| UniProt ID | POTE1_HUMAN | |
|---|---|---|
| UniProt AC | Q9NUX5 | |
| Protein Name | Protection of telomeres protein 1 | |
| Gene Name | POT1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 634 | |
| Subcellular Localization | Nucleus . Chromosome, telomere . Colocalizes with telomeric DNA. | |
| Protein Description | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity.. | |
| Protein Sequence | MSLVPATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNVKLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLTFEGTLGAPIIPRTSSKYFNFTTEDHKMVEALRVWASTHMSPSWTLLKLCDVQPMQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLIQDLVLEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSMNSENQTMLSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTANQHSDVICQSEPDDSFPSSGSVSLYEVERCQQLSATILTDHQYLERTPLCAILKQKAPQQYRIRAKLRSYKPRRLFQSVKLHCPKCHLLQEVPHEGDLDIIFQDGATKTPDVKLQNTSLYDSKIWTTKNQKGRKVAVHFVKNNGILPLSNECLLLIEGGTLSEICKLSNKFNSVIPVRSGHEDLELLDLSAPFLIQGTIHHYGCKQCSSLRSIQNLNSLVDKTSWIPSSVAEALGIVPLQYVFVMTFTLDDGTGVLEAYLMDSDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPGIKIDAYPWLECFIKSYNVTNGTDNQICYQIFDTTVAEDVI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 193 | Phosphorylation | GTRTPFPSWRVLIQD CCCCCCCHHHHHHHH | 28.08 | 26091039 | |
| 242 | Phosphorylation | VGSFLRIYSLHTKLQ HHHHHHHHHHHHHHH | 9.95 | 24719451 | |
| 243 | Phosphorylation | GSFLRIYSLHTKLQS HHHHHHHHHHHHHHH | 16.00 | 24719451 | |
| 353 | Acetylation | TPLCAILKQKAPQQY CCHHHHHHCCCCHHH | 43.57 | 25953088 | |
| 353 | Methylation | TPLCAILKQKAPQQY CCHHHHHHCCCCHHH | 43.57 | 116253849 | |
| 355 | Ubiquitination | LCAILKQKAPQQYRI HHHHHHCCCCHHHHH | 61.52 | - | |
| 412 | Ubiquitination | ATKTPDVKLQNTSLY CCCCCCCCCCCCCCC | 52.30 | - | |
| 416 | Phosphorylation | PDVKLQNTSLYDSKI CCCCCCCCCCCCCEE | 13.72 | 29759185 | |
| 419 | Phosphorylation | KLQNTSLYDSKIWTT CCCCCCCCCCEEEEC | 20.24 | 29759185 | |
| 422 | Ubiquitination | NTSLYDSKIWTTKNQ CCCCCCCEEEECCCC | 39.09 | - | |
| 427 | Ubiquitination | DSKIWTTKNQKGRKV CCEEEECCCCCCCEE | 50.43 | - | |
| 469 | Ubiquitination | EICKLSNKFNSVIPV HHHHHHHCCCCEEEC | 42.41 | 21890473 | |
| 469 (in isoform 1) | Ubiquitination | - | 42.41 | 21890473 | |
| 469 (in isoform 2) | Ubiquitination | - | 42.41 | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of POTE1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of POTE1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of POTE1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615848 | Melanoma, cutaneous malignant 10 (CMM10) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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