SNX11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNX11_HUMAN
• UniProt AC: Q9Y5W9
• Protein Name: Sorting nexin-11
• Gene Name: SNX11
• Organism: Homo sapiens (Human).
• Sequence Length: 270
• Subcellular Localization: Membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome .
• Protein Description: Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes..
• Protein Sequence: MGFWCRMSENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQRNAGLVPVPELPGKSTFFGTSDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQLSVPEIEACVQGRSTMTVSDAILRYAMSNCGWAQEERQSSSHLAKGDQPKSCCFLPRSGRRSSPSPPPSEEKDHLEVWAPVVDSEVPSLESPTLPPLSSPLCCDFGRPKEGTSTLQSVRRAVGGDHAVPLDPGQLETVLEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGFWCRMSENQEQEE CCCEEECCCCCCCEE	17.65	25954137
18	Phosphorylation	QEQEEVITVRVQDPR CCCEEEEEEEECCCC	13.87	25954137
60	Phosphorylation	TSCVRRRYREFVWLR HHHHHHHHHHHHHHH	16.81	24275569
77	Ubiquitination	LQRNAGLVPVPELPG HHHHCCCCCCCCCCC	4.37	29967540
85	Ubiquitination	PVPELPGKSTFFGTS CCCCCCCCCCCCCCC	44.37	29967540
90	Ubiquitination	PGKSTFFGTSDEFIE CCCCCCCCCCHHHHH	21.81	23000965
98	Ubiquitination	TSDEFIEKRRQGLQH CCHHHHHHHHHHHHH	48.33	23000965
143	Phosphorylation	EACVQGRSTMTVSDA HHHHCCCCCCCHHHH	29.38	30108239
144	Phosphorylation	ACVQGRSTMTVSDAI HHHCCCCCCCHHHHH	18.59	28857561
145	Sulfoxidation	CVQGRSTMTVSDAIL HHCCCCCCCHHHHHH	3.52	21406390
146	Phosphorylation	VQGRSTMTVSDAILR HCCCCCCCHHHHHHH	19.56	30108239
168	Phosphorylation	WAQEERQSSSHLAKG CCHHHHHCCCCHHCC	39.78	26657352
169	Phosphorylation	AQEERQSSSHLAKGD CHHHHHCCCCHHCCC	17.28	30266825
170	Phosphorylation	QEERQSSSHLAKGDQ HHHHHCCCCHHCCCC	27.97	30266825
171	Ubiquitination	EERQSSSHLAKGDQP HHHHCCCCHHCCCCC	31.58	29967540
179	Ubiquitination	LAKGDQPKSCCFLPR HHCCCCCCCCEECCC	50.95	29967540
180	Phosphorylation	AKGDQPKSCCFLPRS HCCCCCCCCEECCCC	23.85	26074081
187	Phosphorylation	SCCFLPRSGRRSSPS CCEECCCCCCCCCCC	34.41	26074081
191	Phosphorylation	LPRSGRRSSPSPPPS CCCCCCCCCCCCCCC	45.28	29255136
192	Phosphorylation	PRSGRRSSPSPPPSE CCCCCCCCCCCCCCC	27.82	29255136
194	Phosphorylation	SGRRSSPSPPPSEEK CCCCCCCCCCCCCCC	52.57	29255136
198	Phosphorylation	SSPSPPPSEEKDHLE CCCCCCCCCCCCCEE	65.25	29255136
217	Phosphorylation	VVDSEVPSLESPTLP EECCCCCCCCCCCCC	50.36	28450419
220	Phosphorylation	SEVPSLESPTLPPLS CCCCCCCCCCCCCCC	28.60	28450419
222	Phosphorylation	VPSLESPTLPPLSSP CCCCCCCCCCCCCCC	62.26	28450419
227	Phosphorylation	SPTLPPLSSPLCCDF CCCCCCCCCCEECCC	35.37	28450419
228	Phosphorylation	PTLPPLSSPLCCDFG CCCCCCCCCEECCCC	29.58	28450419
230	Ubiquitination	LPPLSSPLCCDFGRP CCCCCCCEECCCCCC	4.98	29967540
238	Ubiquitination	CCDFGRPKEGTSTLQ ECCCCCCCCCCCHHH	68.37	29967540
241	Phosphorylation	FGRPKEGTSTLQSVR CCCCCCCCCHHHHHH	21.45	30266825
242	Phosphorylation	GRPKEGTSTLQSVRR CCCCCCCCHHHHHHH	37.67	30266825
243	Phosphorylation	RPKEGTSTLQSVRRA CCCCCCCHHHHHHHH	28.75	30266825
246	Phosphorylation	EGTSTLQSVRRAVGG CCCCHHHHHHHHHCC	22.24	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNX11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNX11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNX11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STK40_HUMAN	STK40	physical	26186194
NPHP3_HUMAN	NPHP3	physical	26186194
PML_HUMAN	PML	physical	26186194
AP3B1_HUMAN	AP3B1	physical	26186194
BMR1A_HUMAN	BMPR1A	physical	26186194
FGFR3_HUMAN	FGFR3	physical	26186194
CHK1_HUMAN	CHEK1	physical	26186194
ZG16B_HUMAN	ZG16B	physical	26186194
P5CR3_HUMAN	PYCRL	physical	26186194
DCA10_HUMAN	DCAF10	physical	26186194
ORC3_HUMAN	ORC3	physical	26186194
CTU1_HUMAN	CTU1	physical	26186194
MIC1_HUMAN	C18orf8	physical	26186194
PLCG1_HUMAN	PLCG1	physical	26186194
NPHP3_HUMAN	NPHP3	physical	28514442
ORC3_HUMAN	ORC3	physical	28514442
PML_HUMAN	PML	physical	28514442
FGFR3_HUMAN	FGFR3	physical	28514442
STK40_HUMAN	STK40	physical	28514442
DCA10_HUMAN	DCAF10	physical	28514442
BMR1A_HUMAN	BMPR1A	physical	28514442
CHK1_HUMAN	CHEK1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.