dbPTM

TAB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TAB1_HUMAN
UniProt AC	Q15750
Protein Name	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Gene Name	TAB1
Organism	Homo sapiens (Human).
Sequence Length	504
Subcellular Localization
Protein Description	May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis..
Protein Sequence	MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGAHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVVTAP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAAQRRSLLQSEQQ -CHHHHHHHHHCCCC	35.30	23927012
11	Phosphorylation	QRRSLLQSEQQPSWT HHHHHHHCCCCCCCC	37.02	30266825
16	Phosphorylation	LQSEQQPSWTDDLPL HHCCCCCCCCCCCCC	37.97	30266825
18	Phosphorylation	SEQQPSWTDDLPLCH CCCCCCCCCCCCCEE	24.79	30266825
27	Phosphorylation	DLPLCHLSGVGSASN CCCCEECCCCCCCCC	14.04	20068231
31	Phosphorylation	CHLSGVGSASNRSYS EECCCCCCCCCCCCC	26.56	20068231
33	Phosphorylation	LSGVGSASNRSYSAD CCCCCCCCCCCCCCC	34.18	20068231
42	Ubiquitination	RSYSADGKGTESHPP CCCCCCCCCCCCCCC	64.31	-
46	O-linked_Glycosylation	ADGKGTESHPPEDSW CCCCCCCCCCCCCCC	40.92	32574038
52	O-linked_Glycosylation	ESHPPEDSWLKFRSE CCCCCCCCCEEEECC	32.42	32574038
150	Ubiquitination	QLPPQYQKILERLKT HCCHHHHHHHHHHHH	44.30	21890473
150	Ubiquitination	QLPPQYQKILERLKT HCCHHHHHHHHHHHH	44.30	21890473
157	Phosphorylation	KILERLKTLEREISG HHHHHHHHHHHHHHH	38.14	28122231
163	Phosphorylation	KTLEREISGGAMAVV HHHHHHHHHHHHHHH	26.82	28857561
179	Phosphorylation	VLLNNKLYVANVGTN HHHCCEEEEEECCCC	10.10	21406692
185	Phosphorylation	LYVANVGTNRALLCK EEEEECCCCCEEEEE	19.76	21406692
192	Ubiquitination	TNRALLCKSTVDGLQ CCCEEEEECCCCCEE	49.48	-
227	Ubiquitination	QLGLDAGKIKQVGII HCCCCCCCCCEEEEE	48.75	-
229	Ubiquitination	GLDAGKIKQVGIICG CCCCCCCCEEEEEEC	42.28	-
249	Ubiquitination	RIGDYKVKYGYTDID CCCCEEEEECCCCHH	28.89	-
259	Phosphorylation	YTDIDLLSAAKSKPI CCCHHHHHHHHCCCE	33.21	24719451
262	Ubiquitination	IDLLSAAKSKPIIAE HHHHHHHHCCCEEEC	59.74	-
264	Ubiquitination	LLSAAKSKPIIAEPE HHHHHHCCCEEECCC	39.26	-
339	Phosphorylation	DRVKRIHSDTFASGG HHHHHHHCCCCCCCC	35.65	27251275
373	Phosphorylation	GYPLGEMSQPTPSPA CCCCCCCCCCCCCCC	28.80	29978859
376	Phosphorylation	LGEMSQPTPSPAPAA CCCCCCCCCCCCCCC	28.85	29978859
378	Phosphorylation	EMSQPTPSPAPAAGG CCCCCCCCCCCCCCC	35.85	26055452
391	O-linked_Glycosylation	GGRVYPVSVPYSSAQ CCCEEEEECCCCCCC	16.93	32574038
395	O-linked_Glycosylation	YPVSVPYSSAQSTSK EEEECCCCCCCCCCC	17.09	32574038
396	O-linked_Glycosylation	PVSVPYSSAQSTSKT EEECCCCCCCCCCCC	25.20	32574038
396	Phosphorylation	PVSVPYSSAQSTSKT EEECCCCCCCCCCCC	25.20	28555341
399	O-linked_Glycosylation	VPYSSAQSTSKTSVT CCCCCCCCCCCCEEE	34.07	32574038
399	Phosphorylation	VPYSSAQSTSKTSVT CCCCCCCCCCCCEEE	34.07	28555341
400	O-linked_Glycosylation	PYSSAQSTSKTSVTL CCCCCCCCCCCEEEE	23.35	32574038
401	Phosphorylation	YSSAQSTSKTSVTLS CCCCCCCCCCEEEEE	38.90	28555341
401	O-linked_Glycosylation	YSSAQSTSKTSVTLS CCCCCCCCCCEEEEE	38.90	32574038
403	O-linked_Glycosylation	SAQSTSKTSVTLSLV CCCCCCCCEEEEEEE	28.35	32574038
406	O-linked_Glycosylation	STSKTSVTLSLVMPS CCCCCEEEEEEECCC	15.47	32574038
423	O-linked_Glycosylation	QMVNGAHSASTLDEA CEECCCCCCCCCCCC	24.31	32574038
423	Phosphorylation	QMVNGAHSASTLDEA CEECCCCCCCCCCCC	24.31	19076070
431	Phosphorylation	ASTLDEATPTLTNQS CCCCCCCCCCCCCCC	18.11	15590691
433	Phosphorylation	TLDEATPTLTNQSPT CCCCCCCCCCCCCCE	41.69	26074081
435	Phosphorylation	DEATPTLTNQSPTLT CCCCCCCCCCCCEEE	33.42	26074081
438	Phosphorylation	TPTLTNQSPTLTLQS CCCCCCCCCEEEEEE	23.17	26074081
440	Phosphorylation	TLTNQSPTLTLQSTN CCCCCCCEEEEEECC	37.31	26074081
442	Phosphorylation	TNQSPTLTLQSTNTH CCCCCEEEEEECCCC	25.81	26074081
445	Phosphorylation	SPTLTLQSTNTHTQS CCEEEEEECCCCCCC	27.08	26074081
446	Phosphorylation	PTLTLQSTNTHTQSS CEEEEEECCCCCCCC	31.04	26074081
450	O-linked_Glycosylation	LQSTNTHTQSSSSSS EEECCCCCCCCCCCC	28.27	32574038
452	Phosphorylation	STNTHTQSSSSSSDG ECCCCCCCCCCCCCC	33.09	22216226
453	Phosphorylation	TNTHTQSSSSSSDGG CCCCCCCCCCCCCCC	25.15	22216226
456	Phosphorylation	HTQSSSSSSDGGLFR CCCCCCCCCCCCCCC	34.10	22216226
457	Phosphorylation	TQSSSSSSDGGLFRS CCCCCCCCCCCCCCC	42.07	22216226
469	Phosphorylation	FRSRPAHSLPPGEDG CCCCCCCCCCCCCCC	44.68	28857561
481	Phosphorylation	EDGRVEPYVDFAEFY CCCCCCCCCCHHHHH	10.11	27642862
488	Phosphorylation	YVDFAEFYRLWSVDH CCCHHHHHHHHCCCC	9.05	27642862
492	Phosphorylation	AEFYRLWSVDHGEQS HHHHHHHCCCCCCCC	23.43	28348404
499	Phosphorylation	SVDHGEQSVVTAP-- CCCCCCCCEEECC--	17.79	28555341
502	O-linked_Glycosylation	HGEQSVVTAP----- CCCCCEEECC-----	30.93	32574038
502	Phosphorylation	HGEQSVVTAP----- CCCCCEEECC-----	30.93	29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
423	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
431	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
438	S	Phosphorylation	Kinase	ERK2	P28482	PSP
438	S	Phosphorylation	Kinase	ERK1	P27361	PSP
438	S	Phosphorylation	Kinase	JNK1	P45983	PSP
438	S	Phosphorylation	Kinase	JNK2	P45984	PSP
438	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
452	S	Phosphorylation	Kinase	MAP3K7	O43318	GPS
452	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
453	S	Phosphorylation	Kinase	MAP3K7	O43318	GPS
453	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
456	S	Phosphorylation	Kinase	MAP3K7	O43318	GPS
456	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
457	S	Phosphorylation	Kinase	MAP3K7	O43318	GPS
457	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:25714464

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TAB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TAB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRAF2_HUMAN	TRAF2	physical	14743216
TAB2_HUMAN	TAB2	physical	14670075
TAB3_HUMAN	TAB3	physical	14670075
M3K7_HUMAN	MAP3K7	physical	14670075
M3K7_HUMAN	MAP3K7	physical	12975377
XIAP_HUMAN	XIAP	physical	9878061
MK14_HUMAN	MAPK14	physical	11847341
ZMY11_HUMAN	ZMYND11	physical	9663660
TAB3_HUMAN	TAB3	physical	21903422
M3K7_HUMAN	MAP3K7	physical	21903422
MO4L1_HUMAN	MORF4L1	physical	21903422
MO4L2_HUMAN	MORF4L2	physical	21903422
TAB2_HUMAN	TAB2	physical	21903422
MTG2_HUMAN	MTG2	physical	21900206
PHAR3_HUMAN	PHACTR3	physical	21900206
TLS1_HUMAN	C9orf78	physical	21900206
CAR11_HUMAN	CARD11	physical	21900206
PDC6I_HUMAN	PDCD6IP	physical	21900206
CASP6_HUMAN	CASP6	physical	21900206
PP1R7_HUMAN	PPP1R7	physical	21900206
GIT1_HUMAN	GIT1	physical	21900206
XPO7_HUMAN	XPO7	physical	21900206
MK14_HUMAN	MAPK14	physical	21900206
NXPH3_HUMAN	NXPH3	physical	21900206
NPA1P_HUMAN	URB1	physical	21900206
PHC2_HUMAN	PHC2	physical	21900206
RPC4_HUMAN	POLR3D	physical	21900206
RL10_HUMAN	RPL10	physical	21900206
ACAP3_HUMAN	ACAP3	physical	21900206
KAIN_HUMAN	SERPINA4	physical	21900206
KCRB_HUMAN	CKB	physical	21900206
COF1_HUMAN	CFL1	physical	21900206
DREB_HUMAN	DBN1	physical	21900206
MICA1_HUMAN	MICAL1	physical	21900206
KIFC2_HUMAN	KIFC2	physical	21900206
MON1A_HUMAN	MON1A	physical	21900206
AMPL_HUMAN	LAP3	physical	21900206
ASGL1_HUMAN	ASRGL1	physical	21900206
RBX1_HUMAN	RBX1	physical	21900206
MAPK5_HUMAN	MAPKAPK5	physical	21900206
PDIP2_HUMAN	POLDIP2	physical	21900206
FADD_HUMAN	FADD	physical	21900206
LCMT1_HUMAN	LCMT1	physical	21900206
PTPM1_HUMAN	PTPMT1	physical	21900206
SYEP_HUMAN	EPRS	physical	21900206
WDCP_HUMAN	C2orf44	physical	21900206
HNRPR_HUMAN	HNRNPR	physical	21900206
ARAP1_HUMAN	ARAP1	physical	21900206
RLA1_HUMAN	RPLP1	physical	21900206
U1SBP_HUMAN	SNRNP35	physical	21900206
TSSC4_HUMAN	TSSC4	physical	21900206
TP4AP_HUMAN	TRPC4AP	physical	21900206
KAP0_HUMAN	PRKAR1A	physical	21900206
IKKB_HUMAN	IKBKB	physical	18316610
BST2_HUMAN	BST2	physical	23221546
M3K7_HUMAN	MAP3K7	physical	16260783
TRIP6_HUMAN	TRIP6	physical	21988832
FL2D_HUMAN	WTAP	physical	21988832
PP2AB_HUMAN	PPP2CB	physical	21988832
2AAA_HUMAN	PPP2R1A	physical	21988832
TAB2_HUMAN	TAB2	physical	21988832
MDM2_HUMAN	MDM2	physical	23934659
M3K7_HUMAN	MAP3K7	physical	23934659
XIAP_HUMAN	XIAP	physical	11865055
BIRC1_HUMAN	NAIP	physical	11865055
BIRC7_HUMAN	BIRC7	physical	11865055
TAB2_HUMAN	TAB2	physical	19675569
TAB2_HUMAN	TAB2	physical	25260751
ITCH_HUMAN	ITCH	physical	25714464
UBP18_HUMAN	USP18	physical	26240016
M3K7_HUMAN	MAP3K7	physical	27880917
TAB2_HUMAN	TAB2	physical	27880917
TAB3_HUMAN	TAB3	physical	27880917

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TAB1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-378, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7, AND MASSSPECTROMETRY.	18220336 [Abstract]
"The Yersinia enterocolitica effector YopP inhibits host cellsignalling by inactivating the protein kinase TAK1 in the IL-1signalling pathway."; Thiefes A., Wolf A., Doerrie A., Grassl G.A., Matsumoto K.,Autenrieth I., Bohn E., Sakurai H., Niedenthal R., Resch K.,Kracht M.; EMBO Rep. 7:838-844(2006). Cited for: UBIQUITINATION, PHOSPHORYLATION AT SER-438, MUTAGENESIS OF SER-438,AND DEUBIQUITINATION BY YOPP.	16845370 [Abstract]