KAD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAD8_HUMAN
• UniProt AC: Q96MA6
• Protein Name: Adenylate kinase 8
• Gene Name: AK8
• Organism: Homo sapiens (Human).
• Sequence Length: 479
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity..
• Protein Sequence: MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRIVILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQLIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRIDPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVISADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCGQLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLDQAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQNPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MDATIAPHRIP ----CCCCCCCCCCC	17.26	23532336
83	Phosphorylation	WLCKHLNSSLLTLEN HHHHHHCCHHCHHHH	28.82	19690332
84	Phosphorylation	LCKHLNSSLLTLENL HHHHHCCHHCHHHHH	26.73	19690332
98	Phosphorylation	LILNEFSYTATEARR HHHHCCCCCHHHHHH	13.00	19690332
101	Phosphorylation	NEFSYTATEARRLYL HCCCCCHHHHHHHHH	23.52	19690332
107	Phosphorylation	ATEARRLYLQRKTVP HHHHHHHHHHHCCCC	10.04	21712546
111	Ubiquitination	RRLYLQRKTVPSALL HHHHHHHCCCCHHHH	40.70	-
133	Ubiquitination	LAEEDCIKQGWILDG HHHCHHHHCCCCCCC	49.44	-
169	Phosphorylation	IVLSAPDTVLIERNL EEECCCCEEEEECCC	19.02	22210691
184	Phosphorylation	GKRIDPQTGEIYHTT CCCCCCCCCCEEEEC	42.02	46178971
191	Phosphorylation	TGEIYHTTFDWPPES CCCEEEECCCCCCHH	13.29	46178977
232	Phosphorylation	NIVRVIPSYPKILKV HHHHHCCCCHHHHHH	42.83	24719451
281	Ubiquitination	LGPVGSGKSLQAALL ECCCCCCHHHHHHHH	50.09	-
311	Phosphorylation	KEAVADRTTFGELIQ HHHHHCCCCHHHHHH	27.33	30622161
312	Phosphorylation	EAVADRTTFGELIQP HHHHCCCCHHHHHHH	30.45	30622161
330	Phosphorylation	KEMAVPDSLLMKVLS HHCCCCHHHHHHHHH	19.82	30622161

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAD8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM6_HUMAN	PRMT6	physical	23455924
ALKB3_HUMAN	ALKBH3	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.