E41LB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E41LB_HUMAN
• UniProt AC: Q9H329
• Protein Name: Band 4.1-like protein 4B
• Gene Name: EPB41L4B
• Organism: Homo sapiens (Human).
• Sequence Length: 900
• Subcellular Localization: Cytoplasm . Cell junction, tight junction . Accumulates along apical cell-cell boundaries and is also detected in the cytoplasm in a punctate manner.
• Protein Description: Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells. [PubMed: 22006950 Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing]
• Protein Sequence: MLRFLRRTFGRRSMQRYARGAAGRGAAGLGDERDGGPRGGPAAAASSSALPAAPGGSVFPAGGGPLLTGGAAVHISAAGAAKATLYCRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPIKKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTLVVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKSNRSDFIRLGSRFRFSGRTEYQATHGSRLRRTSTFERKPSKRYPSRRHSTFKASNPVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVSYPLPSPVLSSSDRLPFGIEENGGTPFLTAASGRHHHQHQHQHQHQHHSNYSLSLTLENKEGPLRSPNSSSKSLTKLSPGTPALFSEAAAHLKKLELETVKAAGPWPPLHININKAEEKKVSEKTLQTPLLPSPVADHVKCNILKAQLENASRVNIQGGKEESPFVNINKKSSLQDASVRSPIPIRVETAQPAVEKPEIKPPRVRKLTRQYSFDEDDLPPDLAEAVGVTTSTTTNTTTAATQVSVPLPSPKVQNVSSPHKSEGKGLLSPGAKSPSDRGGAFTLEPGDLLMDFTEATPLAEPASNPHCAHSRCSPPLSLPMKEETTGVCMYPPIKTRLIKTFPVDTMNPFPDTFTTGPQFTADFRDSKLQCCPGPTSPLIPAATLRPLTETVSTVQTIYTTRKPVSLAASAETLRQELEREKMMKRLLMTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Methylation	RSMQRYARGAAGRGA HHHHHHHCCCCCCCC	26.75	-
24	Methylation	YARGAAGRGAAGLGD HHCCCCCCCCCCCCC	27.18	-
164	Phosphorylation	ALHFRVKYYSSEPNN EEEEEEEECCCCCCC	13.01	-
254	Phosphorylation	WKECRGKSPAQAELS HHHHCCCCHHHHHHH	28.43	25159151
265 (in isoform 2)	Ubiquitination	-	49.07	21890473
265 (in isoform 1)	Ubiquitination	-	49.07	21890473
265	Ubiquitination	AELSYLNKAKWLEMY HHHHHHHHHHHHHHH	49.07	21890473
272	Phosphorylation	KAKWLEMYGVDMHVV HHHHHHHHCCEEEEE	12.48	22817900
369	Phosphorylation	HAFFRLRTPGNSKSN CEEEEECCCCCCCCC	39.89	26657352
378	Phosphorylation	GNSKSNRSDFIRLGS CCCCCCHHHCEECCC	40.92	23403867
390	Phosphorylation	LGSRFRFSGRTEYQA CCCCEEECCCCEEEE	24.10	20873877
393	Phosphorylation	RFRFSGRTEYQATHG CEEECCCCEEEECCC	42.44	24719451
395	Phosphorylation	RFSGRTEYQATHGSR EECCCCEEEECCCCC	11.66	28796482
398	Phosphorylation	GRTEYQATHGSRLRR CCCEEEECCCCCCCC	15.96	27794612
401	Phosphorylation	EYQATHGSRLRRTST EEEECCCCCCCCCCC	22.12	25849741
406	Phosphorylation	HGSRLRRTSTFERKP CCCCCCCCCCCCCCC	26.19	23312004
407	Phosphorylation	GSRLRRTSTFERKPS CCCCCCCCCCCCCCC	29.32	28102081
408	Phosphorylation	SRLRRTSTFERKPSK CCCCCCCCCCCCCCC	28.98	23312004
414	Phosphorylation	STFERKPSKRYPSRR CCCCCCCCCCCCCCC	32.57	-
423	Phosphorylation	RYPSRRHSTFKASNP CCCCCCCCCCCCCCH	33.46	20873877
424	Phosphorylation	YPSRRHSTFKASNPV CCCCCCCCCCCCCHH	24.03	20873877
426	Methylation	SRRHSTFKASNPVIA CCCCCCCCCCCHHHH	51.50	-
428	Phosphorylation	RHSTFKASNPVIAAQ CCCCCCCCCHHHHHH	42.11	28985074
440	Phosphorylation	AAQLCSKTNPEVHNY HHHHHCCCCHHHHCC	39.45	21945579
447	Phosphorylation	TNPEVHNYQPQYHPN CCHHHHCCCCCCCCC	13.49	21945579
451	Phosphorylation	VHNYQPQYHPNIHPS HHCCCCCCCCCCCCC	26.40	21945579
466 (in isoform 2)	Phosphorylation	-	23.71	26657352
466	Phosphorylation	QPRWHPHSPNVSYPL CCCCCCCCCCCCCCC	23.71	22798277
472 (in isoform 2)	Phosphorylation	-	30.23	27794612
479	Phosphorylation	PLPSPVLSSSDRLPF CCCCCCCCCCCCCCC	28.20	17389395
480	Phosphorylation	LPSPVLSSSDRLPFG CCCCCCCCCCCCCCC	31.90	22798277
483 (in isoform 2)	Phosphorylation	-	46.32	24719451
485 (in isoform 2)	Phosphorylation	-	26.72	25849741
489 (in isoform 2)	Phosphorylation	-	45.87	28796482
493 (in isoform 2)	Phosphorylation	-	41.62	25884760
510 (in isoform 2)	Phosphorylation	-	25.60	-
539	Phosphorylation	PLRSPNSSSKSLTKL CCCCCCCCCCCCCCC	48.72	24719451
568	Phosphorylation	LKKLELETVKAAGPW HHHCCCEEHHHCCCC	39.67	24114839
591	Phosphorylation	KAEEKKVSEKTLQTP HHHHHCCCCCCCCCC	42.11	-
594	Phosphorylation	EKKVSEKTLQTPLLP HHCCCCCCCCCCCCC	21.75	-
597	Phosphorylation	VSEKTLQTPLLPSPV CCCCCCCCCCCCCCC	21.01	-
602	Phosphorylation	LQTPLLPSPVADHVK CCCCCCCCCCCCHHH	31.79	24076635
718	Phosphorylation	QVSVPLPSPKVQNVS EEECCCCCCCCCCCC	45.06	24719451
737	Phosphorylation	SEGKGLLSPGAKSPS CCCCCCCCCCCCCCC	26.74	25307156
794	Phosphorylation	LPMKEETTGVCMYPP CCCCCCCCCEECCCC	30.78	-
804	Phosphorylation	CMYPPIKTRLIKTFP ECCCCCCEEEEEEEC	31.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E41LB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E41LB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E41LB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LAMC3_HUMAN	LAMC3	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.