HYEP_HUMAN - dbPTM
HYEP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HYEP_HUMAN
UniProt AC P07099
Protein Name Epoxide hydrolase 1
Gene Name EPHX1
Organism Homo sapiens (Human).
Sequence Length 455
Subcellular Localization Microsome membrane
Single-pass type III membrane protein . Endoplasmic reticulum membrane
Single-pass type III membrane protein .
Protein Description Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. [PubMed: 22798687]
Protein Sequence MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
47PhosphorylationSAAREDDSIRPFKVE
HCCCCCCCCCCEECC		32.5828857561
52UbiquitinationDDSIRPFKVETSDEE
CCCCCCEECCCCHHH		41.6721890473
52UbiquitinationDDSIRPFKVETSDEE
CCCCCCEECCCCHHH		41.6721890473
55PhosphorylationIRPFKVETSDEEIHD
CCCEECCCCHHHHHH		44.4525072903
56PhosphorylationRPFKVETSDEEIHDL
CCEECCCCHHHHHHH		29.5325072903
912-HydroxyisobutyrylationGFNSNYLKKVISYWR
CCCHHHHHHHHHHHH		34.33-
91UbiquitinationGFNSNYLKKVISYWR
CCCHHHHHHHHHHHH		34.33-
922-HydroxyisobutyrylationFNSNYLKKVISYWRN
CCHHHHHHHHHHHHH		42.05-
92UbiquitinationFNSNYLKKVISYWRN
CCHHHHHHHHHHHHH		42.05-
95PhosphorylationNYLKKVISYWRNEFD
HHHHHHHHHHHHCCC		22.9426437602
1042-HydroxyisobutyrylationWRNEFDWKKQVEILN
HHHCCCHHHHHHHHH		34.86-
105UbiquitinationRNEFDWKKQVEILNR
HHCCCHHHHHHHHHC		56.15-
117MethylationLNRYPHFKTKIEGLD
HHCCCCHHHEECCEE		45.96-
119MethylationRYPHFKTKIEGLDIH
CCCCHHHEECCEEEE		39.07-
131AcetylationDIHFIHVKPPQLPAG
EEEEEEECCCCCCCC		36.5020167786
165PhosphorylationYKIIPLLTDPKNHGL
HHHHHHHCCCCCCCC		58.9224719451
168UbiquitinationIPLLTDPKNHGLSDE
HHHHCCCCCCCCCCC		65.47-
1682-HydroxyisobutyrylationIPLLTDPKNHGLSDE
HHHHCCCCCCCCCCC		65.47-
173PhosphorylationDPKNHGLSDEHVFEV
CCCCCCCCCCCEEEE		45.6124275569
196UbiquitinationGFSEASSKKGFNSVA
CCCHHHCCCCCCHHH		55.19-
197UbiquitinationFSEASSKKGFNSVAT
CCHHHCCCCCCHHHH		71.35-
204PhosphorylationKGFNSVATARIFYKL
CCCCHHHHHHHHHHH		17.82-
210AcetylationATARIFYKLMLRLGF
HHHHHHHHHHHHHCC		19.3725825284
283PhosphorylationERDVELLYPVKEKVF
HHHHHHHHCHHHHHH		20.7128152594
286UbiquitinationVELLYPVKEKVFYSL
HHHHHCHHHHHHHHH		47.5221906983
2862-HydroxyisobutyrylationVELLYPVKEKVFYSL
HHHHHCHHHHHHHHH		47.52-
288UbiquitinationLLYPVKEKVFYSLMR
HHHCHHHHHHHHHHH		31.74-
288UbiquitinationLLYPVKEKVFYSLMR
HHHCHHHHHHHHHHH		31.74-
291PhosphorylationPVKEKVFYSLMRESG
CHHHHHHHHHHHHHC		12.1321253578
292PhosphorylationVKEKVFYSLMRESGY
HHHHHHHHHHHHHCC		12.2924275569
295MethylationKVFYSLMRESGYMHI
HHHHHHHHHHCCEEE		39.98-
297PhosphorylationFYSLMRESGYMHIQC
HHHHHHHHCCEEEEE		25.51-
299PhosphorylationSLMRESGYMHIQCTK
HHHHHHCCEEEEECC		8.52-
339PhosphorylationWTNTEFRYLEDGGLE
CCCCCEEEECCCCCC		21.5521253578
361PhosphorylationLLTNVMLYWTTGTII
HHHHHHHHHHHCCHH		5.21-
3752-HydroxyisobutyrylationISSQRFYKENLGQGW
HHCHHHHHHHCCCCC		37.10-
386UbiquitinationGQGWMTQKHERMKVY
CCCCCCCCCCCEEEE		37.962190698
386AcetylationGQGWMTQKHERMKVY
CCCCCCCCCCCEEEE		37.9625825284
3862-HydroxyisobutyrylationGQGWMTQKHERMKVY
CCCCCCCCCCCEEEE		37.96-
393PhosphorylationKHERMKVYVPTGFSA
CCCCEEEEECCCCCC		8.66-
408PhosphorylationFPFELLHTPEKWVRF
CCHHHHCCCCCCEEC		32.86-
417PhosphorylationEKWVRFKYPKLISYS
CCCEECCCCCCEEEE		11.6821406692
422PhosphorylationFKYPKLISYSYMVRG
CCCCCCEEEEEEECC		20.6120068231
423PhosphorylationKYPKLISYSYMVRGG
CCCCCEEEEEEECCC		9.2320068231
424PhosphorylationYPKLISYSYMVRGGH
CCCCEEEEEEECCCC		10.4421406692
425PhosphorylationPKLISYSYMVRGGHF
CCCEEEEEEECCCCE		7.4420068231
447AcetylationLLAQDIRKFLSVLER
HHHHHHHHHHHHHHH		51.4927178108
450PhosphorylationQDIRKFLSVLERQ--
HHHHHHHHHHHHC--		27.9925072903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HYEP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HYEP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HYEP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ECHA_HUMANHADHAphysical
26344197
TMEDA_HUMANTMED10physical
26344197
TMX1_HUMANTMX1physical
26344197
RAB34_HUMANRAB34physical
28514442
MFSD8_HUMANMFSD8physical
28514442
Drug and Disease Associations
Kegg Disease
H00516 Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
OMIM Disease
0000269|PubMedNote=In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls. {ECO
607748
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HYEP_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory