ALKB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ALKB3_HUMAN
• UniProt AC: Q96Q83
• Protein Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 {ECO:0000305}
• Gene Name: ALKBH3 {ECO:0000312|HGNC:HGNC:30141}
• Organism: Homo sapiens (Human).
• Sequence Length: 286
• Subcellular Localization: Nucleus . Cytoplasm . Predominantly localizes to the nucleus.
• Protein Description: Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). [PubMed: 12486230]
• Protein Sequence: MEEKRRRARVQGAWAAPVKSQAIAQPATTAKSHLHQKPGQTWKNKEHHLSDREFVFKEPQQVVRRAPEPRVIDREGVYEISLSPTGVSRVCLYPGFVDVKEADWILEQLCQDVPWKQRTGIREDITYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLRTLKNRIEENTGHTFNSLLCNLYRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRTFEMRKKPPPEENGDYTYVERVKIPLDHGTLLIMEGATQADWQHRVPKEYHSREPRVNLTFRTVYPDPRGAPW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Acetylation	GAWAAPVKSQAIAQP CCCCCCCCCCCCCCC	35.47	25953088
19	Ubiquitination	GAWAAPVKSQAIAQP CCCCCCCCCCCCCCC	35.47	-
50	Phosphorylation	KNKEHHLSDREFVFK CCCCCCCCCCCEECC	30.20	27251275
78	Phosphorylation	VIDREGVYEISLSPT EECCCCEEEEECCCC	20.57	27642862
83	Phosphorylation	GVYEISLSPTGVSRV CEEEEECCCCCCCEE	17.39	27642862
126	Phosphorylation	TGIREDITYQQPRLT CCCCCCCCCCCCCCE	27.83	28796482
127	Phosphorylation	GIREDITYQQPRLTA CCCCCCCCCCCCCEE	12.89	28796482
133	Phosphorylation	TYQQPRLTAWYGELP CCCCCCCEEEECCCC	19.20	24043423
136	Phosphorylation	QPRLTAWYGELPYTY CCCCEEEECCCCCEE	9.77	24043423
141	Phosphorylation	AWYGELPYTYSRITM EEECCCCCEEEEEEC	30.82	24043423
142	Phosphorylation	WYGELPYTYSRITME EECCCCCEEEEEECC	17.06	24043423
143	Phosphorylation	YGELPYTYSRITMEP ECCCCCEEEEEECCC	7.07	24043423
144	Phosphorylation	GELPYTYSRITMEPN CCCCCEEEEEECCCC	14.92	24043423
177	Hydroxylation	GHTFNSLLCNLYRNE CCCHHHHHHHHHCCC	1.50	16858410
177	Oxidation	GHTFNSLLCNLYRNE CCCHHHHHHHHHCCC	1.50	16858410
212	Phosphorylation	ASLSFGATRTFEMRK EEECCCCEEEEEECC	30.53	46162413
214	Phosphorylation	LSFGATRTFEMRKKP ECCCCEEEEEECCCC	21.42	46162419
263	Phosphorylation	QHRVPKEYHSREPRV HHCCCHHHHCCCCCE	15.95	26074081
265	Phosphorylation	RVPKEYHSREPRVNL CCCHHHHCCCCCEEE	37.12	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ALKB3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
48	K	ubiquitylation	OTUD4 promotes USP7 and USP9X-dependent deubiquitination of 'Lys-48'-polyubiquitinated ALKBH3 promoting the repair of alkylated DNA lesions.	25944111

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ALKB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ASCC3_HUMAN	ASCC3	physical	26186194
P4R3A_HUMAN	SMEK1	physical	26186194
ASCC2_HUMAN	ASCC2	physical	26186194
TRIP4_HUMAN	TRIP4	physical	26186194
SHIP2_HUMAN	INPPL1	physical	26186194
ASCC1_HUMAN	ASCC1	physical	26186194
GRP78_HUMAN	HSPA5	physical	25944111
MAP1B_HUMAN	MAP1B	physical	25944111
TBB2A_HUMAN	TUBB2A	physical	25944111
TBA1A_HUMAN	TUBA1A	physical	25944111
HSP7C_HUMAN	HSPA8	physical	25944111
TR150_HUMAN	THRAP3	physical	25944111
ANM5_HUMAN	PRMT5	physical	25944111
FLNA_HUMAN	FLNA	physical	25944111
RIF1_HUMAN	RIF1	physical	25944111
MGAP_HUMAN	MGA	physical	25944111
TBB5_HUMAN	TUBB	physical	25944111
TCPA_HUMAN	TCP1	physical	25944111
TCPB_HUMAN	CCT2	physical	25944111
ASCC3_HUMAN	ASCC3	physical	25944111
TCPD_HUMAN	CCT4	physical	25944111
DHX15_HUMAN	DHX15	physical	25944111
LTBP1_HUMAN	LTBP1	physical	25944111
TCPZ_HUMAN	CCT6A	physical	25944111
OTUD4_HUMAN	OTUD4	physical	25944111
HSP72_HUMAN	HSPA2	physical	25944111
TBB3_HUMAN	TUBB3	physical	25944111
TCPQ_HUMAN	CCT8	physical	25944111
BCLF1_HUMAN	BCLAF1	physical	25944111
ICLN_HUMAN	CLNS1A	physical	25944111
HNRH1_HUMAN	HNRNPH1	physical	25944111
MATR3_HUMAN	MATR3	physical	25944111
SF3B2_HUMAN	SF3B2	physical	25944111
TAB1_HUMAN	TAB1	physical	25944111
EF1A1_HUMAN	EEF1A1	physical	25944111
TCPE_HUMAN	CCT5	physical	25944111
TBB4A_HUMAN	TUBB4A	physical	25944111
GRP75_HUMAN	HSPA9	physical	25944111
UBP7_HUMAN	USP7	physical	25944111
USP9X_HUMAN	USP9X	physical	25944111
TRIP4_HUMAN	TRIP4	physical	28514442
ASCC2_HUMAN	ASCC2	physical	28514442
ASCC3_HUMAN	ASCC3	physical	28514442
P4R3A_HUMAN	SMEK1	physical	28514442
ASCC1_HUMAN	ASCC1	physical	28514442
SHIP2_HUMAN	INPPL1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00126: Vitamin C