPVQPVKRELLRHR CCCCCHHHHHHHHCC	47.00	28112733
45	Ubiquitination	GKPVQPVKRELLRHR CCCCCHHHHHHHHCC	47.00	33845483
54	Phosphorylation	ELLRHRDYKVDLESK HHHHCCCCEEEHHHH	16.93	-
55	Sumoylation	LLRHRDYKVDLESKL HHHCCCCEEEHHHHC	33.30	-
55	Sumoylation	LLRHRDYKVDLESKL HHHCCCCEEEHHHHC	33.30	28112733
60	Phosphorylation	DYKVDLESKLGKTIV CCEEEHHHHCCCEEE	40.24	-
61	Acetylation	YKVDLESKLGKTIVI CEEEHHHHCCCEEEE	52.46	25953088
61	Ubiquitination	YKVDLESKLGKTIVI CEEEHHHHCCCEEEE	52.46	33845483
61	Sumoylation	YKVDLESKLGKTIVI CEEEHHHHCCCEEEE	52.46	-
61	Sumoylation	YKVDLESKLGKTIVI CEEEHHHHCCCEEEE	52.46	28112733
64	Sumoylation	DLESKLGKTIVITKT EHHHHCCCEEEEECC	45.58	28112733
64	Acetylation	DLESKLGKTIVITKT EHHHHCCCEEEEECC	45.58	25953088
64	Sumoylation	DLESKLGKTIVITKT EHHHHCCCEEEEECC	45.58	-
64	Ubiquitination	DLESKLGKTIVITKT EHHHHCCCEEEEECC	45.58	33845483
70	Ubiquitination	GKTIVITKTTPQSEM CCEEEEECCCCHHHH	39.00	33845483
70	Sumoylation	GKTIVITKTTPQSEM CCEEEEECCCCHHHH	39.00	28112733
70	Acetylation	GKTIVITKTTPQSEM CCEEEEECCCCHHHH	39.00	25953088
71	Phosphorylation	KTIVITKTTPQSEMG CEEEEECCCCHHHHC	34.75	25159151
72	Phosphorylation	TIVITKTTPQSEMGG EEEEECCCCHHHHCC	22.38	25159151
75	Phosphorylation	ITKTTPQSEMGGYYC EECCCCHHHHCCEEE	30.65	28555341
102	Sumoylation	FLDHINGKKHQRNLG HHHHCCCHHHHHHCC	42.46	28112733
102	Acetylation	FLDHINGKKHQRNLG HHHHCCCHHHHHHCC	42.46	25953088
102	Ubiquitination	FLDHINGKKHQRNLG HHHHCCCHHHHHHCC	42.46	33845483
102	Sumoylation	FLDHINGKKHQRNLG HHHHCCCHHHHHHCC	42.46	-
103	Ubiquitination	LDHINGKKHQRNLGM HHHCCCHHHHHHCCC	46.50	-
111	Phosphorylation	HQRNLGMSMRVERST HHHHCCCCCEECHHH	11.13	28555341
123	Sumoylation	RSTLDQVKKRFEVNK HHHHHHHHHHHHHCH	32.38	28112733
123	2-Hydroxyisobutyrylation	RSTLDQVKKRFEVNK HHHHHHHHHHHHHCH	32.38	-
123	Ubiquitination	RSTLDQVKKRFEVNK HHHHHHHHHHHHHCH	32.38	33845483
138	Ubiquitination	KKMEEKQKDYDFEER HHHHHHHHCCCHHHH	70.13	29967540
140	Phosphorylation	MEEKQKDYDFEERMK HHHHHHCCCHHHHHH	29.57	22817900
190	Phosphorylation	MAAVMGFSGFGSTKK HHHHHCCCCCCCCCC	27.73	26074081
194	Phosphorylation	MGFSGFGSTKKSY-- HCCCCCCCCCCCC--	34.49	26074081
195	Phosphorylation	GFSGFGSTKKSY--- CCCCCCCCCCCC---	42.76	26074081
198	Phosphorylation	GFGSTKKSY------ CCCCCCCCC------	37.32	26074081
199	Phosphorylation	FGSTKKSY------- CCCCCCCC-------	31.30	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZMAT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZMAT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZMAT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HD_HUMAN	HTT	physical	23275563
KAD8_HUMAN	AK8	physical	25416956
SPERT_HUMAN	SPERT	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956
LSM2_HUMAN	LSM2	physical	26344197
LSM3_HUMAN	LSM3	physical	26344197
LSM6_HUMAN	LSM6	physical	26344197
MAP11_HUMAN	METAP1	physical	26344197
NF2IP_HUMAN	NFATC2IP	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.