SSU72_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSU72_HUMAN
• UniProt AC: Q9NP77
• Protein Name: RNA polymerase II subunit A C-terminal domain phosphatase SSU72
• Gene Name: SSU72
• Organism: Homo sapiens (Human).
• Sequence Length: 194
• Subcellular Localization: Nucleus. Cytoplasm. Predominantly in the cytosol.
• Protein Description: Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK..
• Protein Sequence: MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSSPLRVAV -----CCCCCCEEEE	43.20	30266825
4	Phosphorylation	----MPSSPLRVAVV ----CCCCCCEEEEE	23.29	30266825
13	Phosphorylation	LRVAVVCSSNQNRSM CEEEEEECCCCCHHH	22.25	28102081
14	Phosphorylation	RVAVVCSSNQNRSME EEEEEECCCCCHHHH	36.99	30631047
19	Phosphorylation	CSSNQNRSMEAHNIL ECCCCCHHHHHHHHH	28.64	28857561
27	Phosphorylation	MEAHNILSKRGFSVR HHHHHHHHHCCCEEE	19.26	22210691
28 (in isoform 1)	Ubiquitination	-	53.76	21890473
28 (in isoform 2)	Ubiquitination	-	53.76	21890473
28	Ubiquitination	EAHNILSKRGFSVRS HHHHHHHHCCCEEEE	53.76	22817900
35	Phosphorylation	KRGFSVRSFGTGTHV HCCCEEEEECCCCEE	26.35	20068231
38	Phosphorylation	FSVRSFGTGTHVKLP CEEEEECCCCEEECC	36.58	20068231
40	Phosphorylation	VRSFGTGTHVKLPGP EEEECCCCEEECCCC	24.27	20068231
43 (in isoform 2)	Ubiquitination	-	41.16	21890473
43	Ubiquitination	FGTGTHVKLPGPAPD ECCCCEEECCCCCCC	41.16	21890473
43 (in isoform 1)	Ubiquitination	-	41.16	21890473
43	Acetylation	FGTGTHVKLPGPAPD ECCCCEEECCCCCCC	41.16	25953088
51	Ubiquitination	LPGPAPDKPNVYDFK CCCCCCCCCCEEEHH	37.12	21906983
51	Acetylation	LPGPAPDKPNVYDFK CCCCCCCCCCEEEHH	37.12	26051181
51 (in isoform 2)	Ubiquitination	-	37.12	21890473
51 (in isoform 1)	Ubiquitination	-	37.12	21890473
55	Phosphorylation	APDKPNVYDFKTTYD CCCCCCEEEHHHCHH	23.46	27642862
58 (in isoform 1)	Ubiquitination	-	36.74	21890473
58 (in isoform 2)	Ubiquitination	-	36.74	21890473
58	Ubiquitination	KPNVYDFKTTYDQMY CCCEEEHHHCHHHHH	36.74	21906983
61	Phosphorylation	VYDFKTTYDQMYNDL EEEHHHCHHHHHHHH	14.92	27642862
65	Phosphorylation	KTTYDQMYNDLLRKD HHCHHHHHHHHHHHC	10.41	27642862
71	Ubiquitination	MYNDLLRKDKELYTQ HHHHHHHHCHHHHHH	73.46	23000965
73 (in isoform 1)	Ubiquitination	-	53.29	21890473
73	Ubiquitination	NDLLRKDKELYTQNG HHHHHHCHHHHHHCC	53.29	23000965
102	Ubiquitination	PERFQNCKDLFDLIL HHHHHCHHHHHHHHH	66.08	33845483
116	Phosphorylation	LTCEERVYDQVVEDL HHHHHHHHHHHHHHH	13.59	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
3	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
4	S	Phosphorylation	Kinase	AURB	Q96GD4	PSP
19	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSU72_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSU72_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD21_HUMAN	RAD21	physical	20818333
STAG2_HUMAN	STAG2	physical	20818333
SMC1A_HUMAN	SMC1A	physical	20818333
SMC3_HUMAN	SMC3	physical	20818333
THIC_HUMAN	ACAT2	physical	22939629
STXB2_HUMAN	STXBP2	physical	22939629
VINC_HUMAN	VCL	physical	22939629
XPO1_HUMAN	XPO1	physical	22939629
TEBP_HUMAN	PTGES3	physical	22939629
THOP1_HUMAN	THOP1	physical	22939629
UBE2H_HUMAN	UBE2H	physical	22939629
TIPRL_HUMAN	TIPRL	physical	22939629
TPIS_HUMAN	TPI1	physical	22939629
RPB1_YEAST	RPO21	physical	24413056
RPB1_HUMAN	POLR2A	physical	20861839
CPSF1_HUMAN	CPSF1	physical	27880917
CPSF2_HUMAN	CPSF2	physical	27880917
CPSF3_HUMAN	CPSF3	physical	27880917
CSTF2_HUMAN	CSTF2	physical	27880917
CSTF3_HUMAN	CSTF3	physical	27880917
HNRPL_HUMAN	HNRNPL	physical	27880917
SYMPK_HUMAN	SYMPK	physical	27880917
CARF_HUMAN	CDKN2AIP	physical	27880917
ZN638_HUMAN	ZNF638	physical	27880917
NCOA5_HUMAN	NCOA5	physical	27880917
PCF11_HUMAN	PCF11	physical	27880917
ELP5_HUMAN	ELP5	physical	27880917

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.