LAMC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAMC3_HUMAN
• UniProt AC: Q9Y6N6
• Protein Name: Laminin subunit gamma-3
• Gene Name: LAMC3
• Organism: Homo sapiens (Human).
• Sequence Length: 1575
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane.
• Protein Description: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components..
• Protein Sequence: MAAAALLLGLALLAPRAAGAGMGACYDGAGRPQRCLPVFENAAFGRLAQASHTCGSPPEDFCPHVGAAGAGAHCQRCDAADPQRHHNASYLTDFHSQDESTWWQSPSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGVLLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPLPPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQHGTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHHLLPGAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEARALARSHRDTATKIAATAWRALLASNTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAPYLALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMGARTLLADLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLTSQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQWALERLRLQLGSPGSLQRKLSLLEQESQQQELQIQGFESDLAEIRADKQNLEAILHSLPENCASWQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	N-linked_Glycosylation	ADPQRHHNASYLTDF CCCCCCCCCCHHCCC	25.18	UniProtKB CARBOHYD
119	N-linked_Glycosylation	VQYPTSVNITLRLGK CCCCCEEEEEEECCC	22.69	UniProtKB CARBOHYD
121	Phosphorylation	YPTSVNITLRLGKAY CCCEEEEEEECCCEE	10.71	24719451
139	Phosphorylation	YVRLKFHTSRPESFA EEEEEEECCCCCCEE	29.57	20068231
140	Phosphorylation	VRLKFHTSRPESFAI EEEEEECCCCCCEEE	36.95	20068231
144	Phosphorylation	FHTSRPESFAIYKRS EECCCCCCEEEEEEC	23.74	20068231
148	Phosphorylation	RPESFAIYKRSRADG CCCCEEEEEECCCCC	9.27	20068231
149	Ubiquitination	PESFAIYKRSRADGP CCCEEEEEECCCCCC	37.47	-
151	Phosphorylation	SFAIYKRSRADGPWE CEEEEEECCCCCCCC	27.89	-
160	Phosphorylation	ADGPWEPYQFYSASC CCCCCCCCEEEECCC	10.35	-
295	N-linked_Glycosylation	LACRCQHNTTGTDCE HHHHCCCCCCCCCHH	17.29	UniProtKB CARBOHYD
328	N-linked_Glycosylation	AHECLPCNCSGRSEE HHHHCCCCCCCCCCC	22.50	UniProtKB CARBOHYD
585	Phosphorylation	EGTGLALSLRHSSLS ECCCEEEEEHHHHCC	20.11	24719451
631	N-linked_Glycosylation	HFQRLLANLTSLRLR HHHHHHHHHHHCEEE	43.77	UniProtKB CARBOHYD
837	N-linked_Glycosylation	HCLRCLHNTTGDHCE CHHHHHCCCCCCCCH	26.79	UniProtKB CARBOHYD
980	N-linked_Glycosylation	ASAQCHENGTCVCRP CCCEECCCCCEEECC	27.66	UniProtKB CARBOHYD
1082	Phosphorylation	AFLEQMMSLEGAVKA HHHHHHHHHHHHHHH	20.23	29978859
1185	N-linked_Glycosylation	WRALLASNTSYALLW HHHHHHCCHHHHHHH	27.69	UniProtKB CARBOHYD
1278	Phosphorylation	KAKALEKTVASWQHM HHHHHHHHHHHHHHH	16.36	-
1281	Phosphorylation	ALEKTVASWQHMATE HHHHHHHHHHHHHHH	23.96	-
1287	Phosphorylation	ASWQHMATEAARTLQ HHHHHHHHHHHHHHH	20.69	-
1300	Phosphorylation	LQTAAQATLRQTEPL HHHHHHHHHHCCCCH	15.47	22210691
1351	Methylation	GMKLQFPRPKDQAAL CCCCCCCCHHHHHHH	52.79	115389629
1413	Sumoylation	KDSAKLAKALLRERK HHHHHHHHHHHHHHH	50.43	-
1413	Sumoylation	KDSAKLAKALLRERK HHHHHHHHHHHHHHH	50.43	-
1465	Phosphorylation	ERVGAGLSEMEQQIR HHHCCCHHHHHHHHH	33.70	22468782
1521	Phosphorylation	RLRLQLGSPGSLQRK HHHHHHCCCHHHHHH	34.38	30177828
1524	Phosphorylation	LQLGSPGSLQRKLSL HHHCCCHHHHHHHHH	25.39	30177828

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAMC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAMC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAMC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL35_HUMAN	RPL35	physical	21988832
S43A3_HUMAN	SLC43A3	physical	21988832
TRFE_HUMAN	TF	physical	21988832
AACT_HUMAN	SERPINA3	physical	21988832
LGMN_HUMAN	LGMN	physical	21988832
NR1H2_HUMAN	NR1H2	physical	21988832
POTE1_HUMAN	POT1	physical	21988832
PELI2_HUMAN	PELI2	physical	21988832
ZN160_HUMAN	ZNF160	physical	21988832
YTDC1_HUMAN	YTHDC1	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.