| UniProt ID | RAB34_HUMAN | |
|---|---|---|
| UniProt AC | Q9BZG1 | |
| Protein Name | Ras-related protein Rab-34 | |
| Gene Name | RAB34 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 259 | |
| Subcellular Localization |
Cytoplasm . Golgi apparatus . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane Lipid-anchor Cytoplasmic side . Cell projection, cilium . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). |
|
| Protein Description | Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. [PubMed: 21255211 Plays a role in the fusion of phagosomes with lysosomes] | |
| Protein Sequence | MNILAPVRRDRVLAELPQCLRKEAALHGHKDFHPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGIPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLADALKENDPSSVLLFLVGSKKDLSTPAQYALMEKDALQVAQEMKAEYWAVSSLTGENVREFFFRVAALTFEANVLAELEKSGARRIGDVVRINSDDSNLYLTASKKKPTCCP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MNILAPVR -------CCCCCCCC | 6.76 | 22223895 | |
| 22 | Ubiquitination | ELPQCLRKEAALHGH HHHHHHHHHHHHCCC | 38.46 | - | |
| 30 | Ubiquitination | EAALHGHKDFHPRVT HHHHCCCCCCCCCCE | 67.68 | - | |
| 51 | Ubiquitination | RTGTVGFKISKVIVV CCCCCCEEEEEEEEE | 39.89 | - | |
| 62 | Phosphorylation | VIVVGDLSVGKTCLI EEEECCCCCCCCHHH | 33.30 | - | |
| 74 | Ubiquitination | CLINRFCKDTFDKNY HHHCHHCHHCCCCCC | 58.03 | - | |
| 76 | Phosphorylation | INRFCKDTFDKNYKA HCHHCHHCCCCCCCE | 21.16 | 29255136 | |
| 79 | Ubiquitination | FCKDTFDKNYKATIG HCHHCCCCCCCEEEE | 58.97 | - | |
| 81 | Phosphorylation | KDTFDKNYKATIGVD HHCCCCCCCEEEECE | 14.03 | 22817900 | |
| 108 | Phosphorylation | FSLQLWDTAGQERFK EEEEEECCCCHHHHH | 22.55 | 28857561 | |
| 146 | Ubiquitination | SLEHTKQWLADALKE CHHHHHHHHHHHHHH | 8.62 | 21890473 | |
| 157 | Phosphorylation | ALKENDPSSVLLFLV HHHHCCCCCEEEEEE | 35.62 | 20068231 | |
| 157 (in isoform 2) | Phosphorylation | - | 35.62 | 22210691 | |
| 158 | Phosphorylation | LKENDPSSVLLFLVG HHHCCCCCEEEEEEC | 23.36 | 20068231 | |
| 158 (in isoform 2) | Phosphorylation | - | 23.36 | 22210691 | |
| 164 (in isoform 2) | Phosphorylation | - | 6.79 | 22210691 | |
| 166 | Phosphorylation | VLLFLVGSKKDLSTP EEEEEECCCCCCCCH | 29.11 | 20068231 | |
| 167 | 2-Hydroxyisobutyrylation | LLFLVGSKKDLSTPA EEEEECCCCCCCCHH | 44.36 | - | |
| 168 (in isoform 1) | Ubiquitination | - | 66.65 | 21890473 | |
| 168 | Ubiquitination | LFLVGSKKDLSTPAQ EEEECCCCCCCCHHH | 66.65 | 2189047 | |
| 168 (in isoform 2) | Phosphorylation | - | 66.65 | 22210691 | |
| 181 | Ubiquitination | AQYALMEKDALQVAQ HHHHHHHHHHHHHHH | 34.04 | - | |
| 227 | Ubiquitination | NVLAELEKSGARRIG HHHHHHHHCCCCEEC | 67.81 | - | |
| 230 | Ubiquitination | AELEKSGARRIGDVV HHHHHCCCCEECCEE | 12.50 | 21890473 | |
| 241 | Phosphorylation | GDVVRINSDDSNLYL CCEEEECCCCCCEEE | 40.18 | 23401153 | |
| 244 | Phosphorylation | VRINSDDSNLYLTAS EEECCCCCCEEEEEC | 33.45 | 25159151 | |
| 244 (in isoform 2) | Ubiquitination | - | 33.45 | 21890473 | |
| 247 | Phosphorylation | NSDDSNLYLTASKKK CCCCCCEEEEECCCC | 13.27 | 21945579 | |
| 249 | Phosphorylation | DDSNLYLTASKKKPT CCCCEEEEECCCCCC | 18.48 | 21945579 | |
| 251 | Phosphorylation | SNLYLTASKKKPTCC CCEEEEECCCCCCCC | 39.51 | 21945579 | |
| 252 | Ubiquitination | NLYLTASKKKPTCCP CEEEEECCCCCCCCC | 63.45 | 21139048 | |
| 252 | 2-Hydroxyisobutyrylation | NLYLTASKKKPTCCP CEEEEECCCCCCCCC | 63.45 | - | |
| 252 (in isoform 1) | Ubiquitination | - | 63.45 | 21890473 | |
| 257 | Geranylgeranylation | ASKKKPTCCP----- ECCCCCCCCC----- | 4.39 | - | |
| 258 | Geranylgeranylation | SKKKPTCCP------ CCCCCCCCC------ | 5.02 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 247 | Y | Phosphorylation | Kinase | SRC | P12931 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAB34_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAB34_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GDS1_HUMAN | RAP1GDS1 | physical | 26186194 | |
| GDS1_HUMAN | RAP1GDS1 | physical | 28514442 | |
| SNX11_HUMAN | SNX11 | physical | 28514442 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, AND MASSSPECTROMETRY. | |
