ZN593_HUMAN - dbPTM
ZN593_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ZN593_HUMAN
UniProt AC O00488
Protein Name Zinc finger protein 593
Gene Name ZNF593
Organism Homo sapiens (Human).
Sequence Length 134
Subcellular Localization Nucleus, nucleolus .
Protein Description Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins..
Protein Sequence MGRSRRTGAHRAHSLARQMKAKRRRPDLDEIHRELRPQGSARPQPDPNAEFDPDLPGGGLHRCLACARYFIDSTNLKTHFRSKDHKKRLKQLSVEPYSQEEAERAAGMGSYVPPRRLAVPTEVSTEVPEMDTST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationRELRPQGSARPQPDP
HHHCCCCCCCCCCCC
18.8328555341
73PhosphorylationCARYFIDSTNLKTHF
HHHHHHHCCCHHHHC
17.8729214152
90UbiquitinationKDHKKRLKQLSVEPY
HHHHHHHHHCCCCCC
53.912190698
97PhosphorylationKQLSVEPYSQEEAER
HHCCCCCCCHHHHHH
14.9623663014
98PhosphorylationQLSVEPYSQEEAERA
HCCCCCCCHHHHHHH
41.6623663014
114PhosphorylationGMGSYVPPRRLAVPT
CCCCCCCHHHCCCCC
24.7918669648
115PhosphorylationMGSYVPPRRLAVPTE
CCCCCCHHHCCCCCE
39.9318669648
116PhosphorylationGSYVPPRRLAVPTEV
CCCCCHHHCCCCCEE
32.5418669648
121PhosphorylationPRRLAVPTEVSTEVP
HHHCCCCCEECCCCC
42.2824732914
124PhosphorylationLAVPTEVSTEVPEMD
CCCCCEECCCCCCCC
16.7824732914
125PhosphorylationAVPTEVSTEVPEMDT
CCCCEECCCCCCCCC
46.2924732914
132PhosphorylationTEVPEMDTST-----
CCCCCCCCCC-----
32.7130278072
133PhosphorylationEVPEMDTST------
CCCCCCCCC------
28.0530278072
134PhosphorylationVPEMDTST-------
CCCCCCCC-------
44.7330278072

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ZN593_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ZN593_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ZN593_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LNX1_HUMANLNX1physical
25416956

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ZN593_HUMAN

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Related Literatures of Post-Translational Modification

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