ARAP1_HUMAN - dbPTM
ARAP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ARAP1_HUMAN
UniProt AC Q96P48
Protein Name Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
Gene Name ARAP1
Organism Homo sapiens (Human).
Sequence Length 1450
Subcellular Localization Cytoplasm. Golgi apparatus, Golgi stack membrane
Peripheral membrane protein. Cell membrane. Associated with Golgi stacks in resting cells. Throughout the cytoplasm and in surface protrusion in cells that are in the process of attaching to a surface
Protein Description Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity)..
Protein Sequence MAEAGDAALSVAEWLRALHLEQYTGLFEQHGLVWATECQGLSDTRLMDMGMLLPGHRRRILAGLLRAHTSPAPAPRPTPRPVPMKRHIFRSPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEEPLSTLPQGPPQPPSPPPCPPEIPPKPVRLFPEFDDSDYDEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSLPSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2 (in isoform 1)Phosphorylation-27.0122617229
2 (in isoform 2)Phosphorylation-27.0122617229
4 (in isoform 1)Phosphorylation-28.3822617229
4 (in isoform 2)Phosphorylation-28.3822617229
6 (in isoform 1)Phosphorylation-35.4022617229
6 (in isoform 2)Phosphorylation-35.4022617229
15 (in isoform 1)Phosphorylation-1.4020068231
15 (in isoform 2)Phosphorylation-1.4020068231
42PhosphorylationATECQGLSDTRLMDM
EEECCCCCCCCCCHH		43.70-
44PhosphorylationECQGLSDTRLMDMGM
ECCCCCCCCCCHHHC		23.48-
69PhosphorylationAGLLRAHTSPAPAPR
HHHHHHCCCCCCCCC		35.1129496963
70PhosphorylationGLLRAHTSPAPAPRP
HHHHHCCCCCCCCCC		14.8126055452
78PhosphorylationPAPAPRPTPRPVPMK
CCCCCCCCCCCCCCC		32.9630576142
91PhosphorylationMKRHIFRSPPVPATP
CCCCCCCCCCCCCCC		23.8629255136
91UbiquitinationMKRHIFRSPPVPATP
CCCCCCCCCCCCCCC		23.8629967540
97PhosphorylationRSPPVPATPPEPLPT
CCCCCCCCCCCCCCC		33.0529255136
104PhosphorylationTPPEPLPTTTEDEGL
CCCCCCCCCCCCCCC		54.7729255136
105PhosphorylationPPEPLPTTTEDEGLP
CCCCCCCCCCCCCCC		26.6729255136
106PhosphorylationPEPLPTTTEDEGLPA
CCCCCCCCCCCCCCC		43.8729255136
119UbiquitinationPAAPPIPPRRSCLPP
CCCCCCCCCCCCCCC		45.0729967540
170PhosphorylationGPPRLLVSLPTKEEE
CCCCEEEECCCCCHH		28.7126074081
173PhosphorylationRLLVSLPTKEEESLL
CEEEECCCCCHHHCC		57.2820068231
178PhosphorylationLPTKEEESLLPSLSS
CCCCCHHHCCCCCCC		38.1926074081
182PhosphorylationEEESLLPSLSSPPQP
CHHHCCCCCCCCCCC		40.6326074081
207PhosphorylationQGPPQPPSPPPCPPE
CCCCCCCCCCCCCCC		57.6426091039
229PhosphorylationLFPEFDDSDYDEVPE
ECCCCCCCCCCCCCC		39.6623927012
229 (in isoform 6)Phosphorylation-39.6618669648
231PhosphorylationPEFDDSDYDEVPEEG
CCCCCCCCCCCCCCC		20.2523927012
231 (in isoform 6)Phosphorylation-20.2518669648
255PhosphorylationKKEEPPPSRVPRAVR
CCCCCCCCCCCHHHH		52.2423828894
265PhosphorylationPRAVRVASLLSEGEE
CHHHHHHHHHHCCCC		27.3020736484
268PhosphorylationVRVASLLSEGEELSG
HHHHHHHHCCCCCCC		49.1820736484
274PhosphorylationLSEGEELSGDDQGDE
HHCCCCCCCCCCCCC		43.38-
323PhosphorylationDGPPGGSTPVTPVIK
CCCCCCCCCCCCEEE		25.6726074081
326PhosphorylationPGGSTPVTPVIKAGW
CCCCCCCCCEEECCC		17.0326074081
336UbiquitinationIKAGWLDKNPPQGSY
EECCCCCCCCCCCCE		70.0029967540
341UbiquitinationLDKNPPQGSYIYQKR
CCCCCCCCCEEEEEE		28.3429967540
342PhosphorylationDKNPPQGSYIYQKRW
CCCCCCCCEEEEEEE		11.7819690332
343PhosphorylationKNPPQGSYIYQKRWV
CCCCCCCEEEEEEEE		15.5219690332
345PhosphorylationPPQGSYIYQKRWVRL
CCCCCEEEEEEEEEE		10.3523917254
354PhosphorylationKRWVRLDTDHLRYFD
EEEEEECCCCHHCCC		29.8822817900
359PhosphorylationLDTDHLRYFDSNKDA
ECCCCHHCCCCCCCH		20.3528270605
362PhosphorylationDHLRYFDSNKDAYSK
CCHHCCCCCCCHHCH		35.5628270605
364UbiquitinationLRYFDSNKDAYSKRF
HHCCCCCCCHHCHHH		47.9229967540
367PhosphorylationFDSNKDAYSKRFISV
CCCCCCHHCHHHHHH		25.5128270605
368PhosphorylationDSNKDAYSKRFISVA
CCCCCHHCHHHHHHH		21.0528270605
428PhosphorylationQRARARLSSAYLLGV
HHHHHHHHHHHHCCC		13.8423401153
428 (in isoform 6)Phosphorylation-13.8418669648
429PhosphorylationRARARLSSAYLLGVP
HHHHHHHHHHHCCCC		26.0621712546
429 (in isoform 6)Phosphorylation-26.0618220336
431PhosphorylationRARLSSAYLLGVPGS
HHHHHHHHHCCCCCC		12.3821712546
431 (in isoform 6)Phosphorylation-12.3818669648
438PhosphorylationYLLGVPGSEQPDRAG
HHCCCCCCCCCCCCC		27.3029978859
446PhosphorylationEQPDRAGSLELRGFK
CCCCCCCCEEECCCC		20.0624719451
446UbiquitinationEQPDRAGSLELRGFK
CCCCCCCCEEECCCC		20.0629967540
497PhosphorylationVKEVDRRSFDLTTPY
CEEECCCCCCCCCCE		24.8130108239
502PhosphorylationRRSFDLTTPYRIFSF
CCCCCCCCCEEEEEC		26.14-
504PhosphorylationSFDLTTPYRIFSFSA
CCCCCCCEEEEECCC		17.7823917254
507UbiquitinationLTTPYRIFSFSADSE
CCCCEEEEECCCCCH		4.4529967540
513PhosphorylationIFSFSADSELEKEQW
EEECCCCCHHHHHHH		43.74-
565UbiquitinationPDWASINLCVVICKR
CCHHHCEEHHHHHHH		1.9221890473
565UbiquitinationPDWASINLCVVICKR
CCHHHCEEHHHHHHH		1.9221890473
565 (in isoform 5)Ubiquitination-1.9221890473
586UbiquitinationGLGAGVSKVRSLKMD
CCCCCHHHHHHCCCC		38.9829967540
624PhosphorylationWAANVPPSEALQPSS
EECCCCHHHHCCCCC		29.4530108239
626UbiquitinationANVPPSEALQPSSSP
CCCCHHHHCCCCCCC		18.8121890473
626 (in isoform 4)Ubiquitination-18.8121890473
630PhosphorylationPSEALQPSSSPSTRR
HHHHCCCCCCCCCCC		30.4130108239
631PhosphorylationSEALQPSSSPSTRRC
HHHCCCCCCCCCCCE		53.6130108239
631 (in isoform 1)Ubiquitination-53.6121890473
631 (in isoform 2)Ubiquitination-53.6121890473
632PhosphorylationEALQPSSSPSTRRCH
HHCCCCCCCCCCCEE		27.4930108239
634PhosphorylationLQPSSSPSTRRCHLE
CCCCCCCCCCCEEEE		36.1730108239
635PhosphorylationQPSSSPSTRRCHLEA
CCCCCCCCCCEEEEH		26.0530108239
694UbiquitinationGINCFSGDPEAPTPL
CCCCCCCCCCCCCHH		36.3529967540
712UbiquitinationEQAGQTLQMEFLRNN
HHHCCCHHHHHHHCC		32.5229967540
722O-linked_GlycosylationFLRNNRTTEVPRLDS
HHHCCCCCCCCCCCC		31.5729351928
726UbiquitinationNRTTEVPRLDSMKPL
CCCCCCCCCCCCCCH		57.1929967540
729PhosphorylationTEVPRLDSMKPLEKH
CCCCCCCCCCCHHHC		33.0428857561
735PhosphorylationDSMKPLEKHYSVVLP
CCCCCHHHCCEEEEE		56.3716497976
737PhosphorylationMKPLEKHYSVVLPTV
CCCHHHCCEEEEECC		17.7721945579
738PhosphorylationKPLEKHYSVVLPTVS
CCHHHCCEEEEECCC		12.8821945579
743PhosphorylationHYSVVLPTVSHSGFL
CCEEEEECCCCCCCE		30.4021945579
745PhosphorylationSVVLPTVSHSGFLYK
EEEEECCCCCCCEEE		17.8921945579
747PhosphorylationVLPTVSHSGFLYKTA
EEECCCCCCCEEEEC		24.5921945579
751PhosphorylationVSHSGFLYKTASAGK
CCCCCCEEEECCHHH		12.2021945579
752MalonylationSHSGFLYKTASAGKL
CCCCCEEEECCHHHH		39.5026320211
752UbiquitinationSHSGFLYKTASAGKL
CCCCCEEEECCHHHH		39.5029967540
755UbiquitinationGFLYKTASAGKLLQD
CCEEEECCHHHHHHH		42.6729967540
773UbiquitinationREEFSRRWCVLGDGV
HHHHHHHEECCCCCH		3.8829967540
782PhosphorylationVLGDGVLSYFENERA
CCCCCHHHHHCCCCC		25.93-
783PhosphorylationLGDGVLSYFENERAV
CCCCHHHHHCCCCCC		15.68-
787UbiquitinationVLSYFENERAVTPNG
HHHHHCCCCCCCCCC		34.5229967540
791PhosphorylationFENERAVTPNGEIRA
HCCCCCCCCCCCEEC		15.2824719451
828PhosphorylationYTEGERLYLFGLESA
EECCCEEEEEECCCH		13.25-
871UbiquitinationRLGRLPYKAGLSLQR
HHCCCCCCCCCCCCH		33.7621890473
871 (in isoform 3)Ubiquitination-33.7621890473
871 (in isoform 6)Ubiquitination-33.7621890473
875PhosphorylationLPYKAGLSLQRAQEG
CCCCCCCCCCHHHHC		22.8724719451
956SulfoxidationIQKAAASMGDTLSEQ
HHHHHHHCCCCCCHH		4.8930846556
975PhosphorylationSDIPVIVYRCVDYIT
CCCCEEEEEHHHHHH		6.2825147952
992PhosphorylationGLTSEGIYRKCGQTS
CCCCHHHHHHHCCCH		18.1823917254
1000UbiquitinationRKCGQTSKTQRLLES
HHHCCCHHHHHHHHH		52.6529967540
1007PhosphorylationKTQRLLESLRQDARS
HHHHHHHHHHHHHHH		28.9028674151
1018UbiquitinationDARSVHLKEGEQHVD
HHHHCCCCCCCHHHH		49.1229967540
1032AcetylationDDVSSALKRFLRDLP
HHHHHHHHHHHHHCC		40.6025953088
1032MalonylationDDVSSALKRFLRDLP
HHHHHHHHHHHHHCC		40.6026320211
1032UbiquitinationDDVSSALKRFLRDLP
HHHHHHHHHHHHHCC		40.6029967540
1044PhosphorylationDLPDGLFTRAQRLTW
HCCCCCCHHHHHCEE		30.0921406692
1050PhosphorylationFTRAQRLTWLEASEI
CHHHHHCEEHHHHCC		30.1430377224
1055PhosphorylationRLTWLEASEIEDEEE
HCEEHHHHCCCCHHH		29.7230377224
1090UbiquitinationKALISHLYCVQCFSD
HHHHHHHHHHHHCCC		5.7829967540
1219PhosphorylationVGIREKDYWTCFEVN
CCCCCCCEEEEEEEC		17.43-
1268PhosphorylationAMEAMLLYLASRVGD
HHHHHHHHHHHHHCC		9.0319690332
1271PhosphorylationAMLLYLASRVGDTKH
HHHHHHHHHHCCCCC		25.5524719451
1324PhosphorylationVRSQRPWSGAPETSH
HHHCCCCCCCCCCCC		27.9724719451
1335UbiquitinationETSHRPEKEWPIKSL
CCCCCCCCCCCCCCE		68.6929967540
1419PhosphorylationVPEVRLGSVSLIPLR
CCCEECCCEEEEECC		17.0825106551
1421PhosphorylationEVRLGSVSLIPLRGS
CEECCCEEEEECCCC		23.4420873877
1426MethylationSVSLIPLRGSENEMR
CEEEEECCCCHHHHH		41.03-
1428PhosphorylationSLIPLRGSENEMRRS
EEEECCCCHHHHHHH		30.7126657352
1435PhosphorylationSENEMRRSVAAFTAD
CHHHHHHHHHHHHCC		13.0211804590
1435 (in isoform 6)Phosphorylation-13.0218669648
1440PhosphorylationRRSVAAFTADPLSLL
HHHHHHHHCCHHHHH		25.9828634120
1445PhosphorylationAFTADPLSLLRNV--
HHHCCHHHHHHCC--		30.6427251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
231YPhosphorylationKinasePTK6Q13882
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ARAP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ARAP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
XRCC6_HUMANXRCC6physical
16169070
SH3K1_HUMANSH3KBP1physical
21275903
SHIP1_HUMANINPP5Dphysical
21275903
KCD12_HUMANKCTD12physical
21275903
PSD3_HUMANPSD3physical
21275903
TP53B_HUMANTP53BP1physical
21275903
TES_HUMANTESphysical
21275903
WAPL_HUMANWAPALphysical
21275903
A4_HUMANAPPphysical
21832049
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ARAP1_HUMAN

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; TYR-343; SER-738;TYR-1268 AND SER-1435, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-431 AND SER-1435, ANDMASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-428, AND MASSSPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229; TYR-231; THR-354AND TYR-737, AND MASS SPECTROMETRY.
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-737, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory