dbPTM

WAPL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WAPL_HUMAN
UniProt AC	Q7Z5K2
Protein Name	Wings apart-like protein homolog
Gene Name	WAPL {ECO:0000312\|HGNC:HGNC:23293}
Organism	Homo sapiens (Human).
Sequence Length	1190
Subcellular Localization	Isoform 2: Nucleus. Nucleus. Chromosome. Cytoplasm. Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
Protein Description	Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair..
Protein Sequence	MTSRFGKTYSRKGGNGSSKFDEVFSNKRTTLSTKWGETTFMAKLGQKRPNFKPDIQEIPKKPKVEEESTGDPFGFDSDDESLPVSSKNLAQVKCSSYSESSEAAQLEEVTSVLEANSKISHVVVEDTVVSDKCFPLEDTLLGKEKSTNRIVEDDASISSCNKLITSDKVENFHEEHEKNSHHIHKNADDSTKKPNAETTVASEIKETNDTWNSQFGKRPESPSEISPIKGSVRTGLFEWDNDFEDIRSEDCILSLDSDPLLEMKDDDFKNRLENLNEAIEEDIVQSVLRPTNCRTYCRANKTKSSQGASNFDKLMDGTSQALAKANSESSKDGLNQAKKGGVSCGTSFRGTVGRTRDYTVLHPSCLSVCNVTIQDTMERSMDEFTASTPADLGEAGRLRKKADIATSKTTTRFRPSNTKSKKDVKLEFFGFEDHETGGDEGGSGSSNYKIKYFGFDDLSESEDDEDDDCQVERKTSKKRTKTAPSPSLQPPPESNDNSQDSQSGTNNAENLDFTEDLPGVPESVKKPINKQGDKSKENTRKIFSGPKRSPTKAVYNARHWNHPDSEELPGPPVVKPQSVTVRLSSKEPNQKDDGVFKAPAPPSKVIKTVTIPTQPYQDIVTALKCRREDKELYTVVQHVKHFNDVVEFGENQEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRLNMDLDRASLDLMIRLLELEQDASSAKLLNEKDMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGGLDHIVDKVKECVDHLSRDEDEEKLVASLWGAERCLRVLESVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLPHQNVTNHVGKAVEDCMRAIIGVLLNLTNDNEWGSTKTGEQDGLIGTALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNMETSCSFDSSICSGEGDDSLRIGGQVHAVQALVQLFLERERAAQLAESKTDELIKDAPTTQHDKSGEWQETSGEIQWVSTEKTDGTEEKHKKEEEDEELDLNKALQHAGKHMEDCIVASYTALLLGCLCQESPINVTTVREYLPEGDFSIMTEMLKKFLSFMNLTCAVGTTGQKSISRVIEYLEHC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Acetylation	-MTSRFGKTYSRKGG -CCCCCCCCCCCCCC	41.39	26051181
8	Phosphorylation	MTSRFGKTYSRKGGN CCCCCCCCCCCCCCC	27.40	26074081
8 (in isoform 2)	Phosphorylation	-	27.40	24043423
8 (in isoform 3)	Phosphorylation	-	27.40	24043423
9	Phosphorylation	TSRFGKTYSRKGGNG CCCCCCCCCCCCCCC	15.23	26074081
10	Phosphorylation	SRFGKTYSRKGGNGS CCCCCCCCCCCCCCC	32.52	26074081
12	Acetylation	FGKTYSRKGGNGSSK CCCCCCCCCCCCCCC	66.29	7934579
12 (in isoform 2)	Phosphorylation	-	66.29	24043423
12 (in isoform 3)	Phosphorylation	-	66.29	24043423
17	Phosphorylation	SRKGGNGSSKFDEVF CCCCCCCCCCHHHHH	34.06	26074081
18	Phosphorylation	RKGGNGSSKFDEVFS CCCCCCCCCHHHHHC	38.45	26074081
19	Acetylation	KGGNGSSKFDEVFSN CCCCCCCCHHHHHCC	59.54	7934589
27	Acetylation	FDEVFSNKRTTLSTK HHHHHCCCCEEECCC	50.34	7934599
27	Ubiquitination	FDEVFSNKRTTLSTK HHHHHCCCCEEECCC	50.34	-
34	Acetylation	KRTTLSTKWGETTFM CCEEECCCCCHHHHH	50.23	25953088
38	Phosphorylation	LSTKWGETTFMAKLG ECCCCCHHHHHHHCC	22.77	28555341
52	Acetylation	GQKRPNFKPDIQEIP CCCCCCCCCCHHHCC	48.71	21339330
68	Phosphorylation	KPKVEEESTGDPFGF CCCCCCCCCCCCCCC	40.75	23927012
69	Phosphorylation	PKVEEESTGDPFGFD CCCCCCCCCCCCCCC	49.21	30266825
77	Phosphorylation	GDPFGFDSDDESLPV CCCCCCCCCCCCCCC	44.70	29255136
81	Phosphorylation	GFDSDDESLPVSSKN CCCCCCCCCCCCCCC	44.99	30266825
85	Phosphorylation	DDESLPVSSKNLAQV CCCCCCCCCCCEEEE	33.39	23927012
86	Phosphorylation	DESLPVSSKNLAQVK CCCCCCCCCCEEEEE	26.29	23927012
93	Ubiquitination	SKNLAQVKCSSYSES CCCEEEEECCCCCCC	19.13	-
95	Phosphorylation	NLAQVKCSSYSESSE CEEEEECCCCCCCCH	26.96	29116813
96	Phosphorylation	LAQVKCSSYSESSEA EEEEECCCCCCCCHH	41.99	26074081
97	Phosphorylation	AQVKCSSYSESSEAA EEEECCCCCCCCHHH	10.52	26074081
98	Phosphorylation	QVKCSSYSESSEAAQ EEECCCCCCCCHHHH	32.71	26074081
100	Phosphorylation	KCSSYSESSEAAQLE ECCCCCCCCHHHHHH	27.77	26074081
101	Phosphorylation	CSSYSESSEAAQLEE CCCCCCCCHHHHHHH	27.48	26074081
120	Phosphorylation	LEANSKISHVVVEDT HHHCCCCCEEEEECC	17.61	19664995
127	Phosphorylation	SHVVVEDTVVSDKCF CEEEEECCEEECCEE	14.86	25849741
130	Phosphorylation	VVEDTVVSDKCFPLE EEECCEEECCEEEHH	27.32	25849741
132	Acetylation	EDTVVSDKCFPLEDT ECCEEECCEEEHHHH	30.21	26051181
143	Acetylation	LEDTLLGKEKSTNRI HHHHHCCCCCCCCCC	63.04	26051181
146	Phosphorylation	TLLGKEKSTNRIVED HHCCCCCCCCCCCCC	31.82	29759185
147	Phosphorylation	LLGKEKSTNRIVEDD HCCCCCCCCCCCCCC	39.31	29759185
156	Phosphorylation	RIVEDDASISSCNKL CCCCCCCCHHHHCCC	29.96	23401153
158	Phosphorylation	VEDDASISSCNKLIT CCCCCCHHHHCCCCC	26.75	25159151
159	Phosphorylation	EDDASISSCNKLITS CCCCCHHHHCCCCCC	21.75	20164059
162 (in isoform 3)	Phosphorylation	-	45.66	21406692
162	Acetylation	ASISSCNKLITSDKV CCHHHHCCCCCCHHH	45.66	25953088
165	Phosphorylation	SSCNKLITSDKVENF HHHCCCCCCHHHHHH	41.11	28555341
166 (in isoform 3)	Phosphorylation	-	28.57	21406692
166	Phosphorylation	SCNKLITSDKVENFH HHCCCCCCHHHHHHH	28.57	28555341
168	Acetylation	NKLITSDKVENFHEE CCCCCCHHHHHHHHH	51.74	19608861
180	Phosphorylation	HEEHEKNSHHIHKNA HHHHHHCCCCCCCCC	27.75	24719451
190	Phosphorylation	IHKNADDSTKKPNAE CCCCCCCCCCCCCCC	42.55	26055452
191	Phosphorylation	HKNADDSTKKPNAET CCCCCCCCCCCCCCC	50.51	21712546
199	Phosphorylation	KKPNAETTVASEIKE CCCCCCCHHHHHHHH	12.94	28555341
202	Phosphorylation	NAETTVASEIKETND CCCCHHHHHHHHHCC	35.20	25159151
205	Ubiquitination	TTVASEIKETNDTWN CHHHHHHHHHCCHHH	55.20	-
207	Phosphorylation	VASEIKETNDTWNSQ HHHHHHHHCCHHHHC	33.13	26074081
210	Phosphorylation	EIKETNDTWNSQFGK HHHHHCCHHHHCCCC	28.72	26074081
213	Phosphorylation	ETNDTWNSQFGKRPE HHCCHHHHCCCCCCC	20.60	22115753
221	Phosphorylation	QFGKRPESPSEISPI CCCCCCCCHHHCCCC	36.09	29255136
223	Phosphorylation	GKRPESPSEISPIKG CCCCCCHHHCCCCCC	57.76	22167270
226	Phosphorylation	PESPSEISPIKGSVR CCCHHHCCCCCCCCC	19.27	29255136
231	Phosphorylation	EISPIKGSVRTGLFE HCCCCCCCCCCCCCC	11.92	23927012
234	Phosphorylation	PIKGSVRTGLFEWDN CCCCCCCCCCCCCCC	35.76	26074081
254	Phosphorylation	RSEDCILSLDSDPLL CCCCEEEECCCCCCH	15.37	23663014
257	Phosphorylation	DCILSLDSDPLLEMK CEEEECCCCCCHHCC	46.55	23663014
286	Phosphorylation	IEEDIVQSVLRPTNC HHHHHHHHHHCCCCH	16.54	22067460
291	Phosphorylation	VQSVLRPTNCRTYCR HHHHHCCCCHHHHHH	40.28	22067460
293	Glutathionylation	SVLRPTNCRTYCRAN HHHCCCCHHHHHHCC	3.65	22555962
302	Phosphorylation	TYCRANKTKSSQGAS HHHHCCCCCCCCCCC	35.65	24719451
303	Ubiquitination	YCRANKTKSSQGASN HHHCCCCCCCCCCCC	50.12	-
304	Phosphorylation	CRANKTKSSQGASNF HHCCCCCCCCCCCCH	32.88	-
305	Phosphorylation	RANKTKSSQGASNFD HCCCCCCCCCCCCHH	33.90	28985074
306 (in isoform 3)	Phosphorylation	-	59.57	21406692
308 (in isoform 3)	Phosphorylation	-	8.15	21406692
309	Phosphorylation	TKSSQGASNFDKLMD CCCCCCCCCHHHHHC	44.87	30387612
311 (in isoform 3)	Phosphorylation	-	8.97	21406692
313	Ubiquitination	QGASNFDKLMDGTSQ CCCCCHHHHHCHHHH	41.39	-
313	Acetylation	QGASNFDKLMDGTSQ CCCCCHHHHHCHHHH	41.39	25953088
315	Sulfoxidation	ASNFDKLMDGTSQAL CCCHHHHHCHHHHHH	5.71	21406390
318	Phosphorylation	FDKLMDGTSQALAKA HHHHHCHHHHHHHHH	17.25	22468782
319	Phosphorylation	DKLMDGTSQALAKAN HHHHCHHHHHHHHHC	20.98	23403867
327	Phosphorylation	QALAKANSESSKDGL HHHHHHCCCCCHHHH	43.65	22468782
329	Phosphorylation	LAKANSESSKDGLNQ HHHHCCCCCHHHHHH	42.37	23403867
330	Phosphorylation	AKANSESSKDGLNQA HHHCCCCCHHHHHHH	30.62	23403867
343	Phosphorylation	QAKKGGVSCGTSFRG HHHHCCCCCCCCCCC	15.31	28450419
346	Phosphorylation	KGGVSCGTSFRGTVG HCCCCCCCCCCCCCC	29.08	28450419
347	Phosphorylation	GGVSCGTSFRGTVGR CCCCCCCCCCCCCCC	9.76	23401153
351	Phosphorylation	CGTSFRGTVGRTRDY CCCCCCCCCCCCCCE	18.61	26074081
355	Phosphorylation	FRGTVGRTRDYTVLH CCCCCCCCCCEEEEC	23.20	-
359	Phosphorylation	VGRTRDYTVLHPSCL CCCCCCEEEECHHHH	22.38	-
380	Phosphorylation	IQDTMERSMDEFTAS HHHHHHHHHHHHHCC	19.78	30266825
385	Phosphorylation	ERSMDEFTASTPADL HHHHHHHHCCCCHHH	20.04	30266825
387	Phosphorylation	SMDEFTASTPADLGE HHHHHHCCCCHHHHH	31.69	30266825
388	Phosphorylation	MDEFTASTPADLGEA HHHHHCCCCHHHHHH	21.74	30266825
408	Ubiquitination	KADIATSKTTTRFRP HHCCCCCCCCCCCCC	45.60	-
420	Phosphorylation	FRPSNTKSKKDVKLE CCCCCCCCCCCEEEE	42.79	22067460
436	Phosphorylation	FGFEDHETGGDEGGS EEECCCCCCCCCCCC	42.94	29523821
443	Phosphorylation	TGGDEGGSGSSNYKI CCCCCCCCCCCCCEE	46.49	25159151
445	Phosphorylation	GDEGGSGSSNYKIKY CCCCCCCCCCCEEEE	19.67	22199227
446	Phosphorylation	DEGGSGSSNYKIKYF CCCCCCCCCCEEEEE	47.94	22199227
448	Phosphorylation	GGSGSSNYKIKYFGF CCCCCCCCEEEEEEE	18.95	22199227
452	Phosphorylation	SSNYKIKYFGFDDLS CCCCEEEEEEECCCC	16.65	26503892
459	Phosphorylation	YFGFDDLSESEDDED EEEECCCCCCCCCCC	46.18	23927012
461	Phosphorylation	GFDDLSESEDDEDDD EECCCCCCCCCCCCC	42.84	23927012
482	Phosphorylation	TSKKRTKTAPSPSLQ HCCCCCCCCCCCCCC	43.09	28985074
485	Phosphorylation	KRTKTAPSPSLQPPP CCCCCCCCCCCCCCC	25.34	25137130
487	Phosphorylation	TKTAPSPSLQPPPES CCCCCCCCCCCCCCC	43.93	30576142
494	Phosphorylation	SLQPPPESNDNSQDS CCCCCCCCCCCCCCC	56.08	27251275
498	Phosphorylation	PPESNDNSQDSQSGT CCCCCCCCCCCCCCC	37.92	27251275
501	Phosphorylation	SNDNSQDSQSGTNNA CCCCCCCCCCCCCCH	20.71	27251275
503	Phosphorylation	DNSQDSQSGTNNAEN CCCCCCCCCCCCHHH	52.08	25137130
505	Phosphorylation	SQDSQSGTNNAENLD CCCCCCCCCCHHHCC	30.46	25137130
514	Phosphorylation	NAENLDFTEDLPGVP CHHHCCCCCCCCCCC	28.40	20873877
523	Phosphorylation	DLPGVPESVKKPINK CCCCCCHHHCCCCCC	32.92	20873877
541	Methylation	KSKENTRKIFSGPKR CCCCCCCHHHCCCCC	46.17	116253061
544	Phosphorylation	ENTRKIFSGPKRSPT CCCCHHHCCCCCCCC	58.62	23403867
544 (in isoform 3)	Phosphorylation	-	58.62	21406692
546 (in isoform 3)	Phosphorylation	-	27.91	21406692
549	Phosphorylation	IFSGPKRSPTKAVYN HHCCCCCCCCHHHHC	42.94	25159151
551	Phosphorylation	SGPKRSPTKAVYNAR CCCCCCCCHHHHCCC	32.65	23403867
555	Phosphorylation	RSPTKAVYNARHWNH CCCCHHHHCCCCCCC	14.15	24719451
580	Phosphorylation	VVKPQSVTVRLSSKE CCCCCEEEEEECCCC	12.73	24719451
597	Ubiquitination	QKDDGVFKAPAPPSK CCCCCCEECCCCCCC	51.56	-
603	Phosphorylation	FKAPAPPSKVIKTVT EECCCCCCCEEEEEE	38.20	29743597
604	Acetylation	KAPAPPSKVIKTVTI ECCCCCCCEEEEEEE	54.47	19608861
604	Ubiquitination	KAPAPPSKVIKTVTI ECCCCCCCEEEEEEE	54.47	-
608	Phosphorylation	PPSKVIKTVTIPTQP CCCCEEEEEEECCCC	16.26	20068231
610	Phosphorylation	SKVIKTVTIPTQPYQ CCEEEEEEECCCCHH	26.86	20068231
613	Phosphorylation	IKTVTIPTQPYQDIV EEEEEECCCCHHHHH	38.02	20068231
616	Phosphorylation	VTIPTQPYQDIVTAL EEECCCCHHHHHHHH	14.70	28796482
621	Phosphorylation	QPYQDIVTALKCRRE CCHHHHHHHHHCCCC	26.97	20068231
624	Ubiquitination	QDIVTALKCRREDKE HHHHHHHHCCCCCHH	24.19	-
629 (in isoform 3)	Phosphorylation	-	48.17	21406692
630	Acetylation	LKCRREDKELYTVVQ HHCCCCCHHHHHHHH	44.88	26051181
633	Phosphorylation	RREDKELYTVVQHVK CCCCHHHHHHHHHHH	9.89	28796482
634	Phosphorylation	REDKELYTVVQHVKH CCCHHHHHHHHHHHH	27.16	28796482
680	Phosphorylation	TRCLSVISLATKCAM HHHHHHHHHHHHCCC	15.14	29083192
683	Phosphorylation	LSVISLATKCAMPSF HHHHHHHHHCCCCHH	31.76	29083192
701 (in isoform 3)	Phosphorylation	-	4.59	27642862
718 (in isoform 3)	Phosphorylation	-	3.20	27642862
734	Sulfoxidation	LSRDRLNMDLDRASL HHHHCCCCCCCHHHH	6.83	21406390
740	Phosphorylation	NMDLDRASLDLMIRL CCCCCHHHHHHHHHH	24.26	21955146
744	Sulfoxidation	DRASLDLMIRLLELE CHHHHHHHHHHHHHH	1.35	21406390
758	Acetylation	EQDASSAKLLNEKDM HCCHHHHHHCCHHHH	56.29	25953088
763	Acetylation	SAKLLNEKDMNKIKE HHHHCCHHHHHHHHH	62.29	23749302
763	Ubiquitination	SAKLLNEKDMNKIKE HHHHCCHHHHHHHHH	62.29	-
790	Phosphorylation	HLDLENITTGHLAME CCCCCCCCHHHHHHH	38.00	26552605
791	Phosphorylation	LDLENITTGHLAMET CCCCCCCHHHHHHHH	20.85	26552605
798	Phosphorylation	TGHLAMETLLSLTSK HHHHHHHHHHHHHHH	21.66	26552605
801	Phosphorylation	LAMETLLSLTSKRAG HHHHHHHHHHHHHCC	32.49	26552605
803	Phosphorylation	METLLSLTSKRAGDW HHHHHHHHHHHCCHH	28.91	26552605
804	Phosphorylation	ETLLSLTSKRAGDWF HHHHHHHHHHCCHHH	25.99	26552605
812	Ubiquitination	KRAGDWFKEELRLLG HHCCHHHHHHHHHCC	46.13	-
827	Ubiquitination	GLDHIVDKVKECVDH CHHHHHHHHHHHHHH	44.29	-
829	Ubiquitination	DHIVDKVKECVDHLS HHHHHHHHHHHHHHC	51.65	-
843	Ubiquitination	SRDEDEEKLVASLWG CCCCCHHHHHHHHHH	46.33	-
848 (in isoform 3)	Ubiquitination	-	3.36	-
886	Ubiquitination	QLIVSSAKALQHCEE HHHHCHHHHHHHHHH	52.13	-
904	Phosphorylation	QYNRAEDSICLADSK HHHHCCCCEEECCCC	13.50	30266825
910	Phosphorylation	DSICLADSKPLPHQN CCEEECCCCCCCCCC	30.48	24732914
911	Ubiquitination	SICLADSKPLPHQNV CEEECCCCCCCCCCC	51.63	-
911	Acetylation	SICLADSKPLPHQNV CEEECCCCCCCCCCC	51.63	26051181
919	Phosphorylation	PLPHQNVTNHVGKAV CCCCCCCCHHHHHHH	27.44	24732914
964	Glutathionylation	LIGTALNCVLQVPKY CHHHHHHHHHHCCCC	3.17	22555962
1017	Phosphorylation	SFDSSICSGEGDDSL ECCCHHCCCCCCCCE	37.90	28985074
1059	Ubiquitination	SKTDELIKDAPTTQH HCCHHHHHCCCCCCC	61.53	-
1059	Acetylation	SKTDELIKDAPTTQH HCCHHHHHCCCCCCC	61.53	26051181
1063	Phosphorylation	ELIKDAPTTQHDKSG HHHHCCCCCCCCCCC	40.59	23663014
1064	Phosphorylation	LIKDAPTTQHDKSGE HHHCCCCCCCCCCCC	23.89	23663014
1069	Phosphorylation	PTTQHDKSGEWQETS CCCCCCCCCCCEECC	48.26	25159151
1075	Phosphorylation	KSGEWQETSGEIQWV CCCCCEECCCEEEEE	27.25	25159151
1076	Phosphorylation	SGEWQETSGEIQWVS CCCCEECCCEEEEEE	33.41	25159151
1107	Ubiquitination	DEELDLNKALQHAGK HHHCHHHHHHHHHHH	58.74	-
1146	Phosphorylation	NVTTVREYLPEGDFS CEEEHHHHCCCCCHH	19.59	20068231
1153	Phosphorylation	YLPEGDFSIMTEMLK HCCCCCHHHHHHHHH	19.05	20068231
1156	Phosphorylation	EGDFSIMTEMLKKFL CCCHHHHHHHHHHHH	19.30	20068231
1164	Phosphorylation	EMLKKFLSFMNLTCA HHHHHHHHHCCCCCC	26.11	20860994
1169	Phosphorylation	FLSFMNLTCAVGTTG HHHHCCCCCCCCCCC	8.07	25219547
1174	Phosphorylation	NLTCAVGTTGQKSIS CCCCCCCCCCCHHHH	22.58	25219547
1175	Phosphorylation	LTCAVGTTGQKSISR CCCCCCCCCCHHHHH	31.52	25219547
1178	Ubiquitination	AVGTTGQKSISRVIE CCCCCCCHHHHHHHH	51.61	-
1263 (in isoform 3)	Ubiquitination	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WAPL_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WAPL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WAPL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDS5A_HUMAN	PDS5A	physical	20360068
RAD21_HUMAN	RAD21	physical	20360068
STAG2_HUMAN	STAG2	physical	20360068
STAG1_HUMAN	STAG1	physical	20360068
SMC1A_HUMAN	SMC1A	physical	20360068
SMC3_HUMAN	SMC3	physical	20360068
PDS5B_HUMAN	PDS5B	physical	20360068
WAPL_HUMAN	WAPAL	physical	20360068
PDS5A_HUMAN	PDS5A	physical	17113138
PDS5B_HUMAN	PDS5B	physical	17113138
SMC3_HUMAN	SMC3	physical	17113138
STAG2_HUMAN	STAG2	physical	17113138
SMC1A_HUMAN	SMC1A	physical	17113138
RAD21_HUMAN	RAD21	physical	17113138
STAG1_HUMAN	STAG1	physical	17113138
RAD21_HUMAN	RAD21	physical	26496610
RL10_HUMAN	RPL10	physical	26496610
TTC3_HUMAN	TTC3	physical	26496610
SMC1A_HUMAN	SMC1A	physical	26496610
SMC3_HUMAN	SMC3	physical	26496610
STAG1_HUMAN	STAG1	physical	26496610
STAG2_HUMAN	STAG2	physical	26496610
PDS5B_HUMAN	PDS5B	physical	26496610
ATG2A_HUMAN	ATG2A	physical	26496610
PDS5A_HUMAN	PDS5A	physical	26496610
E41LB_HUMAN	EPB41L4B	physical	26496610
REN3A_HUMAN	UPF3A	physical	26496610
ZSWM9_HUMAN	C19orf68	physical	26496610
UBP37_HUMAN	USP37	physical	26299517

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WAPL_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-168, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-221; SER-226 ANDSER-380, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-221, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-221, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-221; SER-226; SER-459AND SER-461, AND MASS SPECTROMETRY.	17081983 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-221; SER-223;SER-226; SER-380; SER-459; SER-461 AND SER-904, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77; SER-221 AND SER-226,AND MASS SPECTROMETRY.	18691976 [Abstract]
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226, AND MASSSPECTROMETRY.	18187866 [Abstract]