DNPH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNPH1_HUMAN
• UniProt AC: O43598
• Protein Name: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 {ECO:0000255|HAMAP-Rule:MF_03036}
• Gene Name: DNPH1 {ECO:0000255|HAMAP-Rule:MF_03036}
• Organism: Homo sapiens (Human).
• Sequence Length: 174
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases..
• Protein Sequence: MAAAMVPGRSESWERGEPGRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQPSLGVGYELGRAVAFNKRILCLFRPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADPPGQVAASPDPTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAMVPGR ------CCCCCCCCC		22223895
10	Phosphorylation	AAMVPGRSESWERGE CCCCCCCCCCCCCCC		23927012
12	Phosphorylation	MVPGRSESWERGEPG CCCCCCCCCCCCCCC		28355574
24	Phosphorylation	EPGRPALYFCGSIRG CCCCEEEEECCCCCC		20068231
28	Phosphorylation	PALYFCGSIRGGRED EEEEECCCCCCCCCC		22617229
30	Methylation	LYFCGSIRGGREDRT EEECCCCCCCCCCHH		-
36	Methylation	IRGGREDRTLYERIV CCCCCCCHHHHHHHH		-
41	Methylation	EDRTLYERIVSRLRR CCHHHHHHHHHHHHH		-
48	Methylation	RIVSRLRRFGTVLTE HHHHHHHHHHHHHHH		-
65	Methylation	AAAELGARGEEAAGG HHHHHHHCCCHHCCC		-
95	Phosphorylation	DVVVAEVTQPSLGVG CEEEEECCCCCCCCC		24275569
98	Phosphorylation	VAEVTQPSLGVGYEL EEECCCCCCCCCHHH		24275569
113	Acetylation	GRAVAFNKRILCLFR HHHHHCCCEEEEEEC		25953088
113	2-Hydroxyisobutyrylation	GRAVAFNKRILCLFR HHHHHCCCEEEEEEC		-
113	Ubiquitination	GRAVAFNKRILCLFR HHHHHCCCEEEEEEC		24816145
117	S-palmitoylation	AFNKRILCLFRPQSG HCCCEEEEEECCCCC		29575903
123	Phosphorylation	LCLFRPQSGRVLSAM EEEECCCCCCCHHHH		22617229
128	Phosphorylation	PQSGRVLSAMIRGAA CCCCCCHHHHHHCCC		22617229
132	Methylation	RVLSAMIRGAADGSR CCHHHHHHCCCCCCC		-
138	Phosphorylation	IRGAADGSRFQVWDY HHCCCCCCCEEEEEC		28857561
145	Phosphorylation	SRFQVWDYEEGEVEA CCEEEEECCCCHHHH		28857561
157	Phosphorylation	VEALLDRYFEADPPG HHHHHHHHCCCCCCC		23403867
169	Phosphorylation	PPGQVAASPDPTT-- CCCCCCCCCCCCC--		25159151
173	Phosphorylation	VAASPDPTT------ CCCCCCCCC------		25159151
174	Phosphorylation	AASPDPTT------- CCCCCCCC-------		25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNPH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNPH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNPH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNPH1_HUMAN	DNPH1	physical	16189514
SSU72_HUMAN	SSU72	physical	22939629
UBR1_HUMAN	UBR1	physical	22939629
ZN593_HUMAN	ZNF593	physical	22939629
UBA1_HUMAN	UBA1	physical	22939629
PILRA_HUMAN	PILRA	physical	21988832
DNPH1_HUMAN	DNPH1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.