dbPTM

LTBP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LTBP1_HUMAN
UniProt AC	Q14766
Protein Name	Latent-transforming growth factor beta-binding protein 1
Gene Name	LTBP1
Organism	Homo sapiens (Human).
Sequence Length	1721
Subcellular Localization	Secreted.
Protein Description	May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM)..
Protein Sequence	MAGAWLRWGLLLWAGLLASSAHGRLRRITYVVHPGPGLAAGALPLSGPPRSRTFNVALNARYSRSSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHPNPGGHPAAAPFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASSWGPPEQAAKHTSSKKADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVVIHHGQTQEYVLKPKYFPAQKGISGEQSTEGSFPLRYVQDQVAAPFQLSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTTLISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLSKQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSCVPDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEALTFSREHGPGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPVVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNLEKDSDLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	NVALNARYSRSSAAA EEEEEEEECCHHHCC	13.16	22210691
66	Phosphorylation	NARYSRSSAAAGAPS EEEECCHHHCCCCCC	22.33	24719451
73	Phosphorylation	SAAAGAPSRASPGVP HHCCCCCCCCCCCCC	39.69	22210691
149	Phosphorylation	KVPQETQSGGGSRLQ CCCCCCCCCCCCCEE	46.99	28060719
153	Phosphorylation	ETQSGGGSRLQVHQK CCCCCCCCCEEEECC	32.85	28060719
241	O-linked_Glycosylation	QSPGAASSWGPPEQA CCCCCHHHCCCHHHH	31.18	OGP
259	Phosphorylation	TSSKKADTLPRVSPV CCCCCCCCCCCCCCE	43.45	28060719
264	Phosphorylation	ADTLPRVSPVAQMTL CCCCCCCCCEEEEEE	18.22	24719451
270	Phosphorylation	VSPVAQMTLTLKPKP CCCEEEEEEEECCCC	12.43	25332170
272	Phosphorylation	PVAQMTLTLKPKPSV CEEEEEEEECCCCCC	24.46	24719451
278	O-linked_Glycosylation	LTLKPKPSVGLPQQI EEECCCCCCCCCCCC	34.64	OGP
290	O-linked_Glycosylation	QQIHSQVTPLSSQSV CCCCCCCCCCCCCEE	15.75	OGP
294	O-linked_Glycosylation	SQVTPLSSQSVVIHH CCCCCCCCCEEEEEC	33.87	OGP
296	O-linked_Glycosylation	VTPLSSQSVVIHHGQ CCCCCCCEEEEECCC	21.94	55834691
304	O-linked_Glycosylation	VVIHHGQTQEYVLKP EEEECCCEEEEEECC	28.14	55834695
318	Ubiquitination	PKYFPAQKGISGEQS CCCCCCCCCCCCCCC	61.39	-
321	Phosphorylation	FPAQKGISGEQSTEG CCCCCCCCCCCCCCC	44.97	24505115
325	Phosphorylation	KGISGEQSTEGSFPL CCCCCCCCCCCCCCC	24.91	24505115
326	O-linked_Glycosylation	GISGEQSTEGSFPLR CCCCCCCCCCCCCCH	44.02	55835759
326	Phosphorylation	GISGEQSTEGSFPLR CCCCCCCCCCCCCCH	44.02	24961811
347	N-linked_Glycosylation	AAPFQLSNHTGRIKV ECCEECCCCCCCEEE	45.38	UniProtKB CARBOHYD
357	O-linked_Glycosylation	GRIKVVFTPSICKVT CCEEEEECCCEEEEE	12.43	55832355
357	Phosphorylation	GRIKVVFTPSICKVT CCEEEEECCCEEEEE	12.43	28270605
359	Phosphorylation	IKVVFTPSICKVTCT EEEEECCCEEEEEEC	37.25	28270605
378	N-linked_Glycosylation	QNSCEKGNTTTLISE CCCCCCCCEEEEECC	45.37	UniProtKB CARBOHYD
408	Phosphorylation	VICHLPCMNGGQCSS EEEECCCCCCCCCCC	5.02	24719451
408 (in isoform 3)	Phosphorylation	-	5.02	24670416
424	N-linked_Glycosylation	DKCQCPPNFTGKLCQ CCCCCCCCCCCCCCC	32.05	UniProtKB CARBOHYD
438	O-linked_Glycosylation	QIPVHGASVPKLYQH CEECCCCCHHHHHHC	43.47	55832021
438	Phosphorylation	QIPVHGASVPKLYQH CEECCCCCHHHHHHC	43.47	28060719
446	Phosphorylation	VPKLYQHSQQPGKAL HHHHHHCCCCCCCCC	18.26	28060719
460	O-linked_Glycosylation	LGTHVIHSTHTLPLT CCCEEEEECCEECCE	15.68	55829253
461	O-linked_Glycosylation	GTHVIHSTHTLPLTV CCEEEEECCEECCEE	12.52	55829259
463	O-linked_Glycosylation	HVIHSTHTLPLTVTS EEEEECCEECCEEEC	30.11	55829265
467	O-linked_Glycosylation	STHTLPLTVTSQQGV ECCEECCEEECCCCC	21.57	55829271
469	O-linked_Glycosylation	HTLPLTVTSQQGVKV CEECCEEECCCCCEE	18.64	55829277
470	O-linked_Glycosylation	TLPLTVTSQQGVKVK EECCEEECCCCCEEE	19.03	55829283
494	Phosphorylation	VKHPPEASVQIHQVS ECCCCCCCEEEEEEE	16.94	28060719
501	O-linked_Glycosylation	SVQIHQVSRIDGPTG CEEEEEEEEECCCCC	19.56	55833665
501	Phosphorylation	SVQIHQVSRIDGPTG CEEEEEEEEECCCCC	19.56	28060719
523	Phosphorylation	PGQSQVSYQGLPVQK CCCCCCEECCCCCCC	14.03	-
531	Phosphorylation	QGLPVQKTQTIHSTY CCCCCCCCEEEEEEC	17.54	-
533	O-linked_Glycosylation	LPVQKTQTIHSTYSH CCCCCCEEEEEECCC	26.37	55834859
533	Phosphorylation	LPVQKTQTIHSTYSH CCCCCCEEEEEECCC	26.37	28060719
536	O-linked_Glycosylation	QKTQTIHSTYSHQQV CCCEEEEEECCCCCC	25.78	55834865
536	Phosphorylation	QKTQTIHSTYSHQQV CCCEEEEEECCCCCC	25.78	28060719
537	O-linked_Glycosylation	KTQTIHSTYSHQQVI CCEEEEEECCCCCCC	18.19	55834871
537	Phosphorylation	KTQTIHSTYSHQQVI CCEEEEEECCCCCCC	18.19	28060719
538	Phosphorylation	TQTIHSTYSHQQVIP CEEEEEECCCCCCCC	13.73	28060719
539	O-linked_Glycosylation	QTIHSTYSHQQVIPH EEEEEECCCCCCCCC	18.21	55834877
539	Phosphorylation	QTIHSTYSHQQVIPH EEEEEECCCCCCCCC	18.21	28060719
602	Phosphorylation	QKCPKKPSYHGYNQM CCCCCCCCCCCHHHH	38.34	28270605
603	Phosphorylation	KCPKKPSYHGYNQMM CCCCCCCCCCHHHHH	14.06	28270605
606	Phosphorylation	KKPSYHGYNQMMECL CCCCCCCHHHHHHHC	6.73	28270605
620	N-linked_Glycosylation	LPGYKRVNNTFCQDI CCCCEEECCEECCCH	45.95	UniProtKB CARBOHYD
661	O-linked_Glycosylation	IGFGPDPTFSSCVPD EECCCCCCHHHCCCC	43.46	OGP
680	Phosphorylation	SEEKGPCYRLVSSGR CCCCCCEEEEECCCC	15.32	22210691
684	Phosphorylation	GPCYRLVSSGRQCMH CCEEEEECCCCCCCC	31.50	22210691
685	Phosphorylation	PCYRLVSSGRQCMHP CEEEEECCCCCCCCC	30.43	22210691
738	Phosphorylation	GGMGYTVSGVHRRRP CCCCCCCCCCCCCCC	27.57	-
768	O-linked_Glycosylation	NTQPVAKSTHPPPLP CCCCCCCCCCCCCCC	23.39	55835089
769	O-linked_Glycosylation	TQPVAKSTHPPPLPA CCCCCCCCCCCCCCC	37.38	55835095
785	O-linked_Glycosylation	EEPVEALTFSREHGP CCCCCEEEEECHHCC	26.98	55835101
785	Phosphorylation	EEPVEALTFSREHGP CCCCCEEEEECHHCC	26.98	26657352
787	Phosphorylation	PVEALTFSREHGPGV CCCEEEEECHHCCCC	31.37	22985185
801	O-linked_Glycosylation	VAEPEVATAPPEKEI CCCCCCCCCCCCCCC	44.89	55831787
810	O-linked_Glycosylation	PPEKEIPSLDQEKTK CCCCCCCCCCHHHCC	50.68	55831793
810	Phosphorylation	PPEKEIPSLDQEKTK CCCCCCCCCCHHHCC	50.68	29507054
826	Phosphorylation	EPGQPQLSPGISTIH CCCCCCCCCCEEEEE	18.81	28270605
830	Phosphorylation	PQLSPGISTIHLHPQ CCCCCCEEEEEECCC	27.50	28270605
831	O-linked_Glycosylation	QLSPGISTIHLHPQF CCCCCEEEEEECCCC	15.53	OGP
831	Phosphorylation	QLSPGISTIHLHPQF CCCCCEEEEEECCCC	15.53	28270605
845	O-linked_Glycosylation	FPVVIEKTSPPVPVE CCEEEEECCCCCCEE	33.41	OGP
846	O-linked_Glycosylation	PVVIEKTSPPVPVEV CEEEEECCCCCCEEE	37.97	OGP
869	O-linked_Glycosylation	ASQVIAPTQVTEINE CCEEECCCCEEEEEE	27.01	OGP
872	O-linked_Glycosylation	VIAPTQVTEINECTV EECCCCEEEEEEEEC	22.72	OGP
878	O-linked_Glycosylation	VTEINECTVNPDICG EEEEEEEECCCCCCC	19.69	OGP
896	Phosphorylation	CINLPVRYTCICYEG EECCCCCEEEEEECC	13.24	-
897	Phosphorylation	INLPVRYTCICYEGY ECCCCCEEEEEECCC	5.71	-
901	Phosphorylation	VRYTCICYEGYRFSE CCEEEEEECCCCCCH	7.77	-
904	Phosphorylation	TCICYEGYRFSEQQR EEEEECCCCCCHHHH	9.13	-
920	O-linked_Glycosylation	CVDIDECTQVQHLCS CCCHHHHHHHHHHHH	29.72	OGP
974	Hydroxylation	CGEGHCVNTVGAFRC CCCCCCCCCCCEEEC	34.15	2350783
988	Phosphorylation	CEYCDSGYRMTQRGR CEECCCCCCCCCCCC	10.93	-
991	Phosphorylation	CDSGYRMTQRGRCED CCCCCCCCCCCCCCC	13.20	-
1100	Phosphorylation	QCKNTEGSFRCTCGQ EECCCCCCEEECCCC	11.86	24719451
1137	Hydroxylation	CAHGQCRNTEGSFQC ECCCCCCCCCCCEEE	50.54	2350783
1197	N-linked_Glycosylation	DGFQLDDNKTCQDIN CCCEECCCCCCCCHH	41.00	UniProtKB CARBOHYD
1250	N-linked_Glycosylation	EDIDECVNNTVCDSH CCHHHHHHCCCCCCC	50.54	UniProtKB CARBOHYD
1270	Phosphorylation	TAGSFRCLCYQGFQA CCCCEEEEEECCCCC	2.38	18088087
1273	Phosphorylation	SFRCLCYQGFQAPQD CEEEEEECCCCCCCC	45.27	18088087
1274	Phosphorylation	FRCLCYQGFQAPQDG EEEEEECCCCCCCCC	7.08	18088087
1329	Phosphorylation	PMTGQCRSRTSTDLD CCCCCCCCCCCCCCC	47.76	28270605
1331	Phosphorylation	TGQCRSRTSTDLDVD CCCCCCCCCCCCCCC	36.91	28270605
1332	Phosphorylation	GQCRSRTSTDLDVDV CCCCCCCCCCCCCCC	20.86	28270605
1333	O-linked_Glycosylation	QCRSRTSTDLDVDVD CCCCCCCCCCCCCCC	39.71	55825089
1333	Phosphorylation	QCRSRTSTDLDVDVD CCCCCCCCCCCCCCC	39.71	28270605
1366	N-linked_Glycosylation	CDNVLAPNVTKQECC CCCCCCCCCCCCCEE	48.78	10677208
1413	Phosphorylation	GFVPAGESSSEAGGE CCCCCCCCCCCCCCC	37.94	23927012
1414	Phosphorylation	FVPAGESSSEAGGEN CCCCCCCCCCCCCCC	28.09	23927012
1415	Phosphorylation	VPAGESSSEAGGENY CCCCCCCCCCCCCCC	40.52	23927012
1422	Phosphorylation	SEAGGENYKDADECL CCCCCCCCCCHHHHH	13.12	23403867
1512	Phosphorylation	RCIRPAESNEQIEET CCCCCCCCCCCHHCC	48.01	26657352
1596	Phosphorylation	GRDALVDFSEQYTPE CCCCCCCCHHHCCCC	7.26	18088087
1597	Phosphorylation	RDALVDFSEQYTPEA CCCCCCCHHHCCCCC	21.23	19060867
1599	Phosphorylation	ALVDFSEQYTPEADP CCCCCHHHCCCCCCC	46.32	18088087
1600	Phosphorylation	LVDFSEQYTPEADPY CCCCHHHCCCCCCCH	21.88	19060867
1601	O-linked_Glycosylation	VDFSEQYTPEADPYF CCCHHHCCCCCCCHH	17.85	OGP
1601	Phosphorylation	VDFSEQYTPEADPYF CCCHHHCCCCCCCHH	17.85	19060867
1616	Phosphorylation	IQDRFLNSFEELQAE CHHHHHCCHHHHHHH	35.86	26657352
1674	Phosphorylation	DELNNRMSLCKNAKC HHHHHHHHHHCCCEE	27.64	26074081
1684	Phosphorylation	KNAKCINTDGSYKCL CCCEEECCCCCCEEE	23.09	26074081
1687	Phosphorylation	KCINTDGSYKCLCLP EEECCCCCCEEEECC	24.99	26074081
1688	Phosphorylation	CINTDGSYKCLCLPG EECCCCCCEEEECCC	15.96	19702290
1696	Phosphorylation	KCLCLPGYVPSDKPN EEEECCCCCCCCCCC	13.77	26074081
1699	Phosphorylation	CLPGYVPSDKPNYCT ECCCCCCCCCCCCCC	48.50	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1414	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of LTBP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LTBP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGFB1_HUMAN	TGFB1	physical	10930463
IBP3_HUMAN	IGFBP3	physical	12962157
IBP5_HUMAN	IGFBP5	physical	12962157

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LTBP1_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Hybrid and complex glycans are linked to the conserved N-glycosylation site of the third eight-cysteine domain of LTBP-1 ininsect cells."; Rudd P.M., Downing A.K., Cadene M., Harvey D.J., Wormald M.R.,Weir I., Dwek R.A., Rifkin D.B., Gleizes P.E.; Biochemistry 39:1596-1603(2000). Cited for: GLYCOSYLATION AT ASN-1366.	10677208 [Abstract]
Phosphorylation
Reference	PubMed
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1597; TYR-1600 ANDTHR-1601, AND MASS SPECTROMETRY.	18088087 [Abstract]