MAP11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAP11_HUMAN
• UniProt AC: P53582
• Protein Name: Methionine aminopeptidase 1 {ECO:0000255|HAMAP-Rule:MF_03174}
• Gene Name: METAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 386
• Subcellular Localization: Cytoplasm .
• Protein Description: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle..
• Protein Sequence: MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVETRVC ------CCCCEEEEE		19413330
19	Acetylation	DGCSSEAKLQCPTCI CCCCCHHHCCCCCCE		26051181
19	Ubiquitination	DGCSSEAKLQCPTCI CCCCCHHHCCCCCCE		32015554
30	Ubiquitination	PTCIKLGIQGSYFCS CCCEEEEECCCEEEC		23503661
33	Phosphorylation	IKLGIQGSYFCSQEC EEEEECCCEEECHHH		28857561
34	Phosphorylation	KLGIQGSYFCSQECF EEEECCCEEECHHHH		22817900
36	Ubiquitination	GIQGSYFCSQECFKG EECCCEEECHHHHCC		21963094
42	Acetylation	FCSQECFKGSWATHK EECHHHHCCCHHHHH		26051181
49	Malonylation	KGSWATHKLLHKKAK CCCHHHHHHHHHHHH		26320211
49	Ubiquitination	KGSWATHKLLHKKAK CCCHHHHHHHHHHHH		29967540
88	Ubiquitination	YRYTGKLRPHYPLMP CEECCCCCCCCCCCC		23503661
94	Ubiquitination	LRPHYPLMPTRPVPS CCCCCCCCCCCCCCC		21963094
98	Ubiquitination	YPLMPTRPVPSYIQR CCCCCCCCCCCCCCC		21963094
110	Ubiquitination	IQRPDYADHPLGMSE CCCCCCCCCCCCCCH		23503661
116	Ubiquitination	ADHPLGMSESEQALK CCCCCCCCHHHHHHC		21963094
123	Ubiquitination	SESEQALKGTSQIKL CHHHHHHCCCCCEEE		23503661
129	Ubiquitination	LKGTSQIKLLSSEDI HCCCCCEEECCHHHH		21906983
132	Phosphorylation	TSQIKLLSSEDIEGM CCCEEECCHHHHHHH		27499020
133	Phosphorylation	SQIKLLSSEDIEGMR CCEEECCHHHHHHHH		27499020
156	Ubiquitination	VLDVAAGMIKPGVTT HHHHHCCCCCCCCCH		21963094
158	Ubiquitination	DVAAGMIKPGVTTEE HHHCCCCCCCCCHHH		-
178	Ubiquitination	HLACIARNCYPSPLN HHHHHHHCCCCCCCC		21963094
180	Phosphorylation	ACIARNCYPSPLNYY HHHHHCCCCCCCCCC		28152594
182	Phosphorylation	IARNCYPSPLNYYNF HHHCCCCCCCCCCCC		28152594
185	Ubiquitination	NCYPSPLNYYNFPKS CCCCCCCCCCCCCHH		22817900
186	Phosphorylation	CYPSPLNYYNFPKSC CCCCCCCCCCCCHHH		28152594
187	Phosphorylation	YPSPLNYYNFPKSCC CCCCCCCCCCCHHHC		28152594
191	Ubiquitination	LNYYNFPKSCCTSVN CCCCCCCHHHCCCCH		21963094
191	Sumoylation	LNYYNFPKSCCTSVN CCCCCCCHHHCCCCH		-
218	Ubiquitination	LQEGDIVNVDITLYR CCCCCEEEEEEEEEE		22817900
220	Ubiquitination	EGDIVNVDITLYRNG CCCEEEEEEEEEECC		22817900
234	Ubiquitination	GYHGDLNETFFVGEV CCCCCCCCCEEEEEE		22817900
243	Ubiquitination	FFVGEVDDGARKLVQ EEEEEECHHHHHHHH		22817900
251	Phosphorylation	GARKLVQTTYECLMQ HHHHHHHHHHHHHHH		20068231
252	Phosphorylation	ARKLVQTTYECLMQA HHHHHHHHHHHHHHH		20068231
253	Phosphorylation	RKLVQTTYECLMQAI HHHHHHHHHHHHHHH		20068231
265	Ubiquitination	QAIDAVKPGVRYREL HHHHHCCCCCCHHHH		22817900
267	Ubiquitination	IDAVKPGVRYRELGN HHHCCCCCCHHHHHH		22817900
269	Phosphorylation	AVKPGVRYRELGNII HCCCCCCHHHHHHHH		29496907
269	Ubiquitination	AVKPGVRYRELGNII HCCCCCCHHHHHHHH		22817900
276	Ubiquitination	YRELGNIIQKHAQAN HHHHHHHHHHHHHHC		22817900
278	Ubiquitination	ELGNIIQKHAQANGF HHHHHHHHHHHHCCC		21906983
286	Phosphorylation	HAQANGFSVVRSYCG HHHHCCCHHHHHHCC		28857561
290	Phosphorylation	NGFSVVRSYCGHGIH CCCHHHHHHCCCCHH		28152594
291	Phosphorylation	GFSVVRSYCGHGIHK CCHHHHHHCCCCHHH		28152594
298	Ubiquitination	YCGHGIHKLFHTAPN HCCCCHHHHHCCCCC		22817900
298	Acetylation	YCGHGIHKLFHTAPN HCCCCHHHHHCCCCC		26051181
300	Ubiquitination	GHGIHKLFHTAPNVP CCCHHHHHCCCCCCC		22817900
309	Phosphorylation	TAPNVPHYAKNKAVG CCCCCCHHHCCCCCE		20068231
311	Ubiquitination	PNVPHYAKNKAVGVM CCCCHHHCCCCCEEE		22817900
311	Acetylation	PNVPHYAKNKAVGVM CCCCHHHCCCCCEEE		25953088
313	Ubiquitination	VPHYAKNKAVGVMKS CCHHHCCCCCEEEEC		27667366
377	Phosphorylation	ILTRRLDSARPHFMS HHHHHHHHCCHHHHH		23186163
384	Phosphorylation	SARPHFMSQF----- HCCHHHHHCC-----		28464451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAP11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAP11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAP11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MAP11_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.