CARF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CARF_HUMAN
• UniProt AC: Q9NXV6
• Protein Name: CDKN2A-interacting protein
• Gene Name: CDKN2AIP
• Organism: Homo sapiens (Human).
• Sequence Length: 580
• Subcellular Localization: Nucleus, nucleoplasm .
• Protein Description: Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence..
• Protein Sequence: MAQEVSEYLSQNPRVAAWVEALRCDGETDKHWRHRRDFLLRNAGDLAPAGGAASASTDEAADAESGTRNRQLQQLISFSMAWANHVFLGCRYPQKVMDKILSMAEGIKVTDAPTYTTRDELVAKVKKRGISSSNEGVEEPSKKRVIEGKNSSAVEQDHAKTSAKTERASAQQENSSTCIGSAIKSESGNSARSSGISSQNSSTSDGDRSVSSQSSSSVSSQVTTAGSGKASEAEAPDKHGSASFVSLLKSSVNSHMTQSTDSRQQSGSPKKSALEGSSASASQSSSEIEVPLLGSSGSSEVELPLLSSKPSSETASSGLTSKTSSEASVSSSVAKNSSSSGTSLLTPKSSSSTNTSLLTSKSTSQVAASLLASKSSSQTSGSLVSKSTSLASVSQLASKSSSQTSTSQLPSKSTSQSSESSVKFSCKLTNEDVKQKQPFFNRLYKTVAWKLVAVGGFSPNVNHGELLNAAIEALKATLDVFFVPLKELADLPQNKSSQESIVCELRCKSVYLGTGCGKSKENAKAVASREALKLFLKKKVVVKICKRKYRGSEIEDLVLLDEESRPVNLPPALKHPQELL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQEVSEYL ------CHHHHHHHH	17.78	22814378
6	Phosphorylation	--MAQEVSEYLSQNP --CHHHHHHHHHCCH	21.55	25850435
8	Phosphorylation	MAQEVSEYLSQNPRV CHHHHHHHHHCCHHH	12.26	25850435
10	Phosphorylation	QEVSEYLSQNPRVAA HHHHHHHHCCHHHHH	27.32	25850435
54	Phosphorylation	APAGGAASASTDEAA CCCCCCCCCCHHHHH	23.40	21712546
77	Phosphorylation	RQLQQLISFSMAWAN HHHHHHHHHHHHHHH	21.62	24043423
79	Phosphorylation	LQQLISFSMAWANHV HHHHHHHHHHHHHCH	10.78	24043423
95	Ubiquitination	LGCRYPQKVMDKILS HCCCCCHHHHHHHHH	34.71	-
99	Ubiquitination	YPQKVMDKILSMAEG CCHHHHHHHHHHHCC	27.70	21890473
110	Phosphorylation	MAEGIKVTDAPTYTT HHCCCCCCCCCCCCC	22.80	29978859
114	Phosphorylation	IKVTDAPTYTTRDEL CCCCCCCCCCCHHHH	34.91	29978859
115	Phosphorylation	KVTDAPTYTTRDELV CCCCCCCCCCHHHHH	12.68	20068231
116	Phosphorylation	VTDAPTYTTRDELVA CCCCCCCCCHHHHHH	20.17	20068231
117	Phosphorylation	TDAPTYTTRDELVAK CCCCCCCCHHHHHHH	26.21	29978859
124	Acetylation	TRDELVAKVKKRGIS CHHHHHHHHHHCCCC	47.29	25953088
131	Phosphorylation	KVKKRGISSSNEGVE HHHHCCCCCCCCCCC	30.45	25463755
132	Phosphorylation	VKKRGISSSNEGVEE HHHCCCCCCCCCCCC	34.95	25159151
133	Phosphorylation	KKRGISSSNEGVEEP HHCCCCCCCCCCCCC	31.91	25159151
141	Phosphorylation	NEGVEEPSKKRVIEG CCCCCCCHHHCEECC	54.83	26552605
142	Acetylation	EGVEEPSKKRVIEGK CCCCCCHHHCEECCC	56.14	26051181
149	Acetylation	KKRVIEGKNSSAVEQ HHCEECCCCCHHHHH	40.65	26051181
151	Phosphorylation	RVIEGKNSSAVEQDH CEECCCCCHHHHHHH	24.14	23401153
152	Phosphorylation	VIEGKNSSAVEQDHA EECCCCCHHHHHHHH	45.81	28450419
160	2-Hydroxyisobutyrylation	AVEQDHAKTSAKTER HHHHHHHHHHHHHHH	39.32	-
169	Phosphorylation	SAKTERASAQQENSS HHHHHHHHHHHHCCC	32.60	28555341
175	Phosphorylation	ASAQQENSSTCIGSA HHHHHHCCCCCHHHH	26.69	28555341
176	Phosphorylation	SAQQENSSTCIGSAI HHHHHCCCCCHHHHH	38.59	27251275
177	Phosphorylation	AQQENSSTCIGSAIK HHHHCCCCCHHHHHH	14.15	27251275
181	Phosphorylation	NSSTCIGSAIKSESG CCCCCHHHHHHCCCC	13.60	25159151
184	Acetylation	TCIGSAIKSESGNSA CCHHHHHHCCCCCCC	48.14	25953088
184	Sumoylation	TCIGSAIKSESGNSA CCHHHHHHCCCCCCC	48.14	25114211
190	Phosphorylation	IKSESGNSARSSGIS HHCCCCCCCCCCCCC	28.69	30576142
193	Phosphorylation	ESGNSARSSGISSQN CCCCCCCCCCCCCCC	32.41	27251275
194	Phosphorylation	SGNSARSSGISSQNS CCCCCCCCCCCCCCC	34.29	28450419
197	Phosphorylation	SARSSGISSQNSSTS CCCCCCCCCCCCCCC	29.42	28450419
198	Phosphorylation	ARSSGISSQNSSTSD CCCCCCCCCCCCCCC	31.31	30576142
201	Phosphorylation	SGISSQNSSTSDGDR CCCCCCCCCCCCCCC	27.62	28450419
202	Phosphorylation	GISSQNSSTSDGDRS CCCCCCCCCCCCCCC	39.21	28450419
203	Phosphorylation	ISSQNSSTSDGDRSV CCCCCCCCCCCCCCC	30.56	30576142
204	Phosphorylation	SSQNSSTSDGDRSVS CCCCCCCCCCCCCCC	41.36	28450419
209	Phosphorylation	STSDGDRSVSSQSSS CCCCCCCCCCCCCCC	30.96	28450419
211	Phosphorylation	SDGDRSVSSQSSSSV CCCCCCCCCCCCCCC	24.73	29116813
212	Phosphorylation	DGDRSVSSQSSSSVS CCCCCCCCCCCCCCC	31.74	22817901
214	Phosphorylation	DRSVSSQSSSSVSSQ CCCCCCCCCCCCCCC	33.85	29214152
215	Phosphorylation	RSVSSQSSSSVSSQV CCCCCCCCCCCCCCE	20.99	26471730
216	Phosphorylation	SVSSQSSSSVSSQVT CCCCCCCCCCCCCEE	39.75	28555341
217	Phosphorylation	VSSQSSSSVSSQVTT CCCCCCCCCCCCEEE	28.15	26471730
219	Phosphorylation	SQSSSSVSSQVTTAG CCCCCCCCCCEEECC	19.59	29214152
220	Phosphorylation	QSSSSVSSQVTTAGS CCCCCCCCCEEECCC	26.89	18077418
223	Phosphorylation	SSVSSQVTTAGSGKA CCCCCCEEECCCCCC	11.86	26471730
224	Phosphorylation	SVSSQVTTAGSGKAS CCCCCEEECCCCCCC	30.11	26471730
227	Phosphorylation	SQVTTAGSGKASEAE CCEEECCCCCCCCCC	34.36	26471730
238	Acetylation	SEAEAPDKHGSASFV CCCCCCCCCCCHHHH	49.13	26051181
241	Phosphorylation	EAPDKHGSASFVSLL CCCCCCCCHHHHHHH	22.06	29214152
243	Phosphorylation	PDKHGSASFVSLLKS CCCCCCHHHHHHHHH	28.07	27251275
246	Phosphorylation	HGSASFVSLLKSSVN CCCHHHHHHHHHHHH	26.44	24719451
250	Phosphorylation	SFVSLLKSSVNSHMT HHHHHHHHHHHHHCC	39.22	26074081
251	Phosphorylation	FVSLLKSSVNSHMTQ HHHHHHHHHHHHCCC	24.59	26074081
254	Phosphorylation	LLKSSVNSHMTQSTD HHHHHHHHHCCCCCC	16.69	26074081
257	Phosphorylation	SSVNSHMTQSTDSRQ HHHHHHCCCCCCCCC	17.59	29514088
259	Phosphorylation	VNSHMTQSTDSRQQS HHHHCCCCCCCCCCC	25.64	26074081
260	Phosphorylation	NSHMTQSTDSRQQSG HHHCCCCCCCCCCCC	28.33	26074081
262	Phosphorylation	HMTQSTDSRQQSGSP HCCCCCCCCCCCCCC	31.88	25159151
266	Phosphorylation	STDSRQQSGSPKKSA CCCCCCCCCCCCHHH	32.66	25159151
268	Phosphorylation	DSRQQSGSPKKSALE CCCCCCCCCCHHHHC	38.50	25159151
277	O-linked_Glycosylation	KKSALEGSSASASQS CHHHHCCCCCCCCCC	17.23	30059200
295	Phosphorylation	IEVPLLGSSGSSEVE EEEEECCCCCCCCEE	31.34	27251275
296	Phosphorylation	EVPLLGSSGSSEVEL EEEECCCCCCCCEEE	40.68	27251275
298	Phosphorylation	PLLGSSGSSEVELPL EECCCCCCCCEEEEE	25.85	27251275
299	Phosphorylation	LLGSSGSSEVELPLL ECCCCCCCCEEEEEC	49.54	27251275
308	O-linked_Glycosylation	VELPLLSSKPSSETA EEEEECCCCCCCCCC	48.86	30059200
312	O-linked_Glycosylation	LLSSKPSSETASSGL ECCCCCCCCCCCCCC	47.71	30059200
314	Phosphorylation	SSKPSSETASSGLTS CCCCCCCCCCCCCCC	33.51	30576142
316	Phosphorylation	KPSSETASSGLTSKT CCCCCCCCCCCCCCC	32.15	22468782
323	O-linked_Glycosylation	SSGLTSKTSSEASVS CCCCCCCCCCCCCCC	36.93	30059200
323	O-linked_Glycosylation	SSGLTSKTSSEASVS CCCCCCCCCCCCCCC	36.93	20068230
323	Phosphorylation	SSGLTSKTSSEASVS CCCCCCCCCCCCCCC	36.93	25278378
324	O-linked_Glycosylation	SGLTSKTSSEASVSS CCCCCCCCCCCCCCC	29.89	30059200
324	Phosphorylation	SGLTSKTSSEASVSS CCCCCCCCCCCCCCC	29.89	25278378
325	Phosphorylation	GLTSKTSSEASVSSS CCCCCCCCCCCCCCH	42.27	30576142
328	O-linked_Glycosylation	SKTSSEASVSSSVAK CCCCCCCCCCCHHHC	20.62	30059200
330	O-linked_Glycosylation	TSSEASVSSSVAKNS CCCCCCCCCHHHCCC	17.88	30059200
331	Phosphorylation	SSEASVSSSVAKNSS CCCCCCCCHHHCCCC	27.03	30576142
332	O-linked_Glycosylation	SEASVSSSVAKNSSS CCCCCCCHHHCCCCC	20.70	30059200
332	Phosphorylation	SEASVSSSVAKNSSS CCCCCCCHHHCCCCC	20.70	25627689
337	Phosphorylation	SSSVAKNSSSSGTSL CCHHHCCCCCCCCCC	30.78	29396449
338	Phosphorylation	SSVAKNSSSSGTSLL CHHHCCCCCCCCCCC	37.61	25278378
339	Phosphorylation	SVAKNSSSSGTSLLT HHHCCCCCCCCCCCC	32.38	20068231
340	Phosphorylation	VAKNSSSSGTSLLTP HHCCCCCCCCCCCCC	48.30	20068231
342	Phosphorylation	KNSSSSGTSLLTPKS CCCCCCCCCCCCCCC	20.39	20068231
343	Phosphorylation	NSSSSGTSLLTPKSS CCCCCCCCCCCCCCC	25.55	20068231
346	O-linked_Glycosylation	SSGTSLLTPKSSSST CCCCCCCCCCCCCCC	33.68	30059200
346	Phosphorylation	SSGTSLLTPKSSSST CCCCCCCCCCCCCCC	33.68	25159151
349	O-linked_Glycosylation	TSLLTPKSSSSTNTS CCCCCCCCCCCCCCC	36.33	30059200
349	O-linked_Glycosylation	TSLLTPKSSSSTNTS CCCCCCCCCCCCCCC	36.33	20068230
349	Phosphorylation	TSLLTPKSSSSTNTS CCCCCCCCCCCCCCC	36.33	-
350	O-linked_Glycosylation	SLLTPKSSSSTNTSL CCCCCCCCCCCCCCC	34.14	30059200
351	O-linked_Glycosylation	LLTPKSSSSTNTSLL CCCCCCCCCCCCCCC	48.55	30059200
351	Phosphorylation	LLTPKSSSSTNTSLL CCCCCCCCCCCCCCC	48.55	-
352	O-linked_Glycosylation	LTPKSSSSTNTSLLT CCCCCCCCCCCCCCC	27.85	30059200
352	Phosphorylation	LTPKSSSSTNTSLLT CCCCCCCCCCCCCCC	27.85	28555341
353	O-linked_Glycosylation	TPKSSSSTNTSLLTS CCCCCCCCCCCCCCC	44.45	30059200
355	Phosphorylation	KSSSSTNTSLLTSKS CCCCCCCCCCCCCCC	22.35	21712546
356	O-linked_Glycosylation	SSSSTNTSLLTSKST CCCCCCCCCCCCCCH	24.37	30059200
356	Phosphorylation	SSSSTNTSLLTSKST CCCCCCCCCCCCCCH	24.37	25159151
359	O-linked_Glycosylation	STNTSLLTSKSTSQV CCCCCCCCCCCHHHH	39.13	30059200
359	Phosphorylation	STNTSLLTSKSTSQV CCCCCCCCCCCHHHH	39.13	-
360	O-linked_Glycosylation	TNTSLLTSKSTSQVA CCCCCCCCCCHHHHH	25.28	30059200
360	Phosphorylation	TNTSLLTSKSTSQVA CCCCCCCCCCHHHHH	25.28	-
362	Phosphorylation	TSLLTSKSTSQVAAS CCCCCCCCHHHHHHH	32.81	20068231
363	Phosphorylation	SLLTSKSTSQVAASL CCCCCCCHHHHHHHH	27.24	29978859
364	Phosphorylation	LLTSKSTSQVAASLL CCCCCCHHHHHHHHH	29.73	29978859
369	O-linked_Glycosylation	STSQVAASLLASKSS CHHHHHHHHHHHCCC	17.74	30059200
369	Phosphorylation	STSQVAASLLASKSS CHHHHHHHHHHHCCC	17.74	20068231
373	O-linked_Glycosylation	VAASLLASKSSSQTS HHHHHHHHCCCCCCC	32.80	30059200
373	Phosphorylation	VAASLLASKSSSQTS HHHHHHHHCCCCCCC	32.80	20068231
375	O-linked_Glycosylation	ASLLASKSSSQTSGS HHHHHHCCCCCCCCC	32.50	30059200
375	Phosphorylation	ASLLASKSSSQTSGS HHHHHHCCCCCCCCC	32.50	20068231
376	Phosphorylation	SLLASKSSSQTSGSL HHHHHCCCCCCCCCC	30.15	20068231
377	Phosphorylation	LLASKSSSQTSGSLV HHHHCCCCCCCCCCC	44.56	22199227
379	O-linked_Glycosylation	ASKSSSQTSGSLVSK HHCCCCCCCCCCCCH	36.68	30059200
379	O-linked_Glycosylation	ASKSSSQTSGSLVSK HHCCCCCCCCCCCCH	36.68	20068230
379	Phosphorylation	ASKSSSQTSGSLVSK HHCCCCCCCCCCCCH	36.68	22199227
380	Phosphorylation	SKSSSQTSGSLVSKS HCCCCCCCCCCCCHH	20.81	22199227
382	Phosphorylation	SSSQTSGSLVSKSTS CCCCCCCCCCCHHHC	25.93	25262027
385	O-linked_Glycosylation	QTSGSLVSKSTSLAS CCCCCCCCHHHCHHH	26.61	30059200
385	Phosphorylation	QTSGSLVSKSTSLAS CCCCCCCCHHHCHHH	26.61	-
387	O-linked_Glycosylation	SGSLVSKSTSLASVS CCCCCCHHHCHHHHH	18.74	30059200
387	Phosphorylation	SGSLVSKSTSLASVS CCCCCCHHHCHHHHH	18.74	23186163
388	O-linked_Glycosylation	GSLVSKSTSLASVSQ CCCCCHHHCHHHHHH	31.34	30059200
388	Phosphorylation	GSLVSKSTSLASVSQ CCCCCHHHCHHHHHH	31.34	23186163
389	Phosphorylation	SLVSKSTSLASVSQL CCCCHHHCHHHHHHH	29.09	20068231
392	Phosphorylation	SKSTSLASVSQLASK CHHHCHHHHHHHHHC	27.82	27134283
394	Phosphorylation	STSLASVSQLASKSS HHCHHHHHHHHHCCC	19.58	28555341
398	O-linked_Glycosylation	ASVSQLASKSSSQTS HHHHHHHHCCCCCCC	41.48	30059200
398	Phosphorylation	ASVSQLASKSSSQTS HHHHHHHHCCCCCCC	41.48	20068231
399	Acetylation	SVSQLASKSSSQTST HHHHHHHCCCCCCCC	49.07	30583995
400	Phosphorylation	VSQLASKSSSQTSTS HHHHHHCCCCCCCCC	32.50	27282143
401	Phosphorylation	SQLASKSSSQTSTSQ HHHHHCCCCCCCCCC	30.15	27282143
402	Phosphorylation	QLASKSSSQTSTSQL HHHHCCCCCCCCCCC	44.56	25159151
404	Phosphorylation	ASKSSSQTSTSQLPS HHCCCCCCCCCCCCC	35.60	27282143
406	Phosphorylation	KSSSQTSTSQLPSKS CCCCCCCCCCCCCCC	24.71	21712546
407	Phosphorylation	SSSQTSTSQLPSKST CCCCCCCCCCCCCCC	29.50	27282143
411	O-linked_Glycosylation	TSTSQLPSKSTSQSS CCCCCCCCCCCCCCC	48.07	30059200
411	Phosphorylation	TSTSQLPSKSTSQSS CCCCCCCCCCCCCCC	48.07	24719451
412	Ubiquitination	STSQLPSKSTSQSSE CCCCCCCCCCCCCCH	56.67	-
420	Phosphorylation	STSQSSESSVKFSCK CCCCCCHHHEEEEEE	42.24	-
421	Phosphorylation	TSQSSESSVKFSCKL CCCCCHHHEEEEEEC	25.85	-
423	Acetylation	QSSESSVKFSCKLTN CCCHHHEEEEEECCC	33.24	26051181
423	Ubiquitination	QSSESSVKFSCKLTN CCCHHHEEEEEECCC	33.24	-
427	Ubiquitination	SSVKFSCKLTNEDVK HHEEEEEECCCHHHH	58.09	-
436	Ubiquitination	TNEDVKQKQPFFNRL CCHHHHHHCHHHHHH	54.97	-
444	Phosphorylation	QPFFNRLYKTVAWKL CHHHHHHHHHHHHHH	11.02	-
458	Phosphorylation	LVAVGGFSPNVNHGE HHEECCCCCCCCHHH	20.88	-
486	Ubiquitination	DVFFVPLKELADLPQ EEEEEEHHHHHCCCC	44.61	-
495	Ubiquitination	LADLPQNKSSQESIV HHCCCCCCCCCCCEE	46.35	-
508	Ubiquitination	IVCELRCKSVYLGTG EEEEEECCEEEECCC	36.20	-
518	Ubiquitination	YLGTGCGKSKENAKA EECCCCCCCHHHHHH	63.53	-
524	Ubiquitination	GKSKENAKAVASREA CCCHHHHHHHHCHHH	55.78	-
533	Acetylation	VASREALKLFLKKKV HHCHHHHHHHHHCHH	44.21	25953088
564	Phosphorylation	LVLLDEESRPVNLPP EEEECCCCCCCCCCH	39.58	20886841
574	Ubiquitination	VNLPPALKHPQELL- CCCCHHHCCHHHHC-	56.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CARF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CARF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CARF_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MDM2_HUMAN	MDM2	physical	18292944
CDN2A_HUMAN	CDKN2A	physical	17460193
ARF_HUMAN	CDKN2A	physical	17460193
MDM2_HUMAN	MDM2	physical	17460193
HYEP_HUMAN	EPHX1	physical	22939629
GGH_HUMAN	GGH	physical	22939629
ADDA_HUMAN	ADD1	physical	26496610
BUB1_HUMAN	BUB1	physical	26496610
CO1A2_HUMAN	COL1A2	physical	26496610
ZEP1_HUMAN	HIVEP1	physical	26496610
HNRPU_HUMAN	HNRNPU	physical	26496610
CH60_HUMAN	HSPD1	physical	26496610
IMA5_HUMAN	KPNA1	physical	26496610
PAK2_HUMAN	PAK2	physical	26496610
RPB9_HUMAN	POLR2I	physical	26496610
PTPRF_HUMAN	PTPRF	physical	26496610
S12A2_HUMAN	SLC12A2	physical	26496610
IFT88_HUMAN	IFT88	physical	26496610
ARPC4_HUMAN	ARPC4	physical	26496610
TMEDA_HUMAN	TMED10	physical	26496610
TRIM1_HUMAN	MID2	physical	26496610
XRN2_HUMAN	XRN2	physical	26496610
DIEXF_HUMAN	DIEXF	physical	26496610
PCF11_HUMAN	PCF11	physical	26496610
RT33_HUMAN	MRPS33	physical	26496610
FANCM_HUMAN	FANCM	physical	26496610
CHAC2_HUMAN	CHAC2	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-131, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-346, AND MASSSPECTROMETRY.
PubMed: 18669648

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-346, AND MASSSPECTROMETRY.
PubMed: 16964243